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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PCS-00001736
Title: RP-HPLC method for simultaneous estimation of Metformin Hcl, Ramipril and Glimepiride in bulk and their combination tablet dosage form
Category: Pharmaceutics
Section: Research Article
Country: India
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A simple, accurate, precise assay and rapid stability-indicating reversed phase high performance liquid chromatography (RP-HPLC) method has been developed with an effective resolution and subsequently validated for the simultaneous estimation of Metformin HCl, Ramipril and Glimiperide from their combination drug product. The method was developed using Inertsil ODS C18, 150 x 4.6 mm, L1 packing, maintained at an ambient temperature. The optimum mobile phase used in this method was a mixture of Methanol and pH 3.0 KH2PO4 buffer in the ratio of proportional v/v, flow rate of mobile phase was set 1.0 mL min-1. At 228 nm compounds were eluted and monitored. Metformin HCl, Ramipril and Glimepiride are subjected to stress conditions of acid, base, oxidative, thermal and photolytic degradation. The degradation products were well separated from the main peak proving the stability-indicating ability of the method. The developed method was validated as per International Conference on Harmonization (ICH) guidelines.[ICHQ2 (R 1)]

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-ND-00001743
Title: Essential Oil Extraction, Characterization and Anti microbial study of Cythocline purpurea from Konkan Region
Category: Natural Drugs
Section: Research Article
Country: India
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Objective: The present study of was designed to evaluate the methods of essential oil, phytochemical composition and Anti Microbial Study of essential oil from Cythocline purpurea DC collected from Bhramhanwadi, Taluka Dapoli District Ratnagiri in Konkan Region. Methods: The Essential Oil was extracted by Hydro distillation using Clevenger’s type Apparatus and characterization of essential oil was done by IR, GC-MS, GC-FID and Anti Microbial Activity. Results: Total 32 compounds were identified using Gas Chromatography with Mass Spectroscopy. The main components of essential oil are 4- hexen-1-ol, 5-methyl-2-(1-methylethenyl) (70.2%), 1,6 octadiene 3-ol, 3,7-dimethyl (39.9), Phenol, 2-methyl-5- (1-methylethenyl) (42.2%), etc. GC-FID shows number of components of present essential oil. IR confirms the identification of components. Chemical Investigation were done to determine its molecular formula and structure.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PC-00001717
Title: Synthesis, biological evaluation and molecular docking studies of furo[3,2-H]quinoline-2-carbimidates
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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An operationally simple and efficient protocol for the construction of quinoline fused dihydrofuran derivatives 3(a-h) has been achieved via a sequential addition of N-chloro succinimide and base to pyrano[3,2-h]carbonitrile derivatives in alcohol medium. Tandem oxidative difunctionalization was accomplished with N-chloro succinimide reagent by the addition of both chlorine and alkoxy groups across the chromene double bond. Further addition of piperidine base results in the formation of dihydrofuran derivatives by ring contraction. The structures of synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and elemental analysis.The synthesized compounds were evaluated for in vitro antibacterial and cytotoxic activity studies. Further these compounds were screened for computational molecular docking studies against vascular epidermal growth factor receptor tyrosine kinase. Anti bacterial activity results showed that compounds 2g, 2h, 3c, 3d, 3e, 3f and 3h were active against all the four strains of bacteria and their MIC ranged between 1.56 and 12.55 µg/mL. Cytotoxic activity studies revealed that compounds, 2f, and 3b exhibited significant percentage inhibition in cell proliferation at an IC50 value of 4.54 µg/ml and 7.75 µg/ml as well as in silico docking studies also reveal that compounds 2f, 2h, 3b & 3e have good dock score, binding affinity and binding energies towards epidermal growth factor receptor tyrosine kinase.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-P'Col-00001739
Title: Influences of the methanol extract of the leaves of Anacardium occidentale on selected oxidative stress indices of indomethacin-ulcerated rats
Category: Pharmacology
Section: Research Article
Country: India
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Background and Aim: Researches into medicinal plants with potent anti-oxidant activity will continue to receive the attention of researchers due to the role of oxidative stress in many disease conditions and hence, this study was aimed at investigating the influences of the methanol extract of the leaves of A. occidentale on selected oxidative stress indices of indomethacin-ulcerated rats. Methods: The effects of the methanol extract of the leaves of A. occidentale on the activity of superoxide dismutase (SOD), concentrations of reduced glutathione (GSH) and malondialdehyde (MDA) were evaluated using standard methods. Results: The extract at the administered doses (100, 200 and 400 mg/kg b.w), caused significant (p < 0.05) and dose-related increases in the activities and amounts of SOD and GSH respectively in the rats of the test groups compared to those of the rats in the ulcer-untreated group. The extract treatment also led to significant (p < 0.05) reductions in the concentrations of MDA in the rats of the test groups compared to that of the rats in the ulcer-untreated group. The 400 mg/kg b.w of the extract exerted the greatest effects which were analogous to those of the standard anti-ulcer drug, famotidine at the dose of 50 mg/kg b.w. Conclusion: The methanol extract of the leaves of A. occidentale remarkably ameliorated the gastric ulcer-associated indices in the ulcerated rats and these findings thus support the local application of the leaves of the plant in the treatment of gastric ulcer.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-NDDS-00001738
Title: Formulation and Evaluation of Nano Copper Gel For Treatment of Clinical Mastitis
Category: Novel Drug Delivery Systems
Section: Research Article
Country: India
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Clinical mastitis is considered to be a sizeable clinical problem in dairy industry. Apart from cows it is also reported in sheep and even in breast feeding mothers. Staphylococcus aureus bacteria accounts for infections to a great extent and its control is a vital part in curing programs. Metal nano copper has gathered much attention in antifungal/antimicrobial applications. In the present work Carbapol-934 gel, infused with nano copper was formulated and evaluated, which can be a remarkable breakthrough in the field. The antimicrobial test on nano copper against Staphylococcus aureus and Escherichia coli proved the antimicrobial property of the former. The prepared gel was evaluated for PH, homogeneity, spreadability, drug content, in-vitro drug release and ex-vivo permeation. The accelerated stability studies and rheological studies were also conducted. The results of above tests were encouraging for the evolution of the above gel to cure clinical mastitis.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PHDRS-00001737
Title: A Review on traditional plants and herbs are used to evaluation for their anticancer potential
Category: Pharmacognosy and Herbal Drugs related study
Section: Review Article
Country: India
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India is the largest producer of medicinal plants and is appropriately call the “Botanical garden of the World”. The medicinal plants, besides having natural therapeutic values against various diseases, also provide high quality of food and raw materials for livelihood. Considerable works have been done on medicinal plants to treatment of cancer, and some plant products have been marketed as anticancer drugs, based on the traditional uses and scientific reports. These plants may promote host resistance against infection by re-stabilizing body equilibrium and conditioning the body tissues. Several reports illustrate that the anticancer activity of medicinal plants is due to the existence of antioxidants in them. Thus, the various combinations of the active components of these plants after isolation and identification can be made and have to be further assessed for their synergistic effects. In fact, the medicinal plants are easily obtainable, cheaper and possess no toxicity as compared to the modern (allopathic) drugs. Preparation of standardized dose and dosage regimen may play a critical role in the remedy of cancer. The rate with which cancer is continuing, it seems to have an urgent and effective exertion for making good health of humans as well as animals. There is a broad scope to derive potent anticancer agents from medicinal plants, which need thorough research.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-MB-00001735
Title: Mentha piperita Silver Nanoparticles Controlling the Antibiotic Resistance in Bacteria and Fungi – A Study
Category: Microbiology
Section: Research Article
Country: India
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Aim: Plant based nanoparticle was considered to be potential agent to control the drug resistant pathogenic bacteria and fungi. Mentha piperita leaf extract was used to prepare silver nanoparticles to control three Gram negative pathogens and two phytopathogenic Fungi. Materials and Methods: Mentha piperita leaf extract has been treated with 1mM AgNO3 to prepare silver nanoparticles which has been confirmed by UV-VIS spectroscopy, TEM, Zeta potential, XRD analysis and FTIR. Potential of AgNPs has been tested versus Escherichia coli (ATCC8739), Klebsiella pneumoniae (ATCC700603) and Gram-positive Staphylococcus aureus (ATCC6338) and Fungi P. exigua (MTCC-2315) and Fusarium tricinctum (MTCC-2080) by disc diffusion method along with fuconazole (10µg) and streptomycin (10µg). Results: AgNPs controlled the existing drug resistance in both bacteria and fungi when used either alone or in combination with drug, which has indicated the success of Mentha piperita leaf extract in preparing AgNPs with this potential. Conclusion: Mentha piperita leaf extract proves its feature to prepare AgNPs having antibacterial and antifungal activity and can even be useful in controlling drug resistance of pathogens.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PA-00001734
Title: Novel RP-HPLC method development and validation for the estimation of Ceftriaxone sodium sterile in bulk and its formulations
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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A simple, specific, accurate, and precise reverse phase high performance liquid chromatographic (RP-HPLC) method was developed and validated for the estimation of Ceftriaxone Sodium Sterile in pharmaceutical dosage forms. The chromatographic separation was done on Phenomenex Luna reversed phase C18 (250 mm x 4.6 mm, 5 ìm) column in isocratic mode, with mobile phase containing HPLC grade Acetonitrile: Phosphate buffer at pH 6.8 (10:90, v/v) was used. The flow rate was 1 ml / min and effluents were monitored at 254 nm. Chromatogram showed a main peak of Ceftriaxone Sodium Sterile at retention time was 3.093 min. The concentration range was 3-18 μg/ml with correlation coefficient 0.999. The method was validated for linearity, accuracy, precision, and limit of detection, limit of Quantitation, robustness and ruggedness. The limit of detection and limit of Quantitation for estimation of Ceftriaxone Sodium Sterile was found to be 0.192585 and 0.583592 μg/ml respectively. Recovery of Ceftriaxone Sodium Sterile was found in the range of 98.0-102.0%. Proposed method was successfully applied for the quantitative determination of Ceftriaxone Sodium Sterile in its pharmaceutical dosage forms.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PCS-00001733
Title: Oral dissolving films of Celecoxib inclusion complexes using Musa paradisiaca as super disintegrant in treatment of Psoriatic arthritis
Category: Pharmaceutics
Section: Research Article
Country: India
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Celecoxib is a poorly water soluble drug which is a selective COX-2 inhibitor used in treating Psoriatic arthritis. It shows poor dissolution and flow properties. So physical mixures of the drug using solubilizers like β CD were prepared in order to enhance its solubility and dissolution rate. Super disintegrant plays a vital role in increasing drug release. Musa paradisiaca, a natural excepient is used in this study as a super disintegrant. The aim of present study was to formulate oral dissolving films of Celecoxib using solubilizer and evaluate them for in vitro disintegration and dissolution rates. It was found that β CD had shown good impact on increasing solubility and dissolution rate. Drug excepient compatibility was studied by FTIR studies.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PA-00001723
Title: Isocratic HPLC method for simultaneous determination of Tramadol hydrochloride and Pantoprazole sodium synthetic mixture in pure forms and injection formulations
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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The aim of this work is to perform a validated High Performance Liquid chromatographic (HPLC) method for simple estimation of tramadol hydrochloride (TH) and pantoprazole sodium (PNT)  synthetic mixture simultaneously in bulk form and in I.V. pharmaceutical dosage form.The chemical stability of the mixture was studied after dilution with different I.V. infusion solutions as 5% Dextrose, 0.9% Sodium chloride and Ringer -Lactate  solutions  at  4°C, 25°C and 35°C at several time intervals  with physical examination. Chromatographic separation was carried on reversed-phase agilent ZORBAX ODS ® C18 column (250x4.6 mm I.D., 5 μm) at ambient temperature. Isocratic mobile phase wascomposed of methanol, acetonitrile and 0.03 M phosphate buffer with 0.1% triethylamine, pH=3.5, (15:45:45, v/v) at 1.2 ml/min and detected at 210 nm. The assay showed good  linearity over the concentration range of  10-200, 2.5-60 μg/ml for TH and PNT respectively. The analytical performance of the proposed method including linearity ranges, precision, accuracy,   detection, and quantification limits were statistically validated according to ICH guidelines.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-P'Col-00001732
Title: Pharmacological actions of Anethum graveolens (Dill)
Category: Pharmacology
Section: Review Article
Country: India
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Anethum graveolens contains various chemical constituents like essential oils, proteins, fatty oils, carbohydrates, furanocoumarin, polyphenols, minerals & many other biologically active compounds. Traditionally it is very useful. Studies have shown that Anethum graveolens possess some of the pharmacological actions as antimicrobial agents, anti-inflammatory agent, analgesics, gastric mucosal protective & antisecretory effects, smooth muscles relaxant effect, hyperlipideamic agent, increased progesterone concentration & many other effects. This review article will be focusing on some of the major pharmacological actions of Anethum graveolens.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-P'Col-00001730
Title: A Review on Pharmacological approaches for the Treatment of Learning and Memory Impairment
Category: Pharmacology
Section: Review Article
Country: India
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Alzheimer’s disease (AD) is a neurodegenerative disorder that causes progressive memory and cognitive impairment.However, it can be managed using certain pharmacological and, non-pharmacological treatments. Investigating how altered pharmacological compounds may enhance learning, memory, and higher-order cognitive functions in laboratory animals is the first critical step toward the development of cognitive enhancers that may be used to ameliorate impairments in these functions in patients suffering from neuropsychiatric disorders. Rather than focus on one aspect of cognition, or class of drug, in this review we deliver a broad overview of how distinct classes of pharmacological compounds may enhance different types of memory and executive functioning. These include recognition memory, attention, working memory, and different components of behavioural flexibility. The main classes of agents used to treat learning and memory impairment are antidiabetic, antiepileptic’s, antipsychotic, antidepressants, Orexin-1 and other various medications. A key emphasis is positioned on comparing and contrasting the effects of certain drugs on different cognitive and mnemonic functions, highlighting methodological issues associated with this type of research, tasks used to investigate these functions, and avenues for upcoming research. Viewed collectively, studies of the neuropharmacological basis of cognition in rodents and human primates have identified targets that will hopefully open new avenues for the treatment of cognitive disabilities in persons affected by mental disorders.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PA-00001729
Title: Analytical method development and validation for the simultaneous estimation of Nebivolol and Valsartan by RP-HPLC in bulk and tablet dosage forms
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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The objective of this work is to develop a rapid, precise, accurate and sensitive reverse phase liquid chromatographic method for the simultaneous estimation of Nebivolol and Valsartan in tablet dosage form. The separation was carried out on Youngline (S.K.) Gradient System UV Detector. Equipped with Reverse Phase (Agilent) C18 column (4.6mm x 150mm; 5µm), a SP930Dpump, a 20µl injection loop and UV730D Absorbance detector and running autochro-3000 software. The retention time of Nebivolol and Valsartan were found to be retention time at 3.383min and 6.100min. respectively. The linear dynamic range was 5-25μg/ml for nebivolol and 80-400μg/ml for valsartan. Percentage recoveries for Nebivolol and Valsartan were 100.53- 100.27% and 101.40-102.57%, respectively. All the analytical validation parameters were determined and found in the limit as per ICH guidelines, which indicates the validity of the method. The method was statistically validated and %RSD was found to be less than 2 indicating high degree of accuracy and precision. Hence proposed method can be successfully applied for the simultaneous estimation of Nebivolol and Valsartan in marketed formulation.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-P'Col-00001726
Title: Neuroprotective effect of potassium channel openers against hydrogen peroxide (H2O2) induced neuronal stress: IN-VITRO study
Category: Pharmacology
Section: Research Article
Country: India
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Aim: This study was design to assess and establish in-vitro neuroprotective role of potassium channel openers (KCOs) against hydrogen peroxide (H2O2) induced neuronal stress. Material and methods: Cell viability assay was done using MTT (3-(4, 5 dimethyl thiazole-2-yl)-2, 5-diphenyl tetrazolium bromide) method to determine IC50 value of H2O2. Based on 50 % Inhibitory Concentration (IC50) results of H2O2, neuroprotective effect of KCOs cromakalim, nicorandil , cinnarizine, and standard vitamin E was determined using U87 cells (human primary glioblastoma cell line). Results: Cromakalim, nicorandil and vitamin E significantly produce neuroprotective effects against H2O2 induced neuronal damage while cinnarizine did not produce significant activity. Conclusion: Results of our study demonstrated the neuroprotective role of potassium channel openers against H2O2 induced oxidative damage to neuronal cells.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PCS-00001725
Title: Formulation design and development of gastro retentive floating tablets of Atenolol
Category: Pharmaceutics
Section: Research Article
Country: India
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Atenolol is a selective â1 receptor antagonist. Atenolol is employed in the therapy of angina pectoris and hypertension. Hence the current study is employed to design a floating delivery system of atenolol by swelling polymer through direct compression method. Fourier transform Infrared spectroscopy (FTIR) confirmed the absence of any drug/excipients interactions. The tablets were evaluated for hardness, thickness, friability and drug content and were subjected to a 12 h In vitro drug release studies (USP dissolution rate test apparatus II, 50 r/m, 370C ± 0.50C) using 0.1N hydrochloric acid. In this study, gastro retentive dosage form using HPMC-K100M, Guar gum was prepared to build up a prolonged release tablets, that could retain in the stomach for longer periods of time delivering drug to the site of action that is in the stomach. In-vitro dissolution studies of the formulation, concluded that the formulation F6 containing 87.5 mg of HPMC-K100M, 40mg of Sodium bicarbonate, 4mg of Mg. Stearate, 4mg of Talc and 39.5mg of micro crystalline cellulose is the superlative composition. Obtained results of the study concluded that floating tablets accomplishing HPMC-K100M, a hydrophilic polymer increases the GRT of the dissolution fluid in the stomach to deliver the drug in a prolonged manner. The concept of formulating floating tablets of model drug renders a suitable and practical approach in serving the needed objectives of gastro retentive floating tablets.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PA-00001722
Title: QbD Approach for Analytical Method Development and Validation of Melatonin by spectroscopic Method
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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Spectroscopic method was developed according to Quality by Design(QbD) approach as per ICH Q8 (R2) guidelines for Melatonin. QbD approach was carried out by varying various parameters and these variable parameters were designed into Ishikwa diagram. The critical parameters were determined by using principle component analysis as well as by observation. The estimated critical parameters in zero order spectroscopic method were Methanol, sample preparation tablet, wavelength 222 nm, slit width: 1.0, scan speed medium, and sampling interval: 0.2, The above methods were validated according to ICH Q2(R1) guidelines. Proposed methods can be used for routine analysis of Melatonin in tablet dosage form as they were found to be robust and specific.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-MB-00001720
Title: Biosynthesis of Nickel Nanoparticles from Bacteria and Evaluation of Their Biological Activity
Category: Microbiology
Section: Research Article
Country: India
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Nickel nanoparticles were biosynthesized by using P. penneri bacteria and the production was confirmed by observing the change in the color of the reaction. Further, Nickel nanoparticles were characterized by UV-visible, SEM and FT-IR spectral studies. The surface morphology of the synthesized nickel nanoparticles coated with secondary metabolites of the bacteria was studied by SEM and confirmed by FT-IR spectroscopy. The possible role of proteins and secondary metabolites as a reducing and capping agents was thus inferred. Biosynthesized nickel nanoparticles showed antimicrobial, anti-inflammatory and anti-proliferative activity.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PHDRS-00001713
Title: A Review on Antidepressant Plants
Category: Pharmacognosy and Herbal Drugs related study
Section: Review Article
Country: India
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Depression is a heterogeneous group of brain disorders characterized by a wide range of symptoms that result in psychomotor and cognitive impairments. Depression is accompanied with loss of pleasure or interest, feeling of guilt, decreased energy and low self worth. Depression is also a major cause of morbidity worldwide, estimated to affect 350 million people. It is highly prevalent, accounting for more disability than any other disorder and its prognosis and management are also poor due to the little understanding of the disorder. Many categories of synthetic and natural compounds have been reported to possess neuropsychiatric activity. Various adverse effects are associated with synthetic drugs which are used in the treatment of depression. Loss of libido, tolerance, physical dependence and insomnia is associated with selective serotonin (5 HT) reuptake inhibitors and tricyclic antidepressants; several drug-drug interactions may occur. The aim of this review is to enlist those plants which have antidepressant activity.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-P'Col-00001719
Title: Assessment of phytochemical & pharmacological activities of the ethanol leaves extracts of Myrica esculenta BUCH. HAM.
Category: Pharmacology
Section: Research Article
Country: India
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OBJECTIVE: To elucidate potential antioxidant, antidiarrheal, anthelmintic and antibacterial activity of ethanol leaves extract of Myrica esculenta Buch. Hum. in different experimental models established in vitro and in vivo. METHODS: In vitro antioxidant activity was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay. In vivo antidiarrheal studies was carried out in mice, and the activity was evaluated in castor oil induced diarrhea, anthelmintic activity on Paramphistomum cervi and Haemonchus contortus, and Disk diffusion assay was utilized to determine antibacterial activity against a number of pathogenic bacterial strains. RESULTS: In DPPH radical-scavenging assay, the extract exhibited strong radical-scavenging activity with the 50% inhibitory concentration value of 48.28 ìg/ml. The extract significantly (p<0.001) enhanced the latent period and decreased the defecation in castor-oil induced diarrhea. The extract exhibited dose-dependent decrease in paralysis and death time of the helminthes. Potential antibacterial activity was exhibited by the extract against all the tested bacterial strains in disk diffusion assay. CONCLUSION: The result demonstrated that the ethanol leaves extract of M. esculenta has potential antioxidant, antidiarrheal, anthelmintic and antibacterial activity.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PCS-00001718
Title: Isolation and assessment of natural mucoadhesive agent isolated from Abelmoschus esculents
Category: Pharmaceutics
Section: Research Article
Country: India
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Aim of present investigation was to isolate mucoadhesive agent from Abelmoschus esculents and characterize through in-vitro and ex-vivo mucoadhesion methods. Okra gum (OG) was extracted from fresh pods Abelmoschus esculents. Mucoadhesion force of isolated okra gum was determined by wilhelmy‘s method, falling sphere method and modified physical balance method etc and compared with carbopol and sodium alginate. The formation of hydrogen bond by okra gum with mucosa was confirmed by FTIR spectra showing carboxyl and hydroxyl groups. The result shows that mucoadhesive properties of okra gum were comparable to carbopol but lesser than sodium alginate under the experimental conditions used in this study. The adhesive impact of the majority these polymers relies upon non covalent chemical bonds such as hydrogen bonds, ionic interactions and vanderwaal‘s forces and so forth. These interactions are moderately feeble in contrast to covalent bonds, accordingly cant assure localization of dosage forms. OG bears good mucoadhesion property, but there is a need enhance mucadhesion potential by suitable approaches such as thiolation etc., to employ in mucoadhesion drug delivery systems.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-P'Col-00001712
Title: Pharmacological Agents Involved In The Treatment Of Diabetic Neuropathy
Category: Pharmacology
Section: Review Article
Country: India
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Diabetic neuropathy is the presence of signs &symptoms of peripheral nerve dysfunction in persons with diabetes after the exclusion of other causes. Till date there is no effective treatment available for diabetic neuropathy. However, it can be managed using certain pharmacological and non-pharmacological treatments.Diabetic peripheral neuropathic pain affects the functionality, sleepandmood patterns of nearly 10 to 20 percent of patients with diabetes mellitus. Treatment goals include improving pain control and restoring function. Patients can realistically expect reduction in discomfort a 30 to 50 percent with improved functionality. The tricyclic antidepressants, anticonvulsants, serotonin-norepinephrine reuptake inhibitors, opiates and opiate-like substances and topical medications are the main classes of agents used to treat diabetic peripheral neuropathic pain. Physicians should ask patients whether they have tried alternative and complementary medicine remedies for their pain. For the treatment of diabetic peripheral neuropathic pain only two medications are approved specifically: Duloxetine and Pregabalin. However, evidence supports the routine of other therapies and unless contraindications are there, the first-line treatment is tricyclic antidepressants. Physicians must consider potential drug interactions and possible adverse effects before prescribing a medication.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PA-00001716
Title: Method development and validation of stability indicating RP-HPLC method for the estimation of Dasatinib in tablet dosage form
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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A simple, rapid and accurate RP-HPLC method was developed for the determination of Dasatinib in pure and tablet dosage form by RP-HPLC method using Cosmisil C18 BDS (150 x 4.6 mm) 5µm in isocratic mode. The mobile phase consisted of Tri ethyl amine Buffer, Solvent mixture (Methanol and Acetonitrile)[50:25:25%v/v] was used and maintain the pH 6.5±0.5. The flow rate was maintained at 1 mL/min and the injection volume was 10 μL. Detection wavelength with UV detector at 315 nm and run time was kept 12 min. The retention time of Dasatinib was 6.882 min. The method was linear over the concentration range 5.2-31.2 μg/ml. The % assay for formulation was found to be 98.71. The validation of method was carried out utilizing ICH-guidelines. The described HPLC method was successfully employed for the analysis of pharmaceutical formulations.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-P'Col-00001731
Title: Cessation of Smoking By Nicotine Replacement Therapy
Category: Pharmacology
Section: Review Article
Country: India
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The nicotine in cigarettes and tobacco leads to actual physical dependence which can cause unpleasant withdrawal symptoms when a person tries to quit. Nicotine replacement therapy (NRT) is a medically-approved way to take nicotine by means other than tobacco. It is the most commonly used family of quit smoking medications. It is helpful for quitting smoking or stopping chewing tobacco. NRT can help relieve some of the physical withdrawal symptoms so that one can focus on the psychological (emotional) aspects of quitting. It uses products that supply low doses of nicotine. These products do not contain many of the toxins found in cigarette. The goal of therapy is to cut down cravings for nicotine and ease the symptoms of nicotine withdrawal. People may notice that nicotine withdrawal symptoms and cravings are not so strong when using NRT, therefore reduces the risk of smoking. Clinical trials show that NRT can increase the chance of quitting smoking by 50-70% when compared to quitting without help – making it a good option to include in their quit smoking plan. All forms of nicotine replacement products appear to be about equally effective when used properly.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-ND-00001715
Title: Chemical composition of essential oil of Hyptis suaveolens (L.) POIT and its invitro anticancer activity
Category: Natural Drugs
Section: Research Article
Country: India
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The present investigation aimed to evaluate the chemical composition of essential oil of the leaves of Hyptis suaveolens (L.) and its invitro anticancer activity. The hydrodistilled essential oil of H.suaveolens contains total of 24 components by GC-MS analysis. The major compounds of H. suaveolens were Sabinene (29.42%), Trans caryophyllene (13.66), E-spathulenol (7.10%), Rimuene (5.73%), the minor compounds were 1,8-Cineole (4.61%), β-Elemene (4.25%), Eucaliptol (3.00%), Bergamotol ,Z-α-trans (2.47%), α-Selinene (2.32%), Caryophyllene oxide (2.08%), γ-Elemene (1.97%), α-Humulene (1.37%). The obtained essential oil was tested against Human breast cancer cell line (MCF-7) for its anticancer activity by MTT assay with different concentrations of essential oil (18.5-300 µg/ml). The result revealed that the essential oil showed concentration dependant activity against cell line. The IC50 value of MCF-7 cell line was 90.6 µg/ml. This may be due to the presence of important terpenoid. This is the first kind of report against invitro anticancer activity of H. suaveolens essential oil.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-P'Col-00001714
Title: Molecular Mechanism of Resveratrol: A Systematic Review
Category: Pharmacology
Section: Review Article
Country: India
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Resveratrol is a naturally occurring compound of therapeutically importance due to its diverse pharmacological action. Resveratrol (RV) posses significant role viral infections, cancer and diabetes. In case of viral infection, it shows synergistic actions with antiviral drugs. Its anticancer action is due to antioxidant action, inhibition of hexsosamine pathway, and proappoptotic action. Anti-diabetic action is due to increase glucose uptake and beta cells protective action. It is also useful in CNS disorders. Resveratrol also shows anti-aging action. Extensive preclinical studies have been completed more clinical research should be carried out to establish as a lead compound.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PCS-00001740
Title: A Brief Review On Niosomes
Category: Pharmaceutics
Section: Review Article
Country: India
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Controlled release drug products are highly used for the formation and maintenance of whichever concentration needed at target site for longer duration of time, and this drug targeting method named as Niosomes. The niosomal vesicles are basically non-ionic surfactant based uni-lamellar (single) or multi-lamellar (multiple) carriers where in an aqueous solution of solute is totally enclosed by a membrane due to the arrangement of surfactant macromolecules as bilayer, thus emerging as a class of novel vesicular systems. Niosomes are currently the major alternative to liposomes as niosome being stable and economic. They potentiate the pharmacological action of the drug molecules by delaying the clearance of the drug from the circulation, shielding the drug from harsh biological environment and restricting the effects only to the target cells. This article aim to provide a brief knowledge about current advances made in niosome drug delivery system, various formulation methods, along with techniques of characterization, its applications and the current research made in the study of niosomes.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-PHDRS-00001752
Title: Study of Bioactive Phytoconstituents and In-Vitro Pharmacological Properties of Thallose Liverworts of Darjeeling Himalaya
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Background: Study on bryophytes has long been neglected although many biological activities and many phytochemicals unique to plant kingdom are reported from them. Objective: This work aims to study the in vitro antioxidant along with anti-diabetic activities and phytochemical constituents of three liverworts of Marchantiales group namely Plagiochasma cordatum, Marchantia subintegra and Marchantia emarginata. Furthermore an effort was made to find out the solvent system for extraction of phytochemicals showing better pharmacological activities and also the correlation between pharmacological activities and bioactive components. Materials and methods: For the said purpose DPPH, ABTS, nitric oxide, superoxide, metal chelating, reducing power, α-amylase inhibitory and α-glucosidase inhibitory assay were performed. Quantitative test for phenol, flavonoid, ortho-dihydric phenol, steroid and tannin was done. Qualitative test and thin layer chromatographic analysis was performed for detection of constituent phytochemicals. Pearson correlation analysis, Principle component analysis and Heatmap were done for studying the association between the bioactive components of the studied plants and their pharmacological activities. Results: All the studied plants showed free radical scavenging and anti-diabetic activity but the activity of Plagiochasma sp. was superior to Marchantia spp. Among different extracts, diethyl ether extract showed significant potential to scavenge different free radicals analyzed, thus suitable for extraction of bioactive phytoconstituents for oxidative stress management. Conclusion: Potent pharmacological activities of this less explored group of plants pave the pathway for isolation of bioactive compounds of therapeutic and medicinal value.

Journal: Journal of Pharmacy Research , Volume: 11, Issue: 5.
Article Id: JPRS-P'Col-00001774
Title: Diabetes Related to Heart Failure & Possible Treatment
Category: Pharmacology
Section: Review Article
Country: India
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The aim is to summarize the literature regarding link of heart failure with diabetes. Diabetes is a metabolic disease whose prevalence significantly increased in recent decades. WHO estimates there will be 300 million diabetic patients by year 2025. Various epidemiological studies have demonstrated the increase in risk of heart failure in diabetics. Mechanisms linking diabetes and heart failure include hypertension, development of atherosclerosis, myocardial fibrosis, experimental and clinical studies. It has been suggested that an association between hyperglycemia and metabolic changes resulted in inflammation, oxidative stress, endothelial dysfunction. Alarge body of evidence suggestthat metabolic abnormalities plays a major role in developing diabetic vascular disease. The knowledge of diabetic status helps to define optimal therapeutic strategy for heart failure patients.