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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-MPDI-00001647
Title: Biosynthetic Potential of Marine Microbial Symbionts
Category: Marine Pharmacy Drug Investigation
Section: Review Article
Country: India
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Marine plants and animals are well known to harbor diverse microorganisms. These marine microbial symbionts are a prolific source of a large variety of bioactive natural products with diverse pharmacological potential. Genome mining of marine microbial symbionts is widely developing techniques to discover novel natural products biosynthetic genes and metabolites. The ever rapidly increasing available whole-genomes of microbes has revealed plethora of secondary metabolites encoding genes than discovered metabolites. The development in genome sequencing technology has triggered the natural products biosynthesis genetics and biochemistry. This review, highlights biosynthetic potential of marine symbiotic microorganisms and their metabolites.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-P'Col-00001642
Title: A study on the Outcomes of Modified Tight Glucose Control for the Management of Glycemic Control in Diabetic Patients Undergoing Cardiac Surgery
Category: Pharmacology
Section: Research Article
Country: India
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Background and Objective: Diabetes mellitus is associated with increased surgical morbidity and mortality.Its relatively high risk may be related to the level of perioperative hyperglycemia. Thisstudy was aimed to compare the outcomes of patients undergoing open cardiac surgery byglucose control in two ways: modified tight versus conventional method. Methods: This open-labeled, randomized control trial was conducted on 75diabetic patients (18-70 years old) with ASA II- III undergoing open cardiac surgery from Shahid Faghihi Hospital, Shiraz, Iran. The patients were randomly divided into modified tight control(Blood Sugar maintained between 100-120 mg/dl) and conventional method (Blood Sugar < 200mg/dl). Primary end points included: hospitalmortality, sternal wound infection, duration of mechanical ventilation, cardiacarrhythmia, cerebrovascular attack and acute renal failure. The secondary end point waslength of ICU staying. Complications after 30 days of surgery were recorded. We used student’s t test, chi-squareand repeated measurement tests. Results: Although the trend of change in blood glucose during surgery and in ICU was notsignificantly different between groups, blood sugar measurement showed a significantdifference at the different times (P<0.001). In terms of primary end pointsandsecondary end pointwere not significantly different between two groups. The occurrence of hypoglycemiawas low in both groups (one patient in each group) and were not significantly different between two groups.Hypokalemia was the most prominent sideeffect in the 34 patients of modified tight control group compared with eight patients in theconventional group (P<0.001). After 30 days sternal wound infection was seen in1 patient oftreatment group versus 7 in control group (P<0.05), which was significant. Conclusion: Modified tight control of blood glucose close tonormal values during cardiac surgery was associated with decreased occurrence of episodes of hypoglycemia andhyperglycemic complications.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-ND-00001639
Title: Phytochemical studies on Cichorium intybus L. (chicory) from Kashmir Himalaya using GC-MS
Category: Natural Drugs
Section: Research Article
Country: India
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Background:Cichorium intybus commonly called as chicory, coffee weed and blue sailor’s succory is traditionally used for the treatment of almost every disease particularly diseases related to heart, kidney and liver. Method: 0.2 g of the powdered seed, roots, stem and flower samples of Cichorium intybus from Kashmir Himalaya was equilibrated with 200 d/m of Cichorium intybus methanol for 24 h, separately. Supernatant was later reduced by heating to 2 d/m. The concentrated methanolic extracts were further subjected to GC-MS analysis.  Results: The GC-MS analysis determined the presence of 109 compounds from different parts of Cichorium intybus L. (chicory) in which 24 compounds were identified from seed, 22 compounds from root, 28 compounds from stem and 35 compounds from flower. The major metabolites from seed were 9,12-Octadecadienoic acid (Z,Z)- (35.03) and n-Hexadecanoic acid (34), from root were n-Hexadecanoic acid (24.37), 1,2-Benzenedicarboxylic acid, mono(2-ethylhexyl) ester (1.6), from stem were n-Hexadecanoic acid (35.14), 9,12-octadecadienoic acid (16.01) and from flower were 5-(hydroxymethyl)-2-furaldehyde (33.26), 9,12-Octadecadienoic acid (Z,Z)- (26.86) in terms of their percent area.  Conclusion: This study helps to predict the formula and structures of metabolites which can be further used in drug formulations and chicory from Kashmir Himalaya can be considered as potent candidate for pharmaceutical sector.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-ND-00001641
Title: Phytochemical and Biological Study of Some Constituents of Asparagus sprengeri Regel., Growing in Egypt
Category: Natural Drugs
Section: Research Article
Country: India
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Background: Asparagus sprengeri  Regel. is an ornamental small shrub native to coastal southeastern South Africa. The main objective of this study was the phytochemical and biological evaluation of ethanolic extract of non-flowering aerial parts of Asparagus sprengeri Regel., growing in Egypt. Methods: The investigation included analysis of the lipoidal compounds in the unsaponifiable and fatty acids fractions by GC/MS. Quantitative estimation of polyphenols, flavonoids and saponins by colourimetric methods. HPLC analysis of polyphenolic compounds was undergone, in addition to LC/MS of the saponins. Isolation of flavonoids was undergone using chromatographic methods and the identification was accomplished on the basis of their spectral data. Results: The unsaponifiable fraction was composed mainly of hydrocarbons (52.99%) and alcohols (31.54%). Moreover, the fatty acids fraction was composed of saturated (52.12%) and unsaturated (21.61%) ones. Determination of total polyphenols (9.83%) and flavonoids (1.87%) was undergone. HPLC analysis of polyphenols revealed that flavonoids were detected in higher amounts than phenolic acids. Extraction, isolation and identification of three flavonoids (kaempferol, quercetin and genistin) was achieved. Saponins (2.44%) were determined, while LC/MS of the n-butanol fraction indicated the presence of sprengerinin A,B,C&D. The ethanolic (70%) extract exhibited moderate antioxidant (IC50 = 56 µg ml-1) and potent cytotoxic activities. The most potent activity was that on colon cell line (IC50 = 3.73 µg ml-1), followed by the breast cell line (IC50 = 10.20 µg ml-1). Conclusion:  Thus, non-flowering aerial parts of Asparagus sprengeri Regel. could be considered as a potential source for different bioactive metabolites. 

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-P'Col-00001638
Title: Terminalia arjuna aqueous bark extract protects against cadmium acetate-induced injury to rat liver and heart through antioxidant mechanisms: a dose response study
Category: Pharmacology
Section: Research Article
Country: India
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Background: Cadmium-acetate is a potent hepatotoxic and cardiotoxic heavy metal, which induces oxidative stress by disturbing a number of antioxidant enzymes in rat heart and liver. Terminalia arjuna is an effective antioxidant and free radical scavenger against cadmium acetate induced oxidative stress. The present study was designed to investigate the efficacy of Terminalia arjuna aqueous bark extract in protecting against the cadmium induced oxidative injury in rat heart and liver. Materials and method: The dose and time dependent changes were studied in heart and liver of male Wister rats following the subcutaneous administration of increasing concentrations of cadmium acetate (0.22, 0.44, and 0.88 mg/kg body weight), in every alternate day for a period of 5, 10, and 15 days respectively, to determine the maximum effective dose of cadmium acetate without any mortality. Pre-treatment of rats with aqueous bark extract of Terminalia arjuna (TA) was also studied by oral administration with the increasing doses (10, 20, and 40 mg/kg BW) against cadmium-acetate (0.44mg/kg BW, s.c.,) induced oxidative stress in rat heart and liver to determine the minimum effective dose of TA which can be protected these alterations in both the organs in a concentration dependent manner. The alterations in the activity of the different bio-markers of hepatic and cardiac damage, biomarkers of oxidative stress, and activities of the antioxidant enzymes were studied. Histo-pathological and histo-chemical alterations were also studied through H-E staining, PAS staining and Picrosirius red staining respectively. Structural integrity of hepatic and cardiac tissue were also studied through scanning electron microscopy. Results: The studies revealed that pre-treatment of aqueous bark extract of Terminalia arjuna protects the biomarkers of organ damage, oxidative stress, antioxidant enzymes, from getting altered in the rat heart and liver tissue following treatment with cadmium acetate.  Conclusion: The results of the present study suggest that the treatment of aqueous bark extract of Terminalia arjuna might be beneficial to alleviate cadmium induced toxicity in rat heart and liver.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-PC-00001635
Title: Synthesis of 1-(5-Substituted Benzofuran-2-yl)-3-Arylurea Derivatives as Antimicrobial Agents
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Background: Benzofurans are very interesting heterocycles, which are available in nature and show a wide range of pharmacological activities viz antifungal, antibacterial, antitumor, antimalarial, molluscicidal and antioxidant activity etc.  Methods: A convenient method for the preparation of 1-(5-substituted benzofuran-2-yl)-3-arylurea derivatives 6a-6r have been developed. The target compounds 1-(5-nitrobenzofuran-2-yl)-3arylurea 6a-6i and 1-(5-bromobenzofuran-2-yl)-3arylurea 6j-6r has been prepared by reacting 5-nitrobenzofuran-2-carbonyl azide 5a or 5-bromobenzofuran-2-carbonyl azide 5b with aromatic amines in reasonable overall yields. All the synthesized compounds were characterized using FT-IR, 1H NMR and mass spectrometry and were subjected to antimicrobial screening against two Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis) two Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and two fungi (Candida albicans, Aspergillus niger) using two fold dilution method. Results and discussion: All the values of FTIR, 1H NMR and mass spectra were found to be prominent. The results indicate that synthesized compound 6d showed potent antimicrobial activity comparable to standard. Conclusion: The detailed synthesis, spectroscopic data and antimicrobial activities of synthesized compounds were reported. 

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-P'Col-00001634
Title: Evaluation of the protective effects of Sapindus trifoliatus aqueous extract on vincristine induced neuropathic pain in rats
Category: Pharmacology
Section: Research Article
Country: India
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Aim: Evidences have been generated over past years that saponins possess anti-convulsant, neuroprotective, anti-neuralgic, anti-nociceptive, anti-migraine and anti-inflammatory effects. It has been documented that saponin is one of the major constituents in aqueous extract of Sapindus trifoliatus. Present study investigated the protective effects of Sapindus trifoliatus aqueous extract (AE-ST) on vincristine induced neuropathic pain in rats.  Materials and methods: Seven groups, each comprising of six SD rats, were employed in the present study. Painful neuropathy was induced in rats by administration of vincristine sulfate (75 µg/kg, i.p.) for 10 consecutive days. Spontaneous, mechanical, chemical and thermal nociceptive sensations were assessed at different time intervals i.e., 0, 3, 7, 9, 14 and 21. Biochemical alterations were determined on 21st day along with histopathological evaluations. Vincristine rats were co-administered aqueous extract of Sapindus trifoliatus (300, 100 and 30 mg/kg, p.o.) and pregabalin (10 mg/kg, p.o.) for 21 consecutive days. The data from the behavioral results were statistically analyzed by two-way ANOVA followed by Bonferonni’s post test. Data from the biochemical results were statistically analyzed by one-way ANOVA followed by Tukey’s multiple range test. Comparison results p < 0.05 were considered statistically significant.  Results: Administration of AE-ST significantly (p < 0.05) attenuated vincristine induced development of painful behavioral, biochemical and histological changes in a dose dependent manner similar to that of standard drug pregabalin as compared to vincristine control.  Conclusion: On the basis of data in hand, it may be concluded that AE-ST has potential ameliorating role in vincristine induced neuropathy which may be attributed to its multiple actions including anti-oxidative, anti-inflammatory and neuroprotective actions. 

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-PB-00001633
Title: Pseudomonas aeruginosa involves biosurfactants in Hydrocarbon degradation of oil contaminated water
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Aim: The ability of Pseudomonas aeruginosa strains of hydrocarbon degradation by producing biosurfactant has been investigated. Methods: The water samples were collected from reservoir receiving soybean oil waste and detected for the presence of P. aeruginosa  by 16S rRNA having potential of biosurfactant production when tested by oil spreading and emulsification assays. These isolates also recorded for the hydrocarbon degradation when tested by the COD reduction. Results and Discussion: The water bodies receiving heavy load of soybean oil was found to be positive for the several strains of P. aeruginosa capable of degrading hydrocarbon due to production of biosurfactant with different inherent capabilities. Conclusion: Isolated P. aeruginosa strains were found to be capable of degrading hydrocarbon due to overproduction of biosurfactant when tested in lab conditions. 

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-PC-00001632
Title: Green nanoparticles synthesized from roots of Datura metel and evaluation of anti microbial activity
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Metal Nanoparticles are explored in recent years as an alternative approach to effectively kill drug resistant pathogenic microorganisms. Silver nanoparticles (AgNPs) are the metal of choice for anti microbial agents. In this study, phytochemicals extracted from roots of Datura metel using n-hexane as solvent by Soxhlet extract technique. The extract were treated with silver nitrate and kept in the dark conditions for 48 hrs, for the appearance of colour change. The Plasmon peak was observed at 448nm. The physical appearance of these silver  nanoparticles was characterized using ultraviolet-visible spectroscopy, FT-IR, SEM, EDAX, TEM and X-ray diffraction techniques. Scanning electron microscopy (SEM) showed the clustered and irregular shapes of AgNPs, with a mean size of 50-85 nm. EDAX results confirmed the presence of silver nanoparticles in the adsorption peak of  2.30 keV. Nanoparticles average size determined by TEM studies and in identified in the range of  50-80nm. The antibacterial activity of the synthesized silver nanoparticles was tested against two micro-organisms using the disk diffusion method. The results reveal that silver nanoparticles synthesized using Datura metel root extract have potential antibacterial activity against Pseudomonas aeruginosa, Escherichia coli.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-PA-00001631
Title: Simultaneous HPLC Determination of Lidocaine-Epinephrine-Tetracaine in a topical solution for pediatric anesthesia
Category: Pharmaceutical Analysis
Section: Editorial
Country: India
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Background: A simple and rapid reversed phase-high performance liquid chromatographic method was developed for simultaneous determination of lidocaine, epinephrine and tetracaine in specific pharmaceutical children anaesthetic solution.  Method: The elution was done with a mobile phase gradient composed of methanol:phosphate buffer(v:v) on Chromosil C18 column (4 × 150 mm, 3 ìm particle size). The gradient elution started with 40% (V/V) methanol, ramped up linearly to 55% in 8 min, then kept constant until the end of the run. The mobile phase was pumped at a flow rate of 0.8 mL/min. The wavelength detector was set at 254 nm for lidocaine and tetracaine and 220 nm for epinephrine. Results and discussion: Retention times for lidocaine, epinephrine and tetracaine were around 3.058 min, 1.867 min and 6.917 min respectively. The reliability and analytical performance of the proposed HPLC procedure were statistically validated according to the respect of linearity, ranges, precision, accuracy, repeatibility, reproducibility, detection and quantification limits. Linear ranges were establish between 1,2-2,8mg/mL for lidocaine (r2=0,9973), 15-35μg/mL for epinephrine (r2= 0,9858) and 150-350μg/mL for tetracaine (r2=0,9968). Conclusion: This is the first time that a study combining simultaneous routinely determination of these three compounds has been performed in lidocaine, epinephrine and tetracaine paediatric anaesthetic solution.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-PB-00001630
Title: GC-MS profile of Biosurfactant producing and Hydrocarbon degrading P. aeruginosa NGB4 in liquid culture system
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Aim: The ability of biosurfactant and hydrocarbon degrading capability of the P. aeruginosa NGB4 has been evident by GC -MS profiling. Materials and Methods: Industrial waste water supplemented with soybean oil, P. aeruginosa CFU set at 2 x 108 per ml has been tested for the formation of biosurfactant and metabolites under laboratory studies in liquid culture systems and further identified by GC-MS analysis. Results and Discussion: The ability of P. aeruginosa NGB4 to form biosurfactant found to enhance the degradation capability of the waste water which has resulted in faster degradation and confirmed by number of intermediate metabolites formed. Conclusion: Potential feature of P. aeruginosa NGB4 for hydrocarbon degradation by virtue of biosurfactant production has been elucidated which could be utilized in waste water hydrocarbon degradation.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-PCS-00001629
Title: Formulation and evaluation of antidandruff shampoo
Category: Pharmaceutics
Section: Research Article
Country: India
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Shampooing is the most common  form of hair treatment to remove dirt, grease and debris from the hair, scalp and other parts of  body without damaging the natural gloss of hair and to keep the hair fragrant, lustrous, soft and manageable. The shampoo is prepared by using two Antidandruff agents such as Sulphur and Benzoic acid. The other ingredients used are sodium lauryl sulphate as surfactant, urea as solubilizing agent, sodium EDTA as chelating agent, guar gum as foam stabilizer and thickening agent, tween 80, distilled water is used as vehicle. It was evaluated for various tests and the ranges were in acceptable limits. The pH range was 6.3 to 6.8, physical appearance was pale yellow, The percentage (%) of solid contents ranges from 22.3 to 26.7, viscosity was in the range of 1209 to 1729, surface tension was 31.16 to 34.19 and foam value 143 to 171. The anti-microbial activity was done by using staphylococcus aureus, The zone of inhibition by 1% solution using Sulphur : Benzoic acid in the ratio of 1: 1.25 have shown 3.1mm of inhibitory action.  The present research emphasizes about the preparation & evaluation of synthetic antidandruff cosmetic shampoo.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-P'Col-00001628
Title: Counteracting the Arthritis : A Retrospection of Methotrexate Sustained Release System
Category: Pharmacology
Section: Review Article
Country: India
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Aim of review is to treat the arthritis. Rheumatoid arthritis is an auto-immune joint disorder involving pain and inflammation. Various drugs are used for pain management and relief from arthritis with single and multiple dose therapy. Different drugs are especially suitable for achieving controlled and delayed release profile with low risk of dose dumping. These systems have received great attention of thus increasing patient compliance and economic feasibility and avoiding drug associated side effects. Present review mainly deals with the problem of rheumatoid arthritis in pain management, various approaches to overcome this and specifically explore the possibilities to apply modified drug delivery systems for this purpose.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 11.
Article Id: JPRS-PC-00001627
Title: Cd (II) complex of some novel 5-nitroimidazole derivatives: Synthesis, characterization and antibacterial activity
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Background: Bacterial resistance development to the existing drugs has encouraged the search for novel targets. The novel metal complexes and their derivatives may represent an interesting approach for designing new antibacterial drugs. This may be due to the dual mechanism of both ligands and metal ion interacting in different stages of life cycle of bacteria.The aim of the present work was to synthesize a novel series of Cd (II) complexes of 2-(1-substituted-5-nitro-1H-imidazol-2-yl)-1-substitutedethanone and evaluate their in-vitro antibacterial activity. Methods: The metal-ligand complexes of cadmium have been synthesized in good yield. Synthesized complexes were evaluated in-vitro for their antibacterial activity by agar well diffusion method. Results: All the synthesized compounds were characterized by IR, 1H NMR, mass spectra and molar conductance. Some of the metal complexes were found to be moderately active against Gram-positive bacteria, B. pumilus ATCC 14884 and S. aureus ATCC 29737. Conclusion: Cd (II) complexes of 2-(1-substituted-5-nitro-1H-imidazol-2-yl)-1 substituted-ethanone have been synthesized and characterized. The synthesized complexes show inhibitory activity against only Gram-positive bacteria.