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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 8.
Article Id: JPRS-PCS-00001404
Title: Comparative Study of Binding Properties of Lipidium sativum Seed Mucilage with Methyl cellulose and Gelatin
Category: Pharmaceutics
Section: Research Article
Country: India
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Objective: To compare the binding capabilities of Lepidium sativum seed mucilage (LSM) with standard binders i.e. methyl cellulose and gelatin as binder in uncoated tablet dosage form in similar experimental conditions. Method: We isolated seed mucilage from Lepidium sativum seeds and prepared different tablet formulations with varying concentration of LSM (0.5% w/w to 5% w/w) as binder. Similar formulation were prepared using methyl cellulose and gelatin as binder in same concentrations i.e. 0.5% w/w to 5 % w/w. All three batches of tablets were prepared by wet granulation technique and performance were compared in terms of their official tests (hardness, weight variation, friability, drug assay, disintegration time, dissolution profile) prescribed by Indian Pharmacopoeia 2007. Results: LSM in concentration from 1% to 5 % w/w of tablet weight produced tablets with acceptable hardness and friability. All the formulations disintegrated within 15 minutes and releases more than 80 % drug within 20 minutes in phosphate buffer when tested with in-vitro dissolution apparatus. Geltin produced almost similar results at same concentrations when compared to LSM as binder although methyl cellulose produced harder tablets and disintegration time was also found to be on higher side in comparison with LSM and gelatin at same concentrations. Conclusion: LSM can be used in uncoated tablets as binder in concentration 1%-5% w/w. It is a good alternative to gelatin but it may not be used in place of methyl cellulose as binder in same concentration.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 8.
Article Id: JPRS-ND-00001392
Title: Evaluation of antibacterial activity of successive extract of Lantana camara flower
Category: Natural Drugs
Section: Research Article
Country: India
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Background: Various plant extracts has formed the basis of many alternative medicines and natural therapies. Methods: Powdered sample of flower of Lantana camara   was extracted with petroleum ether, ethyl acetate, ethanol and water. Various extract each of 50 mg/ml concentrations was prepared and antibacterial activity was carried out by disc diffusion method against gram positive and gram negative bacteria. Results and discussion: Ethyl acetate extract produced zone of inhibition 35mm and 34mm, 33mm 32mm, 32mm, and against E. coli, S. typhi, B. Subtilis, Pseudomonas, S. aureus respectively. The value of zone of inhibition for ethanol extract was found 34mm, 34mm 30mm 30mm and  25mm against S. typhi, S. aureus, E. coli., Pseudomonas and B. subtilis respectively. Significantly higher activity was shown by ethyl acetate extract against Pseudomonas, Staphylococcus aureus, and Bacillus and by ethanol extract against S. typhi, Pseudomonas and S. aureus as compared to positive control. Conclusion: The present research work showed that ethyl acetate and ethanol extract of flower of lantana camara possesses strong antibacterial effect against E. coli, S. typhi, Pseudomonas, S.  aureus, and B. Subtilis.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 8.
Article Id: JPRS-BMB-00001395
Title: Phenotypic Detection of Various β-Lactamase from Urinary Isolates
Category: Biochemistry and Molecular Biology
Section: Research Article
Country: India
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Background:  Resistance to antibiotics and other drugs has emerged in most bacterial infections, which constitutes a significant proportion of the burden of health care and disease management in developing countries. The incidence of infections due to organisms resistant to β - lactam agents due to production of various enzymes has increased in recent years. The extensive use of antibiotics in the community and hospitals has fuelled this crisis. Methods: Urine samples were collected from various hospitals and private pathological laboratories. Bacterial strains were identified according to standard microbiological investigations approved by CLSI guideline. Isolated pathogens were undergone for screening test to find out the prevalence of β -lactam resistance towards various generations of β-lactam drugs. Resistant isolates were classified by phenotypic detection method. Result & discussion: The study was conducted to evaluate the prevalence of various types of β -lactamase among urinary isolates. Out of 175 samples 152 pathogens were isolated in pure culture. 42.10% resistance were observed among this urinary isolates against various generation of β-lactam drugs. Conclusion: Increasing levels of resistance are being found among common community-acquired urinary pathogens, and nosocomial pathogens. The increasing resistance has made empirical treatment more difficult. UTIs complicated by ESBL organisms tend to lead in our study.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 8.
Article Id: JPRS-PA-00001387
Title: Stability of extemporanously compounded bosentan liquid
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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Background: Bosentan is an endothelin receptor antagonist used for the treatment of pulmonary arterial hypertension. While it is approved for use in adults, it is frequently used off label for children under 12 years. Since no liquid formulation is available in the U.S., the tablets must be compounded into a liquid suspension for use in children. Current practice requires that bosentan be compounded daily, with two doses drawn from a single suspension. This results in significant waste. We tested the hypothesis that compounded bosentan was stable for longer than 24 hours. Methods: We tested water and Ora-Blend® as diluents and storage at both room temperature and 4o C. Bosentan concentrations and known degradation products were measured by LC/MS-MS. Results: Our data demonstrated that bosentan retained >90% of starting concentration through 48hours. Modest improvement in reproducibility was observed when bosentan was suspended in the Ora-Blend® solution, suggesting improved distribution, andreduced loss was observed when stored at 4o C. Conclusion: While more comprehensive studies are needed, our data indicate that compounded bosentan retains greater than 90% of its original concentration for at least 48 hours and suggests that hospitals could use these formulations for longer than currently indicated.

Cite this article as: Nicholas S. Jones, Molly S. Augustine, Lynette K. Rogers,Stability of extemporanously compounded bosentan liquid,Journal of Pharmacy Research 2016,10(8),537-542.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 8.
Article Id: JPRS-QA-00001388
Title: Impurity profile of pharmaceuticals ingredient: a review
Category: Quality Assurance
Section: Review Article
Country: India
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Various regulatory authorities like ICH, USFDA, Canadian Drug and Health Agency areemphasizing on the purity requirements and the identification of impurities in ActivePharmaceutical Ingredient’s (API’s). Qualification of the impurities is the process of acquiringand evaluating data that establishes biological safety of an individual impurity; thus, revealingthe need and scope of impurity profiling of drugs in pharmaceutical research. Impurities in pharmaceuticals are the surplus chemicals that stay behind with the active pharmaceutical ingredients or develop during formulation or upon aging of both active content and formulated active ingredients to medicines. The efficacy and safety of pharmaceutical product is affected by presence of unwanted traces of impurities. Impurity profiling is deals with detection, identification/structure elucidation and quantitative determination of organic and inorganic impurities as well as residual solvents in bulk drugs and pharmaceutical formulations. Impurities in pharmaceuticals are the surplus chemicals that stay behind with the active pharmaceutical ingredients or develop during formulation or upon aging of both active content and formulated active ingredients to medicines. The efficacy and safety of pharmaceutical product is affected by presence of unwanted traces of impurities. The advent of hyphenated techniques has revolutionized impurity profiling, by not only separation but structural identification of impurities as well. The present review covers various aspects related to the analytical method development for impurity profiling of an active pharmaceutical ingredient.

Cite this article as: Warad T.A., Bhusnure O.G, Gholve S.B.,Impurity profile of pharmaceuticals ingredient: a review,Journal of Pharmacy Research 2016,10(7),523-533.

Journal: Journal of Pharmacy Research , Volume: 10, Issue: 8.
Article Id: JPRS-P'Col-00001397
Title: Oleic acid, one of the major components of ethyl acetate partitioned fraction of aqueous extract of bark of Terminalia arjuna, protects against adrenaline induced myocardial injury in male albino rats
Category: Pharmacology
Section: Research Article
Country: India
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Background: Our earlier studies demonstrate the protective role of aqueous extract of bark of Terminalia arjuna against adrenaline-bitartrate induced myocardial injury in male albino rats. In the present study, GCMS analysis of the ethyl acetate partitioned fraction of this aqueous extract revealed the presence of oleic acid as one of the major components. Hence, in the present study, we also investigated the protective role of oleic acid against adrenaline induced myocardial injury in male albino rats and tried to elucidate the underlying mechanism of such protection. Methods: In this set of experiments a total number of 40 adult healthy male albino rats were divided into 10 groups comprising of 4 animals each. First group constituted of the vehicle-treated control. The rats of the second group were treated with sub-cutaneous (s.c.) injection of adrenaline-bitartrate at the dose of 0.3mg/ kg body weight. The rats of the third, fourth, fifth and sixth groups were orally fed, respectively, with different doses of oleic acid (2.5, 5, 10, 20 mg/kg body weight) where water was used as the vehicle. The rats of seventh, eighth, ninth and tenth groups were orally fed with different doses of  oleic acid (2.5,5,10,20 mg/kg body weight) and subjected to sub-cutaneous (s.c.) injection of adrenaline-bitartrate  at the dose of 0.3mg/ kg body weight. Results: Treatment of rats in this set of experiment with adrenaline-bitartrate altered the activities of serum lactate dehydrogenase total (LDH-T), lactate dehydrogenase-1 (LDH-1), serum glutamate pyruvate transaminase (SGPT) and elevated the level of lipid peroxidation and protein carbonylation, decreased the glutathione content as well as altered the activities of antioxidant enzymes and the enzymes of  Kreb’s cycle and respiratory chain. Tissue histo-morphological studies also showed considerable damage following adrenaline- bitartrate treatment. Pre-treatment of rats with different doses of oleic acid significantly protected against these myocardial damages in a dose dependent manner. Conclusion: Oleic acid, one of the major components of the ethyl acetate partitioned fraction of aqueous extract of bark of Terminalia arjuna, significantly protected against adrenaline induced myocardial injury in male albino rats in a dose dependent manner.