Journal: Journal of Pharmacy Research

Article Id: JPRS-PB-0000999
Title: Chrysoeriol a bioactive flavonoid, in Cardiospermum halicacabum L. leaves and their free radical scavenging activities
Category: Pharmaceutical Biotechnology
Section: Research Article
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    Objective: The aim of the present study was to evaluate the free radical scavenging activity of the compound Chrysoeriol (CS).Methods: Free radical scavenging was determined by using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2’-azinobis 3 ethylbenzthiazoline-6-sulphonic acid (ABTS), ferric reducing antioxidant power (FRAP), nitric oxide scavenging assay (NO), reducing power, hydroxyl, superoxide radical scavenging and hydrogen peroxide radical assay, metal chelating activity, phosphomolybdneum, ferric thiocyanate (FTC) and also peroxynitrite scavenging assay.Results: Free radical scavenging potentiality of DPPH (37.62 µg/ml), ABTS (35.31 µg/ml), FRAP (34.79 µg/ml), NO (36.28 µg/ml), reducing power (40.09 µg/ml), hydroxyl (36.56 µg/ml), superoxide (40.48 µg/ml), and hydrogen peroxide (38.02 µg/ml), metal chelating (35.96 µg/ml), phosphomolybdneum (36.90 µg/ml), FTC (34.96 µg/ml), and also peroxynitrite (37.49 µg/ml) for the CS and compared to standard drug BHT (32.74 µg/ml) respectively.Conclusion: The present investigation clearly indicated that the CS possesses antioxidant properties and serve as free radical inhibitors or scavengers, acting possibly as primary antioxidants.

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    Author(s) Name:

    Krishnan Baskaran, Kodukkur Viswanathan Pugalendi and Ramalingam Saravanan*

    Affiliation(s) Name:

    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India.

    *Corresponding author.
    Dr. R. Saravanan,
    Assistant Professor
    Department of Biochemistry and Biotechnology,
    Annamalai University, Annamalainagar–608 002,
    Tamilnadu, India

    Received on:12-05-2015; Revised on: 20-06-2015; Accepted on: 23-07-2015

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    Author:

    Krishnan Baskaran, Kodukkur Viswanathan Pugalendi and Ramalingam Saravanan*

    Title:Chrysoeriol a bioactive flavonoid, in Cardiospermum halicacabum L. leaves and their free radical scavenging activities
    Journal:Journal of Pharmacy Research
    Vol(issue):9 (July)
    Year:2015
    Page No: (419-427)
  • Experimental Methods Keywords

    Methodology:free radical scavenging activities, Antioxidant Activity
    Research Materials:Cardiospermum halicacabum L. leaves

Keywords

Chrysoeriol; Free radical scavenging; Antioxidant.

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