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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-PCS-00001676
Title: Formulation Development and Evaluation of Gastro Retentive Drug Delivery Systems- A Review
Category: Pharmaceutics
Section: Review Article
Country: India
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In recent years many advancement has been made in research and development of Oral Drug Delivery System. Concept of Novel Drug Delivery System arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. Purpose of this review is to compile the recent literature with special focus on Gastro Retentive Drug Delivery Systems to give an update on pharmaceutical approaches used in enhancing the Gastric Residence Time (GRT). Various approaches are currently used including Gastro Retentive Floating Drug Delivery Systems(GRFDDS),swelling and expanding system, polymeric bioadhesive systems, modified-shape systems, high density system and other delayed gastric emptying devices. These systems are very helpful to different problem solve during the formulation of different dosage form. The present work also focuses on the polymers used in floating drug delivery systems mostly from natural origin. Floating drug delivery systems are less dense than gastric fluids; hence remain buoyant in the upper GIT for a prolonged period, releasing the drug at the desired/ predeterminedrate. This review article focuses on the recent technological development in floating drug delivery systems with special emphasis on the principal mechanism of floatation and advantages of achieving gastric retention, brief collection on various polymers employed for floating drug delivery systems etc. In addition this review also summarizes the In –Vitro and In -Vivo studies to evaluate their performance and also their future potential.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-PCS-00001675
Title: Starch Based Mucoadhesive Oral Thin Film with Antimigraine Drug Zolmitriptan
Category: Pharmaceutics
Section: Research Article
Country: India
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With the current focus on sustainability, starch is a material for interest and has been getting attention all over the world. Though lot of research work had been done in developing starch based biodegradable films as edible food   packaging material its exploration for drug delivery is still limited. In the present work we are exploring the possibility of using Indian sago starch obtained from sago pearls for its potential to form mucoadhesive thin films for the delivery of antimigraine drug, zolmitriptan. Total nine batches of the films with different concentration of sago starch and beta cyclodextrin as bioenhancer using glycerin as plasticizer were prepared successfully and had good mechanical properties like folding endurance, elongation and tensile strength along with mucoadhesion.In-vitro studies through Franz diffusion cell  in simulated salivary fluid showed  the 96.45% to 99.43%  of drug release in six hours by non-fickian or anomalous diffusion mechanism. Thus it was concluded that sago starch based mucoadhesive oral films can be formulated successfully.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-PC-00001680
Title: Synthesis and anticonvulsant activity of N-(substituted phenyl-4,5-dihydro-1H-pyrazol-3-ylamino)-2-(4-methoxyphenyl) quinazolin-4(3H)-ones derivatives
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Epilepsy is a neurological disorder marked by abnormal electric discharge in the brain remitting in seziures. The clinically existing antiepileptic drugs suffers from various side effects. Therefore, a search for novel antiepileptic drugs with higher efficiency & less toxicity still continues to be an area of investigation. A series of N-(substituted phenyl-4,5-dihydro-1H-pyrazol-3-ylamino)-2-(4-methoxyphenyl) quinazolin-4(3H)-ones was synthesized & evaluated for the anticonvulsant activity using maximal electroshock seizure (MES) & subcutaneous pentylenetetrazole (scPTZ) models. The structures of the synthesized compounds were confirmed by spectral data and elemental analysis. The compounds were also assessed for the minimal motor impairment using rotarod apparatus. All the compounds showed significant anticonvulsant & neurotoxic activities. 3-(5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-ylamino)-2-(4-methoxyphenyl)quinazolin-4(3H)-one, 6 (x) was found to be the most active compound at a dose of 25 mg/kg with percentage protection of 84.32% and 82.85% respectively in MES &scPTZ models without any neurotoxicity.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-MB-00001679
Title: Stress response of Escherichia coli on exposure to First transition series elements in well diffusion assay
Category: Microbiology
Section: Research Article
Country: India
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Aim: Escherichia coli ability to remain sensitized to the first series elements by well diffusion assay has been carried out. Observation and results: E. coli remain increasingly inhibited to the increasing concentration of vandanium peroxide, chromium nitrate, magnous acetate, ferric oxide, cobalt chloride, nickel nitrate, cupric sulphate and zinc sulphate in variable percentage as per well diffusion assay. Conclusion: These first series elements could be the future drugs which may control the antibiotic resistant E. coli.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-CPRMS-00001678
Title: Iatrogenic mistake lead to loss of movement
Category: Clinical Pharmacy and Related Medical Science
Section: Research Article
Country: India
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Objective: to discuss a medical error lead to loss of movement. Method: A prospective case report and analysis from the hospital. Results:The patient underwent a Lumbar Spinal Fusion Surgery and he had a history of osteoporosis, which in turn lead to osteopenic texture of the lumbar vertebra, vertebras erosion and severeosteolysis. Conclusion: Risk analysis and the pharmacist directed role in the management of osteoporosis should be implemented in such cases.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-ND-00001677
Title: Efficacy of Artesunate Against Parasitic Nematode
Category: Natural Drugs
Section: Research Article
Country: India
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Background: Artesunate is one of the semi-synthetic derivatives of artemisinin, isolated from the medicinal plant Artemisia annua. It is a prescription drug for falciparum malaria, and applicable in human schistosomiasis. We have previously shown that it is also effective against tapeworm (cestode). This study investigates its probable anthelmintic activity on the roundworm (nematode) in vitro. Method: Intestinal nematodes were collected from the entrails of local fowls, and were cultured in phosphate-buffed saline (PBS) at 37 ± 1°C. An untreated control was maintained and the rest were exposed to multiple doses of artesunate (Falcigo) to assess the  relative survival under different treatment regimes. Result and discussion: Of the varying doses tested, only the highest doses,  namely 10, and 20 mg/ml, indicated significant nematocidal of the worms. However, the lower doses did not have any significant effect. Conclusion: Although artesunate is a potent anthelmintic agent against cestodes and trematodes, its activity is delayed against nematodes, and requires higher doses. To my knowledge, this is the first report of the efficacy of artesunate on parasitic nematodes.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-ND-00001673
Title: Diverse mechanisms of the anti-ulcer feature of the methanol fraction of the ethanol layer of the chloroform-ethanol extract of the leaves of Dacryodes edulis: Are anti-oxidant approaches and anti-lip
Category: Natural Drugs
Section: Research Article
Country: India
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Background and Aim: Investigations into medicinal plants with potent anti-oxidant activity will continue to garner the attention of researchers due to the contributory role of oxidative stress in a number of disease conditions and thus, the aqueous extract, chloroform and ethanol layers of the chloroform-ethanol extract of the leaves of Dacryodes edulis were evaluated for their anti-oxidant vitamin contents. Based on the outcomes of the preliminary investigations, the most promising of the three (ethanol layer) was further fractionated and the effects of the most desirable fraction (methanol fraction) on the activity of superoxide dismutase (SOD) and concentrations of reduced glutathione (GSH) and malondealdehyde (MDA) of diclofenac-ulcerated Wistar rats were determined. Methods: The anti-oxidant vitamin contents of the aqueous extract, chloroform and ethanol layers as well as the effects of the methanol fraction of the ethanol layer of the chloroform-ethanol extract of the leaves of D. edulis on the activity of SOD and concentrations of GSH and MDA of diclofenac-ulcerated Wistar rats were examined using standard methods. Results: The ethanol layer contained the highest concentration of vitamin C (0.79 ± 0.03 mg/100 g) while the chloroform layer contained the highest concentrations of vitamins A (1.83 ± 0.08 μg/g) and E (1.17 ± 0.07 mg/100 g). The aqueous extract contained the least concentrations of vitamins A (1.34 ± 0.06 μg/g) and E (0.86 ± 0.05 mg/100 g). At the administered doses (100, 200 and 400 mg/kg b.w), the methanol fraction caused significant (p < 0.05) and dose-related increases in SOD activity and GSH concentration as well as decrease in MDA concentration of the rats in the test groups compared with those of the rats in the ulcer-untreated group. Conclusion: This study reveals that the leaves of D. edulis possess remarkable anti-oxidant feature and anti-lipid peroxidation effect which may be crucial in the amelioration of gastric ulceration.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-ND-00001674
Title: In-vitro Antibacterial Activity of Sri Lankan Traditional Rice (Oryza sativa L.) Extracts against Bacteria Causing Skin and Soft Tissue Infections
Category: Natural Drugs
Section: Research Article
Country: India
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The aim of this study was to evaluate the potential antibacterial activity of the extracts of selected parboiled and un-parboiled Sri Lankan traditional rice against bacteria causing skin and soft tissue infections. Methanolic extracts of five Sri Lankan traditional rice including Kalu Heenati, Pokkali, Rathdal, Kahawanu and Sudu Murunga were used for in vitro antibacterial analysis. Antibacterial activity was evaluated in both the parboiled and un-parboiled rice samples. Concentrations of rice extracts used for the assays were 1000 µg/mL and 2000 µg/mL from the each extract. The antibacterial activity was evaluated against common bacteria causing skin and soft tissue infections (Staphylococcus aureus (ATCC 25923), Pseudomonas aeroginosa (ATCC 27853), Escherichia coli (ATCC 25922) and three clinical isolates of Methicillin resistant staphylococcus aureus (MRSA)) by well diffusion method and viable colony count technique. According to the results, methanolic extracts of all the selected Sri Lankan traditional rice varieties exhibited a potent antibacterial activity against Staphylococcus aureus with minimum bactericidal concentrations (MBC) of 200 µg/mL (minimum incubation time (MIT); 30 min) for Rathdal, 200 µg/mL (MIT; 60 min) for  Kalu Heenati, Pokkali and Kahawanu, and 2000 µg/mL (MIT; 60 min) forSudu Murunga. The largest inhibition zones were observed in the extracts of Kalu Heenati and Rathdal. Kalu Heenati, Pokkali and Rathdal showed an efficacious inhibitory effect against MRSA (MBC; 200 µg/mL, MIT; 60 min), whereas the highest inhibitory activity was observed for Rathdal. Only the extract of Kalu Heenati was slightly active against Pseudomonas aeroginosa. None of the rice extracts studied showed an antibacterial activity against Escherichia coli.Reduction and loss of antibacterial activity was detected in rice after subjected to parboiling. In conclusion, Sri Lankan traditional rice varieties with red pericarp are good sources of antibacterial compounds mainly against Gram positive bacteria. Methanolic extract of Rathdal and Kalu Heenati showed a high efficacious inhibitory effect against skin and wound pathogens of Staphylococcus aureus and MRSA.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-PCS-00001672
Title: Process Validation of Extended Release Bi-Layered Tablet Containing Metformin, Pioglitazone and Glimipiride
Category: Pharmaceutics
Section: Research Article
Country: India
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Background of the study: The prime objective of any work in pharmaceutical plant, whether in production or quality control is to manufacture product of requisite quality at the lowest possible cost. Validation is attaining and documentation of sufficient evidence to give reasonable assurance that the process under consideration does and what it purports to do. Methods: In the present study, process validation studies were carried out for a bilayer tablet containing extended release Metformin, Pioglitazone and Glimepiride as per the protocol. The parameters used during the studies were dispensing, sifting, mixing, preparation of granulating solution, granulation, drying and sizing, lubrication (flow property & assay lubricated granules), compression (weight variation, hardness, thickness, friability, content uniformity), labeling and packing. Results and Discussion: The samples collected at different stages were analyzed using UV and HPLC method as per protocol. The results were found to be within the acceptance criteria. Conclusion: From the validation studies carried out, it was observed that no modification was required in present manufacturing process. The method requires further validation only when there is change in raw materials or equipment or process.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-P'Col-00001671
Title: Role of Cactus grandiflorus in reversal of histological disruption and extent of infarction on isoproterenol-induced myocardial damage in wistar rats
Category: Pharmacology
Section: Research Article
Country: India
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Background: Isoproterenol (ISO) is a known drug that is used experimentally to induce myocardial infarction (MI) in rats. Beside various disturbances, histopathological disturbances are a prominent marker of myocardial toxicity. Several molecules are continuously being explored for their efficacy in reversing these changes. Cactus grandiflorus is frequently used in homeopath as a cardioprotective drug but its scientific validation is still not established. This study is therefore a move in this direction. Methods:Wistar rats were randomly divided into (1) Normal (normal saline) (2) Toxic (ISO, 85 mg/kg, s.c). (3) C. grandiflorus (0.5 ml/kg, p.o.) and ISO (85 mg/kg, s.c). (4) C. grandiflorus (1.0 ml/kg, p.o.) and ISO (85 mg/kg, s.c). (5) Vitamin-E (100 mg/kg, p.o.) and (6) C. grandiflorus per se (1.0 ml/kg, p.o.). Study was done for a period of 15 days.  C. grandiflorus was administered twice daily and ISO on 14th and 15th day. After 15 days treatment rats were sacrificed and hearts were isolated. Infarct size measurement and histopathological evaluation of the heart tissues were then performed. Results and discussion: Pre-treatment with C. grandiflorus (0.5 ml/kg and 1.0 ml/kg) showed reversal of cellular damage and myocardial infarction on dose-dependent manner. This could be due to antioxidant effect of C. grandiflorus that normalized the oxidative stress created by isoproterenol.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-PCS-00001670
Title: Spectroscopic Quantitation and analytical validation of Indomethacin in bulk drug and capsule formulation
Category: Pharmaceutics
Section: Research Article
Country: India
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Background: In this manuscript spectroscopic quantitation and analytical validation of indomethacin in bulk drug and capsule formulation by UV spectroscopy. Materials and Methods: In present investigation 0.1 N NaOH was employed as  the solubilizing agent to solubilize the poorly water-soluble drug, indomethacin, from the capsule dosage form for spectrophotometric determination in ultraviolet region. Results: The adequate drug solubility and maximum assay sensitivity (235nm) in the wavelength range of (200-400 nm), the linear calibration curve was obeyed in the concentration range of (5-25 µg/ml) show regression equation (Y =0.029X+0.057), and correlation Coefficient (R2= 0.999). Discussions: This method was validated and applied to the determination of IND in capsules form, no interference was found from capsule excipients at the selected wavelength and analysis conditions. Conclusion: It was concluded that the developed method is accurate, sensitive, precise, and reproducible and indirectly for the estimation of IND content in pharmaceutical formulation.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-QA-00001669
Title: Temperature Mapping of Hot Air Oven (Dry Heat Sterilizer)
Category: Quality Assurance
Section: Research Article
Country: India
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Background of the study: Dry heat is sometimes used as a substitute for moist heat for the purpose of sterilization, even though the latter being more efficient than the former since certain materials are heat sensitive in nature. It ensures complete removal of pyrogen during sterilization of glass and other laboratory equipment’s. The process of sterilization within a chamber or hot air tunnel is a critical process, and there is a regulatory requirement for validation of the process in most countries.  Objective of the study: The primary objective of this work was to ensure the operational and performance qualification of dry heat sterilizer.  Methods: Dry heat sterilizer validation comprises of accurately measuring the temperature at critical points within the sterilization chamber throughout the process. The process of sterilization employed during the study was carried out at a temperature ranging between 250±15°C. The sterilizer was done to ensure complete heating of all parts of its load up to the afore-mentioned temperature for a specified period long enough to achieve the desired sterility. Results and Discussion: All the results were found to be within the acceptance criteria and the study was successful. Conclusion: The dry heat sterilizer qualifies for its operation and performance.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-PB-00001668
Title: The impacts and biodegradation studies of Bacillus subtilis (MTCC1427) on tannery effluents
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Setting up of new industries or expansion of existing industrial establishments resulted in the disposal of industrial effluents which discharge untreated effluents causing air, water, soil and soil solid waste pollution. In recent years, industrial effluents have been regarded as common source of pollution due to inappropriate disposal methods by industries. Water pollution is the major pollution that effects the environment much and one of the sources of this pollution is tannery industrial effluents. Effluents are so toxic that fishes cannot survive in it even for two hours and also effects the drinking water and hence it should be treated effectively before release. Bioremediation is the only way to tackle these xenobiotics and reduce the pollutants which is ecofriendly. The present work is an attempt which has been made to analyze the effectiveness of bacillus subtilis against tannery effluents. Results of the above project giving a brief note on level of turbidity (O.D), pH and physio chemical parameters found to decreases from high to optimum level and resulted water can be used for agricultural purpose.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-PA-00001666
Title: Analytical method development and validation for the simultaneous estimation of Phenylephrine and Ebastine by using RP-HPLC method in pure and tablet dosage form
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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A simple, rapid, accurate and precise method has been developed for the simultaneous determination of Phenylephrine and Ebastine from pharmaceutical formulation by reversed-phase high performance liquid chromatography. The separation was carried out on Akzonobel chiral kromasil C18 (150×4.6mm,5m) column using mobile phase consisting of a mixture of  buffer : acentonitrile: methanol in the ratio (30:45:25 v/v). The flow rate was maintained at 0.8 ml/min. The UV detection was carried out at a wavelength of 211 nm. The retention time for Phenylephrine and Ebastine was found to be 2.286 min and 4.304 min respectively. Linear response obtained for Phenylephrine was in the concentration range 25- 150 ìg/ml (r2 = 0.999) and Ebastine in the range 25-150 ìg/ml (r2 = 0.999). The relative standard deviation in the tablets was found less than 2% for six replicates. The method was validated according to the ICH guidelines with respect to linearity, precision, accuracy, limit of detection, limit of quantification and robustness. The formulation was subjected to oxidation, hydrolysis, photolysis and dry heat as stress conditions. Thus proposed method can be successfully applicable to the pharmaceutical preparation containing the above mentioned drugs without any interference of excipients.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-PHDRS-00001665
Title: Medicinal Importance and Pharmacological Significance of Eugenia jambolana Lam.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Eugenia  jambolana (Myrtaceae) is a large evergreen tree up to 30 m high. Bark pale brown, slightly rough on old stems. It is a widely used medicinal plant throughout India and popular in various Indigenous System of Medicine like Ayurveda and Siddha. In the Traditional System of Medicine, the various plant parts such as bark, fruit, seed and leaf are used as astringent, sweet, sour, acrid, refrigerant, carminative, diuretic, digestive, in diabetes, leucorrhoea, gastric disorder, The present review and research is therefore an effort to give a detailed survey of the literature on pharmacognosy, phytochemistry and pharmacological activities. 

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-PCS-00001664
Title: Formulation and evaluation of biodegaredable nanoparticle of Glimepiride by ionic gelation method
Category: Pharmaceutics
Section: Research Article
Country: India
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Aim:To explore the water solubility of drug and increase oral bioavailability of Glimepiride. Nanoparticles of Glimepiride for oral drug delivery were prepared by ionic gelation method using polyelectrolyte charge interaction. Glimepiride is an effective antidiabetic agent; however, it suffers from short biological half-life. Therefore, it was selected as amodel drug. Method:The prepared Nanoparticles were evaluated for Physico-chemical studies like drug polymer interaction through FT-IR analysis, Melting Point by Differential Scanning Calorimetry, surface morphology by Scanning Electron Microscopy (SEM), Percent drug entrapment, production yield, in-vitro drug release characteristics and release kinetics. The result of FT-IR studies showed that there was no drug polymer interaction found. Results and Discussion:The SEM studies confirmed that with increase of polymer concentration the nanoparticles become smooth, and in-vitro release studies showed that the drug release followed diffusion for formulation F5, F6, and F7 and for the formulation F8, F9 and F10 followed non-fickian mechanism, moreover all the formulations exhibited high percentage yield as well as high percent drug entrapment. Conclusion:The method proves to be beneficial in designing control release formulations of Glimepiride Chitosan-Gelatin-B ionic gelation method, using polyelectrolyte charge interaction.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-P'Col-00001662
Title: Evaluating effect of Cap PMA on platelet count in endemic fevers -A case series study in Pune (Maharashtra, India)
Category: Pharmacology
Section: Research Article
Country: India
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Dengue, Chikungunya, Viral Fever and FUO are major threats for social health to India with many patients falling prey to such disorders in recent days. Several patients suffer from long term complications of these endemic fevers such as thrombocytopenia, weakness, joint pains, bleeding problems and occasionally death. Ayurveda, the traditional Indian science of medicine can offer effective solution to manage these endemic fevers. Cap PMA is an Ayurvedic formulation containing extracts of Tinospora cordifolia, Carica papaya and Swertia chirata processed in their juices targeted to increase platelet count affected by endemic fevers. A case series observational study was conducted at different private practitioners’ clinics in Pune, Maharashtra to evaluate the efficacy and safety of Cap PMA in endemic fevers. Total 37 adult patients (19 Males, 18 Females) were recruited using intention to treat model and treated with Cap PMA for 7 days. Primary objective was to assess effect of formulation on different clinical and hematological parameters and secondary objective was to assess tolerability of the formulation. The study revealed excellent tolerability of the formulation with no patient lost to follow up. The patients on treatment did not report any complications or adverse events during study period. All patients showed improvement in clinical and hematological parameters with significant increase in platelet count (p=0.0010, 95% Confidence interval). Other hematological parameters were not significantly affected by the disease as well as the formulation suggesting a protective role of the formulation in endemic fevers. The study reports a promising activity of Cap PMA in endemic fevers for restoration and increase in platelet count and preventing complications.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-PCS-00001663
Title: Taste Abatement of An Anthelmintic Drug Using Ion Exchange Resin
Category: Pharmaceutics
Section: Research Article
Country: India
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Aim: The thrust of present research work was to masking the taste of Levamisole Hydrochloride with strong cation exchange resin i.e Tulsion 343. The complex formation of drug with Tulsion 343 was carried out using batch method to block the functional group responsible for causing bitter taste. Methods: DSC analysis, FTIR spectra, X-RD spectra and decomplexation studies gave evidences of complex formation. Drug release from drug: resin complex was obtained at salivary pH (6.8) and gastric pH (1.2).  Accelerated stability study (AST) on drug: resin complexes were performed by keeping sample of complexes at 40º C for period of 1 month. Results: The efficient drug loading was evident in batch process using Tulsion-343 with a drug: resin ratios 1:1, 1:1.5, and 1:2 (% w/w). Drug release from selected drug: resin complex at salivary pH was insufficient to impart bitter taste. Drug release has no significant effect using different media at same pH: salivary pH (phosphate buffer pH 6.8 and simulated salivary fluid) and at gastric pH (0.1 N HCl and simulated gastric fluid). Drug: resin complexes were found stable at elevated temperature. Conclusion: Depending upon percent complexation, release study at different pH, Levamisole Hydrochloride: Tulsion-343 complex of ratio 1:1 (%w/w) was gives good results.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 2.
Article Id: JPRS-PHDRS-00001667
Title: Cytotoxic activities of flavonoid glycosides isolated from Leucaena leucocephala pods cultivated in Egypt
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Background: This study aim to carry out phytochemical investigation of Leucaena leucocephala (Lam.) pods and evaluation of cytotoxic activity in-vitro against hepatocellular carcinoma (HepG2) cells hopping to find natural cytotoxic from plant materials. Results: Isolation of the new acylated flavone glycoside; luteolin-7-O-[2'’-O-(5'’’-O- coumaroyl)-ß- D-apiofuranosyl]-ß-D-glucopyranoside (1) besides two known sulphated compounds: Isoorientin 7-sulphate (2), Tamarixetin-3-sulphate (3) in addition to Rutin (4) and Luteolin (5). Their chemical identification was established by NMR spectroscopic methods including 2D-NMR, as well as UV and ESI-MS analyses. Compounds 1, 4 , 5 and defatted aqueous 80% methanol pods extract exhibited inhibitory activity against liver carcinoma cells (Hep-G2) with IC50 value 38.6, 39.9, 45.9 and >100ìg/ml respectively. Conclusion: Thus, the investigated plant pods extract showed weak cytotoxic activity for their active compounds and reported herein for the first time.