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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 11, Issue: January
Article Id: JPRS-P'Col-00001659
Title: Studies of the role of the methanol fraction of the ethanol layer of the chloroform-ethanol leaf extract of Dacryodes edulis on diclofenac-induced gastric ulcer in rats
Category: Pharmacology
Section: Research Article
Country: India
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Background and Aim: The leaves of Dacryodes edulis are used in traditional medicine for the treatment of gastric ulcer among other ailments in Nigeria. The aqueous extract, chloroform and ethanol layers of the chloroform-ethanol leaf extract of D. edulis were investigated for their qualitative and quantitative phytochemical compositions. Based on the outcomes of the preliminary investigations, the most promising of the three (ethanol layer) was further fractionated and the effects of the most desirable fraction (methanol fraction) on ulcer index, gastric juice volume, gastric juice pH and histopathology of diclofenac-ulcerated Wistar rats were determined. Methods: The qualitative and quantitative phytochemical compositions and acute toxicities of the aqueous extract, chloroform and ethanol layers as well as the effects of the methanol fraction of the ethanol layer of the chloroform-ethanol leaf extract of D. edulis on ulcer index, gastric juice volume, gastric juice pH and histopathology of diclofenac-ulcerated Wistar rats were determined using standard methods. Results:The qualitative and quantitative phytochemical analyses of the aqueous extract, chloroform and ethanol layers showed the presence and amounts of the following:  alkaloids, flavonoids, tannins, saponins and steroids. Each of the aqueous extract, chloroform and ethanol layers was found to be safe at 5000 mg/kg body weight (b.w). At the tested doses (100, 200 and 400 mg/kg b.w), the methanol fraction caused significant (p < 0.05) and dose-dependent decreases in the ulcer indices and gastric juice volumes as well as increases in the gastric juice pH of the rats in the test groups compared with those of the rats in the ulcer-untreated group. Results of the histopathological evaluation supported the gastroprotective effects of the fraction. Results of the fraction were comparable with those of the standard anti-ulcer drug, ranitidine at the dose of 150 mg/kg b.w. Conclusion: Experimental findings indicate that the leaves of D. edulis possess remarkable anti-ulcer effect probably due to their phytochemical constituents.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: January
Article Id: JPRS-PCS-00001661
Title: Process Validation of Pioglitazone 30mg Tablets
Category: Pharmaceutics
Section: Research Article
Country: India
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Background of the study: The primary objective of pharmaceutical industry now a days is to manufacture products of the good quality at the lowest possible cost and to supply quality products to the customers. In order to achieve the objective, the industries must validate all the operations of the business. Validation is attaining and documentation of sufficient evidence to give reasonable assurance that the process under consideration does what it purports to do.  Methods: This study is intended to demonstrate the process validation of Pioglitazone 30 mg tablets with special reference to the requirements stipulated by the US Food and Drug Administration (USFDA). The process was limited to the three batches manufactured of specific batch size with specific equipment and control parameters for tablets.  Results: During the study the critical process parameters of Pioglitazone 30 mg tablets like dry mixing, wet granulation, drying, lubrication, and compression were identified and samples collected from each stage was evaluated as per validation protocol. They were within specifications. From the results, it is inferred that the manufacturing process of Pioglitazone 30 mg tablets will produce a product meeting its predetermined specification and quality attributes. Conclusion: Finished product was found meeting the specification in all three batches and the results of all three batches showed that the manufacturing process was effective and produced a product meeting the specification consistently. Hence the manufacturing process is validated and can be used for routine manufacturing of Pioglitazone 30 mg tablets.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: January
Article Id: JPRS-QA-00001660
Title: Development and validation of RP-HPLC method for simultaneous estimation of Irbesartan and Atorvastatin in synthetic mixture
Category: Quality Assurance
Section: Research Article
Country: India
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Background: The combination of Irbesartan and Atorvastatin is prescribed for the treatment of hypertension. Objective: To develop and validate HPLC Method for simultaneous estimation of Irbesartan and Atorvastatin in synthetic mixture. Materials and method: The chromatographic separation was performed on Shimadzu HPLC instrument on a Thermo C18 column (250 × 4.6 mm, 5 µm particle size) using 50: 10: 40 %, v/v/v acetonitrile: methanol: 0.1 % formic acid (pH adjusted to 3.5 with triethylamine) as isocratic mobile phase at flow rate of 1 mL/min. Spectro-densitometric scanning was performed at 271 nm. The developed method was validated according to ICH Q2R1 guideline. Results and discussion: The linearity was established over a concentration range of 300-1500 ng and 20-100 ng with correlation coefficient r2 = 0.9993 and 0.9996 for Irbesartan and Atorvastatin, respectively. The Rt of Irbesartan and Atorvastatin were found to be 4.01±0.03 and 7.03±0.03 respectively. Recovery of drug was achieved in the range of 99.84–99.98% and 99.90–100.67% for Irbesartan and Atorvastatin, respectively by developed method. Limit of detection was found to be 10.94 and 1.33 ng for Irbesartan and Atorvastatin, respectively. Limit of quantitation was found to be 33.14 and 4.03 ng for Irbesartan and Atorvastatin, respectively. Application: The developed HPLC method was applied for simultaneous estimation of two drugs in their synthetic mixture and results were found to be in good agreement with the labeled claim. Conclusion: The developed HPLC method was found to be accurate, precise, specific and sensitive. It can be applied for routine analysis (assay) of tablets containing combination of Irbesartan and Atorvastatin.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: January
Article Id: JPRS-P'Col-00001656
Title: A Study of Attention Set- Shifting Ability in Chronic Epileptic Patients in a Tertiary Care Centre in Kolkata, India
Category: Pharmacology
Section: Research Article
Country: India
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Objective:  Neuropsychological impairment is an important comorbidity of chronic epilepsy. Wisconsin Card Sorting Test (WCST) performance is used in this study to investigate the executive functioning in general tonic clonic seizure (GTCS) and complex partial seizure (CPS) groups and to identify the neuroanatomical substrates underlying set-shifting ability in epileptic patients. Methods: Epileptic groups (n= 28) with GTCS (n=14 and age= 24±3.7years) and CPS with temporal lobe origin patients (n=14 and mean age=22.2±3years) matched with healthy control (HC) (n=23, mean age=25.9 ± 5.48 years) in terms of age, sex, education, handedness, and IQ were compared. t-test was carried to compare the epileptic group with the HC counterparts on WCST task and Wilcoxon-Mann-Whitney test was used to compare  the  GTCS and CPS group on WCST task. To find out the effect of duration of illness, age of onset and frequency of seizure in epileptic group on cognitive function step-wise multiple regressions were carried out. Results: Greater perseverative response (PR), perseverative error (PE), total no. of error is observed in the epileptic groups but in non-perseverative error (NPE), failure to maintain set (FTMS) epileptic groups is as per with the HC. No significant difference observed between GTCS and CPS on any parameter of the WCST task. Conclusion: This study indicates epileptic group have impaired set shifting function, cue identification and poor feedback utilization capacity. CPS performance is as per with GTCS on WCST task indicates the epileptogenic discharge is not localized but involves distributed neural network. 

Journal: Journal of Pharmacy Research , Volume: 11, Issue: January
Article Id: JPRS-ND-00001657
Title: Phytochemical Screening, GC-MS Analysis of Bioactive Compounds and Antibacterial activity from Justicia gendarussa Burm.F. Stem
Category: Natural Drugs
Section: Research Article
Country: India
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Background: The aim of the present study was to analyzed the phytochemical screening of methanol, chloroform and petroleum ether extract of the Justicia gendarussa stem and GC-MS technique to study the major and minor phytoconstituents and their antibacterial activity.   Methods: In the present study, preliminary phytochemical analysis and GC–MS was carried out on the methanol, chloroform and petroleum ether extract of stem of Justicia gendarussa for identification of phytocompounds in the plant stem. The disc diffusion Method (Bauer et al. 1996) was used to screen the anti bacterial activity. Result : The preliminary phytochemical analysis of methanol, chloroform and petroleum ether extract of Justicia gendarussa stem showed the presence of bioactive components like carbohydrates, steroids, alkaloids, glycosides, flavonoids, tannins and saponins. Pharmacognosy studies In Stem Physico – chemical values were analysed such as foreign organic matter, Moisture content, Total ash. Florescence analysed in stem on Justicia gendarussa various solvents for Visible light condition under the UV rays (254nm, 366nm). The different extract showed varying degree of antibacterial activity against the P. vulgaris and P. pneumonia tested. Conclusion: Results confirmed the presence of therapeutically potent compounds in the stem of various extract. This study will also helps to predict the formula of biomolecules which can be used as drugs and further investigation may lead to the development of drug formulation and this plant extract in developing a novel broad spectrum antibacterial agent.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: January
Article Id: JPRS-PHDRS-00001652
Title: Anthelmintic activity of Tephrosia calophylla
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Objective: Nature has provided a completely store house of remedies to cure all ailments of mankind. A large number of populations have to rely upon traditional medicines, which are mainly derived from plant source. Methods: In this connection a critical analysis was done on Tephrosia genus by thorough literature survey from this Tephrosia calophylla plant was selected for the present study. The various species of Tephrosia is ascribed to have many medicinal and therapeutic uses for the treatment of various ailments. Results:The present study aims to investigate its qualitative phytochemical analysis and anthelmintic activity of roots of Tephrosia calophylla. Ethanolic extracts of Tephrosia calophylla roots were subjected for the preliminary phyto chemical analysis and found the presence of alkaloids, glycosides, saponins, flavonoids, carbohydrates compounds and ethanol extract contains flavanoids. The above said activity shown by the Tephrosia calophylla roots may be due to the presence of secondary metabolites like flavanoids.Conclusion: Anthelmintic activity was performed by using the ethanol extracts of Tephrosia calophylla roots at various concentration .Tephrosia calophylla roots shown potent activity when compared to control and equipotent activity when compared to standard Albendazole.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: January
Article Id: JPRS-P'Col-00001651
Title: Screening of Isolated Phytosterol from Leaves of  Holoptelea integrifolia (Roxb.) Planch  for it’s Antiarthritic Activity in Experimental Animals
Category: Pharmacology
Section: Research Article
Country: India
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Background: The majority of scientific documentation suggested prominent role of  Phytosterols towards  anti arthritic  activity. The main objective of the work was to evaluate  antiarthritic activity of  Holoptelea integrifolia isolated Phytosterol  (HIIP) from  petroleum ether extract (PEHI) of leaves of Holoptelea  integrifolia in Complete Freund’s Adjuvant  (CFA) model. Methods: The antiarthritic activity of different doses of HIIP (10 and 30 mg/kg) in rats was evaluated on 7th, 14th and 21st day  of treatment. The paw volume displacement and secondary lesions changes were measured, as a mark of antiarthritic activity.  Results and discussion: HIIP  30 mg/kg  was more potent than HIIP 10 mg/kg for  showing antiarthritic activity. Conclusion: The results indicate that HIIP  shows antiarthritic activity which was dose dependent. 

Journal: Journal of Pharmacy Research , Volume: 11, Issue: January
Article Id: JPRS-PCS-00001654
Title: Lyoequivalency, dissolution kinetics and drug – excipient compatibility of some commercially available acetaminophen tablets
Category: Pharmaceutics
Section: Research Article
Country: India
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Objective: The main objective of this work was to study the lyoequvailency, dissolution kinetic and drug – excipient compatibility of commercially available acetaminophen tablets. Methodology: In vitro dissolution studies were carried out using a dissolution apparatus USP (Paddle type) at a paddle speed of 50 rpm. Differential Scanning Calorimetry (DSC) and FT-IR spectroscopy were used to study the possibility of drug–excipient interaction.  Results: The dissolution data for all products of acetaminophen used in this study were fit to the first-order equation with a linear regression coefficient of determination r2 values between 0.886 and 0.977. Also results showed that the best equation that fit to the dissolution data and describe the mechanism of drug release was the Weibull distribution function for Panadol®, Tylenol and Adol®, while the dissolution data for Actifast® was best fit to the Higuchi equation. The dissimilarity factor showed that Actifast® was non lyoequivalent with the other three products. Differential scanning calorimetry (DSC) curve for Actifast® showed an interaction of acetaminophen with some excipient(s) present in the product; this interaction was indicated by the decrease of the melting peak of acetaminophen from 170.5oC to 166.5oC. Acetaminophen–excipient(s) interaction observed in the DSC curves for Actifast® was also confirmed from the FT-IR spectra.  Conclusion: It can be concluded that beneficial drug–excipient interaction was observed in Actifast® due to the presence of polyethylene glycol (Macrogol) produced an increase in the dissolution rate of Actifast® in comparison with Tylenol®, Adol® and Panadol®.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: January
Article Id: JPRS-PCS-00001649
Title: Formulation and Evaluation of Niosomal Cream Containing Dithranol
Category: Pharmaceutics
Section: Research Article
Country: India
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Aim: The present study is aimed to use non-ionic surfactants with cholesterol for the development of niosomes for delivery of Dithranol. Methods : Vesicular diameter, entrapment efficiency, zeta potential, drug leakage from vesicles and in-vitro drug release characteristics were determined for the niosomal formulations. It showed that surfactant quantity had an impact on entrapmeat efficiency. Formulation with TDS does not require sonication to form nano size vesicles. Results and discussion: The formulation F22 having maximum entrapment efficiency i.e. 78.47% and 26% vesicles having 76.44 nm diameter, 62.1% vesicles having 484.4 nm diameter and 11.9% vesicles having 4336 nm diameter. The formulation F22 having -15.8 zeta potential, this indicates good particle distribution. In vitro release of Dithranol from the niosomes studied containing TDS was highest for F22 formulation 80.032%. The F22 having stability at 40C. Conclusion: TDS is found to be more effective surfactant than the conventional Spans for the vesicle structure. Entrapment efficiency clearly tells that TDS has profound influence on the drug entrapment efficiency.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: January
Article Id: JPRS-P'Col-00001648
Title: Various rodent models for inducing Hepatotoxicity and evaluating Hepatoprotective drugs
Category: Pharmacology
Section: Review Article
Country: India
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Liver is the principal organ for maintaining the body’s internal environment. There is no substitute for the liver function. Its major influence is on the flow of nutrients and control of carbohydrate, protein and fats metabolism. Liver undergo various kinds of stress and hepatocytes get damaged in presence of toxins resulting into acute liver disease. Acute liver disease when remain undiagnosed progresses into chronic liver disease (CLDs) and become life threatening. Autoimmune disorders, viral infection, metabolic disorder and alcohol abuse are some common driving factors for CLDs. Advanced stage of CLDs can’t be managed & only option left is organ transplantation. Therefore it is very important to understand the molecular mechanism of hepatic damage. Rodents are routinely being used by researchers for preclinical studies but they possess distinct immune system and have different metabolic rates for hepatic homeostasis. Nevertheless, traditional as well as newer animal models (genetically modified models) mimic certain attributes of CLDs. Thus in this review we have discussed traditional animal models as well as recent advances in animal models.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: January
Article Id: JPRS-ND-00001776
Title: Isolation and identification of bioactive compound from Ipomoea obscura (L.) Ker Gawl
Category: Natural Drugs
Section: Research Article
Country: India
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Objectives : The present study was carried out to isolate and characterize bioactive compound from Ipomoea obscura (L.). Methods : The chemical structure of Ipomoea obscura (L.) leaf extract was elucidated by column chromatography and Thin layer chromatography was used for the separation of spots from the fraction of the crude extract. The potential spots were subjected to FTIR, UV, NMR and Mass spectroscopy techniques. Results : The crude extract was subjected to column chromatography, 87 fractions were collected and TLC was performed. Among them 66th fraction showed a single band in TLC, which was further characterized by FTIR, UV, NMR spectroscopy and Mass spectroscopy and the structure was identified as ursodeoxycholic acid. Conclusion : The results of the present study indicate that the ethanolic fraction of Ipomoea obscura (L.) has a potential bioactive compound.