Journal Menu

Issues

Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 10, Issue: April
Article Id: JPRS-BMB-00001234
Title: Local tissue damage induced by Echis carinatus venom: Neutralization by Albizia lebbeck seed aqueous extract in mice model
Category: Biochemistry and Molecular Biology
Section: Research Article
Country: India
View Article

Background: Albizia lebbeck L. (Fabaceae) is an Indian traditional medicinal plant used in treatment of snakebite and scorpion sting. The present study aims to determine its scientific basis. Methods: Pulverized seed aqueous extracts (cold and hot) was evaluated for neutralization of enzyme activities (hyaluronidases, proteases and PLA2s) of Echis carinatus S. (Viperidae) venom (ECV), in vitro and local tissue damage using murine model. Results and discussion: Cold extract contained proteins which resolved into three fractions on Sephadex G-50 (ALF-1, ALF-2, and ALF-3), while hot extract (ALHE) contained no proteins. ALF-1 contained proteins and did not inhibit any enzymes. ALF-2 and ALHE contained flavonoids, phenolics, saponins, and steroids. All four fractions were positive for peptides/amino acids. ALF-2 and ALHE demonstrated significant inhibition of hyaluronidase. Only ALHE showed potent inhibition of proteases, ECV induced hemorrhage, myotoxicity and pro-coagulant activity. ALF-3 inhibited PLA2 activity and edema. In summary, hyaluronidases and proteases inhibitory phytochemicals present in A. lebbeck seed get extracted in both cold and hot water. The PLA2s inhibiting peptides/amino acids get extracted largely in cold water. Therefore, this differential extraction method can be used to isolate specific inhibitors. Conclusion: The results support the significance of A. lebbeck extracts towards management of snakebite by the local traditional healers in India.

Cite this article as :  P U Amog, M Yariswamy, Vikram Joshi, A N Nanjaraj Urs, K N Suvilesh, V N Manjuprasanna, M N Savitha, G V Rudresha, Nataraju Angaswamy, B S Vishwanath,T Veerabasappa Gowda,Local tissue damage induced by Echis carinatus venom: Neutralization by Albizia lebbeck seed aqueous extract in mice model,Journal of Pharmacy Research 2016,10(4),167-175.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: April
Article Id: JPRS-B&NPS-00001232
Title: Allelopathic effect of Silene villosa on germination and seedling growth of Triticum aestivum L.
Category: Botany/ Herbal/ Natural Pharmacological Study
Section: Research Article
Country: India
View Article

Background: The aim of the present study was to determine the allelopathy of Silene villosa Forssk collected from District Karak Khyber Pakhtunkhwa Pakistan. Materials and Methods: For allelopathy stock solution of 1000 ppm (1mg/ml) was prepared in 1% DMSO for each of n-Hexane, Chloroform and Ethyl acetate soluble fractions. For each stock solution 4 dilutions of 10, 30, 100 and 300ppm were prepared. The stock solution and dilutions were tested against Triticum aestivum L. variety Shahkar 2013. The allelopathy was obtained by measuring the germination percentage, root shoot length and fresh and dry weight of root and shoot. Results: The result showed that, Silene villosa have significant inhibitory role against wheat. The germination percentage was reduced in all the fractions as the concentration was increased. Increasing concentration has definite inhibitory effect on root and shoots length, fresh and dry weight of root and shoot. Conclusions: The investigation shows that the plant has remarkable allelopathic activity against wheat plant.

Cite this article as : Waheed Murad, Rehman Ullah, Aziz Ullah, Muhammad Gul Riaz Khan, Hameed ur Rehman, Zulqarnain, Zain Ullah Khan,Allelopathic effect of Silene villosa on germination and seedling growth of Triticum aestivum L.,Journal of Pharmacy Research 2016,10(4),176-180.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: April
Article Id: JPRS-PA-00001231
Title: Simple and rapid method development and validation of RP-HPLC method for the determination of zidovudine in human plasma
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
View Article

Background: Zidovudine, as monotherapy or in combination with other antiretroviral agents, remains a first-choice therapy for the prophylaxis of mother-to-child HIV transmission. Since sufficient bioanalytical methods have not been reported officially for the quantitative estimation of zidovudine, there is necessity for investigation of new analytical method for quantitative estimation of zidovudine in human plasma. Objective: An isocratic, simple, precise and accurate HPLC-UV method was developed and validated for determination of zidovudine in human plasma using nevirapine as an internal standard to support anti-retroviral pharmacology programs. Materials and methods: The extraction process involved a liquid-liquid extraction and were chromtographed on a Phenomenex C18 (250×4.6 mm i.d., 5 µm particle size) column at ambient temperature using a mobile phase consisting of methanol and 0.1% orthophosphoric acid (40:60 %v/v), the flow rate of 1.0 mL/min and UV detection at 265 nm. The method was found to be specific for AZT and no endogenous biological substances were found to be interfering with peaks of drug and internal standard. Results: The method showed good linearity in the range of of 81.70-5263.55 ng/mL and correlation of coefficient (r2) was found to be 0.99784. The day co-efficient of variations was 0.37-4.95%. The overall recovery for AZT was found to be 55.48 % respectively. Stability data revealed that the drugs were stable in plasma under various test conditions. Conclusion: The proposed method was applicable for clinical therapeutic drug monitoring programs of AZT and useful in the determination of pharmacokinetic profile and bioequivalence studies of HIV research.

Cite this article as : Nalanda R. Baby, Srinivasa A. Rao, Pavani S. Naidu, Druga Surla, Nagamani Bolla, Simple and rapid method development and validation of RP-HPLC method for the determination of zidovudine in human plasma,Journal of Pharmacy Research 2016,10(4),160-166.

 

Journal: Journal of Pharmacy Research , Volume: 10, Issue: April
Article Id: JPRS-ND-00001230
Title: Antibacterial Efficacy of Natural Dye from Melia composita Leaves and Its Application in Sanitized and Protective Textiles
Category: Natural Drugs
Section: Research Article
Country: India
View Article

Background: In view of the increasing consciousness on higher level of hygiene and health safety, development of protective textiles through giving antimicrobial finish is in focus. Therefore, the present study was aimed to investigate the antibacterial activity of natural dye from Melia composita leaves and different types of dyed fabrics. Methods: Antibacterial efficacy of natural dye and dyed fabrics were evaluated against gram-positive bacteria, Staphylococcus aureus, Streptococcus epidermidis and Bacillus cereus and gram-negative bacteria, Escherichia coli, Klebsiella pneumonia, Shigella flexneri and Proteus vulgaris using agar well diffusion method. The minimum inhibitory concentration (MIC) was determined by serial dilution method. Results: The dye was found to have potent antibacterial against all the test bacteria at all the tested concentrations. Highest antibacterial activity against all the test bacteria was recorded with 50 mg/ml treatment, which was also higher as compared to positive control whereas minimum activity was found at 5mg/ml treatment. The MIC of natural dye against test bacteria was found in the range of 2.75-4.00 mg/ml. Dyed fabrics substrates (silk, wool and cotton) also showed significant antibacterial efficacy against the test bacteria.  All dyed fabrics showed maximum reduction in S. aureus population and lowest in E. coli. Of the three dyed fabrics, silk exhibited the maximum reduction in all the test bacteria followed by wool and cotton. Conclusion: The study concluded that M. composita leaves can be a potential source of natural dye with remarkable antibacterial potency which can be applied in sanitized fabrics for medical applications and protective clothing.

Cite this article: Anita Pal, Y.C. Tripathi, Rakesh Kumar and Lokesh Upadhyay,Antibacterial Efficacy of Natural Dye from Melia composita Leaves and Its Application in Sanitized and Protective Textiles,Journal of Pharmacy Research 2016,10(4),154-159.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: April
Article Id: JPRS-BGSA-00001229
Title: Cell surface antigen search of Campylobacter jejuni by Reverse vaccinology
Category: Bioinformatics (Genome & Sequence Analysis )
Section: Research Article
Country: India
View Article

Aim: By involving the approach of Reverse vaccinology highly conserved cell surface antigens of Campylobacter jejuni were searched. Materials and Methods: To score and select best scored cell surface protein antigens online servers Signal P 4.1, TMHMM, LipoP 1.0, PsortB and BLASTP were used. Observation and Results: With the complete information available for pathogen C. jejuni  genome, our study reported 27 highly conserved cell surface antigens which may be put into vaccine research in future. Conclusion: Study highlighted the role of Bioinformatics in selecting best scored cell surface antigens available for pathogen C. jejuni.

Cite this article as : Rajni Mishra, Dilip Gore, Avinash Upadhyay,Cell surface antigen search of Campylobacter jejuni by Reverse vaccinology,Journal of Pharmacy Research 2016,10(4),149-153.