Journal: Journal of Pharmacy Research

Article Id: JPRS-QA-0000985
Title: Development and Validation of Extractive spectrophotometric method for determination of Rosuvastatin calcium in pharmaceutical dosage forms
Category: Quality Assurance
Section: Research Article
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  • Abstract

    A sensitive and rapid extractive spectrophotometric method has been developed for the assay of Rosuvastatin calcium ( RSVC) in pharmaceutical formulations. The method is based on the formation of a chloroform soluble ion-pair complex between Rosuvastatin and Safranin ( SFN ) in phosphate buffer medium at pH 7.2. The complex shows absorption maximum at 518 nm and it obeys Beer’s law in the concentration range of 5-25 µg/ml. The average recovery of Rosuvastatin calcium was found to be 100.94 %. The %CV for repeatability of measurement for Rosuvastatin calcium was found to be 1.956. The intra and inter day precision in term of %CV was found to be 0.481-3.866 % and 1.481-4.139 % respectively. Limit of detection and Limit of quantification for Rosuvastatin calcium were found to be 1.5µg/ml and 2.5µg/ml respectively. A market formulation of Rosuvastatin calcium was analyzed with the proposed method. The results obtained are in good agreement with the labeled amount of Rosuvastatin calcium (98.67-103.33 %) in various dosage forms.

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  • About the authors and Affiliations

    Author(s) Name:

    prajapati p.b.1*,Bodiwala K.B.1 ,Marolia B.P.1, Rathod I.S.2,Shah S.A1

    Affiliation(s) Name:

    *1Department of Quality Assurance,Maliba Pharmacy College,Gopal vidya nagar,Tarsadi, To- Mahuva, Dist- Surat-394350, India
    2Department of Quality Assurance, L. M. College of Pharmacy, Ahmedabad-380009, India

    *Corresponding author.
    Mr.P.B.Prajapati
    Department of Quality Assurance,
    Maliba Pharmacy College,
    Gopal vidya nagar,
    Tarsadi, To- Mahuva, Dist- Surat-394350, India


    Received on: 19-05-2010; Revised on: 26-06-2010; Accepted on:25-07-2010

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    Author:

    prajapati p.b.1*,Bodiwala K.B.1 ,Marolia B.P.1, Rathod I.S.2,Shah S.A1
    Title:Development and Validation of Extractive spectrophotometric method for determination of Rosuvastatin calcium in pharmaceutical dosage forms
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (August)
    Year:2010
    Page No: (2036-2038)

  • Experimental Methods Keywords

    Methodology:Development and Validation of Extractive spectrophotometric method
    Research Materials:Rosuvastatin calcium

Keywords

Rosuvastatin calcium 518 nm chloroform soluble ion-pair complex phosphate buffer

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