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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-PA-00001784
Title: Analytical method development and validation of Aripriprazole in bulk and tablet dosage form by UPLC method
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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A novel very rapid, sensitive, reverse phase Ultra Performance Liquid Chromatography (RP-UPLC) technique was developed for the quantitative estimation of Aripriprazole in bulk and tablet dosage form. It was resolved by using a mobile phase 70:30 of Methanol and Water) at a flow rate of 0.8 ml/min. using UV - Visible detector at the wavelength of 273 nm for quantification. Efficient separation was achieved for Aripriprazole on used Symmetry C18, (100 × 2.1 mm), 5µm column, Make: BEH) the retention time Aripriprazole of was 2.29mins. The calibration graphs were linear and the method showed excellent recovery for tablet dosage form. The developed method was validated according to the International Conference on Harmonization (ICH) guidelines with respect to linearity, accuracy, precision, specificity and robustness.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-PRGS-00001785
Title: Investigation of influence of shape on drug loading and entrapment efficiency of nanoparticles
Category: Pharmaceutical and Related General Science
Section: Research Article
Country: India
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Background and Aim: The present study was aimed at investigation of influence of shape on drug loading and entrapment efficiency of nanoparticles. Methods: Different shape of nanoparticles (spherical shape and cube shape) was successfully formulated by using different method. Spherical shape nanoparticles were successfully formulated by using ionic gelation method and cube shape nanoparticles were successfully formulated by top-down method. The amount of drug added, final volume of formulations and particles size were maintained as same for comparing of both shape particles. Results: In ionic gelation method particle size was affected by chitosan concentration and in top-down method size was affected by sonication time. Cube shape has shown high percentage of drug loading and high percentage of entrapment efficiency than spherical shape nanoparticles. However, cube shape provided high surface area than spherical shape nanoparticle for drug entrapment. So cube shape is good for targeted drug delivery system for paracetamol. Conclusion: Cube shape has shown high percentage of drug loading and high percentage of entrapment efficiency than spherical shape nanoparticles. however, cube shape provided high surface area than spherical shape nanoparticle for drug entrapment. So cube shape is good for targeted drug delivery system for paracetamol.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-ND-00001786
Title: Anticancer activity of Opuntia stricta (Flowers) against human liver cancer (HepG2) cell line
Category: Natural Drugs
Section: Research Article
Country: India
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Objective : To investigate the anticancer action of the flowers of Opuntia stricta against the human hepatoma cell line (HepG2). Methods: In vitro anticancer activity was carried out to screen cytotoxicity effectiveness of the ethyl acetate fraction from Opuntia stricta flower extract at different concentrations against the HepG2 cell line. The MTT (methylthiazolyl diphenyl- tetrazolium bromide) assay for cell viability and markers is expected to confirm the cytotoxicity. Result: Ethyl acetate fraction from the flower extract of Opuntia stricta was tested for its anticancer activity against HepG2 cell lines (liver cancer) at various concentrations by MTT assay. It was confirmed that the IC50 value of this sample was 48 ±1.7μg/ml against Liver Cancer HepG2 cell line. Conclusions: Opuntia stricta is a potential plant with anticancer activity. The isolation of the pure compounds and determination of the structure of individual compounds will be further performed.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-PB-00001787
Title: Ehrlichia ruminantium vaccine epitope search by reverse vaccinology approach
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Aim: To search the potent antigens and their corresponding epitopes by involving the genome sequence information for two strains of Ehrlichia ruminantium. Materials and Methods: E. ruminantium strains welgevonden and gardel proteins were screened by TMHMM, LIPOP, Signal P and PSORTB to screen cell surface antigens and thereafter filtered antigens were screened for the conserved nature by searching against other species of Ehrlichia sp using BLASTP. Further only best candidates present in both the strains were checked for epitopes by involving HLA PRED and VaxiJen server scoring system. Result: Study highlighted high scored epitopes of both strain antigens named as type IV secretion system protein, cytochrome c-type biogenesis protein, thioredoxin reductase (NADPH), cytochrome c oxidase subunit II and MAP1-11 (A). Conclusion: Study recorded the high scored epitopes of Ehrlichia ruminantium by involving the bioinformatics approach.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-P'Col-00001788
Title: A review on alternative treatment of Psoriasis
Category: Pharmacology
Section: Review Article
Country: India
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Approximately one third of all traditional medicines are for treatment of skin diseases, compared to only 1-3% of modern drugs. Skin diseases are the major problem in worldwide. Skin diseases are classified in acute and chronic conditions. Generally chronic skin diseases typically aren’t curable, but they can be managed using drugs. But so many medicinal plants are also used for treating skin diseases. The prescribed synthetic drugs for the treatment of psoriasis are associated with severe side effects, thus, researchers around the globe are searching for new, effective, and safer drugs from natural resources. Virtually all cultures worldwide have relied historically, or continue to rely on medicinal plants for Skin diseases. The objective of this paper is to list out the beneficial effects of certain medicinal plants for treating skin diseases. The present review has been prepared with an objective to compile exhaustive literature on pharmacological reports on antipsoriatic plants, plant products, and formulations. Plants selected for the present review are having medicinally significant value and many of them possess active phytochemical constituents.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-PCS-00001790
Title: Formulation and Evaluation of Oral Mucoadhesive Tablets of Cisplatin
Category: Pharmaceutics
Section: Research Article
Country: India
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Background and Aim: Cisplatin, an anticancer drug is used to treat various types of cancer. It is available only in the form of injection to be administered as an i.v. infusion. For that, it needs to be administered under the supervision of an oncologist. The inconvenience and cost of hospitalization can be avoided by the development of oral formulation of cisplatin.There is nomarketed tablet formulation of Cisplatin available till date. In the present study, an attempt was made to develop oral enteric coated, sustained release, mucoadhesive tablets of cisplatin in order to prevent upper GIT side effects like nausea and vomiting and to prolong its residence time in intestine. Methods: Eight formulations were developed by direct compression method using various proportions of mucoadhesive polymers, HPMC (400 cps) and carbopol 940. Prepared tablets were evaluated for physical parameters, swelling index, surface pH, mucoadhesive strength and in vitro drug release.Results: Among all the formulations, F4C was found to be the best as it showed high swelling index 125.51± 1.63 % at 12 h, optimum mucoadhesive strength of 13.11±0.65 g and superior in vitro drug release of 91.30% in 12 h respectively. Optimized F4C batch was further subjected to ex-vivo permeation study by everted gut sac technique and permeability co-efficient was found to be 0.0013 at 12 h. The prepared mucoadhesive sustained release tablets of optimized batch (F4C) were further enteric coated with Eudragit L 100 suspension up to 20 %. The final formulations were studied forin vitro drug release in0.1N HCl for 2 h followed by that in0.2M phosphate buffer pH 6.8 up to 16 h. Data showed no drug release in first 2 h in 0.1N HCl. However, sustained drug release of cisplatin could be observed in 0.2M phosphate buffer pH. A maximum of 82.52% drug release was observed at the end of 12 h.Conclusion: It was concluded that 20% Eudragit coated sustained release mucoadhesive tablets of cisplatin (F4C) containing 100 mg of carbopol has shown desired in vitro drug release as well as mucoadhesive strength and could be further explored for its in vivo performance.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-PCS-00001791
Title: A survey on labeling challenges related to Ayurvedic and proprietary medicines
Category: Pharmaceutics
Section: Research Article
Country: India
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Background and Aim: In present scenario, there are so many Ayurvedic products of various brands available in the market which includes drugs and cosmetics. Specific guidelines are prepared under Part XVII, 161 along with the constitution of various schedules e.g. Schedule X, E1, etc. in the Drug and Cosmetic Act, 1940 for the labeling of Ayurvedic drugs and cosmetics but it has been observed that sometimes these guidelines are ignored by various ways. Hence, the present work is designed to identify the mistakes carried out by various brands on the basis of a checklist provided in the Drug and Cosmetic Act, 1940 for labeling. Methods: A total of 75 labels of Ayurvedic drug container (44 Classical and 31 Proprietary Medicines) were studied. The labels of all the 75 Ayurvedic drug containers of both classical and proprietary medicines exhibited the four basic parameters i.e. Name and address of the manufacturer, License number, Manufacturing date, Net content Results: The results of the present survey explored that nearly 59% of the classical medicines and 12% of proprietary medicines were not fully in compliance with the Drug and Cosmetic Act, 1940. Conclusion: Therefore, it can be concluded that in most of the cases labels of Ayurvedic Classical Medicines were not completely in compliance with the protocols specified in the Drug and Cosmetic Act, 1940.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-P'Col-00001792
Title: Acute and sub-chronic toxicological evaluation of Grewia nervosa (LOUR.) Paniger on wistar albino rats
Category: Pharmacology
Section: Research Article
Country: India
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Background: The current approach has been focused on the evaluation of phytochemical constituents and toxic effects of leaves and bark of Grewia nervosa (Lour) Panigr [HAELGN & HAEBGN] using two pre clinical toxicological models ie., acute and 28 day repeated dose oral toxicity studies in Wistar albino rats. Methodology: Collected leaves and bark of Grewia nervosa were shade dried, powdered and hydroalocholic extracts were made by maceration. The phytoconstituents were identified by standard methods using standard laboratory reagents. Pre clinical toxicity was performed by following acute oral toxicity study [OECD 423 TG] and 28 day repeated dose oral toxicity study [OECD 407 TG] methods. Results: Qualitative analysis of phytochemical constituents revealed that phenols, tannins, saponins, flavonoids and alkaloids were present in both HAELGN & HAEBGN and glycosides and sterols are present only in HAELGN. There were no toxicity related signs visualized in acute oral toxicity study after administration of both extracts. In sub acute toxicity study significant differences in body weight changes and hematology was not observed in extract treated groups with respect to control group. On the contrary, serum glucose and cholesterol levels decreases and protein levels increases in treated groups when compared to control group. In histopathological studies, there were no gross pathological changes and relative organ weight changes found in both treated and non treated rats. Conclusion: Hydro alcoholic extracts of leaf and bark of Grewia nervosa revealed the existence of many bioactive constituents during phytochemical investigation. In acute oral toxicity study it was found that LD 50 of both the extracts was found to be greater than 2000mg/kg b wt. Sub acute toxicity study elicited that ht No Observed Adverse Effect Level [NOAEL] of Grewia nervosa is found to be greater than 800mg per kg b wt/day p.o in rats. There were no with drawl effects monitored in satellite group. In brief, Grewia nervosa was found to be non toxic in tested doses under experimental conditions.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-P'Col-00001793
Title: Life style modification in diabetes mellitus: a review
Category: Pharmacology
Section: Review Article
Country: India
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The diabetes mellitus has reached epidemic proportions worldwide as we enter the new millennium .The World Health Organization (WHO) has commented there is ‘an apparent epidemic of diabetes, which is strongly related to lifestyle and economic change’. Over the next decade, the projected number will exceed 200 million. Most will have type-2 diabetes, and all are at risk for the development of complications. Diabetes represents a spectrum of metabolic disorders, which has become a major health challenge worldwide. Yoga offers the holistic solution to the management of type 2 diabetes mellitus and its complications involving lifestyle changes encompassing kriyas, various asana, changes in diet, management of stress, meditation.Various studies suggest that yoga may improve indices of risk in adults with type 2 DM, including blood sugar levels and reduced resistance to insulin, and improve lipid profiles. Medical research shows that yoga therapy is among effective complementary therapies for several common ailments. Hence it has been concluded that Yoga cannot “cure” diabetes, but there are several ways yoga can be beneficial in controlling diabetes.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-PHDRS-00001795
Title: Ayurceuticals: A progressive opportunity in wellness and medical tourism
Category: Pharmacognosy and Herbal Drugs related study
Section: Review Article
Country: India
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Health care tourism is an important economic activity and continues to be the fastest growing sector. It encompasses both medical tourism (based on western medicine) and wellness tourism (based on traditional therapies suchasAyurveda). The literature commit to medical tourism as the act of travelling to other countries to seek western – style medicine treatments and procedures. The reason for arise medical tourism in India is money saving, shorter waiting periods and improved grade of health care. Ayurvedic healing system has been uniqueselling proposition of health tourism to put forward a complete package of travel experiences with psychological, physical and spiritual welfare. Ayurceuticals are bioactive chemical compound that play role for advancement of health care tourism by promoting health and preventing diseases.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-PHDRS-00001796
Title: Physicochemical screening of Godanti Bhasma : An effort to Pharmaceutical Standardisation
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Rasashastra is branch part of Ayurveda that deals with the purification and formulation of herbo-mineral compounds. Bhasmas cover one of the major part of Rasashastra which are prepared through calcination of metal/mineral further it is treated with Swarasa (Self-expressed juice) or kwath (Decoction) and exposed for certain agnipraman (Quantum of heat) know as Puta; the traditional procedure followed for the manufacturing of Bhasmas has so many hurdles such as difficulty in controlling temperature, excess human effort, consumption of large quantity of fuel, space, time etc. So in the present work the contemporary method was used with reference to the conventional method for the preparation of Godanti Bhasma and an effort has been done for the pharmaceutical standardization of the Godanti Bhasma prepared by contemporary and conventional method.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-P'Col-00001797
Title: Compliance, Non compliance and Discontinuation of Oral Contraceptive Use
Category: Pharmacology
Section: Review Article
Country: India
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Failure to adhere to daily pill taking and gaps in use are common and contribute to the risk of unintended pregnancy among Oral Contraceptives users. This review outlines the evidence base for strategies that have been studied for their impact on OCs compliance and non compliance. Studies published from 1967 through 2017 were identified from electronic databases (MEDLINE, PUBMED, and Dissertation Abstracts Online), bibliographies of pertinent review articles and pertinent original articles and textbooks. OCs compliance influenced by a complex interplay of cognitive, behavioral, logistic, clinical, and social factors. Compliance difficulties are more common among oral contraceptive (OCs) users than generally appreciated by clinicians, in part because unintended pregnancy is a relatively infrequent consequence and in part because more common manifestations such as spotting and bleeding may not recognized as resulting from poor compliance. Analysis of variance showed that self reported symptoms of depression were significantly higher among COCs users than nonusers and causes discontinuation of OCs and some study shown that, 20% gave up in the first year, largely because of these side-effects.There were no overall differences observed in contraceptive efficacy, safety profiles, compliance, discontinuation rates or patient satisfaction between cyclic and continuous users. Combined oral contraceptives are available for all patients, it is critical for providers to understand the physiology, dosing, side effects, and benefits of this form of oral contraceptive. For improving compliance, health care providers should focus on proper counseling of women about the choice of method of contraception, side effects of OCs, misinformation and beneficial effects of OCs, correct use and missed pill instructions.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-P'Col-00001798
Title: Introduction to PUD- a review
Category: Pharmacology
Section: Review Article
Country: India
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Peptic ulcer disease is a infectious disorder. three major causes of peptic ulcer disease are: peptic ulcers are small sores that form in the lining of the esophagus (swallowing pipe), stomach, or duodenum (the first part of the small intestine). Peptic ulcer disease refers to painful sores or ulcers in the lining of the stomach or first part of the small intestine, called the duodenum. Peptic ulcer disease (PUD), also known as a peptic ulcer or stomach ulcer, is a break in the lining of the stomach, first part of the small intestine, or occasionally the lower esophagus. There are three types of ulcers: peptic ulcers, Apthous ulcers, esophageous ulcer. Causes of peptic ulcer include, administration of NSAID, H.pylori, stress, alcohol habits, Smoke, fasting, radiation. Diagnosis include: endoscopy, x- ray, breath test, urine test, and serological test. Drugs or medication therapy that is used for the treatment of peptic ulcer disease are antibiotics, proton pump inhibitor, histamine antagonist, gastric acid neutralization agent, ulcer protective, antacids etc. new advances that have been came fourth are from the family of cucumber, cucurbitaceous. They act as ulcer protective agents and can treat the ulcer.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-PC-00001799
Title: Synthesis, biological evaluation and molecular docking studies of Isoxazole synchronized quinazolinone derivatives
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Quinazolinones and Isoxazoles derivatives acts as potent VEGFR-2 inhibitors hence, in the present study isoxazole heterocycle is conjugated with Quinazolinone scaffold in order to obtain new hybrid molecules with potent VEGFR-2 inhibitor activity. Twelve Novel isoxazole synchronized quinazolinone derivatives were designed and synthesized by the condensation of different 3-aryl-5-methylisoxazole-4-carbohydrazides (5a-h) with 2-phenyl/2-methyl-(4H)-3, 1-benzoxazine-4-ones to give the target compounds that act as anti- inflammatory agents and anticancer agents. The synthesized compounds were characterized on the basis of spectral and elemental analysis data. Anti inflammatory activity results showed that compounds 6b, 6f and 6i exhibited significant protection against at the concentration of 20 mg/kg. . In anti proliferative assay MCF-7 Breast cancer cell line, compounds and 6i and 6j exhibited potent activity with IC50 values in nanomolar concentrations as well as in silico docking studies also reveal that compounds 6d, 6f, 6g, 6h and 6j have good dock score, binding affinity and binding energies towards epidermal growth factor receptor tyrosine kinase.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-QA-00001800
Title: Development, Validation and Stability Study of UV Spectrophotometric Method for Determination of Sofosbuvir in Bulk and Pharmaceutical Dosage Forms
Category: Quality Assurance
Section: Research Article
Country: India
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The aim of this study was to develop a new, rapid and highly sensitive UV spectrophometer method for the Sofosbuvir bulk drug. The mobile phase consisted of Water & Ethanol in the ration of 60:40v/v and the wavelength to maximum absorbance at 260 nm. Analytical calibration curves were linear within a concentration range from 2 to 12μg/ml and coefficient of correlation 0.997. %RSD was found to be less than 2. The result of analysis has been validated statistically. This method will be validated in accordance with ICH requirements included the linearity, precision, accuracy sensitivity, and specificity. Hence the proposed method can be used for the reliable quantification of Sofosbuvir in tablet formulation.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: July
Article Id: JPRS-PCS-00001801
Title: Characterization and formulation of prednisolone acetate reconstituted suspension
Category: Pharmaceutics
Section: Research Article
Country: India
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Objective: An oral suspension is commonly applicable to a drug which poorly soluble or unstable in solutions. Prednisolone acetate is a poor water-soluble corticosteroid used for the treatment of many inflammations. Therefore it was formulated as a reconstituted oral suspension. Methods: Various types and concentrations of the suspending agents, including: xanthan gum, avicel , hydroxyl propyl methylcellulose (HPMC), and sodium carboxymethylcellulose (SCMC) were used in the formulation either alone or in combination. In powder form, flowability tests which include an angle of repose, Carr’s index, and Hausner’s ratio were evaluated. After constitution PH, rheology, sedimentation , resuspendability, palatability and dissolution were investigated in liquid suspension. Results: The results showed that all formulas showed acceptable flowability when evaluated as the powder before the constitution. Rapid sedimentation of constituents was occurred in formulas containing avicel. Formulas contain xanthan gum (0.5%) or HPMC (5%) alone or in combination (xanthan gum 0.25% + HPMC 2%) showed the desired PH, palatability, sedimentation, resuspendability,rheology and dissolution in comparison with formulas contain avicel, SCMC, xanthan gum (0.25%), HPMC (2%) or formula of a combination of (xanthan 0.5% + HPMC 5%) and xanthan gum with SCMC at various concentrations used. Conclusion: The formulas which contains xanthan gum 0.5% and HPMC 2% or combination (xanthan gum 0.25% + HPMC 2%) were the best based on the sedimentation,rheology ,dissolution and stability.