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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 11, Issue: March
Article Id: JPRS-PB-00001682
Title: Coexpression of Adrenomedullin and Its receptors in Uteroimplantation regions of wistar rats in early gestation period
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Concentrations of adrenomedullin (ADM) in circulation increases during pregnancy. The pattern of ADM level and gene expression of ADM, its receptor components from early pregnancy has been studied in our present work. Calcitonin gene-related peptide (CGRP) and its related peptide, adrenomedullin (ADM), have vasorelaxant activity in a variety of tissues. The CGRP   plays an important role in maintaining uterine relaxation during pregnancy. Calcitonin receptor-like receptor (CRLR), a seven-domain transmembrane protein functions as CGRP-á & â receptor in association with receptor activity modifying protein (RAMP1), whereas CRLR and RAMP2 or RAMP3 constitute a receptor for ADM. In our present study we examined the mRNA expression of ADM, CRLR, RAMP1, RAMP2 & RAMP3 by real-time PCR. The changes in mRNA are relative to the GAPDH marker. Administration of peptide receptor antagonist s.c on day 2 of gestation with the help of osmotic mini pump results in decrease in mRNA expression levels mainly in ADM & RAMP2 rather than CRLR and RAMP1&3.The dose response effect of ADM evinced well marked decrease in uterus and implantation weights when administered with 250µg/rat/day rather than control and low doses. Our results demonstrated that both CGRP and ADM along with receptor activity modifying protein (RAMP1) are essential to maintain implantation to full term baby.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: March
Article Id: JPRS-HM-00001692
Title: Phytochemical and Pharmacological Review on Echinacea
Category: Herbal medicine
Section: Review Article
Country: India
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The Echinacea species, Echinacea angustifolia, Echinacea pallida, Echinacea purpurea  have a long history of medicinal uses particularly on infectious diseases. Today Echinacea preparations are used in several countries like America, Germany, Australia, Thailand and some other European countries. Mainly Echinacea is focused on its immunomodulatory effects, anti-inflammatory, antimicrobial, antiviral, antifungal and urinary tract infections. The chemistry and its pharmacological actions are well documented and several groups of  bioactive constituents which includes polysaccharides( arabinogalactan, xyloglycan, echinacin), glycosides: caffeic acid and its derivatives (cichoric acid, echinacoside), alkaloids, alkylamides, polyacetylenes and other fatty acids, essential oils and phytosterols are important for the desired pharmacological action. From the available data it is reported that Echinacea  is well tolerated and can be used as a herbal medicine. In this article we have reviewed the role of phytoconstituents and their pharmacological actions of Echinacea species.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: March
Article Id: JPRS-HM-00001691
Title: Methanol leaf extract of Anacardium occidentale exerts anti-ulcer effect on indomethacin-induced gastric ulcer in rats
Category: Herbal medicine
Section: Research Article
Country: India
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Background and Aim: The reliance on plants and plant-derived products for the treatment of a good number of ailments has been persistent through much of human history and such treatment however, traditional, is still widely in use today such as the application of the leaves of A. occidentale in the cure of gastric ulcer. The aim of this work was therefore, to ascertain whether or not the methanol leaf extract of A. occidentale exerts anti-ulcer effect on indomethacin-induced gastric ulcer in rats. Methods: The phytochemical constituents, acute toxicity and lethality and effects of the extract on ulcer index, gastric juice volume and gastric juice pH were determined using standard methods. Results: The phytochemical screening revealed that the extract contained alkaloids, flavonoids, tannins, saponins, carbohydrates, reducing sugars, proteins, steroids, terpenoids and fats and oil but resins, glycosides and acidic compounds were not detected in the extract. The extract at a dose up to 5000 mg/kg body weight (b.w) was safe for administration. At the tested doses [100, 200 and 400 mg/kg b.w] the extract caused significant (p < 0.05) and dose-dependent decreases in ulcer indices (gastric lesions) and gastric juice volumes of the rats in the test groups compared to the values obtained for the rats in the positive control group (group 2). Significant (p < 0.05) and dose-related increases in gastric juice pH of the rats in the test groups compared to that of the rats in the positive control group was also brought about by the extract. The effects of the 400 mg/kg b.w of the extract were similar to those of the standard anti-ulcer drug, famotidine at the dose of 50 mg/kg b.w. Conclusion: These observations show that the methanol leaf extract of A. occidentale possesses notable anti-ulcer effect and contains some pharmacologically active principles which might be heraldic to the future development of standard anti-ulcer drug(s) from the plant. 

Journal: Journal of Pharmacy Research , Volume: 11, Issue: March
Article Id: JPRS-ND-00001690
Title: Elevating potential of total protein concentration, catalase specific and prostaglandin synthase activities by the methanol fraction of the ethanol layer of Dacryodes edulis chloroform-ethanol leaf ex
Category: Natural Drugs
Section: Research Article
Country: India
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Background and Aim: Increased requirements for proteins and anti-oxidants are needed to promote wound healing. Also, blockage of the synthesis of prostaglandins has been critical to the precipitation of gastric mucosal injuries and hence, this study was aimed at investigating the effects of the methanol fraction of the ethanol layer of the chloroform-ethanol extract of the leaves of Dacryodes edulis on total protein concentration, catalase specific and prostaglandin synthase activities. Methods: The effects of the fraction on total protein concentration, catalase specific and prostaglandin synthase activities were investigated using standard methods. Results: The fraction at the tested doses [100, 200 and 400 mg/kg body weight (b.w)] caused significant (p < 0.05) and dose-dependent increases in total protein concentrations and catalase specific activities in the rats of the test groups compared to those of the rats in the ulcer-untreated group. The effects of the fraction at the dose of 400 mg/kg b.w were similar to those of the standard anti-ulcer drug, ranitidine at the dose of 150 mg/kg b.w. Similar trend of result was obtained with regard to the fraction effect on prostaglandin synthase activity. Conclusion: The findings of this research show that the methanol fraction of the ethanol layer of the chloroform-ethanol extract of the leaves of D. edulis is involved in the protection against gastric ulcer through increases in total protein concentration, catalase specific and prostaglandin synthase activities.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: March
Article Id: JPRS-MB-00001688
Title: In vitro Phytochemical, Antioxidant and Cytotoxic Evaluation of Syzygium jambos L. (Alston)
Category: Microbiology
Section: Research Article
Country: India
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Syzygium jambos commonly called as rose apple is an Asian medicinal plant. Four extracts acetone, aqueous, chloroform and methanol were evaluated for their free radical scavenging properties and cytotoxic activity on Human Embryonic Kidney (HEK 293) cell line. The results showed methanol (IC50 – 115.9μg/mL) and acetone (IC50 – 154.9μg/mL) extracts contain high free radical scavenging properties than chloroform(IC50 – 196.4μg/mL) and aqueous (IC50 – 235.4μg/mL) extracts, as well as acetone , aqueous and methanol extracts showed nontoxic effects against HEK 293 cell line. Although traditionally aqueous extracts are not toxic, we determined that acetone extract also not toxic and achieved better activity in the assays.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: March
Article Id: JPRS-P'Col-00001686
Title: Effect of Morinda umbellata Linn. (Rubiaceae) Leaf Extracts on Antigen Induced Mast Cell Degranulation and Active Paw Anaphylaxis in Wistar rats
Category: Pharmacology
Section: Research Article
Country: India
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Aim: Morinda umbellata Linn. is a climbing shrub distributed in Khasi Hills, Deccan Peninsula, Eastern Ghats and Western Ghats regions of India up to an altitude of 1500 m. It is an important traditional medicinal plant having curative properties against stomach disorders. The aim of the present study is to scientifically evaluate the mast cell stabilizing and anti-anaphylactic effects of M. umbellata leaves.  Methods: The different solvent extracts of M. umbellata leaves were used to evaluate antigen induced mast cell degranulation and active paw anaphylaxis in Wistar albino rats. Results and Discussion: The leaf ethanolic extract (200 mg/kg and 400 mg/kg), n-hexane extract (200 mg/kg and 400 mg/kg) and chloroform extract at 400 mg/kg doses exhibited significant protection against egg albumin induced peritoneal and mesenteric mast cell degranulation. In mesenteric mast cell study in vitro, the ethanolic and n-hexane leaf extracts (2 mg/mL) showed significant activity against egg albumin induced mast cell degranulation. In active paw anaphylaxis, the animals treated with the ethanolic and n-hexane extracts (100, 200 and 400 mg/kg) exhibited significant reduction in ovalbumin induced paw edema. The preliminary phytochemical analysis revealed the presence of flavonoids, phenolic compounds, alkaloids, steroids, tannins and carbohydrates in the leaf extracts. Conclusion: From the present study, it can be concluded that the phenolic compounds and flavonoids present in M. umbellata leaves may contribute to the inhibitory effect on antigen induced mast cell degranulation and active paw anaphylaxis in Wistar rats.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: March
Article Id: JPRS-P'Col-00001685
Title: A Review on Various Pharmacological Interventions Against Gentamicin Renal Toxicity
Category: Pharmacology
Section: Review Article
Country: India
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Gentamicin (GM) is a commonly used broad spectrum antibiotic which comes under the class aminoglycosides. Despite its uses, it is also having several adverse effects in which nephrotoxicity are the most common. GM causes tubular necrosis, cytotoxicity in the epithelial cells of the cortex, proximal and distal tubule along with collecting ducts in the kidney. It produces the various renal dysfunctions by increasing the level of creatinine(Cr) in serum and decreasing their excretion through urine. The main reason of the nephrotoxicity by this antibiotic is the generation free radicals and reduction in antioxidant defense mechanisms, which may lead necrosis in the renal cell. Now, a day we have various ameliorating herbal and synthetic agents to prevent this toxicity. Herbal agents due to their anti-oxidant property and free radical scavenging action can be used in preventing renal damage and necrosis. Various synthetic drugs like oral hypoglycaemics, calcium channel blockers; statins and anti asthmatic drugs also have potent free radical scavenging and anti oxidant activity can also reduce the risk of accumulation of GM in renal tissues. Thus, it can be conclude from this review that there is a emerging scope of herbal medications which can be used alone or in combination with synthetic drugs in overcoming the unfavourable effects caused by the GM in renal tissues.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: March
Article Id: JPRS-P'Col-00001684
Title: Gastroprotective effect of selected antioxidants, vitamins and minerals in ethanol induced ulcer model in rats
Category: Pharmacology
Section: Research Article
Country: India
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 Aim:The investigation was aimed to explore the critical role of few selected antioxidants, vitamins and minerals on gastroprotection by using ethanol induced ulcer model in rats. Further they help to find out its safety in GI disorders when compared with other reference standard drug, and to recommend a safe therapy in managing gastric disorders based on preclinical studies. Materials and Methods: Male Wistar rats weighing between 200-250 g. were divided into 9 groups of 6 animals each (n=6). The groups were treated respectively as follows Group I normal control, and Group II disease control, received normal saline, Group III was treated with standard  drug omeprazole, Group IV to IX received test substances respectively, antioxidants (Vitamin E, Cystine) vitamins (Thiamin, Niacinamide) minerals (Iron, Zinc) administered for 7 days. Various parameters like, the volume and pH of gastric juice, total acidity, ulcer index, percentage protection, biochemical parameters like mucin content, pepsin activity and antioxidant enzymes like, super oxide dismutase, catalase, reduced glutathione, myeloperoxidase, and malondialdehyde were estimated. Histopathology of stomach epithelium was observed. Results: Significant reduction (p<0.05) in ulcer index, total acidity, and increase in pH were observed in ulcer induced rats pretreated with test substances. Mucin content in all rats pretreated with test substances was increased, and pepsin activity was decreased significantly (p<0.05) when compared with disease control treated rats. Test substances treated rats showed significant restoration i.e., increased the level of super oxide dismutase, catalase, reduced glutathione and significantly reduced (p<0.05) the lipid peroxidation and decreased the levels of MPO and MDA. Histopathological observations on gastric mucosa also confirmed the gastroprotective activity of test substances. Conclusions:  it is concluded that, the all test groups Vitamin E, L- Cystine, Thiamin, Niacinamide, Iron, Zinc acts as an antiulcer drugs which may be attributed to its antisecretory, cytoprotective and antioxidant activities.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: March
Article Id: JPRS-CPRMS-00001681
Title: Review on Benefits of Clinical Pharmacy Services and Discussion of Current Scenario in Indian Healthcare System
Category: Clinical Pharmacy and Related Medical Science
Section: Review Article
Country: India
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Clinical Pharmacy is a health science discipline in which Pharmacists provide patient care that optimizes medication therapy and promotes health, wellness, and disease prevention. To achieve desired therapeutic goals, the clinical pharmacist applies evidence based therapeutic guidelines, evolving sciences, emerging technologies, and relevant legal, ethical, social, cultural, economic, and professional Principles. The clinical pharmacist is trained in clinical pharmacy practice and comprehensive medication management and educating the Patient about the importance of strict adherence to the medication schedule and thus enhance patient compliance.Pharmacy Practice integrates the Pharmaceutical sciences with the professional roles of Pharmacists.It includes areas such as clinical pharmacy, pharmaceutical care, health promotion and education, social Pharmacy,health informatics,Pharmacoepidemiology and Pharmacy education.Clinical Pharmacist must have a Doctor of Pharmacy degree and M.Pharm in PharmacyPractice degree responsible for Practice in clinical level.Using of current updated therapeutic guidelines about the disease and drug is acceptable to promote and solve the health care issues in community.The clinical Pharmacy development is currently infant in Indian health care settings and proper awareness is needed to uplift the services in practice. In abroad countries it was well stabilized and well promoted by the health care communities.Promoting Proper awareness about the clinical Pharmacy services is needed.In future we hope that these services will promote the better patient care in India.