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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 6.
Article Id: JPRS-P'Col-00002261
Title: A systematic review on pharmacology of serotonergic receptors including their agonist and antagonist
Category: Pharmacology
Section: Review Article
Country: India
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For the past 5 years, serotonin (5-hydroxytryptamine [5-HT]) receptors were recognized in terms of its complementary DNA sequence. With the detailed knowledge of various types of 5-HT receptors, the synthesis of a number of compounds as agonists (that selectively interact with individual 5-HT receptor subtype) and antagonists was possible. Some 5-HT receptor still lacks any selective ligand (e.g., 5HTE, 5-HTA, and 5-HTB receptor); the present review provides information and data for each 5-HT receptor, subtype, and subsequently details of functional responses attributed to each receptor subtype in the brain. In recent years, the progress is likely to continue at the level of interest in 5-HT receptor activity. The interest is developing by the belief that pharmacological manipulation of the central 5-HT system will have therapeutic potential in various behavioral disorders. In support of which, a number of 5-HT receptor ligands are currently utilized as potential therapeutic remedies for the treatment of several behavioral disorders.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 6.
Article Id: JPRS-PC-00002262
Title: A new pectin from Cissampelos pareira leaves for diclofenac gel formulations
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Aims: The aims of this research were to extract pectin from Cissampelos pareira leaves and the characterized physicochemical properties. In addition, the extracted pectin was used for the gel-forming agent in the diclofenac gel preparation. Methods: The pectin from Cissampelos pareira leaves was extracted by three different solvents; HCl, the mixture of HCl/ sodium hexametaphosphate, and water and then was precipitated by ethanol. The obtained pectin was identified by degree of esterification (DE), galacturonic acid content, and Fourier transform-infrared (FT-IR) spectroscopy which used in gel preparation of diclofenac as the model drug. Drug content was determined by spectrophotometry and in vitro diffusion studies of diclofenac were performed by Franz cell method. Results: The extracted pectin from the mixture of HCl/sodium hexametaphosphate and precipitated by ethanol provided the highest yield of 35.40 ± 6.77%. DE of low methoxy pectin was found in a range of 39.74–39.87%. The dominant structure of the pectin ((1-4)–α–D–galacturonic acid) was interpretated by FT–IR spectroscopy. The diclofenac gel forming, the percentage accumulative drug release was 30–60% for 4 h. Conclusion: The results obtained from this study were a new pectin which can be used for pharmaceutical gel-forming production.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 6.
Article Id: JPRS-PS-00002263
Title: Pharmacoeconomic analysis of antipsychotic drugs: A hospital perspective
Category: Pharmaceutical Sciences
Section: Research Article
Country: India
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Objective: The rationale for the present study is explained by the increase of antipsychotic drugs (APD) indication rate in the hospital segment of Moscow Region. The purpose of the study is to develop a tool that would allow the specialists (in complex with anatomical therapeutic chemical/defined daily dose [DDD] methodology) to perform pharmacoeconomic analysis of the APDs influence on the budget of in-patient psychiatric facilities. Method: The present study was based on the WHO methodology on drug statistics (DDD-analysis). The authors proposed the tool of cost calculation through the cost of 1 DDD, which can be used at planning hospital budget on drugs. Results: The results of the study showed that fluphenazine, solution for injections of prolonged effect, had lower cost of therapy, calculated per DDD dose, and were more effective in preventing relapse in schizophrenic patients in comparison with chlorpromazine (odds ratio 0.31, confidence intervals [CI] 95% 0.11–0.88). Conclusion: The share of patient’s increase, who receives fluphenazine solution for injections of prolonged effect, by 10% and decrease of chlorpromazine utilization, can cut the cost of annual budget, intended for the purchase of drugs for schizophrenic patients, by 1%. The proposed approach can be used for budget impact pharmacoeconomic analysis during budget planning at in-patient psychiatric facilities.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 6.
Article Id: JPRS-PCS-00002264
Title: Novel co-processed superdisintegrants in the development of fast dissolving tablet of venlafaxine hydrochloride
Category: Pharmaceutics
Section: Research Article
Country: India
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Aim: The purpose of this research is to formulate fast dissolving tablets of venlafaxine hydrochloride, a novel antidepressant. Materials and Methods: To improve the compressibility and rapid disintegration of tablet, co-processing of superdisintegrants was done. Drug-excipients compatibility was assessed by Fourier-transform infrared (FT-IR) spectroscopy. The fast dissolving tablets were prepared by direct compression method. Mannitol and microcrystalline cellulose were used as directly compressible fillers, whereas sodium starch glycolate and crospovidone were used as superdisintegrants. In a total of six batches of formulations, F1, F2, F3, F4, F5 and F6 were prepared. Formulation F1 to F5 prepared by solvent evaporation method using different concentrations of co-processed superdisintegrants and formulation F6 was prepared as physical mixture. Results: The results of interpretation of FT-IR spectrum revealed that there is no interaction between the drug venlafaxine hydrochloride and superdisintegrants, sodium starch glycolate, and crospovidone. Prepared tablets were evaluated and the results revealed that the thickness of all the tablets range from 2.48 mm to 2.53 mm, hardness ranges from 2.6 kg/cm2 to 3.0 kg/cm², and the friability ranges from 0.80% to 0.92%. The percent drug content uniformity was found in the range of 98.63%–99.80%. The wetting time of the tablets was found as 38–70 s, disintegration time observed 30–58 s, and in vitro drug release determined as 71.75–98.45%. Conclusion: Formulation F5 containing 3:1 ratio (sodium starch glycolate:crospovidone) found to be most optimized formulation as evident by results observed.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 6.
Article Id: JPRS-PCS-00002265
Title: Preparation and evaluation of sublingual tablet of valsartan for the treatment of hypertension
Category: Pharmaceutics
Section: Research Article
Country: India
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Objective: The objective of this research is to prepare sublingual tablets of valsartan with the aim to increase its solubility and thus improving its oral bioavailability. Materials and Methods: Pure drug, polymer, and other excipients were characterized by infrared spectroscopy and differential scanning calorimetry. The solid dispersion of valsartan was prepared using beta- cyclodextrin in the proportion of (1:0.5). The solubility of valsartan was increased by formulating as solid dispersion by kneading techniques. The prepared solid dispersion was evaluated by scanning electron microscopy, differential scanning calorimetrym and Fourier transform infrared spectroscopy and further used in the formulation of sublingual tablets. Sublingual tablets were formulated using superdisintegrants such as crospovidone and sodium starch glycolate. Results: In a total of seven batches of formulations from F1 to F7 were prepared by varying superdisintegrants concentration. Results of evaluation parameters revealed that formulation F3 containing 4% sodium starch glycolate found to be most optimized formulation in terms of flow properties, hardness, quick wetting, and disintegration time. Results of percent drug release analysis also conferred F3 as a most optimized formulation with the evidence of maximum percent drug release calculated as 96.41% in 30 min as compared with all the other formulations. Conclusion: All the seven formulations were successfully prepared and evaluated. However, results of parameters evaluated conclude that among all prepared formulations, F3 was observed as most optimized formulation.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 6.
Article Id: JPRS-ND-00002266
Title: Phytochemical and in vitro antioxidant activities of methanol leave extract of Alternanthera basiliana.
Category: Natural Drugs
Section: Research Article
Country: India
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Background and Aim: Plant-derived antioxidants can play a role in the prevention of oxidative stress-related diseases. Alternanthera brasiliana has been reported to have many pharmacological properties and thus the need to evaluate its antioxidant and possible mode of actions. The study evaluated the antioxidant properties of methanol extract prepared from A. brasiliana leaves in vitro. Methods: This was done using various in vitro antioxidant assay protocols which includes diphenyl-picrylhydrazyl free radical scavenging, metal chelating, reducing ability, hydroxyl radical, and ferric reducing antioxidant properties assay. The different antioxidant potentials were compared with suitable standard antioxidants such as ascorbic acid, quercetin, Trolox, and ethylenediaminetetraacetic acid. Phytochemical screening of the extract was done qualitatively. Results: The phytochemical results showed the presence of flavonoids, saponin, steroids, and tannin. While the extract elicited a concentration-dependent inhibition (%), its antioxidant activities were significantly less than the standard antioxidants (P < 0.05). Conclusion: The results obtained in this study provide evidence that A.brasiliana scavenges free radicals and can serve as a good source of natural antioxidant and justifies its potential use in the management or prevention of oxidative stress-related diseases.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 6.
Article Id: JPRS-PB-00002267
Title: Green synthesis of silver nanoparticles using stem extract of Berberis aristata and to study its characterization and antimicrobial activity
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Plant-mediated synthesis of nanoparticles has been an emerging research area worldwide for its inherent features such as rapidity, simplicity, environment-friendly, and cost-effectiveness. The rapid and simple approach was used for the synthesis of silver nanoparticles (AgNPs) (AgNO3 ) using stem of Berberis aristata (Daruharidra) by biologically reducing AgNO3 with the aqueous extract of plant. The formation of AgNPs was indicated by the color change from slightly yellowish to yellowish- brown. Various techniques were used to characterize biosynthesized NPs by ultraviolet-visible, Fourier transform infrared, scanning electron microscopy, and transmission electron microscopy analysis. The biosynthesized AgNPs were also tested for antimicrobial activity against pathogenic bacteria such as Escherichia coli and Pseudomonas aeruginosa.

Journal: Journal of Pharmacy Research , Volume: 12, Issue: 6.
Article Id: JPRS-PCS-00002307
Title: Development and evaluation of gastroretentive floating drug delivery system of ranitidine hydrochloride in the treatment of peptic ulcer
Category: Pharmaceutics
Section: Research Article
Country: India
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Aim: The present study was carried out with an objective of the development of gastroretentive floating drug delivery system in which ranitidine hydrochloride used as model drug. Development of ranitidine floating tablet was to increase its bioavailability by increasing residence time so that it releases in the upper part of the gastrointestinal tract for longer therapeutic effect. Materials and Methods: The tablets of ranitidine hydrochloride were prepared by direct compression method, using polymers such as Carbopol934, xanthan gum, and guar gum. The floating tablets were characterized for lag time, floating time, weight variation, drug content, and dissolution profile. The effect of polymer concentration on floating time and drug release was observed from all formulation from F0 (without polymer) to F6. Result: On investigating various parameters, it has been found that F3 and F6 formulations have shown longer buoyant property and prolonged drug release. Conclusion: On the basis of parameter studied above, F3 and F6 formulations could be an advantage in the enhancement of pharmacokinetic profile of drug and increased bioavailability, and hence, drug release of formulation could be sustained for longer time by increasing the concentration of polymer.