Journal: Journal of Pharmacy Research

Article Id: JPRS-QA-0000978
Title: Simultaneous Estimation of Etoricoxib and Paracetamol in the Synthetic Mixtures and Pharmaceutical Dosage Forms by Derivative Spectrophotometry
Category: Quality Assurance
Section: Research Article
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    A derivative spectrophotometric procedure has been established for the simultaneous determination of etoricoxib and paracetamol in combined synthetic mixtures and pharmaceutical formulations. The method consists of the utilization of second derivative absorption spectra of synthetic mixture in sodium hydroxide solution (0.1N) and determining zero crossing point (null point) of analyte concentration in mixture by second derivative method. The concept of zero crossing point was also utilized to estimate the amounts of etoricoxib at 294.0nm and paracetamol at 263.0nm in the bulk powder mixtures and pharmaceutical formulations. The linearity of etoricoxib and paracetamol were in range of 1-4 µg/ml and 5-20 µg/ml respectively. Percentage recoveries obtained for both drugs were 98.50-100.38% and 98.64-101.00% for etoricoxib and paracetamol respectively. The results were found to be precise and free from interferences.

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    Author(s) Name:

    Patel H.M1, Suhagia B.N1., Shah S.A2, Marolia B.P.2*, Bodiwala K.B. 2, prajapati P.B.

    Affiliation(s) Name:

    1Department of Quality Assurance, L. M. College of Pharmacy, Ahmedabad-380009, India
    2Department of Quality Assurance,Maliba Pharmacy College,Gopal vidya nagar,Tarsadi, To- Mahuva, Dist- Surat-394350, India

    *Corresponding author.
    Marolia B.P.
    Department of Quality Assurance,
    Maliba Pharmacy College,
    Tarsadi, Surat 394350


    Received on: 15-05-2010; Revised on: 12-06-2010; Accepted on:13-07-2010

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    Author:

    Patel H.M1, Suhagia B.N1., Shah S.A2, Marolia B.P.2*, Bodiwala K.B. 2, prajapati P.B.

    Title:Simultaneous Estimation of Etoricoxib and Paracetamol in the Synthetic Mixtures and Pharmaceutical Dosage Forms by Derivative Spectrophotometry
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (August)
    Year:2010
    Page No: (1967-1970)
  • Experimental Methods Keywords

    Methodology:Simultaneous Estimation,Derivative Spectrophotometry,
    Research Materials:Etoricoxib, Paracetamol, Synthetic mixture

Keywords

Derivative Spectrophotometry Etoricoxib Paracetamol Synthetic mixture.

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