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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
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Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PCS-00001
Title: Insitu Mucoadhesive Nasal Gels of Metoclopramide Hydrochloride : Preformulation and Formulation Studies
Category: Pharmaceutics
Section: Research Article
Country: India
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The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranasal drug delivery. The objective of the present investigation was to develop a mucoadhesive in situ gel with reduced nasal mucocilliary clearance in order to improve the bioavailability of the antiemetic drug, metoclopramide hydrochloride. The in situ gelation upon contact with nasal mucosa was conferred via the use of the thermogelling Pluronic flake 127 whereas mucoadhesion and drug release enhancement were modulated via the use of sodium alginate and polyethylene glycol polymers respectively. The results revealed that the mucoadhesive polymer increased the gel viscosity but reduced its sol gel transition temperatures and the drug release. The inclusion of polyethylene glycol polymer counteracted the effect of mucoadhesive polymer where by it decreased the gel consistency and increased the sol gel transition as well as in vitro drug diffusion. The in vitro tests performed for mucoadhesive strength and drug diffusion showed that nasal in situ gelling formulations prepared are having good mucoadhesive strength with nearly100% drug diffusion within 4 hours. So this study points to the potential of mucoadhesive in situ nasal gel in terms of ease of administration, accuracy of dosing, prolonged nasal residence and improved nasal bioavailability.

[Cite this article as : Jitendra V. Shinde*1 ,Kailas K. Mali1 ,Remeth J. Dias 1 ,Vijay D. Havaldar 1 and Niranjan S.Mahajan 1, Insitu Mucoadhesive Nasal Gels of Metoclopramide Hydrochloride : Preformulation and Formulation Studies,Journal of Pharmacy Research, Vol.1.Issue 1. July-September, 2008,88-96] 

Key words: Nasal, Pluronic F 127, Mucoadhesive, PEG 6000.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PC-00002
Title: Use of Canna indica Flower Extract As A Natural Indicator In Acid Base Titration
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Canna indica is a species of the Canna genus, belonging to the family Cannaceae. The present work highlights the use of Canna indica flower extract as an acid base indicator in different types of acid base titrations. The equivalence points obtained by the flower extract coincide with the equivalence points obtained by standard indicators. In case of weak acid and weak base titration, the results obtained by the flower extract matched with the results obtained by mixed indicator. This natural indicator is found to be a very useful, economical, simple and accurate for the said titrations.

Cite this article as : Mahajan Niranjan Shishir* 1 , Jadhav Rahul Laxman1 , Pimpodkar Nayana Vinayak1 , Dias Remeth Jacky1 , and Karande Prashant Pradip1 ,Use of Canna indica Flower Extract As A Natural Indicator In Acid Base Titration,Journal of Pharmacy Research, Vol.1.Issue 1. July-September 2008,84-87.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PHDRS-00003
Title: Effect of Ziziphus mauritiana Leaf Extracts on Phagocytosis by Human Neutrophils
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The objective of the present investigation was to study immunomodulatory activity of alcohol, chloroform and aqueous extract of leaves of Ziziphus mauritiana using different invitro methods such as neutrophil locomotion and Nitro Blue Tetrazolium test using human neutrophils. This preliminary study reveals that Ziziphus mauritiana extract has stimulated phagocytic and intracellular killing potency of human neutrophils at different concentration. Thus from the results obtained it can be observed that the alcohol and aqueous extract of Ziziphus mauritiana leaves stimulates cell-mediated immune system by increasing neutrophil function and phagocytic activity.

 

Cite this article as:Wadekar R.R1*, Patil K S, Effect of Ziziphus mauritiana Leaf Extracts on Phagocytosis by Human Neutrophils, Journal of Pharmacy Research ,Vol.1.Issue 1. July-September 2008,79-83.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PCS-00007
Title: Optimization and In Vitro Evaluation of Floating Tablets of Atenolol
Category: Pharmaceutics
Section: Research Article
Country: India
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The main aim of this study was to optimize and evaluate the floating tablets of atenolol that prolongs the gastric residence time. Semisynthetic polymers, HPMC K4M, HPMC K100M and natural polymer, Xanthan gum were used as release retarding agents. Sodium bicarbonate was used as a gas-generating agent. Dicalcium phosphate was  used as a channeling agent. The floating matrix tablets of Atenolol were prepared by direct compression method. The  concentration of polymers and a gas-generating agent was optimized to get the controlled release of atenolol for 8h. The prepared tablets were evaluated for physicochemical parameters and found to be within range. A significant difference in drug release at 0.5, 1, 4 and 8 h (p < 0.0001) was observed. The floating lag time of all the formulations was within the prescribed limit (< 10 min.) Release pattern of Atenolol was fitted to different models based on coefficient of correlation (R). All the formulations showed good matrix integrity. All the formulations retarded the release of drug for 8 h. Based on the diffusion exponent (n) value, drug release was found to be diffusion controlled. The swelling studies of all the formulations showed that formulations containing Xanthan gum has higher swelling indices than HPMC K100M and HPMC K4M. Further it was observed that the formulations, which are having higher swelling indices, retarded the release of drugs than those having low swelling indices.

Cite this article as : Vijay Daulatrao Havaldar, Ajit Shankarrao Kulkarni , Remeth Jacky Dias, Kailas Krishnat Mali.,Optimization and In Vitro Evaluation of Floating Tablets of Atenolol, Journal of Pharmacy Research, Vol.1.Issue 1. July-September 2008,73-78

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PHDRS-00008
Title: In vitro Antioxidant Activity from Leaves of Oroxylum indicum (L.) Vent. -A North Indian Highly Threatened and Vulnerable Medicinal Plant
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Free radical scavenging potential of the different extracts of leaves of Oroxylum indicum (L.) Vent. (Bignoniaceae), one of the widely used medicinal plant, was evaluated in vitro by using diphenyl-picryl-hydrazyl (DPPH) assay. In this method the antioxidants present in the plant extracts reacted with DPPH, which is a stable  free radical and converted it to 1,1-diphenyl-1,2-picryl, hydrazine. The scavenging effect of plant extracts and standard (L-ascorbic acid) on the DPPH radical decreases in the following order: L-ascorbic acid > Ethyl acetate (I) >Methanol (II) > Water (III) and it was found to be 97.4%, 61.4%, 40.8% and 29.2% at concentration of 100 mg/mL, respectively. The results were expressed as IC50. Ascorbic acid which was used as a standard showed an IC50 of 24.0 mg/mL, whereas, the crude ethyl acetate (I), methanolic (II) and water (III) extracts of leaves of O. indicum showed antioxidant activity with IC50 values of 49.0, 55.0 and 42.5 respectively at 100 mg/mL concentration. None of the extracts were found to be more active than the standard i.e. ascorbic acid. But still, free radical scavenging activity of water (III) and ethyl acetate (I) extracts of leaves of O. indicum (L.) was confirmed in the present investigation. In the present study, different extracts of O. indicum leaves showed concentration dependent free radical scavenging  activity. Significant results were recorded first time in the given estimated parameters from different extracts of leaves of O. indicum, a North Indian highly threatened and vulnerable medicinal plant.

Cite this article as: In vitro Antioxidant Activity from Leaves of Oroxylum indicum (L.) Vent. -A North Indian Highly Threatened and Vulnerable Medicinal Plant,Raghbir C. Gupta1 *, Vivek Sharma1 , Nisha Sharma1 , Neeraj Kumar2 , Bikram Singh2, Journal of Pharmacy Research, Vol.1.Issue 1. July-September 2008,65-72.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-P'Col-00009
Title: Antihyperlipidemic Activity of Premna corymbosa (Burm.f.) Rottl. & Willd. in liver Damaged Wistar Albino Rats
Category: Pharmacology
Section: Research Article
Country: India
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The Premna corymbosa is a common plant, it is used in various ayurvedic preparations. The aim of the  present study is to evaluate the antihyperlipidemic activity of Premna corymbosa leaves in CCl4 induced hepatic  damaged rats.Liver was damaged in wistar rats of both sex by intraperitoneal injection of CCl4 in the concentration of 1 ml/kg body weight for every 72 h. The ethanolic extract of Premna corymbosa leaves were administrated at the  doses of 200 & 400 mg/kg body weight, p.o., daily for 14 days. The Antihyperlipidemic effect of the ethanolic extract  was assessed by the assay of the biochemical parameters like serum triglycerides (STG), serum total cholesterol  (STC) and Very low density lipoprotein cholesterol (VLDL-c).The ethanolic extract, significantly (p<0.01) restored the levels of biochemical parameters as compared to normal. The results obtained shows that the ethanolic extract of  Premna corymbosa has antihyperlipidemic property.

Cite this article as: Karthikeyan.M*1 , Deepa .M.K2,Antihyperlipidemic Activity of Premna corymbosa (Burm.f.) Rottl. & Willd. In liver Damaged Wistar Albino Rats 63 Journal of Pharmacy Research Vol.1.Issue 1. July-September 2008 61-64.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PHDRS-000010
Title: Antiinflammatory Activity of Methanolic Extract of Chlorophytum borivilianum
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The aim of the present study was to evaluate the anti-inflammatory activity of methanolic extracts of leaves and roots of Chlorophytum borivilianum in rats. The anti-inflammatory activity was evaluated by using Digital plethysmometer. The study was carried out using dose of 200 mg/kg orally. Both the methanolic extracts (leaves and roots) produced statistically significant and dose dependent inhibition of edema induced by carrageenan at all doses when compared to the control groups. The percentage inhibition was also noted for both the methanolic extract. Both the extracts did't exhibit toxicity in mice when injected intraperitoneally up to the concentration of 2 g/kg.

Cite this article as: Guno Sindhu Chakraborthy1*, Rasheeduz Zafar2 , Vidhu Aeri2, Antiinflammatory Activity of Methanolic Extract of Chlorophytum borivilianum, Journal of Pharmacy Research Vol.1. Issue 1. July-September 2008,58-60.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PHDRS-000011
Title: Antibacterial activity of Amchur (Dried Pulp of Unripe Mangifera indica) extracts on some food borne bacteria
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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To assess the antimicrobial activities of amchur extract on some food borne bacteria under in-vitro conditions and to determine the MIC (minimum inhibitory concentration) of the herbal extract against the test bacteria.The antibacterial  activity of amchur (dried pulp of unripe Mangifera indica) extract (50% ethanol) was tested against ten bacterial strains (7 Gram-positive and 3 Gram-negative), mostly belongs to foodborne pathogens, by agar well diffusion method. The crude extract showed a broad spectrum of antibacterial activity be inhibiting both the groups of bacteria. Minimal inhibitory concentration of the spice against each test organism was also studied by observing their growth on Mueller Hinton Agar containing the spice extract at various incremental levels, equivalent to 62.5-500mg/mL of spice. The extract was most effective against Staphylococcus aureus (26.0mm). Bacillus mycoides was found to be the most sensitive, survived only up to 62.5mg/mL concentration of the spice, followed by Staphylococcus aureus and Pseudomonas aeruginosa (125mg/mL), whereas Micrococcus luteus was found to be the most resistant organism which survived up to 500mg/mL. The chief significance of the above study was to search for the alternatives to chemical preservatives used in various food industries so as to minimize their side effects and simultaneously improving the shelf life of the food products. This study shows the potential to replace the synthetic  preservatives by the use of natural extracts of amchur in various suitable food products.

Cite this article as:Charu Gupta*1 , Amar P. Garg1 , and Ramesh C Uniyal2, Antibacterial activity of Amchur (Dried Pulp of Unripe Mangifera indica) extracts on some food borne bacteria, Journal of Pharmacy Research ,Vol.1.Issue 1. July-September 2008, 54-57.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PHDRS-000012
Title: Pharmacognostic Studies on Actinodaphne hookeri Meissn leaves.
Category: Pharmacognosy and Herbal Drugs related study
Section: Editorial
Country: India
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Leaves of Actinodaphne hookeri Meissn (Family, Lauraceae) is commonly known as Pisa and traditionally used in the treatment of diabetes and urinary disorders. The fresh leaf was studied for pharmaconostic evaluations, including examination of morphological and microscopic characters, determination of leaf constants, ash values and extractive values. The morphological studies revealed that the leaf is dark green color with characteristic odour and bitter taste, shape accuminate- lanceolate, margin-entire, symmetrical base, and length varying from 7.5 inches to 2.3 inches width. Dorsal side is smooth shining and ventral surface is pubescent and hirsute.In the microscopic studies, the leaves showed the presence of trichomes, collenchyma, vascular bundles, spongy parenchyma, hypodermis, palisade  cells and anisocytic stomata. The total ash, acid insoluble ash, water-soluble ash values and sulfated ash were observed to be 3.6%, 2.6%, 2.3% and 6.24% respectively. Alcohol soluble and water-soluble extractive values of the leaves were observed to be 18% and 19% respectively. The leaves were extracted with ethanol and successively extracted with  Petroleum ether, chloroform, methanol and water in increasing order of polarity. Preliminary phytochemical investigation showed the presence of alkaloids, glycosides, tannins, triterpenoids, carbohydrates and flavonoids.

Cite this article as: Dharmeshkumar. D. Prajapati 1*, N.M.Patel 1 , S.S.Patel1 , M.S.Patel1 R.V. Savadi 2, K.S.Akki2 , K. Mruthunjaya3, Pharmacognostic Studies on Actinodaphne hookeri Meissn leaves, Journal of Pharmacy Research Vol.1.Issue 1. July-September 2008,48-54.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PHDRS-000013
Title: Preliminary Pharmacognostical And Phytochemical Investigation On Feronia elephantum Corr. Fruit
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The fruit pulp of Feronia elephantum corr. was collected and powdered. Methanolic extract was prepared by using soxhlet apparatus and subsequently fractioned with different solvents for detailed chemical analysis. Fluorescence characters of different successive extract and powder were noted under ultra violet light and under normal ordinary light, which signifies their characteristics. The total ash value, acid insoluble ash value and water soluble ash value were 8.56, 0.90 and 4.8 % respectively. The percentage yield for pet. ether, solvent ether, ethyl acetate, n-butanol, chloroform and ethanol were 0.24, 0.52, 1.45, 5.22, 0.89 and 15.7 % respectively. Reaction behaviors of fruit pulp with seven different reagents were also noted, which revealed characteristic development of particular color. Preliminary qualitative chemical tests of extracts were found positive for Phytosterol, flavonoids and triterpenoids in Pet. ether and solvent ether. Ethyl acetate fraction showed positive results for flavanoids and tannin only. n-butanol fraction showed positive reaction to carbohydrate, tannin and amino acid, whereas, Ethanol fraction was positive to carbohydrate, tannin and amino acid and vitamin C. Chloroform fraction did not showed any reaction. Flavonoids and triterpenoids are the active constituents in fruit pulp of Feronia elephantum corr. and may be responsible for its pharmacological activities.

Cite this article as: Kanhiya Mahour1*, Anurag Mishra1 , Ashok Kumar1 and V. S.Vihan1, Preliminary Pharmacognostical And Phytochemical Investigation On Feronia elephantum Corr. Fruit, Journal of Pharmacy Research Vol.1.Issue 1. July-September 2008,44-47.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PHDRS-000014
Title: Pharmacognostic Study Of Plant Euphorbia hirta L
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Euphorbia hirta L (Family: - Euphorbiaceae) is a folklore medicine of India used as antiasthmatic, anthelmetic, wound healing, antibacterial, antioxidant and diuretics. Powdered leaves of Euphorbia hirta linn were subjected to successive soxhelate extraction with petroleum ether (60-800C), chloroform, acetone (70%) and finally macerated with water so as to get respective extracts. Also cold maceration was done using water & Ethanol (70%). The extracts were screened for its physicochemical characteristics, preliminary phytochemical study of extracts and quantitative estimation of total phenolic and flavonoid content. The pharmacognostic study reveals that the plant Euphorbia hirta L contain phenolic and flavonoid constituents.

Cite this article as: Giram Ganesh Bhagwat1* ,Chaulang Ganesh Mahadev1 ,Ghodke Dhananjay Sahebrao1 , Patil Kundan Suresh1 ,Yeole Pramod Govindrao1 ,Ganjiwale Rajendra Onkar1, Pharmacognostic Study Of Plant Euphorbia hirta L, Journal of Pharmacy Research, Vol.1.Issue 1. July-September 2008,39-43.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PHDRS-000015
Title: Annona squamosa L.:Phytochemical analysis and Antimicrobial Screening
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Four different solvent extracts of leaves of Custard apple (Annona squamosa L.) were studied for its antibacterial activity. Agar diffusion method was selected to check antibacterial activity, whereas phytochemical analysis was done by HPTLC instrument of Camag system. Two Gram positive (Staphylococcus aureus and Bacillus subtilis) and two Gram negative (Escherichia coli and Pseudomonas aeruginosa) bacteria were selected for screening. The screening results showed that highest zone of inhibition was observed in methanol extract against Ps. aeruginosa (MIC: 130μg/ml) followed by petroleum ether extract against Ps. aeruginosa (MIC: 165 μg/ml) and methanol extract against E. coli (MIC: 180 μg/ml). The present study demonstrates the presence of some phytochemicals (Linalool, Borneol, Eugenol, Farnesol, and Geraniol) in extracts which provide antibacterial activity.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PHDRS-000016
Title: Antidiabetic And Antihyperlipidaemic Effect of Alcoholic extract of Chlorophytum borivilianum Roots in Alloxan Induced Diabetic Albino Rats.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Chlorophytum borivilianum, commonly known as ‘safed musli’, is widely used in different parts of India for the treatment of diabetes mellitus. The present study was designed to evaluate the antidiabetic and antihyperlipidaemic effect of alcoholic extract of Chlorophytum borivilianum root (CREt) in alloxan induced diabetic rats. Diabetes was induced by single intraperitoneal injection of alloxan (150 mg/kg of body weight). Oral administration of alcoholic CREt to diabetic rats, at a dose of 100 mg/kg body weight, resulted in a significant reduction in blood glucose, urine sugar and serum lipids in alloxan diabetic rats. The extract also increases the total haemoglobin lever. The extract effect was similar to that of insulin. Thus, the investigation clearly shows that alcoholic CREt has both antidiabetic and antihyperlipidaemic effects.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PCS-000017
Title: Effect of Different Viscosity Grades of HPMC on Drug Release Profile
Category: Pharmaceutics
Section: Research Article
Country: India
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In this study, different grades of hydroxyl propyl methyl cellulose (HPMC) were used to develop floating microspheres of Cefpodoxime Proxetil in order to demonstrate the effect of different viscosities on drug release profile. The Cefpodoxime Proxetil microspheres were prepared by non aqueous solvent evaporation method using different grades of HPMC such as HPMC K15M( 15cps), HPMCK4M(4000cps), HPMC100LV(100cps) and ethyl cellulose. The prepared microspheres were characterized by polymer compactibility (FTIR Scan), percentage yield, Buoyancy percentage, Drug Entrapment Efficiency (DEE) and invitro drug release was performed by USP Apparatus type I. The prepared floating microspheres were found to produce the percentage yield of 50.5-72.21%, Drug Entrapment Efficiency of 14.1-28.2%, Buoyancy percentage of 70.1-88.25% and drug release of microspheres of 65.09-101.88%. The better drug release profile was found to be with formulation (F A2 ) with drug:polymer ratio of 1:2, HPMC 15cps showed much significant increase in the drug release while comparing with the other two grades of HPMC.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-P'Col-000018
Title: The Effect Of Polyherbal Formulation - PHF On Experimentally Induced Reflux Esophagitis In Rats
Category: Pharmacology
Section: Research Article
Country: India
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The science of life—Ayurveda is practiced in India since time immemorial. Besides being cheap and easily available, Ayurvedic drugs are considered as safe. Moreover, there is surge in the interest in Ayurveda due to quest of alternative medicines. In Ayurvedic system of medicine, Polyherbal formulations were frequently used to enhance the activity or counteract the toxic effect of compounds, from other plants, but may also act synergistically with other constituents from the same plants. Gastro esophageal reflux disease is a disorder of defense mechanism at the esophageal junction, caused by regurgitation of the gastric contents especially of gastric acid. The purpose of the study was to investigate the effect of Poly Herbal Formulation (PHF) on experimentally induced reflux esophagitis and gastrointestinal motility in animals. The PHF consists of seven medicinal plants namely Aegle marmelos, Elettaria cardamomum, Glycyrrhiza glabra , Citrus aurantifolia, Rosa damascena, Cissus quadrangularis and Saccharum officinarum. Based on acute toxicity study the PHF was considered as safe and 3 dose (100, 200 and 400 mg/kg) levels were employed for pharmacological evaluation. The test drugs were administered orally by suspending in 1% carboxy methyl cellulose solution. The PHF exhibited (P<0.001) significant decrease in lesion index and enhance the % protection of lesion in experimentally induced reflux esophagitis at all the 3 doses in rats. In charcoal meal gastrointestinal transit test, PHF dose-dependently propelled the charcoal meal travel through the small intestines in mice. The study indicates that the PHF has protective effect against surgically induced reflux esophagitis.

Journal: Journal of Pharmacy Research , Volume: 1, Issue: 1.
Article Id: JPRS-PCS-000019
Title: Novel Pharmaceutical Approaches For Colon- Specific Drug Delivery: An Overview
Category: Pharmaceutics
Section: Review Article
Country: India
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Colon specific drug delivery has gained increased importance not just for the delivery of drugs in the treatment associated with the colon, but also as a potential site for the systemic delivery of therapeutic peptide and proteins. To achieve successful colon targeted drug delivery, a drug needs to be protected from degradation, release and/or absorption in the upper portion of the GI tract and then to be ensured abrupt or controlled release in the proximal colon. The necessity and advantages of colon-specific drug delivery systems have been well recognized and documented. The primary approaches to obtain colon-specific delivery are based on prodrugs, pH- and time-dependent systems or microflora-activated systems and have achieved limited success only. Precise colon drug delivery requires that the triggering mechanism in the delivery system only respond to the physiological conditions particular to the colon. Hence, continuous efforts have been focused on designing colon-specific delivery systems with improved site specificity and versatile drug release kinetics to accomplish different therapeutic needs. Among the systems developed most recently for colon-specific delivery, four systems were unique in terms of achieving in vivo site specificity, design rationale, and feasibility of the manufacturing process (pressure-controlled colon delivery capsules (PCDCs), CODES™, colonic drug delivery system based on pectin and galactomannan coating, and Azo hydrogels). The focus of this review is to provide detailed descriptions of the above mentioned approaches.