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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-PB-00001992
Title: Formulation and evaluation of novel organic toothpaste using cow dung coal powder
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Aim: The aim of the present research is to formulate and evaluate organic toothpaste using cow dung powder. Materials and Methods: Cow dung coal powder, sorbitol (humectant), gum tragacanth, gum acacia, sodium CMC (binders), sodium benzoate (preservative), sodium saccharine (sweetener), cinnamon oil (flavoring agent), sodium lauryl sulfate (surfactant), and polyethylene glycol were used for formulating the toothpaste. The cow dung was collected and dried, after that it was burnt to produce cow dung coal powder which was used as a main ingredient in toothpaste formulation. Toothpastes were prepared using different binders such as gum tragacanth, gum acacia, and sodium CMC. Later, different evaluation tests were performed on these formulations. Results and Discussion: The formulated cow dung coal powder toothpaste had shown good results as like the commercial products in the market. Conclusion: As we prepared different formulations using different concentrations of binders, the formulation prepared using sodium CMC 1% was found effective compared with other formulations prepared with different binders.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-P'Col-00001981
Title: An overview on various types of anticancer drugs and their drug-drug interactions: Melphalan, 5-fluorouracil, and hydrazine
Category: Pharmacology
Section: Review Article
Country: India
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Aim: In this review article we primarily try to give more importance in knowing about various drug interactions with anti cancer drugs such as Melphalan, 5-Fluorouracil and Hydrazine which help in increasing their efficiency of action on tumor cells. Materials and methods: As it is a review article we collaborated all the methodologies which were utilized drug combination studies which were used various research scholars. Results and discussion: This review is the therapeutic effects which are involved due to various drug combinations. Drug interactions occur in Pharmacokinetic and Pharmacodynamic levels. There are varied adverse effects which can be caused due to some of the Drug interactions Thus, systematic knowledge on Drug interactions particularly in every levels of absorption, elimination, transport and drug metabolism which may help in preventing these Adverse side effects. Conclusions: Combinations of dexamethasone with melphalan helped in treatment of POEMS syndrome. Melphalan also is helpful in Liposomal Drug delivery systems. One of the studies also proved the efficiency of Intraviteral and Sub-conjunctival injections in killing tumor cells. Cyclophoshamide pretreatment along with High dose of melphalan also helped in increase in efficiency of drug action on tumor cells. High dose of melphalan has also been proved to help in treatment of Neuroblastoma. We could also know the importance of carrier like PLGA by performing Biological evaluation of 5-Fluorouracil. Combination of Capaciatabine along with 5-FU helped in treatment of Oesophageal canecr. Studies on hydrazine proved to act as cancer causative agents. Oxaliplatin when given in combination with 5-FU helped in treatment of metastatic colorectal cancer. 5-FU loaded with microsponges helped in treatment of Colon cancer. Thus all these studies performed helped in providing efficient drug for treatment for various types of cancers.Thus there is an alarming need to perform studies on various relevant drug-drug interactions to treat a specific disease which would help in provision of treatment for any kind of disease which is affecting the patient.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-PCS-00001982
Title: Formulation and evaluation of polymeric thin films of zolmitriptan
Category: Pharmaceutics
Section: Research Article
Country: India
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Background: A lot of work had been done in recent years in the development of oral thin films (OTFs) for drug delivery. Triptans, which are highly selective serotonin agonist used for migraine therapy, were used as a model drug for developing novel thin film drug delivery platform. Aim of the present work was to exploit the combination of hydrophilic polymer and β-cyclodextrin to formulated fast dissolving OTF of Zolmitriptan. Method: A total of nine batches of the thin films with different concentration of hydrophilic Methocel E5(HPMC E5) and β-cyclodextrin reportedly having taste-masking and bioenhancing effect were prepared using glycerin as plasticizer. The mechanical properties such as folding endurance, elongation, and tensile strength along with disintegration time were evaluated. Result and conclusion: In vitro dissolution studies carried out in simulated saliva and gastric fluid indicated that more than 80% of the drug was released in <10 min. A compromise was reached between moderate tensile strength and minimum disintegration time as both in vitro disintegration time and tensile strength of film increased with increase in the concentration of polymer. Thus, it was concluded that the one can successfully formulate novel thin film drug delivery system for triptans using a combination of Methocel E5 and β –cyclodextrin.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-PS-00001980
Title: A review on phytoconstituents: The potent synergistic approach in antimicrobial formulations
Category: Pharmaceutical Sciences
Section: Review Article
Country: India
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Since the past few decades, microbial infections are the main threat to human life and cause a serious series of events. Antibiotics are the main weapon to fight these microbial infections and health of human life has been benefited. However, from past few decades antibiotics are becoming less and less effective in certain infections due to increasing resistance in microbes. This resistance is not specific to antibiotic used, also extended to other classes of antibiotics. Many of antibiotics produce toxic effects due to the emergence of multidrug resistance (MDR) bacteria and cause serious illness to human life. A common approach to treat diseases is to use antibiotics or plant extracts individually and/or an alternative approach is the use of antibiotics and plant extracts combinations or synergistic therapy. The latter therapy, i.e., combination synergistic approach; against multidrug‑resistant bacteria may provide an alternative path to treat infectious diseases and provide a useful area for further investigations in the future. Combination approach provides safe and alternative treatment for patients with severe infections caused by bacteria and fungi. The present review explains in detail, the noticed synergistic effects between natural plant extracts and common antibiotics therapy fighting common fungal and bacterial infections. The mechanism of action of the individual drug is significantly different from the combination therapy; therefore, selecting suitable combination is essential and crucial which entails understanding the mechanism of infection between antimicrobial agents and plant extracts.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-PC-00001983
Title: Production and characterization of animal glue from solid skin waste of Axum town, Ethiopia
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Introduction: Animal glue is an adhesive that is created by prolonged boiling of animal connective tissue collected from slaughterhouse and skin stores. The main aim of this study was to produce glue from solid waste of locally available animal skin and related with this to determine the optimum condition for the production of glue. Materials and Methods: The animal skins were collected from slaughterhouse, Axum town, Ethiopia. The samples were processed by two methods such as lime and sulfuric acid. Further the samples the pH, viscosity, ash content, and moisture content of the resultant samples were analyzed. Results: The glue production using lime method showed relatively higher quality than the one produced from sulfuric acid method. It was possible to extract a high amount of glue within a short period of time from sulfuric acid-treated skin as compared to the lime-treated one. Under lime medium, the adhesive strength of glue was increased with concentration and soaking time and decreased with temperature. Soaking the pelt in 10% lime solution for 4 weeks and boiling at 70°C were found to be the optimum conditions for the production of glue. Conclusion: The percentage of yield was improved as increment in the concentration of both lime and sulfuric acid; however, the quality (viscosity and ash) of glue declined when the concentration went beyond 10% of sulfuric acid at above 80°C.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-PB-00001984
Title: ÄKTA protein purification and matrix-assisted laser desorption -based characterization of Antimicrobial peptides from Staphylococcus epidermidis
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Aim: The present study investigated the presence of bacteriocin in Staphylococcus epidermidis which can inhibit human pathogen and its presence has been confirmed by molecular techniques. Materials and Methods: The S. epidermidis isolated from human skin has been confirmed by sodium dodecylsulfate–polyacrylamide gel electrophoresis (SDS PAGE), ion exchange chromatography, fast protein liquid chromatography (FPLC), and matrix-assisted laser desorption/ionization time- of-flight (MALDI TOF) analysis for its detection, purification, and sequence information. Further, the said fractions were tested for the prominent bacteriocin based bacterial inhibitory activity against Staphylococcus aureus. Result: S. epidermidis broth supernatant found to contain proteins with band sizes (KDa) 63, 60, 44, 37, 35, 30, 25, 23, 16, and 19 KDa. As per FPLC analysis, total of 36 fractions were formed, and in those, four fractions found to contain antibacterial activity, i.e., 21st (12 mm), 25th (13 mm), 33rd (14 mm), and 34th (12 mm). Fraction 25th and 33rd when checked by SDS PAGE they have been recorded with 74–100 KDa protein bands. In MALDI TOF analysis, 25th fraction recorded with two main proteins DNA ligase and one hypothetical protein with probable feature of bacteriocin, and in 33rd fraction, flagellar motor switch protein and glycoside hydrolase family proteins have been sequenced. Conclusion: S. epidermidis demonstrated the antibacterial protein presence (bacteriocin) which could inhibit S. aureus, and four probable bacteriocins have been reported probably for the first time.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-Pe-00001985
Title: Clinical demonstration of border molding using various materials: A review
Category: Periodontics
Section: Review Article
Country: India
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Ideal impressions must be in the mind of the dentist before it is in his hand. He must literally make the impression rather than take it. Proper impressions are crucial in complete dentures as retention of the dentures is primarily dependent on the quality of the impressions. A good master impression will cover as much of the denture supporting areas as possible and has a good border seal. Without adequate retention, the dentures would be ill fitting, causing difficulties in speech and mastication and may even affect the physiological aspect of the denture wearer. Complete denture impression procedure has been evolving from day 1 through continuous development of impression materials. With so many materials available in the market, a dentist is spoilt for choice. Materials used in complete denture impression are however debatable as it can be agreed on that no single impression material is superior than the other. In this review, three materials have been selected to be compared for border molding followed by the final impression. The materials used for border molding are greenstick compound, putty type silicone, and mouth temperature wax followed by light body wash impression. All the three materials were demonstrated on the same patient using a special tray fabricated separately for each material. It was found that putty type silicone was the easiest to use as it can be done in a single step. However, from a learning student’s perspective, border molding using greenstick compound was much beneficial as any corrections could be rectified even though it was a time-consuming method of impression making.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-Pe-00001986
Title: Premature loss of primary teeth and developing malocclusion: A review
Category: Periodontics
Section: Review Article
Country: India
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The effect of premature loss of deciduous dentition on the developing permanent occlusal pattern is a matter of interest among the dentists. Premature loss of primary teeth would result in sagittal, vertical, as well as transverse malocclusion. The pathology of premature loss of primary teeth, especially the molars is a complex issue with profound impact on dental and facial harmony, thus urging the clinician’s interest for an optimal therapeutic approach to attain a proper occlusion of the permanent dentition. The present article reviews the prevalence of premature loss of primary teeth and its effect on malocclusion.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-PB-00001987
Title: Exploring innovative approach to combat multiple drug resistance of Staphylococcus aureus
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Aim: Bacteriocins are ribosomally synthesized antimicrobial peptides which are active against bacteria either of same or closely related species. The protection against the pathogen using bacteriocin was considered as an innovative approach, especially against the multidrug-resistant bacteria. Materials and Methods: Human skin sample has been swabbed and inoculated on Mannitol salt agar to isolate Staphylococcus epidermidis and later on they have been identified by biochemically and by 16S rRNA gene sequencing. Cell-free bacteriocin produced by the S. epidermidis has been checked against the multidrug-resistant Staphylococcus aureus by well diffusion assay. Result: S. epidermidis SE2 identified by 16S rRNA gene sequencing found to be producing the bacteriocin which is inhibiting multiple drug resistant S. aureus with the 13 mm zone of inhibition proving its medical potential. Conclusion: Human skin possesses S. epidermidis having bacteriocin producing ability and that can also be used to control multidrug-resistant S. aureus and proving its potential in medical biotechnology.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-PB-00001988
Title: A trend in future bioenergy - A review
Category: Pharmaceutical Biotechnology
Section: Review Article
Country: India
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The most important demand for today’s world is electricity. This idea helps in generating sustainable energy by a natural phenomenon occurring in humans that is the transmission of nerve impulse from the sensory to the central nervous system or vice versa. The bioelectric potential across a cell membrane is typically about 50 mV, and this potential is known as the resting potential. Once a nerve is activated, an electric pulse is generated due to difference in potential between two neurons. The beauty of such pulse is that it is continuous until it reaches the destination. Hence, we can target one action such as movement of arm, holding objects, or movement of fist so that we can locate the nerve responsible for the impulse from brain to the target tissue and tap the potential between each neuron along the entire length which consists of millions of neurons, where each neuron acts as individual cell, when we consider the entire length, the whole network acts like small individual cell connected in series the voltage adds up nearly producing few hundreds to thousand volts which are sufficient to produce electric energy and store for later use. This can have a huge impact on global economy. This energy can be used up in various applications such as charging of gadgets on the go and as a light weapon for armed force to protect themselves from enemies by producing high electric shock waves for short span and many other useful applications.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-PHDRS-00001989
Title: Phytochemical screening and in vitro antioxidant activities of Senna singueana leaves
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Objective: Senna singueana deciduous shrub that belongs to the Fabaceae family occurs throughout mainland tropical Africa commonly called as scrambled egg, conventionally, in African contents, it has many medicinal uses to cure different types of disease such as anticancer, antimalarial, bilharzia, fever, and wounds caused by leprosy and syphilis. The objective of the study was to perform the qualitative phytochemical analysis and in vitro antioxidant activities of S. singueana leaves. Materials and Methods: The present study was to evaluate the qualitative phytochemical analysis and in vitro antioxidants activities of ethanolic extract of S. singueana leaves by 1,1-diphenyl-2-picrylhydrazyl, reducing power assay, hydroxyl radical, nitric oxide, and superoxide radical scavenging activities using standard methods.. Results: From the phytochemical analysis of different organic extracts, the ethanolic extract contained maximum number of secondary metabolites such as flavonoids, tannins and phenolic compounds, and terpenoid, and further, the in vitro antioxidant activity of ethanolic extract of S. singueana showed significant scavenging activity on increasing order of OH>DPPH>NO>O2 compared to that of ascorbic acid (standard). Conclusion: Based on the present results, the ethanolic leaf extract of S. singueana contained flavonoids and phenols, thereby presented significant antioxidant activity, it can be used as a potential source of desired bioactive natural antioxidants for the development of therapeutic antioxidant drugs.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-Pe-00001990
Title: Ultrastructural changes in dental tissues following exposure to hydrogen peroxide
Category: Periodontics
Section: Research Article
Country: India
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Background: An esthetic smile is always in high demand for which hydrogen peroxide (HP) is used when there is tooth discoloration. HP is capable of oxidizing a wide range of colored organic and inorganic compounds, causing decolorization and hence bleaching of the substrate. Aim: The aim of this study is to observe the effect of varying concentration of HP on the morphology of human enamel and dentin. Maerials and Methods: Dental gel with HP at different concentrations and 150 freshly extracted, caries-free teeth were used for this purpose. The crown and root of the teeth were cleaned and were randomly placed into five groups A, B, C, D, and E. Teeth belonging to Group A were treated with 35% HP, Group B was treated with 25% HP, Group C with 15% HP, Group D with 3% HP, and Group E specimens were stored in wet mouth for 2 h. Moreover, all these specimens were observed under the scanning electron microscope (SEM). Results: Significant morphological changes such as erosions and cracks were observed in enamel and dentin of tooth specimens that were treated with HP of various concentrations, under SEM. Conclusion: HP is largely used as a bleaching agent. Although it improves the esthetics, it also causes prominent and significant changes on enamel and dentin morphology. Clinical Significance: Whiter teeth always have a high demand. Dental bleaching has become the most requested and a common procedure in cosmetic dentistry today. Moreover, HP is largely used as a bleaching agent. Hence, it is necessary to know the effect of HP on human enamel and root dentine.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-PB-00001991
Title: Vitamin D status influences mitochondrial metabolic activity and hyperglycemic condition of skeletal muscle cells
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Background: In the recent past, vitamin D deficiency has been found to be associated with diabetes. As per different studies, an adequate level of vitamin D is important for various cellular activities such as insulin secretion, insulin signalling and glucose uptake by target cells. In addition to vitamin D deficiency, the mitochondrial defect is also known to be an important factor causing hyperglycemia. Though vitamin D deficiency and mitochondrial defects have the same consequence on glucose metabolism, however, there are very few reports available which suggest that vitamin D also affect the mitochondrial defects. Objective: Our current study aims to understand the possible mechanism and link between vitamin D deficiency leading to mitochondrial defects and further causing the hyperglycemia. Material and Methods: The rat skeletal muscle cells (L6) were grown in normal (8mM) and high (25mM) glucose concentration. The cells were further supplemented with MTT optimized dose of vitamin D (10-9 M) and grown at different till different time intervals of 24, 48 and 72 hrs. Results: As a result we have demonstrated that vitamin D supplementation to L6 cells have shown the improved calcium uptake which is a preliminary parameter for vitamin D activity. Ca++ being an important cofactor of different enzymes of Kreb’s cycle, also showed the improved mitochondrial enzyme activity in correlation with increased calcium uptake. The calcium uptake and NADH oxido-reductase activity was also in coordination with improved mitochondrial membrane potential, improved catalase activity and increased glucose uptake by these cells and different time intervals, when supplementated with vitamin D. Conclusion: Thus as per or study we conclude that vitamin D deficiency initially affect the mitochondrial metabolism which ultimately affect the glucose uptake by target cells and causes hyperglycemia. Thus vitamin D supplementation can be suggested as a part of therapy to the patients suffering from diabetes.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-B&NPS-00001993
Title: Nutraceuticals: Potential therapeutic agents for the treatment and prevention of cardiovascular diseases
Category: Botany/ Herbal/ Natural Pharmacological Study
Section: Review Article
Country: India
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Cardiovascular diseases (CVDs) are presently considered a leading cause of death worldwide, ranked first, both in the developing as well as in the developed nations. An estimated number of deaths due to CVDs are found to be more than 17.5 million that accounts for nearly one-third of all deaths annually. The current medications used for the treatment and prevention of CVDs comprise of statins, aspirin, beta-blockers, and angiotensin I-converting enzyme inhibitors. However, some of these conventional medications have serious side effects, and few instances even suggest the discontinuance of such medications. In this context, we have focused on nutraceuticals which have potential preventive and therapeutic values that are now considered as powerful alternatives against CVDs and in the maintenance of good health. Nutraceuticals have ushered in a new era of health and medicine since they comprise of natural dietary products with no or fewer side effects. Nutraceuticals are widely available in various forms including capsules, tablets, and powders and have shown the potential to work as a better and safer alternative against the conventional medical regimen for CVDs. In spite of such progress, each of these nutraceuticals has their own limitations that demand more research in the near future. This review highlights the Indian scenario in the occurrence of CVDs and focuses on a number of nutraceuticals with the potential to prevent and treat CVDs.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-Pe-00001994
Title: Oral hygiene methods followed by patients with malocclusion
Category: Periodontics
Section: Research Article
Country: India
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Background: Orthodontic treatment has been given high importance in the contemporary dental care as the number of people seeking for the treatment is increasing annually. However, the placement of fixed orthodontic appliances has led to difficulties in the maintenance of oral hygiene. Aim: The aim of the study was to determine the oral hygiene methods followed by the orthodontic patients under fixed appliances therapy at Chennai. Methodology: A pretested questionnaire detailing the oral hygiene practices among orthodontic patients was composed and distributed. The study sample consisted of 60 patients undergoing orthodontic treatment at Saveetha Dental College, Chennai, India, satisfying suitable inclusion criteria. The responses were tabulated and analyzed. Results: Results show that the major age group that receives orthodontic treatment is in the group of 11–20 years constituting 46.7%. Besides that in relation to the frequency of toothbrushing among the subjects, most of the patients brush teeth twice daily with a percentage of 68.3%. 46.67% do not use any of the aids. Most of the patients brush teeth twice daily with a percentage of 68.3%. 46.67% do not use any of the aids. However, among the oral hygiene aids, subject prefers using the toothpick with a percentage of 23.3%, followed by dental floss and finally miswak and interdental brush with 6.67%. Conclusion: The orthodontic patients in this study have adequate knowledge on oral hygiene practices with tooth brushing and moderate levels of awareness on other oral hygiene aids. Rigorous health education on oral hygiene measures can be attributed for this achievement.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-Pe-00001995
Title: Role of platelet-rich fibrin in dentistry
Category: Periodontics
Section: Review Article
Country: India
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Platelet-rich fibrin (PRF) is an autogenous biomaterial which is consist of growth factors and cytokines entrapped in a fibrin matrix. It combines the fibrin sealant properties along with growth factors thereby providing an ideal environment for wound healing and regeneration of tissues. Moreover, PRF has been used in various disciplines in dentistry in a wide range of treatment modalities. The wound healing and sealing capacity, bone growth and maturation, graft stabilization and hemostasis ability of PRF are useful in various fields of dentistry. Thus, this article gives a review of the roles of the PRF in dentistry.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-Pe-00001996
Title: Prophylactic removal of asymptomatic third molar: a review
Category: Periodontics
Section: Review Article
Country: India
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The third molars (wisdom teeth) often develop in abnormal positions and most of the times they are unable to erupt properly. The third molars removal is the most common performed procedure in oral surgery. The prophylactic removal of asymptomatic impacted third molar teeth is defined as the surgical removal in the absence of local pathology. Prophylactic surgical removal of the third molars is common practice either impacted or fully erupted. We cannot reliably predict whether impacted third molars will develop any pathological changes. Surgical removal of the wisdom teeth should be justified, and there is need to determine whether this practice is supported by evidences. The purpose of this article is to review the prophylactic removal of the third molar, and to study the risk, pathological changes associated with it.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-PC-00001997
Title: Simultaneous estimation of bromhexine and diphenhydramine in pharmaceutical formulations by reversed phase-high performance liquid chromatography
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Aim: The purpose of the investigation was to develop a new reverse phase-high performance liquid chromatography method for simultaneous estimation of bromhexine (BEN) and diphenhydramine (DIPH) in pharmaceutical dosage forms. Methods: Chromatography was carried out on an BDS 250 C-18 column (4.6 mm × 250 mm, 5 μ particle size) with an isocratic mobile phase composed of orthophosphoric acid buffer, acetonitrile, (45:55 v/v) at a flow rate of 1 ml/min. The column temperature was maintained at 30°C, and the detection was carried out using a photodiode array detector at 260 nm. Validation parameters such as system suitability, linearity, precision, accuracy, specificity, limit of detection, limit of quantification, stability of sample and standard stock solutions, and robustness were studied as reported in the International Conference on Harmonization guidelines. Results: The retention times for BEN and DIPH and were 2.542 min and 3.378 min, respectively. The percentage recoveries of BEN and DIPH were 99.61% and 100.01%, respectively. The relative standard deviation for assay of tablets was found to be <2%. Conclusion: The method was fast, accurate, precise, and sensitive; hence, it can be employed for routine quality control of tablets containing both drugs in quality control laboratories and pharmaceutical industries.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-Pe-00001998
Title: Knowledge and attitude of magnetic dentures among undergraduate dental students
Category: Periodontics
Section: Research Article
Country: India
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Background: Over a long period of time, magnets have generated great interest within dentistry, and their applications are numerous. Popular method of attaching removable prostheses to retained roots or osseointegrated implants are done by magnetic retention. They are widely used because of their small size and strong attractive forces; these attributes allow them to be placed within prostheses without being obtrusive in the mouth. Aim: The aim of this study is to evaluate the knowledge of dental student regarding magnetic dentures. Material and Method: Questionnaire with 15 questions was prepared for 100 undergraduate students to evaluate their knowledge on the magnetic denture. The questionnaire included 14 structured questions focusing on the following (1) assessing knowledge on importance of magnetic denture, (2) treatment modalities after extraction, and (3) advantages and disadvantages of magnetic denture. Result: A total of 100 students answered the question, 5% students had inserted 0–5 dentures, 20% students had inserted 6–10 denture, and 75% of students had inserted 11–20 dentures. Around 75% of students were aware of magnetic denture, and the other 25% were not aware of it. 70% of students stated it subjected to wear, and demagnetization, 20% of students, stated aluminum‑nickel‑cobalt (AINiCO) alloy corrode rapidly in saliva, and 10% stated it has lower retentive force than those offered by bar or ball attachment. Conclusion: This study showed poor knowledge of fresh undergraduate on the magnetic denture and its advantages and disadvantages. There is urge need to implement laboratory, clinical and preclinical component in a curriculum that would lead to good quality treatment.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 2.
Article Id: JPRS-DE-00001999
Title: Root canal morphology of maxillary first molar using cone-beam computed tomography in south Indian population
Category: Dentistry and Endodontics
Section: Research Article
Country: India
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Aim and objective: The purpose of this study was to determine the prevalence of a number of canals and its morphological variations in maxillary first molars using cone-beam computed tomography (CBCT) of patients reported to Saveetha Dental College and Hospitals. Methods: A total of 500 CBCTs were collected and the CBCTs were evaluated in all three planes to assess the number of canals and its variations. Result: The result of this study showed that around 80% of the maxillary first molars had MB2 canal and around 5% of the maxillary first molar had two palatal and distal canals, respectively. Conclusion: CBCT is a clinically useful tool in understanding the variations in root canal morphology, which guides in the assessment of the root canal morphology aiding in successful root canal treatment.