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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 10, Issue: September
Article Id: JPRS-P'Col-00001485
Title: Estra-1, 3, 5(10) - triene-3, 17 β-diol protects mitochondria against Cu-ascorbate induced oxidative damage in in vitro system: A novel therapeutic approach
Category: Pharmacology
Section: Research Article
Country: India
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Background: Cu-ascorbate is a well-established oxidative stress inducing agent in in vitro system. Terminalia arjuna is also a well known medicinal plant used as an anti-ischemic and cardiotonic agent for over three centuries in India. Estra-1, 3, 5(10) - triene-3, 17 β-diol (β-E) was identified as a component of the aqueous extract of bark of Terminalia arjuna. Aims and Objectives: To determine its antioxidant efficacy against cu-ascorbate induced oxidative stress in isolated goat liver mitochondria in an in vitro system. Methods: Goat liver mitochondria was incubated with Cu-ascorbate and different concentrations of β-E at pH 7.4 and 370C for 60 minutes. Then the reaction was stopped upon addition of EDTA. Enzymes and DNA from incubated mitochondria were isolated to determine the alteration in their activities and the status of the biomarkers of oxidative stress.  Results: Incubation of goat liver mitochondria with Cu-ascorbate at pH 7.4 and 370C has resulted in significant elevation of lipid peroxidation, protein carbonylation , DNA damage, activities of Mn-superoxide dismutase, xanthine oxidase along with a concomitant decrease in reduced glutathione level, activities of the Kreb’s cyle and electron transport chain linked enzymes which  is indicating towards the generation of reactive oxygen species (ROS) mediated mitochondrial dysfunction, that was confirmed by Janus green B staining. All of these changes were prevented from being occurring on co-incubation of mitochondria with β-E.  Conclusion: From these above results it can be concluded that β-E possesses a significant antioxidant potential and provides protection to mitochondria against Cu-ascorbate induced oxidative damage.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: September
Article Id: JPRS-ND-00001484
Title: Phytochemical standardization of the leaves of a medicinal plant Cipadessa baccifera Roth Miq.
Category: Natural Drugs
Section: Research Article
Country: India
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Background: The present study was undertaken for qualitative, quantitative estimation of phytochemicals and standardization of Cipadessa baccifera leaf and to develop HPTLC finger print profile for its alcoholic extract.  Methodology: The shade dried leaves were subjected to analyse physico-chemical parameters as per standard procedures. The qualitative analysis and quantitative estimation of flavonoids, tannins and phenols were carried out by subjecting the specific extraction procedures using UV – Visible Spectrophotometer. TLC/HPTLC finger print profile was developed by using suitable solvent system. Results and discussion:  Physicochemical analysis of the leaves showed moisture content (9.39 %); ash content (4.58%) acid insoluble ash (0.61%); water soluble extractive value (18.63 %) and alcohol soluble extractive value (13.56%). The qualitative analysis of alcohol extract showed positive test for triterpenoid, flavonoid, alkaloid, coumarin, saponin, tannin and phenol. Quantitative estimation of the plant observed 1.90 % of tannin, 4.79 % of flavonoid and 2.48% of phenol.  Conclusion: HPTLC finger print profile was shown the presence of various phytochemical constituents. The present study on physicochemical analysis, qualitative and quantitative analysis revealed the presences of various biologically active constituents in this plant. This information can be utilised for authentication of this plant for the use of drug preparation.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: September
Article Id: JPRS-SM-00001471
Title: Qualitative Analysis of Volatile Constituents from flowers of Acacia leucophloea Willd through Gas Chromatography and Mass Spectrum Analysis
Category: Siddha Medicine
Section: Research Article
Country: India
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Objective: To establish qualitative analysis of volatile Constituents from flowers of Acacia leucophloea Willd through gas chromatography and mass spectrum analysis. Methods: The qualitative analysis of volatile compounds from the flowers of A.leucophloea were carried out by gas chromatography and mass spectrum analysis. Interpretation of massspectrum GCMS was conducted using data base of National Institute of Standard and Technology (NIST) andWiley spectra Libraries. Results & Conclusions: This study provides the scientific data for the proper identification of volatile constituents from flowers of A. leucophloea.  The chromatogram shows 8 prominent peaks in the retention time range from 10.65–35.45. The peak at 38.45 retention time is having the %peak area 34.90. This largest peak is due to the presence of triacontane. The second less prominent peak at 27.88 retention time has the %peak area 29.85 is due to the presence of 9, 12, octadacadienoic acid. The third less significant peak at 22.05 retention time with the % peak area 24.99 is characteristic of n-hexadecanoic acid. The fourth less prominent peak at 28.10 retention time with the % peak area 2.87 denotes octadecanoic acid. Consequently, this fast and simple method can be used for the analysis of the volatile compounds emitted from Acacia leucophloea and it offer a platform of using Acacia leucophloea flowers as herbal alternative for various diseases including diabetic, cancer, cardiovascular etc.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: September
Article Id: JPRS-PCS-00001473
Title: Formulation Development and Evaluation of Risperidone Fast Dissolving Tablets
Category: Pharmaceutics
Section: Research Article
Country: India
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Background:The main aim of present research investigation is to formulate the Risperidone Fast Dissolving tablets. Risperidone, an atypical antipsychotic, belongs to BCS Class-II and used for treating schizophrenia, bipolar mania and autism by blocking D2 and 5-HT2A receptors. Methods: The Fast Dissolving tablets of Risperidone were prepared employing different concentrations of Crospovidone and Croscarmellose sodium in different combinations as a Superdisintegrants by Direct Compression technique using 32 factorial design. The  concentration of Crospovidone and Croscarmellose sodium was selected as independent variables, X1 and X2 respectively whereas, wetting time, Disintegration time, t50% ,t90%were selected as dependent variables.  Results and Discussion: Totally nine formulations were designed, preapred and are evaluated for hardness, friability, thickness, Assay, Wetting time, Disintegration time, In-vitro drug release. From the Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and  the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r)  were calculated. Polynomial equations were developed for Wetting time, Disintegration time, t50%, t90%.  Validity of developed polynomial equations were verified by designing 2 check point formulations (C1, C2). According to SUPAC guidelines the formulation (F5) containing combination of 10% Crospovidone and 10% Croscarmellose, is the most similar formulation (similarity factor f2= 93.556, dissimilarity factor f1= 0.976 & No significant difference, t= 0.022) to marketed product (RISPERDAL-4).  Conclusion:The selected formulation (F5) follows First order, Higuchi’s kinetics, mechanism of drug release was found to be Fickian Diffusion (n= 0.383).