Journal: Drug Invention Today

Article Id: JPRS-D(DD)-0000938
Title: Formulation and evaluation of matrix tablets of acarbose
Category: Drug (Discovery/Development)
Section: Research Article
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    Monolithic matrix tablet of Acarbose were formulated as controlled release tablets employing Hydroxypropyl methylcellulose and Eudragit in different concentration and combination, and sustained release behavior of the fabricated tablets were investigated. controlled released matrix tablets containing 350 mg Acarbose were developed using different drug : polymers combination. Tablet prepared by direct compression method were subjected to physical characterization. Formulation was optimized on the basis of acceptable properties and in-vitro drug release.In-vitro drug release was carried out using USP Type II at 50 rpm in 900 ml of acidic dissolution medium (pH 1.2) for 1hr, followed by 900 ml alkaline dissolution medium (pH 7.4) upto 12 hr. Standard curve and withdrawal samples were analyzed in UV-Vis spectrophotometery 625nm with alkaline potassium permagnate as coloring agent. formulations F1, F2, F3 wherein hydroxypropyl methylcellulose K 100 M was employed, it was found that increasing the concentration of the polymer resulted in linearization of drug release curve and formulation F3 gave satisfactory drug release pattern. Formulations F4, F5, F6 containing Eudragit S-100 showed quite non-linearity in drug release. The drug release rate was strongly influenced by the type of polymer and concentration of polymer. To analyze the release mechanism zero order, Higuchi model and Kosmeyer -Peppa’s model were used. The use of simplified methodology is demonstrated to evolve unified mathematical model.

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    Author(s) Name:

    Ganesh Kumar 1*,V.Juyal2, P.P.Badoni3.

    Affiliation(s) Name:

    1 Department of Pharmacy, S.G.R.R.I.T.S. Patelnagar, Dehradun -248001, India
    2 Department of Pharmaceutical Sciences, Kumaon University, Bheemtal, (UA)
    3 Department of Chemistry, H.N.B. Garhwal University, Pauri Campus (UA)

    *Corresponding author.
    Ganesh Kumar Bhatt
    Sr. Lecturer, Department of Pharmacy,
    S.G.R.R.I.T.S. Patel nagar, Dehradun
    Uttrakhand, India Pin- 248001


    Received on: 18-01-2010; Revised on: 16-03- 2010; Accepted on:12-04-2010

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    Author:

    Ganesh Kumar 1*,V.Juyal2, P.P.Badoni3.

    Title:Formulation and evaluation of matrix tablets of acarbose
    Journal:Drug Invention Today
    Vol(issue):2 (May)
    Year:2010
    Page No: (264-267)
  • Experimental Methods Keywords

    Methodology:Formulation and evaluation
    Research Materials:acarbose

Keywords

Matrix tablet Acarbose Hydroxypropyl methylcellulose K 100 M Eudragit S-100.

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