Journal: Drug Invention Today

Article Id: JPRS-Qs-0000926
Title: QSAR analysis of structurally similar 1, 3, 4 - oxadiazoles as enzyme tyrosinase inhibitors.
Category: QSAR studies
Section: Research Article
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    A series of structurally similar 1, 3, 4-oxadiazoles with enzyme tyrosinase inhibitor activity have been subjected for QSAR analysis using V life MDS 3.5 software. The compounds were divided into training and test set. Best QSAR models were selected on the basis of various statistical parameters like square correlation coefficient (r2), cross validated square correlation coefficient (q2), standard error of estimation (SE) and sequential Fischer test (F). 2D QSAR study reveals that tyrosinase inhibitor activity is governed by Alignment Independent (AI) descriptors whereas as per 3D QSAR studies a new compounds, with more electronegative and less bulky substituent, from this series could have better tyrosinase inhibitor activity.

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    Author(s) Name:

    Ramesh Sawant*, Prashant Lanke, Ganesh Jadhav, Lokesh Bhangale

    Affiliation(s) Name:

    PDVVPF’s College of Pharmacy, Post - MIDC, Vilad Ghat, Ahmednagar 414111, (MS), India.

    *Corresponding author.
    Dr. Ramesh Sawant
    PDVVPF’S College of pharmacy,
    Post MIDC, Vilad Ghat,
    Ahmednagar 414111, (MS), India.


    Received on: 20-11-2009; Revised on: 21-12- 2009; Accepted on:15-02-2010

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    Author:

    Ramesh Sawant*, Prashant Lanke, Ganesh Jadhav, Lokesh Bhangale

    Title:QSAR analysis of structurally similar 1, 3, 4 - oxadiazoles as enzyme tyrosinase inhibitors.
    Journal:Drug Invention Today
    Vol(issue):2 (February)
    Year:2010
    Page No: (169-172)
  • Experimental Methods Keywords

    Methodology:2D, 3D-QSAR
    Research Materials:1, 3, 4-oxadiazoles

Keywords

2D 3D-QSAR 1 3 4-oxadiazoles tyrosinase inhibitors.

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