Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000975
Title: Formulation and evaluation of Bisoprolol fumarate transdermal patches
Category: Pharmaceutics
Section: Research Article
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    The aim of the present work is to investigate the formulation of bisoprolol fumarate transdermal patches for controlled release medication in order to treat the blood pressure and cardiac diseases. Studies disclosed that Bisoprolol is more effective than Propanolol, Atenolol and Metoprolol. In the present study we have developed the bisoprolol transdermal patches by using Poly vinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) using glycerin as plasticizer. After optimizing the polymer ratio the best patches were selected based on the physical evaluation. Then physical evaluation and in vitro studies were performed by using Franz diffusion cell employing porcine ear skin as the membrane. From the above results F2 formulation was found to have good controlled release over the formulation F1. Further in order to find the effect of plasticizer in the drug release for the F2 formulation, glycerin was replaced with Tri ethyl citrate (TEC). Thus the prepared film shows good release of about 98.3% with TEC as plasticizer.

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    Author(s) Name:

    Panati Dinakar*1, C Varalakshmi1, P K Prakash Reddy2, S Mohanlakshmi3

    Affiliation(s) Name:

    1Department of chemistry, SAS, VIT University, Vellore-632014, Tamilnadu, India.
    2Faculty of Pharmacy, Derna, Omar Al-Mukhtar University, Al-Baida, Libya.
    3Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupathi-517102, A.P. India.

    *Corresponding author.
    Mr.P.Dinakar,
    Department of chemistry,
    SAS, VIT University, Vellore-632014, Tamilnadu, India.


    Received on: 15-04-2010; Revised on: 12-05-2010; Accepted on:13-06-2010

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    Author:

    Panati Dinakar*1, C Varalakshmi1, P K Prakash Reddy2, S Mohanlakshmi3

    Title:Formulation and evaluation of Bisoprolol fumarate transdermal patches
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (August)
    Year:2010
    Page No: (1955-1957)
  • Experimental Methods Keywords

    Methodology:Formulation and evaluation
    Research Materials:Bisoprolol fumarate

Keywords

Bisoprolol PVP Glycerol and TEC

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