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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
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Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-NN-00001115
Title: Bio-Reductive Synthesis and Characterization of Copper Oxide Nanoparticles (CuONPs) Using Alternanthera sessilis Linn. Leaf Extract
Category: Nanotechnology & Nanomedicine
Section: Research Article
Country: India
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Objectives: The aim of present study was to synthesize and characterize copper oxide nano particles (CuONPs) from leaf extract of Alternanthera sessilis (Linn). Materials and Methods: Green synthesis of copper oxide nanoparticles has been carried out from aqueous copper sulphate using leaf extract of Alternanthera sessilis (Linn.). The bio-molecules present in the leaf juice react with copper sulphate, upon reduction at room temperature resulted in the formation of copper oxide nanoparticles (CuONPs). Results: Synthesized nanoparticles (NPs) were studied by SEM- EDAX to investigate the morphology. NPs were spherical and the size in the range of 22.6nm to 25.2nm. The EDAX spectrum revealed the presence of copper oxide. FT-IR spectrum examined the occurrence of bioactive functional groups required for the reduction method. The elemental composition of synthesized product was determined by XRF technique. The oxidation state of NPs was confirmed through the XPS spectra. Conclusions: This room temperature, one-pot green synthesis shows promising results for producing CuO nanoparticles in a low cost, eco- friendly process. Metal nanoparticles with antimicrobial activity when embedded and coated on to surfaces can find immense applications in water treatment, synthetic textiles, biomedical and surgical devices, food processing and packaging.

Cite this article as:K.L.Niraimathi, R.Lavanya, V.Sudha, R.Narendran, P.Brindha,Bio-Reductive Synthesis and Characterization of Copper Oxide  Nanoparticles (CuONPs) Using Alternanthera sessilis Linn. Leaf Extract, Journal of Pharmacy Research 2016,10(1),29-32.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-P'Col-00001176
Title: Effects of the methanol extract of the leaves of Azadirachta indica on the concentration of total proteins and specific activity of catalase in ethanol-ulcerated rats
Category: Pharmacology
Section: Research Article
Country: India
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Background and Aim: Increased needs for proteins and anti-oxidants are required to promote wound healing and thus, this study was originated to evaluate the effects of the methanol extract of the leaves of Azadirachta indica on the concentration of total proteins and specific activity of catalase in ethanol-ulcerated rats. Methods : The effects of the methanol extract of the leaves of A. indica on the concentration of total proteins and specific activity of catalase were determined and assayed respectively using standard methods. Results: The extract at the three doses [100, 200 and 400 mg/kg body weight (b.w)] caused significant (p < 0.05) and dose-related increases in the concentration of total proteins and specific activity of catalase in the rats of the test groups compared to those of the rats in the ulcer-untreated group (group 2). The 400 mg/kg b.w of the extract exerted the greatest effects in a manner similar to those of the standard anti-ulcer drug, cimetidine at the dose of 100 mg/kg b.w. Conclusion: The remarkable amelioration of the amount of total proteins and specific activity of catalase in the ulcerated rats by the methanol extract of the leaves of A. indica encourages the local utilisation of the leaves of the plant in the treatment of gastric ulcer.

Cite this article as:Christian E. Odo,Effects of the methanol extract of the leaves of Azadirachta indica on the concentration of total proteins and specific activity of catalase in ethanol-ulcerated rats,Journal of Pharmacy Research 2016,10(1),65-68.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-PA-00001131
Title: Development and validation of HPLC-UV method for the estimation of fulvestrant in bulk drug
Category: Pharmaceutical Analysis
Section: Editorial
Country: India
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Aim: The present work is aimed to develop a simple, rapid, selective, sensitive and validated HPLC method for the determination of fulvestrant in bulk drug. Method: Fulvestrant was measured using a validated HPLC method with UV detector at 225nm chromatographic peaks were separated on Phenomix, C18 column (250 mm x 4.6 mm x3.5µ) using 50% aetonitrile in channel A and acetonitlile in channel B as mobile phase with gradient elution at a flow rate of 1 ml/min. Results & Discussions: The chromatograms showed good peak shapes and no interference of solvent peaks. The retention time of fulvestrant was found to be 13.6 min. LOD and LOQ were found to be 0.0226µg/ml (0.001%) and 0.0712µg/ml,(0.004%) respectively. The percentage recovery of fulvestrant was found to be 99.1% - 100.75% which are within the limit. The method was linear over the concentration range of 0.08to 2ìg/ml with coefficient of correlation (r2) 0.99997. Both intraday and inter day accuracy and precision data showed good reproducibility. Conclusions: The low % RSD values (= 2) indicated that the method was precise and accurate. this method was successfully applied to forced degradation studies and can be adopted for routine estimation of fulvestrant in quality control laboratories.

Cite this article as:Rama Mohan Reddy Thummaluru, Srikanth Gurrala,Development and validation of HPLC-UV method for the estimation of fulvestrant in bulk drug,Journal of Pharmacy Research 2016,10(1),21-24.

 

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-P'Col-00001175
Title: Effects of the methanol extract of the leaves of Azadirachta indica on some haematological parameters of ethanol-ulcerated rats
Category: Pharmacology
Section: Research Article
Country: India
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Background and Aim:Gastric ulceration may involve bleeding which in extreme cases could result in haematologic abnormalities such as anaemia among others. This research was therefore, designed to ascertain the effects of the methanol extract of the leaves of Azadirachta indica on some haematological parameters of ethanol-ulcerated rats. Methods:The effects of the methanol extract of the leaves of A. indica on red blood cell (RBC) count, packed cell volume (PCV), concentration of haemoglobin (Hb) and total white blood cell (tWBC) count were determined with the aids of standard methods. Results:The extract at the graded doses [100, 200 and 400 mg/kg body weight (b.w)] significantly (p < 0.05) and dose-dependently increased the RBC counts, PCV values, Hb concentrations and tWBC counts of the rats in the test groups compared to the values obtained for the rats in the positive control group (group 2). The effects of the 400 mg/kg b.w of the extract were similar to those of the standard anti-ulcer drug, cimetidine at the dose of 100 mg/kg b.w. Conclusion:The methanol extract of the leaves of A. indica remarkably improved the haematological parameters in the ulcerated rats and hence may raise the choice of the plant over some other plants for the treatment of gastric ulcer especially when the ulcer is bleeding-prone.

Cite this article as:Christian E. Odo,Effects of the methanol extract of the leaves of Azadirachta indica on some haematological parameters of ethanol-ulcerated rats,Journal of Pharmacy Research 2016,10(1),54-57.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-P'Col-00001149
Title: Evaluation of antioxidant, antimicrobial and cytotoxic activities of Terminalia citrina Leaves
Category: Pharmacology
Section: Research Article
Country: India
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Objective: To investigate antioxidant, antimicrobial and cytotoxic activities of methanol extract and its derived fractions (petroleum ether, carbon tetrachloride, dichloromethane and ethyl acetate) of leaves of Terminalia citrina plant belonging to the Combretaceae family. Methods: The antioxidant potential were evaluated in terms of total phenolic content, total flavonoid content, DPPH radical scavenging potential, ABTS scavenging potential, reducing power assay and total antioxidant capacity by specific standard procedures. The antimicrobial activity was evaluated using disc diffusion method while cytotoxic was evaluated by using brine shrimp lethality bioassay and compared with vincristine sulfate. Results: The methanolic leaf extract exhibited the highest flavonoid content and antioxidant capacity while ethyl acetate fraction exhibited the highest phenolic content, reducing power, DPPH and ABTS radical scavenging activity. Antioxidant activity was the most notable compared to the positive control and thus could be a potential rich source of natural antioxidant. In case of antimicrobial and cytotoxic activities, the extracts of the leaves does not showed remarkable activities against tested microorganisms and Artemia salina respectively. Conclusions: This study suggests that the leaves of Terminalia citrina possess antioxidant activity.

Cite this article as: Narhari Das, Durajan Goshwami, Md. Sharif Hasan, Zobaer Al Mahmud, Sheikh Zahir Raihan,Evaluation of antioxidant, antimicrobial and cytotoxic activities of Terminalia citrina Leaves,Journal of Pharmacy Research 2016,10(1),8-15.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-PB-00001174
Title: Biofilm formation on contact lenses by bacterial pathogens
Category: Pharmaceutical Biotechnology
Section: Review Article
Country: India
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Biofilm is an assemblage of microbial cells that is irreversibly associated with the surface and usually enclosed in a matrix of polysaccharide material. The process of any contact lens related keratitis usually starts when opportunistic pathogens binds to the cell surface. Lens material characteristics influence bacterial adhesion to lens surface. Various factors affect biofilm formation on contact lens such as substratum effect, conditioning film, hydrodynamics, quorum sensing etc. The effect of bacterial adhesion on lens varies amongst individuals. This is due to difference between the errors, responses of bacterial strain and the ability of certain tear film protein when bound to the cell surface to kill certain types of bacteria. Prevention of biofilm formation is a necessary step in the successful prophylaxis of infections. Polymer surface modification is one approach to inhibit bacterial adhesion.

Cite this article as: Nishita Jain, Preeti Bhosale, Vidya Tale,Biofilm formation on contact lenses by bacterial pathogens,Journal of Pharmacy Research 2016,10(1),50-53.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-PB-00001208
Title: Screening of different growth medium for extracellular bacterial synthesis of silver nanoparticles: ecofriendly method
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Objective: The aim of present study was to select suitable growth medium for bacteria capable of silver nanoparticle synthesis. Background: The synthesis of silver nanoparticles (AgNPs) has received considerable attention with their potential applications in field of life sciences. Silver nanoparticles (SNPs) have extensive applications in civil, therapeutic and industrial areas as catalyst, cryogenic superconductor, biosensor, microelectronic and bacteriostatic materials. Currently, there is a growing need to develop environmentally benevolent nanoparticle synthesis processes that do not use toxic chemicals in the synthesis protocol. Among the various known synthesis methods, biosynthesis of silver nanoparticles is preferred as it is environmentally safe, low cost and less toxic. Methods: In the present study we have screened different culture medium for the growth of bacteria capable of silver nanoparticles synthesis. Different growth medium were screened on the basis of colour and UV-Visible spectrophotometric analysis. Results: Only one culture medium Basal salt medium containing glucose was found to be suitable for synthesis of silver nanoparticles on the basis of colur and UV-Visible spectrophotometric analysis. Conclusion: Basal salt medium containing glucose is suitable for growth of bacteria responsible for ecofriendly synthesis of silver nanoparticles.

Cite this article as :Divya Bhatia,Deepak Kumar Malik, Ashwani Mittal,Screening of different growth medium for extracellular bacterial synthesis of silver nanoparticles: ecofriendly method,Journal of Pharmacy Research 2016,10(1),76-78.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-P'Col-00001148
Title: Hypolipidemic activity of ethanolic extract of Saccharum spontaneum in atherogenic diet induced rats
Category: Pharmacology
Section: Research Article
Country: India
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Background: Saccharum spontaneum (Poaceae) commonly known as Wild sugarcane is a popular folk medicine in traditional systems of medicine in India. The whole plant is used to treat mental diseases, abdominal disorders, dyspnoea, anaemia, obesity, diuretic, lithotriptic, purgative, tonic, aphrodisiac, gynecological troubles, respiratory troubles etc. The present investigation was aimed to study the effect of ethanolic extract of Saccharum spontaneum whole plant (ESSW) in attenuating hyperlipidemia which is associated with many cardiovascular diseases like atherosclerosis. Methods: Hyperlipidemia was induced to rats by feeding atherogenic diet (AD) for a period of 21 days. The lipid profile was taken as the major marker of Hyperlipidemia and accordingly the changes in serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C) were measured (using enzymatic kits) after treatment with the ethanolic extract of Saccharum spontaneum whole plant (ESSW) and standard (atorvastatin). Results and discussion: The oral administration of ESSW (100 and 200 mg/kg body weight) for 21 days significantly lowered the TC, TG and LDL-C levels while increase in HDL levels were observed in a dose dependent manner. Conclusion: Based on the results obtained, it can be concluded that ESSW has significant antihyperlipidemic properties and can be used in the treatment of vascular disorders including atherosclerosis. The potential activity of the extracts can be attributed to the presence of antioxidant principles such as phenolic compounds which were reported from the plant.

Cite this article as:Geetha Kodali and Ahmadi Banu,Hypolipidemic activity of ethanolic extract of  Saccharum spontaneum in atherogenic diet induced rats,Journal of Pharmacy Research 2016,10(1),16-20.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-P'Col-00001173
Title: Effects of the methanol extract of the leaves of Azadirachta indica on some oxidative stress indices of ethanol-ulcerated rats
Category: Pharmacology
Section: Research Article
Country: India
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Background and Aim: Researches into medicinal plants with potent anti-oxidant activity will continue to receive the attention of researchers due to the role of oxidative stress in many disease conditions and hence, this study was undertaken to investigate the effects of the methanol extract of the leaves of Azadirachta indica on oxidative stress indices of ethanol-ulcerated rats. Methods: The effects of the methanol extract of the leaves of A. indica on the activity of superoxide dismutase (SOD), concentrations of reduced glutathione (GSH) and malondialdehyde (MDA) were determined using standard methods. Results:The extract at the administered doses [100, 200 and 400 mg/kg body weight (b.w)] caused significant (p < 0.05) and dose-related increases in the activities and amounts of SOD and GSH respectively in the rats of the test groups compared to those of the rats in the ulcer-untreated group (group 2). The extract treatment also led to significant (p < 0.05) reductions in the concentrations of MDA in the rats of the test groups compared to that of the rats in the ulcer-untreated group. The 400 mg/kg b.w of the extract exerted the greatest effects which were similar to those of the standard anti-ulcer drug, cimetidine at the dose of 100 mg/kg b.w. Conclusion: The methanol extract of the leaves of A. indica remarkably ameliorated the gastric ulcer-associated indices in the ulcerated rats and these findings thus support the local application of the leaves of the plant in the cure of gastric ulcer.

Cite this article as: Christian E. Odo,Effects of the methanol extract of the leaves of Azadirachta indica on some oxidative stress indices of ethanol-ulcerated rats,Journal of Pharmacy Research 2016,10(1),46-49

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-PCS-00001203
Title: Direct compression of cushion layered ethyl cellulose coated extended release pellets into rapidly disintegrating tablets
Category: Pharmaceutics
Section: Research Article
Country: India
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The aim of this study was to develop and optimize cushion layered ethyl cellulose coated extended release pellets into rapidly disintegrating tablets without changes in the release profile. In order to avoid segregation problems resulting from particle size differences between coated pellets and excipients and to protect the integrity of brittle ethyl cellulose coating during compression the tabletting excipients were layered on to the ethyl cellulose (6%) coated metoprolol succinate pellets. However, the drug release from these cushion layered pellets increased upon compression. Incorporation of a glidant (magnesium stearate) between the cushion layer and ethyl cellulose coating reduced the compression effect on the drug release. Glidant was coated to a coating level of 1-3%. The F2 values of optimized formulation (directly compressed cushion layered formulation with 3% magnesium stearate) was found to be greater than 50 and showed similar release as that of uncompressed pellets. The directly compressed cushion layered pellets protected the pellet coating significantly better from damages during compression when compared to the conventional compression of coated pellets and also facilitated segregation free compression of an extended release ethyl cellulose coated pellets in to fast disintegrating tablets.

Cite this article as:M.Yasmin Begum, G.Pavani,M.Sudhakar,Direct compression of cushion layered ethyl cellulose coated extended release pellets into rapidly disintegrating tablets,Journal of Pharmacy Research 2016,10(1),69-75.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-PHDRS-00001133
Title: Assessment of Pharmacognostical Characters of Leaves of Tephrosia Purpurea Linn
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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An attempt has been made to highlight this folk herbal medicine through present study which will assist in the identification of the plant both pharmacognostically as well as physiochemically. Various parameters like macroscopy, microscopy, Physiochemical parameter and Preliminary phytochemical studies of the leaves powder were also carried out. Physiochemical parameters like total ash content, water soluble ash, acid insoluble ash, sulphated ash, alcohol soluble extractive and water soluble extractive were observed. The qualitative parameters are reported. The plant is rich in saponins, glycosides, flavanoids and phytosterol. The present study on pharmacognostical investigation of Tephrosia purpurea Linn. leaves might be useful to supplement information in regard to its identification parameters assumed significantly in the way of acceptability of herbal drugs in present scenario lacking regulatory laws to control quality of herbal drugs.

Cite this article as: Sufiyan Ahmad, Md. Rageeb Md. Usman, Rashid Akthar, Md. Imran,Assessment of Pharmacognostical Characters of Leaves of Tephrosia purpurea Linn,Journal of Pharmacy Research 2016,10(1),25-28.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-PCS-00001172
Title: Formulation and Evaluation of Poorly Aqueous Soluble Drug by Solid Dispersion Method
Category: Pharmaceutics
Section: Research Article
Country: India
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Development of solid dispersions of poorly water soluble drugs is one of the most widely used approaches to enhance the solubility as well as dissolution rate. In the current investigation, Ezetimibe is selected as model drug to improve the solubility and dissolution rate by solid dispersion method. Solid dispersions were prepared using solvent evaporation method by incorporating sol plus as carriers in different ratios and evaluated for solubility studies, FT-IR, X-Ray, DSC studies and in vitro dissolution studies. Based on the solubility and drug release studies, formulations different disintegrates are used and the best natural disintegrating agent i.e. Guar gum was selected to prepare the tablets and in vitro dissolution study is done, tablets containing Guar gum showed almost complete drug release within the 12 min. The percent drug release in 12 min (Q12) and initial dissolution rate for formulation F3 was 94.22±1.08%, 9.26%/min. These were very much higher compared to conventional tablets containing pure drug (23.87±1.13%, 2.38%/min). The relative dissolution rate was found to be 2.14 and dissolution efficiency was found to be 67.52 and it is increased by 4.0 fold with F3 formulation compared to conventional tablets. Thus, it is concluded that the formulation of guar gum as disintegrating agent is a suitable approach to improve the solubility and dissolution rate of Ezetimibe than pure form of drug.

Cite this article as:Omprakash G. Bhusnure, Mohite Yogita, Sachin S. Gholve, Giram P. Sidram,Thonte S.S.,Formulation and Evaluation of Poorly Aqueous Soluble Drug by Solid Dispersion Method,Journal of Pharmacy Research 2016,10(1),33-40.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-P'Col-00001178
Title: In vitro antioxidant and ptp inhibitory activity of methanolic extract of Anogeissus acuminata leaf and bark.
Category: Pharmacology
Section: Research Article
Country: India
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Objective: Anogeissus acuminata is a plant rich in tannins and flavonoids. Various parts of the plant are used in traditional medicine for diabetes mellitus and inflammatory conditions. In the present study, methanolic extracts of leaf and bark are evaluated for their in vitro antioxidant and PTP 1B inhibitory activity. Methods: In vitro antioxidant activity was analyzed by 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, reducing power assay and TBA (thiobarbituric acid) assay, using vitamin C as a standard. Moreover, antidiabetic potential was evaluated using in vitro protein tyrosine phosphatase 1B (PTP1B) inhibition assay using Suramin as a standard. Results: IC50 values for Vitamin C, leaf and bark of the plant in DPPH assay were 45.51 ± 6.657, 111.9 ± 5.534 and 80.9 ± 5.329 ìg/ml, respectively. The extracts also exhibited significant reducing powers and inhibition of lipid peroxidation comparable to that by Vitamin C (P <0.01). Both extracts also demonstrated significant PTP 1B inhibitory activity with IC50 values 20.7± 7.6 and 11.59 ± 7.8 ìg/ml for leaf and bark extracts respectively. Conclusion: Leaf and bark extracts of Anogeissus acuminata demonstrated potent in vitro anti-oxidant and PTP1B inhibitory activity.

Cite this article as:Archana M Navale, Archana N Paranjape, In vitro antioxidant and ptp inhibitory activity of methanolic extract of Anogeissus acuminata leaf and bark,Journal of Pharmacy Research 2016,10(1),65-68.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-BMB-00001151
Title: Effect of the methanol extract of the leaves of Azadirachta indica on ethanol-induced gastric ulcer in rats
Category: Biochemistry and Molecular Biology
Section: Research Article
Country: India
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Background and Aim:Plants have been the bases for medicinal treatments through much of human history and such medicine however, traditional, is still widely in use today such as the application of the leaves of Azadirachta indica in the treatment of gastric ulcer. The thrust of this work was therefore, to evaluate the effect of the methanol extract of the leaves of A. indica on ethanol-induced gastric ulcer in rats. Methods: The phytochemical constituents, acute toxicity and lethality and effects of the extract on ulcer index, gastric juice volume and gastric juice pH were assessed using standard methods. Results: The phytochemical screening revealed that the plant extract contained alkaloids, flavonoids, tannins, saponins, carbohydrates, glycosides, proteins, steroids, terpenoids and fats and oil but resins, reducing sugars and acidic compounds were not detected. The extract at a dose even as high as 5000 mg/kg body weight (b.w) was safe for administration. The extract at the tested doses [100, 200 and 400 mg/kg b.w] caused significant (p < 0.05) and dose-dependent decreases in ulcer indices (gastric lesions) and gastric juice volumes of the rats in the test groups compared to the values obtained for the rats in the positive control group (group 2). Significant (p < 0.05) and dose-related increases in gastric juice pH of the rats in the test groups compared to that of the rats in the positive control group were also brought about by the extract. The effects of the 400 mg/kg b.w of the extract were similar to those of the standard anti-ulcer drug, cimetidine at the dose of 100 mg/kg b.w. Conclusion: These observations show that the methanol extract of the leaves of A. indica possesses notable anti-ulcer effect and contains some pharmacologically active principles which might be cynosures of future modern anti-ulcer drugs.

Cite this article as:Christian E. Odo,Effect of the methanol extract of the leaves of Azadirachta indica on ethanol-induced gastric ulcer in rats, Journal of Pharmacy Research 2016,10(1),41-45.

 

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-ND-00001177
Title: Influence of solvent extraction on phenolic content, antioxidant and anti-inflammatory activities of aerial parts extract from Algerian Artemisia Herba-alba
Category: Natural Drugs
Section: Research Article
Country: India
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Artemisia Herba-alba is a commonly consumed medicinal and culinary herb in Algeria. This current study aimed to obtain the proper solvent for extracting bioactive compounds from Artemisa Herba-alba guided by phenolic content, flavonoid content, proanthocyanidins, antioxidant and anti-inflammatory activity. The results showed that ethyl acetate extract of exhibited the highest phytochemical composition (total phenolic content 92.29±3.25 mg GAE/g W, total flavonoids content 61.24±2.04 mg RT/g DW and proanthocyanidins 25.47±0.95 mg CAE/g DW), while butanol extract (BE), water extract (WE) and the minimum value in chloroform extract (CE). The best DPPH. scavenging capacity (IC50= 36.85±1.17 µm/mL), beta-carotene (23.83± 0.53) and ferric reducing power (IC50= 14.71± 0.51 µm/mL) were observed in EAE followed by BE. Our study also revealed the high anti-inflammatory potential of EAE, BE, WE and CE. Ethyl acetate can be an efficient solvent for extracting antioxidants from Artemisa Herba-alba based on this study. All these biological activities are well correlated with the phenolic contents of these extracts. These findings demonstrate the remarkable potential of these plants as valuable source of antioxidants with exhibit original and interesting anti-inflammatory and anticancer capacities.

Cite this article as:Laouini S Eddine, Ouahrani M Redha, Segni Ladjel,Influence of solvent extraction on phenolic content, antioxidant and anti-inflammatory activities of aerial parts extract from Algerian Artemisia Herba-alba,Journal of Pharmacy Research 2016,10(1),58-64.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 1.
Article Id: JPRS-ND-00001146
Title: Evaluation of Phenolic Content and Antioxidant Capacity of leaf extract from Phoenix Dactylifera L obtained by different pH of aqueous extraction
Category: Natural Drugs
Section: Research Article
Country: India
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Influence of pH aqueous medium extraction on phenolic content, flavonoid content, proanthocyanidins, phytochemical composition, antioxidant activities of leaves extract from Phoenix dactylifera L was investigated. It was observed that extraction yield increased at weak acidic condition (value of pH between 2 and 3), and the pH effects on the composition extraction process were illustrated. For the low value of pH, the yield extraction increase, similar phenomena for the antioxidant activity and concentration of individual phenolic compounds obtained by HPLC, but the phenolic content decrease. For the high value of pH, the yield extraction decrease, the low antioxidant activity and concentration of individual phenolic compounds obtained by HPLC, but the phenolic content increase. The optimum pH value of medium extraction solvent it is 2.

Cite this article as:Rouiha Zohra, Ouahrani Mohammed Redha, Laouini Salah Eddine,Evaluation of Phenolic Content and Antioxidant Capacity of leaf extract from Phoenix Dactylifera L obtained by different pH of aqueous extraction,Journal of Pharmacy Research 2016,10(1),1-7.