Journal: Drug Invention Today

Article Id: JPRS-DFA-0000923
Title: Method development for spherical crystallization of glibenclamide and evaluation of micromeritic properties
Category: Drug or Formulation Analysis
Section: Research Article
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    Glibenclamide is an anti-diabetic drug with water insolubility and compressibility. The pure drug (Glibenclamide) was converted into spherical crystal agglomerates via the spherical crystallization technique using dichloromethane-water-chloroform solvent system. The various parameters optimized were type, amount and mode of addition of bridging liquid, temperature and agitation speed to get maximum amount of spherical crystals. These were characterized for micromeritic properties (particle size and shape, flow ability), pack ability (bulk density), wet ability (contact angle) and compressibility. It was revealed from the study that spherical agglomerates exhibited improved flow ability, wet ability and compaction behavior.

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    Author(s) Name:

    Vinay K. Mishra1, Sumeet Dwivedi 2*, Parivesh Sakalle3, Gunjan Jain3, Daksha Gupta3 and Divya Gupta3

    Affiliation(s) Name:

    1, Department of Pharm. Analysis, VMCP, Salem (636008), TN-India
    *2Department of Pharmacognosy, Chordia Institute of Pharmacy, Indore (452010), M.P.-India
    3Lakshmi Narain College of Pharmacy, Bhopal, M.P.-India

    *Corresponding author.
    Sumeet Dwivedi
    Department of Pharmacognosy, Chordia Institute of Pharmacy,
    Indore (452010), M.P.-India


    Received on: 19-11-2009; Revised on: 30-12- 2009; Accepted on:15-01-2010

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    Author:

    Vinay K. Mishra1, Sumeet Dwivedi 2*, Parivesh Sakalle3, Gunjan Jain3, Daksha Gupta3 and Divya Gupta3

    Title:Method development for spherical crystallization of glibenclamide and evaluation of micromeritic properties
    Journal:Drug Invention Today
    Vol(issue):2 (February)
    Year:2010
    Page No: (119-122)
  • Experimental Methods Keywords

    Methodology:Method development for spherical crystallization
    Research Materials:Glibenclamide

Keywords

Glibenclamide Crystallization Micromeritic properties

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