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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 10.
Article Id: JPRS-PHDRS-00001637
Title: Standardization of the plant Epaltes pygmaea DC. (Asteraceae)
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Background: To establish the pharmacognostic parameters using pharmacopoeial standards for correct identity of whole plant of Epaltes pygmaea DC. (Asteraceae).  Methods: In pharmacognostic studies different types of evaluations were carried out that focus on taxonomy of the species, macro- and microscopic characters, physico-chemical parameters, fluorescence analysis, preliminary phytochemical screening and HPTLC finger print compared with marker compound stigmosterol. Results and discussion: The taxonomically it is a small annual herb, 8 to 20 cm high, minutely winged branched stem with aromatic roots, leaves are alternate, linear, lanceolate to oblong,  flower pink, solitary, terminal, heterogamous. Microscopically the plant showed the presence of bi or tri-radiate wings of the stem, leaves microscopy indicated the presence of anisocytic type of stomata, thin walled with small spindle shaped cells of leaf epidermis, powder microscopy showed vessel elements with short tail, vertical chain of elongated parenchyma cells with prominent simple pits, large, spherical and spiny pollen grains. Plant extracts showed the presence of flavonoids, steroids, phenols, tannin and sugars. The standard marker stigmosterol detected with Rf 0.54 in alcohol extract has been confirmed by TLC/HPTLC finger print. Conclusions: The study provides the scientific data for the proper identification and establishment of standards for the use of Epaltes pygmaea. These information will also be helpful to differentiate Epaltes pygmaea from closely related other species.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 10.
Article Id: JPRS-SM-00001636
Title: Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation
Category: Siddha Medicine
Section: Research Article
Country: India
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Background: Standardisation is essential for scientific validation of any poly herbo mineral formulation. Nandhi mezhugu is a classical Siddha herbo mineral formulation has indication for many diseases such as all types of arthritis, male and female reproductive tract disorders, different types of cancers eg ovarian cancer, testicular cancer, cancer penis, cancer cervix, oral and cheek cancers, fistula, hydrocele, chronic ulcers, skin diseases eg eczema, leucoderma, diabetic carbuncle, chronic ulcers, Hanson’s disease etc. Aim: The aim of this study was to standardise Nandi mezhugu. Materials and Methods: The drug was prepared as per the procedure mentioned in Siddha Literature and then subjected to the following analysis such as physico chemical, heavy metals, pesticide residue, aflatoxin, qualitative phytochemical, qualitative inorganic analysis, TLC photo documentation and HPTLC finger print profile. Results and conclusion: The drug was free of microbial contamination and aflatoxins and pesticide residues. Hence the drug was safe for consumption.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 10.
Article Id: JPRS-PC-00001626
Title: Synthesis, characterization and antioxidant evaluation of 2-(2-substituted) naphthalene-1,4-dione derivatives
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Background: 1,4- naphthoquinone (Lawsone) are widely distributed in nature and have been used since ancient times in traditional medicine. Lawsone has been used as a dye, and both its natural form and synthetic derivatives exhibit antifungal, antibacterial, antitumor, antimalarial, molluscicidal and antioxidant activity. Methods: 1,4- naphthoquinone (Lawsone) was isolated from the leaves of lawsonia inermis by using pH gradient method. A convenient synthesis of 2-substituted amino naphthalene-1,4-dione (3a-e) has been achieved by reaction of  isolated 1,4- naphthoquinone with substituted aniline in the presence of ethanol and evaluated for in- vitro antioxidant activity using DPPH model. The structure of the final analogues has been confirmed on the basis of elemental analysis, FTIR, 1H NMR and mass spectra. All the values of elemental analysis, FTIR, 1H NMR and mass spectra were found to be prominent. Results and discussion: The results indicate that synthesized compound 3d having IC50 75.39 ± 4.12 mg/ml showed potent antioxidant activity comparable to standard ascorbic acid (IC50 45.54 ± 3.06 mg/ml). Conclusion: This study suggests that leaves of Lawsonia inermis have bioactive compounds for a new antioxidant drug development.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 10.
Article Id: JPRS-PHDRS-00001625
Title: Eucalyptus genus: a review
Category: Pharmacognosy and Herbal Drugs related study
Section: Review Article
Country: India
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Eucalyptus is a diverse genus of flowering trees (and a few shrubs) in the myrtle family, Myrtaceae. This review article is presented to compile all the updated information on its phytochemical and pharmacological Activities of Eucalyptus species which were performed by widely different methods.  Literature indicates various Eucalyptus Species  possesses analgesic, antifungal, antiinflamatory, antibacterial, antidiabetic, antioxidative properties. Literature also indicates various other effect of  Eucalyptus species  such as  Antiviral, Antitumour, antihistaminic, anticancer cytochrome p450  inhibitor and hepatoprotective effect have also been reported by many  Researcher. The present review articles critically discusses some Eucalyptus Species and about their Chemical constituents and Biological activities. This review indicate that  Eucalyptus species have potential therapeutic effects.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 10.
Article Id: JPRS-PHDRS-00001624
Title: Phytochemical profiling and histochemical localization in leaf and stem of Trichosanthes cucumerina (L) var. cucumerina with reference to the influence of plant age and geographical variations
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The study report comprises the results of an investigation on phytochemical evaluation, and histochemical localization in leaf and stem of medicinal species - T. cucumerina (L) var. cucumerina. This medicinal herb has wide application in folkloric medicine and Ayurveda owing to its antiinflammatory, antioxidant, hepatoprotective and antihelmintic potential. It is procured on a range of 35 -40 tonnes per year by various Ayurvedic pharmaceutical firms in Kerala for preparing herbal formulations. Parameters studied are the assessment of the efficacy of different extractant solvents in release of plant secondary metabolites, preliminary qualitative and quantitative analysis and evaluation of the occurrence and pattern of distibution of phytochemicals in tissues of leaf and stem through histochemical localization. The stem samples from two localities were compared for the influence of climatic and edaphic conditions on quantity of phytochemicals. Besides, these a comparison on stem of different maturity level (1 year and 2 years old) was also evaluated to assess the impact, if any, of the metabolic state of plant on quantity of secondary metabolites. Extraction of dried and powdered plant parts was carried out successively in five different solvents– petroleum ether, chloroform, ethyl acetate, methanol and water. The results of the study suggested that among the solvents, methanol and water were effective extractants in which most of the common secondary metabolites –alkaloids, flavonoids, phenolics, tannins, terpenoids and saponins – were released. Quantitative analysis of the methanolic and aqueous extracts concluded that both stem and leaf contain appreciable quantity (mg/g tissue) of alkaloids, phenolics and tannins in comparison to flavonoids and terpenoids. Studies on histochemical localization carried out using Wagner’s reagent concluded that alkaloids are mostly located in the parenchyma cells bordering the vascular bundles of stem and petiole. Flavonoids, localized with NaOH revealed that they were marked as a distinct yellow band in the sub hypodermal layer of stem. Tannin localization with FeCl3 also suggested their storage in parenchyma cells.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 10.
Article Id: JPRS-P'Col-00001623
Title: Effect of a model lipophilic compound on the phase behaviour of hydrophilic self-micro-emulsifying lipid formulations
Category: Pharmacology
Section: Research Article
Country: India
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Background:There has been growing interest in the self-emulsifying lipid technology in recent years as an approach to improve the oral bioavailability of poorly water-soluble compounds. Nonetheless, for the design of successful lipid formulations with a potential to maximize the bioavailability of lipophilic drugs, key elements in the lipid composite in relation to the physicochemical state of drug after dispersion needs to be optimized. Methods:In this study, various lipid formulations were optimized for oil-in-water micro-emulsion drug delivery systems. The effect of Ibuprofen (a model lipophilic drug) on the emulsification behavior of these systems was also investigated by constructing ternary phase equilibrium diagrams using dynamic phase behavior study method. Results and Discussion: Optimum self-micro-emulsifying systems were obtained by using oil blends of {Miglyol 812/Imwitor 308} at ratio of 5:5 in the case of Cremophor RH40 and 4:6 for Tagat S2 or Tagat S Ternary phase equilibrium diagrams reveal extended regions of L2 phase when no drug was added to the lipid mixtures. However, in the case of lipid formulations containing Ibuprofen at 100mg/g, small limited areas of L2 phase was observed which suggests that the drug can interfere in the mechanistic processes of emulsification. Conclusion: in order to design successful self-micro-emulsifying lipid systems, pre-formulation studies which affect the performance of resultant dispersions of these systems with and without drug should be carried using suitable emulsification media.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 10.
Article Id: JPRS-PC-00001621
Title: Design, Synthesis, Spectral Characterization and Biological Evaluation of Mononuclear Ruthenium(II) Complexes
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Background: Two new mixed ligand ruthenium(II) complexes of the type [Ru(bpy)2(L)](PF6)2, where 2-[ 4,5-bis(4-dimethylaminophenyl)-1H- imidazol -2-yl]-1H-benzimidazole (1) and 2-[ 4,5-bis(4-fluorophenyl)-1H-imidazol-2-yl]-1H-benzimidazole (2) have been synthesized. Methods: Both the complexes were characterized by elemental analyses, UV-visible, IR and ESI-MS techniques. Cyclic and differential pulse voltammetry methods have been employed to study the redox behavior of complexes. Results and Discussion: Electrophoretic studies showed that the complexes are able to cleave supercoiled plasmid DNA more effectively in the presence of light at the wavelength of 480 nm. Moreover the newly synthesized complexes show better antimicrobial activity compared to that of the ligands. Cytotoxic activity against MCF7 cancer cell lines has been studied using MTT assay. Conclusion: Both the complexes exhibit significant biological activities against DNA, microbes and MCF7 cancer cell lines.  

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 10.
Article Id: JPRS-PC-00001614
Title: Design and synthesis of acridone-4-carboximide derivatives and their cytotoxic studies in cancer cells
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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In search of developing potent cytotoxic molecules we have designed and synthesized novel scaffold by linking amines to acridone moiety. Novel acridone-4-carboximide derivatives were evaluated for their cytotoxic potentials against drug sensitive, resistant breast cancer cell lines (MCF7/wt, MCF7/mr and MCF7/dx) by using SRB assay. Moreover, Protein ligand interactions of acridone-4-carboxamide derivatives with P-glycoprotein was performed.  Compound 1 and 2 have shown relatively potent cytotoxic activity among the derivatives against sensitive, resistant cell lines. Further, compound 8 has shown good cytoxicity against sensitive cells, but it has poor activity in resistant cells. Perhaps, these derivatives were substrate for MDR pumps P-gp and BCRP. The predicted dock score was in the range of -10.48 to -4.71 attributed for compound 1 and 5 respectively. Protein residues such as TYR953, LEU339 and TYR310 were the major contributors for the H-bonding with docked ligands. Compound 1 showed 2 H-bonds, one each with TYR953, and TYR310 with a bond distance of 2.33Å, and 1.81Å respectively. Hydrogen bonds with both the residues were formed with 2 carbonyl oxygen. Additionally, dominant hydrophobic interactions were formed each between a phenyl ring of acridone nucleus and PHE983, toluene nucleus and PHE72 an TYR953.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 10.
Article Id: JPRS-P'Col-00001616
Title: Resveratrol in combination with Green Tea reduces myocardial infarct area and improves histological changes in isoproterenol-induced cardiotoxic rats
Category: Pharmacology
Section: Research Article
Country: India
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Background: Cardiovascular problem is a growing menace which is affecting people globally. Isoproterenol creates oxidative stress that leads to myocardial infarction. The extent of infarcted area in heart reflects the severity of toxicity. Histopathological changes induced by Isoproterenol become another tool for evaluating the effectiveness of the test drugs. In this study we therefore have considered these parameters to evaluate the effectiveness of our test drugs resveratrol, green tea and their combination. Methods: Thirty animals (n=5) were taken and randomly divided into Control, Isoproterenol (ISO), Resveratrol (RES) + ISO, Green Tea Extract (GTE) + ISO, RES + GTE+ ISO and RES + GTE groups. Rats were treated with the test drugs for thirty days and with ISO on 29th and 30th day. Animals were sacrificed on 31st day and histopathological studies and infarct size calculations were performed. Results and Discussions: Myofibril disintegration, vacuolation and pyknotic nucleus were observed in ISO treated rats which were considerably reversed by resveratrol, green tea extract and by their combination. The size of infarcted area in the heart of ISO treated rats was also significantly reduced when the rats were treated with these test drugs. Conclusion: Resveratrol and green tea extract both showed cardio protection in terms of restoration of histological changes and reduction of infarcted area but their combination was found to be better than them.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 10.
Article Id: JPRS-MB-00001568
Title: Antimicrobial activities of Coleus aromaticus Benth.
Category: Microbiology
Section: Review Article
Country: India
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Medicinal plants play a vital role to preserve human health. Currently plants are attracting more attention for new drugs as human diseases caused by antibiotic resistant microorganisms have gained worldwide concern. Coleus aromaticus Benth. (syn. Coleus amboinicus Lour. or Plectranthus amboinicus Lour. Spreng) is an aromatic plant species from the family Lamiaceae having therapeutic and nutraceutical importance. It is large succulent aromatic perennial herb found throughout India. It has wide medicinal properties including antimicrobial activities. The leaves of the plant are bitter, acrid and were being widely used traditionally for the treatment of severe bronchitis, asthma, diarrhoea, epilepsy, vaginal discharge, renal and vesical calculi, fever, etc. It is reported to act as an antilithotic, chemopreventive, antiepileptic and antioxidant. The juice of leaves has been used in wound healing and swelling disorder by the tribal people. This article is an effort to compile the information reported on its antimicrobial activities.