Journal: Drug Invention Today

Article Id: JPRS-BSN-0000925
Title: Effect of Different Biological Membranes on In Vitro Bioadhesion Property
Category: Biomaterials ( Synthetic and Natural )
Section: Research Article
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    The influence of biological membranes on in vitro bioadhesion property of Carbopol 934P (CP), Polyvinylpyrrolidone (PVP K90) and sodium carboxymethylcellulose (Cekol 10,000) was studied using a texture analyzer equipment. Polymer/biological membrane interaction was significantly influenced by the contact time used during the study. An increase in contact time also increased bioadhesion strength. An intermediate contact time of 180s was deemed to be the most suitable contact time. In addition, different polymers produced different values of bioadhesion strength. Moreover, polymer molecular weight is directly correlated with bioadhesion strength. Biological membrane, such as rabbit gastric mucosa, cow intestine, pig intestine or chicken pouch, is a less significant determinant in affecting the bioadhesion strength as compared to the type of polymer used. Chicken pouch, an easily available and uniform tissue, offers an attractive alternative to be employed as a model biological membrane in bioadhesion study.

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    Author(s) Name:

    Maswadeh M Hamzah*, Kanaan A Reem**, Aljarbou N Ahmad* and Al-Hanbali A Othman***

    Affiliation(s) Name:

    *Faculty of Pharmacy, Qassim University, P .O. Box 1162, Code No. 51431.Buraidah, Kingdom of Saudi Arabia.
    **Faculty of Pharmacy, Al-Zaytoonah Private University, P.O.Box 130, Code No.11733. Amman- Jordan.
    ***Faculty of Pharmacy and Medical Sciences, Al-Ahliyya Amman University, P.O.Box108, Code No. 19828. Amman-Jordan.

    *Corresponding author.
    Dr. Maswadeh Hamzah,
    Faculty of Pharmacy,
    Qassim University,
    P .O. Box 1162,
    Code No. 51431


    Received on: 20-11-2009; Revised on: 21-12- 2009; Accepted on:15-02-2010

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    Author:

    Maswadeh M Hamzah*, Kanaan A Reem**, Aljarbou N Ahmad* and Al-Hanbali A Othman***

    Title:Effect of Different Biological Membranes on In Vitro Bioadhesion Property
    Journal:Drug Invention Today
    Vol(issue):2 (February)
    Year:2010
    Page No: (155-159)
  • Experimental Methods Keywords

    Methodology:In Vitro Bioadhesion Property
    Research Materials:Polyvinylpyrrolidone

Keywords

Bioadhesion Carbopol Polyvinylpyrrolidone Chicken pouch Sodium carboxymethylcellulose.

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