Journal: Drug Invention Today

Article Id: JPRS-PS-0000922
Title: Anxiolytic activity of ethanolic extract of leaves of Ocimum sanctum in rats
Category: Pharmacological Screening
Section: Research Article
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    Anxiety is a normal emotional behaviour. When it is severe and/or chronic, however, it becomes pathological and can precipitate or aggravate cardiovascular and psychiatric disorders. Although many drugs are available in allopathic medicine to treat anxiety disorders, they produce various systemic side effects or exhibit tolerance upon chronic use. Benzodiazepines (BZDs) are the major class of compounds used in anxiety and they remain the most commonly prescribed treatment for anxiety. However BZDs have many unwanted side effects that prompted many researchers to evaluate new compounds in the hope of identifying other anxiolytics with fewer side effects. In the present study, we have attempted to evaluate the anxiolytic-like activity of ethanolic extract of leaves of Ocimum sanctum(OS) in rats by employing the two pharmacologically validated models, elevated plus maze and bright and dark arena. The rats were divided into five groups, each group containing six animals. The effects of the test drug OS (at 1.75, 4.25 and 8.5 mg/kg doses), the standard anxiolytic, diazepam (1.0 mg/kg) and control group 1%gum acacia(10ml/kg) were assessed after single and repeated dose administration for ten days. The results suggest that, behavioural disinhibitory effects of OS exhibited anxiolytic like activity comparable to diazepam.

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    Author(s) Name:

    Sudhakar Pemminati, Swati B, Shreyasi C, Chandrasekhar R, GopalaKrishna HN*,Pai MRSM.

    Affiliation(s) Name:

    Department of Pharmacology, Kasturba Medical College, Manipal University, Mangalore-575 001 Karnataka, INDIA.

    *Corresponding author.
    Dr. Gopalakrishna H.N.,
    Associate Professor,
    Department of Pharmacology,
    Kasturba Medical College,
    Manipal University,
    Mangalore – 575 001.


    Received on: 20-11-2009; Revised on: 27-12- 2009; Accepted on:15-01-2010

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    Author:

    Sudhakar Pemminati, Swati B, Shreyasi C, Chandrasekhar R, GopalaKrishna HN*,Pai MRSM.

    Title:Anxiolytic activity of ethanolic extract of leaves of Ocimum sanctum in rats
    Journal:Drug Invention Today
    Vol(issue):2 (February)
    Year:2010
    Page No: (115-118)
  • Experimental Methods Keywords

    Methodology:Anxiolytic activity
    Research Materials:Ocimum sanctum

Keywords

Anxiolytic Ocimum sanctum Diazepam

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