Journal: Journal of Pharmacy Research

Article Id: JPRS-PA-0000995
Title: Estimation of Tizanidine HCl by UV-Spectrophotometric Method
Category: Pharmaceutical Analysis
Section: Research Article
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    A simple and sensitive spectrophotometric method has been developed for the determination of Tizanidine HCl. The method developed was the absorptivity value E (1%, 1cm) uv-spectrophotometric method. The 0.1N diluted solution of Tizanidine HCl was prepared so as to get concentration of 10.0 µg/mL, the solution obtained was scanned to get a spectrum shows four maxima at 240.0nm, 309.5nm, 318.5nm and 373.5nm. Tizanidine HCl obeys Beer Labert’s law over the range of 1-100 µg/mL for 309.5nm, 318.5nm and 373.5nm and 0-25 µg/mL for 240.0nm. Results along with statistical data are indicative of accuracy and precision of the proposed method at 240.0nm, 309.5nm and 318.5nm. However estimation of 373.5nm is on higher side with less precision. The recovery of the drug from tablet is also about 100% indicating complete extraction and estimation of Tizanidine HCl from matrix tablet.

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    Author(s) Name:

    D.Chakravarty, R. M. Charde, M. S. Charde*, M. R. Tajne

    Affiliation(s) Name:

    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji,Maharaj Nagpur University, Nagpur 440033, India

    *Corresponding author.
    Dr. M.S. Charde
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji,Maharaj Nagpur University, Nagpur 440033, India


    Received on: 15-04-2010; Revised on: 18-05-2010; Accepted on:13-07-2010

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    Author:

    D.Chakravarty, R. M. Charde, M. S. Charde*, M. R. Tajne

    Title:Estimation of Tizanidine HCl by UV-Spectrophotometric Method
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (September)
    Year:2010
    Page No: (2107-2109)
  • Experimental Methods Keywords

    Methodology:UV-spectrophotometer
    Research Materials: Tizanidine HCl

Keywords

UV-spectrophotometer Tizanidine HCl Validation

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