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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 2.
Article Id: JPRS-PB-00001214
Title: In vitro studies on the wound dressing prepared using collagen and teak leaves (Tectonagrandis)
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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The inappropriate caring of the burn wound may delay its healing, causing the area to become infected and subsequently resulting in chronic wounds. In this study, methanolic teak leaves extract (Tectonagrandis) has been incorporated into collagen sheet and the bio-composite has been evaluated for its physical, biological properties and also its in-vitro wound healing efficacy using 3T3 fibroblast cell line. This composite sheet is cost-effective, as collagen is being extracted from chrome shavings a by product of tanneries, in which teak extract is incorporated. The results showed that addition of teak leaves extract increased the water absorption capacity (184 %), tensile strength properties (1.11 N/mm2) and also stability of composite sheet against lysozyme. The characteristic spectra of collagen is shown by IR spectrum of amide I, II and III absorption bands at 1663, 1555 and 1242 cm-1 respectively. The bio-composite sheets have exhibited anti-microbial properties and extract release studies show 80 % extract release in 4 hrs. MTT based proliferation assay shows that collagen–teak bio composite sheets are not cytotoxic to cells and also supports the growth and proliferation as indicated by increase in cell number with respect to time.

Cite this article as: Trikkurmadom Seetharaman Amritha, VijiChandran S, Rajalekshmy G, Sujatha S,Pandima Devi M,In vitro studies on the wound dressing prepared using collagen and teak leaves (Tectonagrandis),Journal of Pharmacy Research 2016,10(2),97-105.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 2.
Article Id: JPRS-QA-00001213
Title: Formulation and Evalution of Immediate Release Tablets of Fexofenadine Hydrochloride
Category: Quality Assurance
Section: Research Article
Country: India
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The present research work is to develop immediate release tablets of Fexofenadine hydrochloride. The rate of dissolution and bioavailability of the Fexofenadine HCL has been increased by using superdisintegrants in its immediate release tablets. Direct compression method was adapted to prepare the tablets by using Sodium lauryl sulphate, microcrystalline cellulose as filler, crospovidone and sodium starch glycolate as superdisintegrant in different concentration (2-8%). Tablets were prepared and evaluated pre and post compressional parameters. In-Vitro Disintegration study shows that as there is increase in disintegration time with increase in concentration of sodium starch glycolate while there is decrease in disintegration time with increase in the level of crospovidone. The results indicate that the selected batch of tablet formulation containing crospovidone provides disintegration time between 3-6 minutes with sufficient crushing strength and accepted friability. It was concluded that immediate release tablet for Fexofenadine hydrochloride can be formulated for fast treatment of allergic rhinitis.

Cite this article as:Sachin Gholve, Ganesh Todkar, Sharad Barhate, Ranjana Suryawanshi, Omprakash Bhusnure,Formulation and Evalution of Immediate Release Tablets of Fexofenadine Hydrochloride,Journal of Pharmacy Research 2016,10(2),90-96.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 2.
Article Id: JPRS-PCS-00001212
Title: Incorporation of METHOCEL E6 PLV by a Novel Foam Granulation Technique for Dissolution Augmentation of the Poor Soluble Silymarin
Category: Pharmaceutics
Section: Research Article
Country: India
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Objective: In the present study Foam Granulation Technique (FGT) TM was employed in the development of IR tablets of high dose of silymarin dried plant extract which is a very fine, poorly compressible material with poor water solubility and these characteristic features poses extensive technological challenge in its manufacturing. Methods: In FGT, the Methocel E6 PLV was used as foam binder in varying concentrations of 1%, 5%, 7% and 10%. The evaluation of potentially important foam properties, foam penetration mechanism assessment and tablet evaluation was carried out in details and compared with direct compression tablet of silymarin. Results and Discussion: The foam penetration followed foam drainage controlled mechanism and was found to be less dependent on the powder hydrophobicity compared to water drop which followed drop controlled mechanism. The foam induced nucleation successfully created nuclei with relatively uniform structure, size and sphericity as compared to water. The dissolution profile of silymarin foam bonded tablets with 5% Methocel E6 exhibited better dissolution profiles with T20%, T50%, T75% at 6, 30 and 120 min, when compared with direct compression control tablets with T20% at 120 min. The drug release from optimized 5% foam tablets followed Higuchi model with R2 = 0.8831 and were found to be stable in accelerated stability studies for a period of 3 months. Conclusion: Thus silymarin with high dose-low solubility characteristics can be easily formulated into IR tablet for clinical and commercial use using this helpful technique.

Cite this article as: Shamama Javed, Kanchan Kohli, Waquar Ahsan,Incorporation of METHOCEL E6 PLV by a Novel Foam Granulation Technique for Dissolution Augmentation of the Poor Soluble Silymarin,Journal of Pharmacy Research 2016,10(2),79-89.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 2.
Article Id: JPRS-PCS-00001221
Title: Swelling Approach A Novel Method For Gastric Retention
Category: Pharmaceutics
Section: Research Article
Country: India
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Present investigation deals with the preparation and characterization of swellable gastroretentive drug delivery system of Pregabalin containing Psyllium Husk, HPMC K4M, Crosspovidone and Polyvinylpyrolidone, as the polymers. The swellable gastroretentive drug delivery system tablets were prepared by wet granulation method. Nine formulations were developed which differed in the ratio of polymers. Formulations PRF-1, PRF-2, PRF-3, PRF-4, PRF-5, PRF-6, PRF-7, PRF-8 and PRF-9 were composed of Psyllium Husk, HPMC K4M, Crosspovidone and Polyvinylpyrolidone respectively. All the formulations were evaluated for swelling index, Mucoadhesive Strength, Mucoadhesive force, Mucoadhesive time and in vitro drug release study. In vitro drug release study was performed using United State Pharmacopoeia (USP) type 2 dissolution test apparatus employing paddle stirrer at 50 rpm using 900 ml of 0.1N HCl maintained at 37ºC ± 0.5ºC as the dissolution medium. On the basis of evaluation parameter formulation PRF-5 was selected as developed formulation. Therefore, it can be concluded that the swellable gastroretentive drug delivery system may be exploited successfully for the delivery of drugs such as Pregabalin.

Cite this article as:Lahoti Swaroop Rameshwarji, Shep Santosh Gyandev,Swelling Approach A Novel Method For Gastric Retention, Journal of Pharmacy Research 2016,10(2),120-125.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 2.
Article Id: JPRS-PCS-00001219
Title: Development and validation of RP-HPLC method for simultaneous estimation of atrovastatin and olmesartan in pharmaceutical formulations
Category: Pharmaceutics
Section: Research Article
Country: India
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Combination therapy of Atorvastatin (AT) and Olmesartan (OLM) is used for the treatment of co existing essential hypertension and hyperlipidemia in adult persons. In the present study a simple, precise, rapid, efficient and reproducible reversed phase high performance liquid chromatography (RP-HPLC) method has been developed for the simultaneous estimation of AT and OLM present in its tablet dosage forms. Chromatographic separations were carried out isocratically at 30°C ± 0.5°C on a hypersil bds C18 (100,4.6 mm,5µ) with a mobile phase composed of Sodium dihydrogen phosphate pH 4.5 with dilute phosphoric acid : Methanol: Acetonitrile in the ratio of 65:20:15 % v/v at a flow rate of 1.0 ml/min. Detection is carried out using a UV detector at 232 nm. The retention times for OLM and AT were 2.23 min and 3.46 min respectively. The linearity range for 20-100 ìg/ml AT and OLM were found to be 40-200 ìg/ml with correlation coefficient of 0.999 and 0.999 respectively. The % recovery of the proposed method was found in the range of 100.39 for AT and 98.53 for OLM. The relative standard deviations for three replicate measurements in three concentrations of standard solution were always less than 2%. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which may be useful for the routine estimation of AT and OM in bulk drug and in its pharmaceutical dosage form.

Cite this article as: P.Koushik koteswara rao, D.Pavan kumar reddy,Dr.Brahma reddy,P.Jitendra kumar, Development and validation of RP-HPLC method for simultaneous estimation of atrovastatin and olmesartan in pharmaceutical formulations,Journal of Pharmacy Research 2016,10(2),116-119.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 2.
Article Id: JPRS-PB-00001216
Title: Keratin degradation by bacterial strain isolated from poultry farm soil
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Objective: The aim of the current study was to isolate keratinolytic bacteria from the soil samples collected from poultry farm. Background: The awareness of importance of microbial degradation of keratin substrate into usable products many efforts are being conducted to isolate keratinolytic microorganisms. Methods: The isolation was performed by using enrichment technique. Total twenty four bacterial strains were isolated from the collected soil samples. All isolates were screened for proteolytic activity by skim milk agar plate method, among twenty four bacterial isolates. Results: Out of 24 only 6 isolate were showing Proteolytic activity as indicated zone of clearance on skim milk agar plate. Out of these 6 Proteolytic strains only 2 strains were showing keratin degradation ability by using chicken feather as a sole carbon source in feather meal broth. Finally out of two isolates MKR9 bacterial strain was selected for further study. Conclusion: Isolated bacterial strain producing keratinases is prominence in degradation of poultry waste feather. These keratinase producing microbial strains have an important application in removal of poultry waste and recycled into valuable by-product.

Cite this article as:Manoj Kumar, Rajesh Kumar and Deepak Kumar Malik,Keratin degradation by bacterial strain isolated from poultry farm soil,Journal of Pharmacy Research 2016,10(2),113-115.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 2.
Article Id: JPRS-ND-00001215
Title: Solvent pH extraction effect on phytochemical composition and antioxidant properties of Algerian Matricaria Pubescens
Category: Natural Drugs
Section: Research Article
Country: India
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This study investigated the phenolic content, flavonoid content, flavonols and antioxidant and anti-inflammatory activities of different pH of solvent aqueous (water) extraction of aerial part from Matricaria Pubescens. Three phenolic acids (gallic acid, chlorogenic, caffeic acid) and two flavonoids (rutin and vanillin) were identified and quantified using HPLC. The total phenolic content, flavonoids content and flavonols were determined by a spectrophotometric method. The assessment of the antioxidant potential of different pH extract (3, 4, 5, 6 and 7) using the ferric reducing antioxidant power (FRAP) assays, diammonium salt (ABTS). Total phenolic contents flavanoïds and flavonols from leaves were the highest at pH 5, but gradually decreased with elevated pH. The FRAP scavenging effects of extraction pH value 5 and 4 were superior to those at other pH, and paralleled the trend of total phenolic content. The ABTS scavenging capacity was found to be the highest for extract at pH between 5 and 4. HPLC analysis showed rutin to be the most abundant phytochemical, followed by gallic acid. The relative phenolic compounds surface hydrophobicity of all extracts was influenced by pH. The highest anti-radical activity is that in the presence of ascorbic acid. Extraction of phenolic compounds and there antioxidant activity can be completely inhibited by some chemicals and extreme pH.

Cite this article as: Laouini Salah Eddine, Berra Djamila, Ouahrani Mohammed Redha,Solvent pH extraction effect on phytochemical composition and antioxidant properties of Algerian Matricaria Pubescens,Journal of Pharmacy Research 2016,10(2)106-112.