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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-MM-00001872
Title: Modeling mice Down syndrome through protein expression: An artificial neural network based approach
Category: Molecular Modelling
Section: Research Article
Country: India
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Objective: Present research aims at artificial neural network (ANN) modeling of expression levels of proteins critical to learning in a mouse model of Down syndrome (DS) and delivered detectable signals in the nuclear fraction of the cortex.Materials and Methods:  In  this  investigation, we demonstrate  the modeling of 77 proteins  expression  levels measured in the cerebral cortex of 8 classes of control and DS mice exposed to context fear conditioning, a task used to assess associative learning. The dataset with 1080 samples of protein was selected for training the network model. The optimum ANN architecture experimented by varying its various attributes such as network algorithm, training function, learning function, transfer function, number of hidden layers, number of neurons in hidden layer, number of epochs, dataset splitting, and performance combinations. Results: The resulted ANN architecture Levenberg-Marquardt Back-propagation  method for training the model reveals preeminent performance at lower numbers of hidden neurons and further higher epochs. Conclusion: The result suggests that the ANN has the potential to exhibit as the best tool for modeling of protein samples, thus learning by examples can be achieved.
Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-P'Col-00001873
Title: Antihypertensive effect of Heterophragma adenophyllum Wall. ex G.Don in dexamethasone-induced hypertensive Wistar rats†
Category: Pharmacology
Section: Research Article
Country: India
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Background: Hypertension is one of the most common cardiovascular diseases in the world, and often, the treatment is limited by huge side effects due to allopathic medicine regimens. Objective: The purpose of this study was to investigate the antihypertensive properties and effects on biochemical parameters of Heterophragma adenophyllum Wall. ex G.Don on dexamethasone (DEX)-induced hypertensive Wistar rats. Methods: H. adenophyllum ethanolic extract (HAE) was orally administered to DEX-induced hypertensive Wistar rats, and their blood pressures were measured by tail-cuff method. Plasma level of insulin, blood glucose, and lipid profile was measured by the enzymatic method, and lipid peroxidation (LPO), catalase (CAT), and nitrite (NO) levels were measured by malondialdehyde (MDA), Beers, and Griese methods, respectively. Results: HAE could lower the blood pressure of Wistar rats dose-dependently by perioral administration. Meanwhile, the plasma levels of glucose and insulin were decreased by HAE administration, and there was a slight alleviation in lipid profile. Furthermore, CAT activity was significantly improved with HAE while LPO activity and NO activity significantly reduced. Finally, cardiac muscle fibrosis caused due to DEX was also normalized. Conclusion: HAE may be effective in lowering blood pressure, and this can perhaps be attributed to its positive effect on underlying biochemical and histological mechanisms, which need further investigations.
Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-PHE-00001874
Title: The model of forming of healthy environment in the conditions of pre‑school educational institution
Category: Public Health Education
Section: Research Article
Country: India
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Aim: The modern world undergoes many  innovative changes  in  the health and educational process. However, due  to  the deterioration of  the environmental ecology,  the  instability of  life situations  in families,  the health of children has become significantly worse than a few years ago. Improving children’s health is the most important task in the world. Materials and Method: Therefore, the Law “On Education in the Russian Federation,” the Federal State Educational Standard of Pre‑school Education, define the main targets. This is the provision of decent education, maintenance, and strengthening of the health of pupils. Today, the pre‑school educational institutions are one of the main institutions that shape the personality of the child. Here, the foundations for the mental and physical health of children are laid, which determine the further development of a person. Result and Discussion: The relevance of this topic is due to the need to introduce a health‑saving environment in pre‑school  educational  institutions,  and  to  form  a  sound health of  the  child. The  results obtained  in  the  course of  the experiment show a positive trend of the physical development of children on the basis of using the model of a health‑saving environment at the pre‑school educational institutions. Conclusion: Analyzing the scientific and methodological literature on the topic of our research, we have developed and tested a model for the formation of a health‑saving environment in the conditions of a pre‑school educational institution.
Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-P'Col-00001875
Title: Doxorubicin-induced cardiomyopathy: New approaches to the assessment of a cardioprotective activity
Category: Pharmacology
Section: Research Article
Country: India
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Introduction: Despite the continuous improvement of methodical approaches to the assessment of the cardioprotective activity of pharmacological agents in an experiment, it should be noted the insufficient level of elaboration of this problem. Research Tasks: Development of the methodical approaches for the evaluation of the cardioprotective activity of pharmacological agents to objectively assess the degree of the cardioprotective activity of commonly used cardioprotectors in cancer patients. Methods: Simulation of the cardiomyopathy was performed by intraperitoneal administration of doxorubicin at a dose of 20 mg/kg. After 48 h, we assessed indices of a left ventricular contractility under conditions of high heart rate (HR) 480 bpm for 15 s on the background of increased concentration of Ca2+in perfusate to 5 mmol in Langendorff heart of rats. As an additional index of the assessment of the cardioprotective action of pharmacological agents, there was used StТТIcoefficient, reflecting the diastole defect, that is, an area under the curve of the buildup of an end diastolic pressure. To evaluate the myocardial damage, there were determined the isoenzyme creatine phosphokinase and lactate dehydrogenase in perfusate flowing from the isolated hearts. For a comprehensive confirmation of the development of the simulated pathological processes, there was performed a morphological study of the hearts. As drugs, there were used enalaprilat (KRKA Slovenia) at the dose of 5 mg/kg intraperitoneally every 12 h, carvedilol (Teva, Israel) per os 1 times a day, verapamil (JSC Alkaloid, Macedonia) at the dose of 5 mg/kg intraperitoneally 1 time a day. Results: In a control group with the doxorubicin-induced cardiomyopathy under the conditions of submaximal stimulation frequencies (480 bpm) and increased concentration of Ca2+ in perfusate (5 mmol/l), we observed the diastolic defect which numerically was StТТI = 8.3 ± 0.3 c.u. that shows significant damage and the failure of the calcium pumps of cardiac myocytes. In an intact group, StТТI coefficient was 1.4 ± 0.1 c.u., that is, 8 times less than in the control group. The results of biochemical and morphological studies confirmed the degree of myocardial damage. In order of activity cardioprotectors located in following sequence: Enalaprilat (5 mg/kg), carvedilol (30 mg/kg), and verapamil (5 mg/kg). Conclusion: The fundamental difference in the area under the curve of the buildup of the end diastolic pressure under the conditions of submaximal stimulation frequencies (480 bpm) for 15 s and increased concentration of Ca2+in perfusate (5 mmol/l) in the intact group and the control group on the background of doxorubicin administration, naturally led to the necessity of introducing StТТIcoefficient, which is quite revealing and informative. The obtained results allow to use StТТIat the screening of innovative molecules.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-PC-00001876
Title: Assessment of urban air pollution by organic compounds
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Aim: The present study deals with the assessment of air pollution degree by volatile organic compounds (VOCs) in the city of Naberezhnye Chelny. There was researched character of the change of the ingredients contained in the atmospheric air and also has been researched the composition of the organic matters which are present in the atmospheric air. Material and Method: Air sampling was carried out for these components, the analysis on a gas chromatograph, and processing results. Result and Discussion: Quantitative content of VOCs in the air samples has been calculated. Defined the nature VOCs concentration gradient toward the city of Nizhnekamsk. The content of light organic compounds (41 compounds) was determined in 23 test plots. With a view to assessing, the level of air pollution was defined by the complex air pollution index for 23 sample plots on the five priority VOCs. Conclusion: The nature of the change in KIZA5 from the VOCs studied (from a low level of air pollution to very high) indicates a very significant air pollution by light organic compounds as we approach Nizhnekamsk that there have been proposals to lower the VOCs contents in the atmospheric air.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-GS-00001877
Title: A mathematical model for influence of physical exercises on psychophysiological adaptation of international students to learning performance at universities
Category: General Sciences
Section: Research Article
Country: India
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Peculiarities of influence of physical exercises and sports activities on psychophysiological adaptation (PPA) of international students to learning performance at Russian universities are considered. A mathematical model establishing relations between adaptation rate of international students and their physical activity level is proposed. The model is represented by a single ordinary differential equation with a boundary condition at the initial instant of time. The sought-for function in the equation is the level of PPA. Graphs explaining  the principle of work of  the model are  included. Optimum physical loading for individual, group, and sports exercises is determined through analysis of results obtained using the developed model. A conclusion is drawn on the necessity of group and individual physical exercises with regularity ranging from 4 to 8 h per week depending on the intensity of sports loading. Potential applications of the model to solving problems other than the problem of adaptation of international students to studying at universities are outlined.
Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-GS-00001878
Title: Gender interpretation of woman lexeme in internet discourse
Category: General Sciences
Section: Research Article
Country: India
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Aim: The paper is devoted to the gender analysis of the lexeme woman functioning in the internet discourse based on the material of the messages of male and female forums. In connection with the popularity of communication through the Internet, the gender aspect of Internet communication and the ways of linguistic representation of sex in the Russian Internet are of scientific interest. Gender can acquire specific features in e-communication. Studies of the lexeme woman in the Russian-language Internet forums made it possible to identify and describe the gender stereotypes of femininity existing in contemporary linguistic culture and to determine the role and place of this lexeme in the system of gender values of users in a virtual environment. Materials and Method: The scientific novelty of the studies is that the lexeme woman is analyzed on the material of the Russian-language Internet for the first time. The following methods were used during the research: Computerized sampling of language data, descriptive analysis, lexical-semantic analysis, contextual analysis, lingua-cognitive approach (description of cognitive structures through analysis of linguistic means of their objectification), and quantitative data processing. Result and Discussion: As a result of the study, the functional specifics of the lexeme woman in the Internet discourse were revealed and described; the non-procedural and procedural characteristics of women reflected in the language of the Russian-language internet users were identified and systematized; gender symmetry/asymmetry of the image of a woman was identified by comparing the results of identification and self-identification by persons of the opposite sex. Conclusion: Quantitative data are the basis for a conclusion that users of female forums think the description of a variety of typical everyday activities of women to be more important while men focus on their relationships with the opposite sex.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-P'Col-00001879
Title: Evaluation of antiovulatory activity of Thespesia populnea (L.) bark in albino rat model
Category: Pharmacology
Section: Research Article
Country: India
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Background and Aim: Several synthetic contraceptive piles and mechanical contraceptive devices are available today but these methods possess several side effects. Herbal medicinal plants have been used as safe alternatives of these contraceptive methods. Methods: In the present study, the effect of oral administration (6.6 mg/kg/bwt/day for 15 days) of Thespesia populnea bark extracts (ethanol, ethyl acetate, and aqueous) on the ovulation of female albino rats was investigated. Changes in the duration of different stages of estrous cycle, number of egg production, and reproductive hormonal levels were assessed after the continuous treatment T. populnea extracts. Results: Treatment with ethanol, ethyl acetate, and aqueous extracts caused extend in the duration of estrus, diestrus, and proestrus stages. They also reduced the number of egg in oviduct especially ethyl acetate extract drastically reduced the egg production. Significant reduction in the follicle-stimulating hormone, luteinizing hormone, progesterone, and estradiol levels and an increase in the prolactin level in the extract treated rats. From the results, it is concluded that all extracts of T. populnea bark exhibited female antiovulation activity. It was found that aqueous extract and ethyl acetate extract of T. populnea bark was more effective than the ethanol extract

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-GS-00001880
Title: Psychological impact of difficulties on mental health with signs of nervous-mental tension and decrease of adaptivity in students
Category: General Sciences
Section: Research Article
Country: India
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Aim: The article contains experimental research materials on the psychological aspects of the student health problem. The aim of the study was to identify the indicators of emotional status and adaptability in terms of risk-gene difficulties for mental health. Material and Methods: The methodological basis of the research is an integrated approach with using traditional and new methods of clinical and psychological analysis. The study included students studying at the initial courses of the State University (Kazan, Russia), representing for the further analysis as the general population (N = 7975). Results: Results of the analysis of health data became the basis for the assessment of other indicators in the framework of the research objectives of the problem. For this purpose, an experimental group was created by random selection (N = 162). On based of the analysis of factual material, three blocks of risk-related difficulties for the health of students are identified such as follows: Psychophysiological level of health - “malnutrition,” “lack of sleep,” and “lack of time;” mental level - “emotionally-cognitive experiences,” “anxiety,” “inability to self-management,” and “low level of self-regulation;” sociopsychological level - “attitudes related to study,” “relationship with the opposite sex,” and“attitude to material problems,” which bear subjective importance for personal and social success of students. The parameters “psychoemotional status” and “adaptability” of students in the situation “at the examination” and “after the examination” are analyzed. In the “at the examination” situation, 6.3% of student’s experience mental stress in the form of disorganization of psychosomatic functions (3rd degree NPS); 79.7% of students experience increased activity, with autonomic dysfunction (2nddegree NPS); At 13.3% of students have stable preservation of characteristics of mental activity (1stdegree of NPS). Analysis of the data “after the examination” showed that almost 40% of students suffer from emotional instability, fatigue, lack of sleep, adaptive resources are poor, and unconstructive. In 48.03% of the students of the experimental sample, the adaptive parameters were reduced from 1 to 4 points. Conclusions: On based of the data obtained, it is concluded that the difficulties accompanied by mental stress are the markers of the risk group for students whose adaptive resources are poor, and ways to overcome difficulties are weak. The materials of the article can be useful for specialists in the science and practice of clinical and social psychology and for all those who are interested in psychology.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-Ay-00001881
Title: Impact of Bhawana Dravya on physicochemical parameters of prepared Shankha Bhasma
Category: Ayurvedic
Section: Editorial
Country: India
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Background: Rasashatra deals with various Ayurvedic pharmaceutical procedures like Shodhana, Bhawana, Marana, Jarana, Murchana with detailed description of metals/minerals/gems/sudha varga/visopavisa varga etc. Bhawana process considered as samansakara, it is a wet trituration method and also a methodology used to reduce the size of particles, Shodhita metals/minerals triturated with specified liquid media for specified period of time or triturate till drying, which help in conversion of course powder to a finer state with the impregnation of newer properties of media to the material. The unwanted properties can be neutralized due to influence of Bhawana dravya. Therefore, knowledge of the Bhawana dravya mentioned in various Bhasma and formulation plays a pivotal role. By virtue of which it significantly reduces not only the soluble impurities but also the toxic property of the material. Consequently impartment of desirable therapeutic effects will appear. Shankha bhasma prepared from conch shell after calcination and intendent to use for gastritis, abdominal pain, malabsorption
syndrome etc. Objectives: To formulate, analyze the physicochemical properties of Shankha bhasma. Materials and methods: Shankha bhasma was prepared from conch shell after calcination by using Ghritkumari swarasa, Nimbu Swarasa, Water and mixture of Ghritkumari swarasa & Nimbu Swarasa respectively as bhawana dravya. Physicochemical parameters were carried out by using standard methods mentioned in official compendium. Results: The Shankha Bhasma prepared by using different Bhawana dravya have shown slightly variations in terms of physicochemical parameters but not significant variation was reported during the study. Thus based on Ayurvedic concept and modern instrumental techniques it is concluded that we can use any Bhawana dravya as per availability in the preparation of Shankha Bhasma. IR spectroscopy also not shown significant variations.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-Ay-00001882
Title: Characterization, organoleptic evaluation and standardization of aqueous extracts of antidiabetic herbs Trigonella foenum, Allium sativum, Aloe vera, Phyllanthus niruri
Category: Ayurvedic
Section: Editorial
Country: India
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Background and Aim: Trigonella foenum (Methi), Allium sativum (Lashuna), Aloe vera (Kumari), and Phyllanthus niruri (Bhumyamalaki) are well known antidiabetic herbs. The present study describes the standardization of the aqueous extracts of these herbs using parameters mentioned in Ayurvedic Pharmacopoeia of India (API). Methods: Aqueous extraction of drugs was carried out either by boiling their coarse powder in water or by subjecting their aqueous dispersion to agitation for 12-48 h based on solubility and nature of phytoconstituents of drugs. Further, they were characterized for physicochemical and microbiological parameters including the test for specific pathogens such as Salmonella and Escherichia coli. Results: The physicochemical and microbial parameters of all four herbs, T. foenum, A. sativum, A. vera, and P. niruri were found within the pharmacopeial limits of foreign matter, loss on drying, ash values, and extractive values. Moreover, physicochemical and microbial parameters of their extracts were also found to be within the limits prescribed by API. Conclusion: In this study, aqueous extracts of four crude herbs possessing antidiabetic activity, i.e. T. foenum, A. sativum, A. vera, and P. niruri were thoroughly investigated for their organoleptic characters, physicochemical parameters, and microbiological standards for their quality and safety.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-PB-00001883
Title: Phytoprofiling and antibiotic sensitivity test of ripe and unripe winter cherry
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Reason of the Study: We evaluated the bioactivity (antibacterial and antifungal) of ethanol, acetone, isopropyl alcohol, toluene, and hexane extract of different aerial parts (ripe and unripe fruit) of Winter cherry (Withania somnifera). The dried and powdered parts were successively extracted using Soxhlet assembly, and then, antibacterial and antifungal activities were investigated with by both antibiotic sensitivity test and serial dilution methods. The extracts of W. somnifera were evaluated or significantly inhibited six important bacteria (two Gram-positive and four Gram-positive bacteria) and two fungi such as Staphylococcus aureus and Bacillus subtilis (Gram-positive), Escherichia coli, Raoultella planticola, Pseudomonas aeruginosa, and Enterobacter aerogenes (Gram-negative), and Candida albicans and Aspergillus flavus (fungi) to varying degrees. Main Findings: Unripe fruit extracts of W. somnifera in toluene showed the highest activity in terms of inhibition zone (IZ), activity index, minimum inhibitory concentration, minimum bactericidal/fungicidal concentration, and total activity. Gentamycin, the standard antibacterial drug used, was effective in inhibiting these bacteria. The effect on S. aureus and B. subtilis was comparable to that of gentamycin. Ketoconazole, the standard antifungal used, was effective against the fungi (C. albicans and A. flavus). Principal Conclusions: B. subtilis (Gram-positive bacteria) was most susceptible organism which show IZ by all the extracts.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-PC-00001884
Title: Virtual screening, optimization of lead molecule selective inhibitors of farnesyl-protein transferase
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Farnesylation of the ras oncogene product by farnesyltransferase (FTase) is known to be a critical step in cell transformation leading to uncontrolled proliferation. Inhibitors of farnesyl-protein transferase (FPTase) have the potential of being anticancer agents for tumors in which ras was found mutated and contributes to cell transformation. As a result of the studies described herein, highly potent FPT inhibitors (FPTIs) with improved pharmacokinetic profiles have been identified. The post-translational addition of a farnesyl moiety to the Ras oncoprotein is essential for its membrane localization and is required for both its biological activity and ability to induce malignant transformation. We have prepared a series of potent ligand, inhibitors of the FPTase. The compounds were found to possess potent activity against enzymes. Mechanistic analysis had shown that the compounds are CAAX (“C” is cysteine, “a” is an aliphatic amino acid, and “X” is variable) competitive for FPTase inhibition. Then, compounds which passed ADMET (or) TOPKAT test were screened out. Based on the lowest energy, non-toxic molecules were docked with the FPTase receptor protein. Binding energy and docking results were observed for the comparative study of a good inhibitor against FPTase protein. The best molecule identified was further evaluated by molecular dynamics simulation of the protein-ligand complex. From the docking studies ligand, 1-[5-tert-butyl-2-(pyrazin-2-ylmethyl) phenyl]-2, 2-di hydroxy propan-1-one is the best ligand which can inhibit the target FPTase.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-PC-00001885
Title: Synthesis, characterization, and antimicrobial activity of fermented fruit juice mediated copper powder: A traditional approach
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Traditional medicinal approaches have deep discernable patterns, which if properly explored and investigated have invaluable human benefits. Their legacy is a living body of literature on transforming even tainted and toxic substances such as metals, minerals, acids, mineral salts, and poisons into precious medical drugs. There are numerous arduous procedures involved in this processes to alter these substances enabling them to fit for internal administration. The present study aims to synthesize copper nanopowder following the ancient lines of thought which is green and eco-friendly. The synthesized copper nanopowder was characterized with different techniques such as powder X-ray diffraction, scanning electron microscopy, transmission electron microscopy, ultraviolet-visible spectrum, and Fourier transform infrared spectroscopy. The antibacterial activity was also performed using Gram-positive and Gram-negative microorganisms. In this work, efficient biosynthesis process devoid of chemicals has been implemented and studied

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-P'Col-00001886
Title: Antidiabetic, antioxidant, and antibacterial potentials of endophytic fungi isolated from Cassia fistula
Category: Pharmacology
Section: Research Article
Country: India
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Objective: The present study was to investigate the antidiabetic, antioxidant, and antibacterial potentials of endophytic fungi isolated from the medicinal plant Cassia fistula. Methods: Endophytic fungi isolated from C. fistula by impregnation method. The fungal broth was extracted with various solvents like petroleum ether, dichloromethane, ethyl acetate, and butanol based increasing polarity. Antidiabetic efficacy of various extracts was determined by in vitro α-amylase and α-glucosidase assay. Furthermore, the extract was evaluated for antioxidant and antibacterial potentials using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay and well-diffusion method, respectively. Results: Six endophytic fungi (CFL1, CFL2, CFL3, CFL4, CFL5, and CFS1) were isolated from the plant C. fistula, and the different solvent extracts possess variation in phenol content which found ranged between 0.36 ± 0.005 and 43.18 ± 0.05 mg gallic acid equivalent/g. The α-amylase inhibition was found to be 17.83–60.86%, and also α-glucosidase enzyme inhibition was ranged from 10.04% to 56.76% against various fungal extracts tested. All fungal extracts possess significant antioxidant activity determined by scavenging potential of DPPH radical, and among all the extracts, dichloromethane of CFS1 was found maximum scavenging activity of 87.65%. The various fungal extracts showed significant bacterial inhibitions against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus. Conclusions: The present study reveals that the endophytic fungi of C. fistula could be the source of the potent lead drug against antidiabetic, antioxidant, and antimicrobial infections.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-Bio-00001887
Title: The effect of Darapladib as a lipoprotein-associated phospholipase A2 inhibitor to interleukin-1β and interleukin-6 on diabetes mellitus Sprague-Dawley rat model: A new therapeutic target of diabe
Category: Biomedicine
Section: Research Article
Country: India
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Background: Death related to cardiovascular events occurs due to atherosclerotic mainly based on plaque disruption. Inflammation is the most important mechanism of it. Interleukin-1β (IL-1β) and IL-6 has already known as inflammatory markers. Recent study reports that lipoprotein-associated phospholipase A2 (Lp-PLA2) regulates the inflammatory process. This study wanted to investigate whether Darapladib as Lp-PLA2 inhibitor can prevent the inflammatory process in type 2 diabetes mellitus (T2DM) rat model by reducing pro-inflammatory cytokine, especially IL-1β and IL-6. Methods: A total of 30 Sprague-Dawley rats were divided into three groups which were normal, T2DM, and T2DM with Darapladib administration (DMDP) group. Each group was divided into 8 and 16 weeks (early and late phase). The parameters in this study are IL-1β and IL-6 expressions measured using immunofluorescence. Results: In the early phase, the IL-1β expression in normal group was significantly different from DM, while in DMDP group showed a decrease trend although not significantly differ from
the DM. The IL-6 expression was significantly different in normal and DM group, and also in DMPDP compared with DM group. In the late phase, the IL-1β expression in normal group was significantly different from the DM group, while in DMDP group showed a decrease trend although not significantly differ from the DM group. The IL-6 expression in normal group was significantly different from the DM group, while in DMDP group showed a decrease trend but not significantly differ from the DM group. Conclusion: Inflammatory process in T2DM Sprague-Dawley rats model could be reduced as the effect of inhibiting Lp-PLA2 activity.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-P'Col-00001888
Title: Effect of red Piper betle leaf (Piper crocatum Ruiz & Pav.) ethanolic extract on plasma biochemical and hematological parameters in vivo
Category: Pharmacology
Section: Research Article
Country: India
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Aim: The objective of this study was to investigate the effect of oral administration of red Piper betle extract at doses of 500 mg/kg BW on plasma biochemical and hematological parameters in the Wistar strain of female rats after long-term use. Materials and Methods: The ethanolic extract of the red P. betle extract was administered  to Wistar rats  for a period of 90 days. After 90 days of  treatment,  the biochemical and hematological parameters were observed. The effect of extracts on plasma biochemical was assessed by measuring the level of aspartate aminotransferase, alanine aminotransferase, and creatinine. Effects on hematological parameters were assessed on hemoglobin levels, red blood cell count (erythrocytes), white blood cell count (leukocytes), platelets, and hematocrit values. Results and Discussions: The result showed that the levels of liver enzymes and creatinine levels significantly decreased. Meanwhile, the number of erythrocytes, leukocytes, hematocrit, and platelets of the test group tends to be lower than the control group, except hemoglobin. However, all parameters tested were still within the normal limit range. Conclusion: The ethanolic extract of red P. betle leaves is selectively toxic to plasma biochemical and hematological parameters at the examined dose or lower.
Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-QA-00001889
Title: Development and validation of mixed hydrotropic solubilisation method for spectrophotometric determination of Ornidazole in bulk drug and tablet
Category: Quality Assurance
Section: Research Article
Country: India
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Objective: A novel method was employed for solubilization and spectrophotometric estimation of poorly water-soluble drug, Ornidazole. In the present manuscript, an analytical method has been prescribed for the estimation of Ornidazole by ultraviolet spectrophotometry using mixed hydrotropic solubilization technique. Mixed hydrotropic solubilization technique is the phenomenon to increase the solubility of poor water-soluble drugs in the blends of hydrotropic agents, which may give miraculous synergistic enhancement effect on solubility of poor water-soluble drugs. Method: The present work was made to obstruct the use of toxic organic solvents by preparing mixed blend of 10% sodium acetate, 10% urea, 10% niacinamide, and 10% sodium tricitrate. Result: Wavelength 319.20 nm was selected for the developed spectrophotometric method of ornidazole. The solubility enhancement for Ornidazole in the mix hydrotropic solution was found to be more than 40-fold as compared to the distilled water. The linearity was found to be 5-25 μg/ml with correlation coefficient 0.999. The inter- and intra-day precision was found 0.9166% and 0.6066% relative standard deviation (RSD), respectively. The repeatability was found 0.23 in %RSD. The limit of detection and limit of quantitation were found to be 0.1264 and 0.38, respectively. Ruggedness study for external parameters was found within limits. The percent recovery was found to be 101.48 (for n = 9). The % purity was found 101.41. Results of method for analysis of tablet were found 99.905%. All validation parameters were found within limits. Conclusion: The developed method was found to be simple, fast, accurate, eco-friendly, precise, and economic.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-P'Col-00001890
Title: Pharmacological evaluation of ellagic acid for the treatment of common dermatological disorders in Wistar rats
Category: Pharmacology
Section: Research Article
Country: India
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Aim: The objective of the study is mainly to perform pharmacological evaluation of ellagic acid for the treatment of common dermatological disorders in Wistar rats. Materials and Methods: (a) For psoriasis control group, rats were treated with the vehicle (water) alone. For disease control group, psoriasis was induced to the rats, did not receive any treatment. For standard group, psoriasis was induced to the rats and treated with salicylic acid at the dose level of 0.1% by applying on to the upper surface of the tail. For the first test group, psoriasis was induced to the rats and treatment was performed once daily by the topical administration for 16 days 0.5% of the ellagic acid. For the second test group, psoriasis was induced to the rats and
treatment was performed once daily by the topical administration for 16 days 1.0% of the ellagic acid. (b) For dermatitis control group, dermatitis was induced to the rats, did not receive any treatment. For low-dose test group, dermatitis was induced to the rats and treatment was performed once daily by oral administration 25 mg/day ellagic acid. For high-dose test group, dermatitis was induced to the rats and treatment was performed once daily by oral administration 50 mg/day ellagic acid. Results: Psoriasis was induced by repeated application of ultraviolet (UV)-light on rat tail, and ellagic acid of concentrations 0.5% and 1% had shown same effects in reducing tail thickness as that of the standard drug salicylic acid had shown.Dermatitis was also induced by UV-light ellagic acid of concentrations 0.5% and 1% had shown more effect in reducing tail weight and epidermal thickness when compared to the standard drug salicylic acid. Conclusion: Histopathological study of ellagic acid does not showed significant effect when compared with standard drug for treating psoriasis, but ellagic acid was proved to be effective for treating dermatitis.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-PB-00001891
Title: Isolation of imidacloprid-degrading bacterial strain with plant growth-promoting rhizobacteria activity
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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A total of 16 bacterial cultures were isolated by enrichment technique, only eight isolates showing significant growth in minimal salt medium (MSM) media containing 0.7 mM imidacloprid, these strains utilized imidacloprid as a sole carbon energy source. The eight selected bacterial isolates were screened for their plant growth-promoting rhizobacteria (PGPR) activity. It was found that strains DC14 and DC16 were showing growth in MSM supplemented with 0.7 mM imidacloprid along with PGPR activity

Journal: Journal of Pharmacy Research , Volume: 11, Issue: Nov
Article Id: JPRS-P'Col-00001893
Title: Phytochemical and Pharmacological aspects of Sarcostemma acidum (Roxb.) Voigt
Category: Pharmacology
Section: Research Article
Country: India
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Natural products had been used by many cultures and traditions from thousands of years for their bioactive pharmacophores by modern pharmaceutical companies. The potential bioactive phytocompounds such as alkaloids, flavonoids, phenolic compounds, and steroids are potential source for drug discovery. The present review deals with chemical compounds, medicinal properties, biological activities, and pharmacological effects of Sarcostemma acidum Roxb. Voigt. The plant species S. acidum Roxb. Voigt is a member of the Asclepiadaceae family, locally known as Khair, Khimp, Khurasni tanto, Art thor, Soma, and Somavalli. In English, Moon plant and Moon creeper, and in Hindi, Somlata used in the Indian traditional system of medicine. This review focused on different properties of S. acidum Roxb. Voigt a multifaceted plant