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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 2, Issue: February
Article Id: JPRS-PCS-0000434
Title: Development and evaluation of sustained release matrix tablet using hydrophilic gums as release modifier
Category: Pharmaceutics
Section: Research Article
Country: India
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The objective of the present study was to design oral sustained drug delivery system for freely water-soluble drug, metoprolol succinate using hydrophilic gums. The gums selected were karaya gum and guar gum and their combination. To study the rheological synergism between karaya gum and guar gum in different ratio (0:10-10:0) was determined and the combination having highest viscosity (6:4) was used for matrix tablet formulation. Nine batches were prepared by using karaya gum and guar gum in 15%, 20% and 25% concentration of the total weight of tablet. Matrix tablets were prepared by wet granulation method and the prepared tablets were evaluated for weight variation, content uniformity, percentage friability, hardness, thickness, swelling index and in vitro dissolution studies. All the formulation showed compliance with pharmacopoeial standards. Formulation F1, F6 and F7 showed sustained release of drug for 12 hrs with 97.65%, 98.23% and 96.98% respectively. The optimized formulation was subjected to accelerated stability studies for one month at temperature of 400C and relative humidity of 75%. and showed physical stability and stability with respect to drug release pattern. The kinetic treatment showed that the formulations follow zero order with release exponent (n) was 0.8275, 0.9633 and 0.8079 for formulation F1, F6 and F7. So the combination of karaya gum and guar gum shows better prosperity for preparation of sustained release tablets as compare to individual gums.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: February
Article Id: JPRS-PHDRS-0000430
Title: Diuretic activity of flowers of Jasminum auriculatum Vahl
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The decoction of flowers of Jasminum auriculatum Vahl of Oleaceae widly used in Ayurvedic system of medicine for the treatment of burning sensation, cardiopathy, urolithiasis, nephrolithiasis, strangury, dermatopathy, cardiotonic, diuretic and depurative. Preliminary phytochemical investigation of alcoholic and aqueous extracts of the flowers of Jasminum auriculatum showed the presence of flavonoids, sterols, tannins and glycosides (flavonoidal). Alcoholic and aqueous extracts of flowers were investigated for its diuretic activity in albino rats. Results revealed that both the extracts showed significant diuretic activity at a dose of 250 mg/kg body weight by increasing the total volume of urine and concentrations of potassium and sodium salts in urine as compared to the standard drug Frusemide (100mg/kg body weight).

Journal: Journal of Pharmacy Research , Volume: 2, Issue: February
Article Id: JPRS-PCS-0000429
Title: Design and development of mucoadhesive microcapsules of glipizide formulated with gum karaya
Category: Pharmaceutics
Section: Research Article
Country: India
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Mucoadhisive microcapsules are proposed for the antidiabetic drug glipizide, to obtain controlled release. Glipizide microcapsules with a coat consisting of alginate and gum karaya were prepared by employing ionic gelation process and emulsification ionotropic gelation process. The microcapsules were evaluated for flow properties, Carr’s index, hausner ratio, microencapsulation efficiency, drug release characteristics, surface characteristics; compatibility studies mucoadhesive properties and in-vivo hypoglycemic activity. As hausner ratio was less than 1.25 and Carr’s index values were less than 15 from both the methods, hence they were found to be free flowing. Sharp endothermic peaks were noticed from the microcapsules formulated with two different techniques at 215oC indicating the compatibility between the drug and the polymer gum karaya. Glipizide release from the microcapsules was slow and followed zero order kinetics (r > 0.98) and followed non–fickian (n value 0.5 to 1) release and depended on the coat: core ratio and the method employed in the preparation of microcapsules. Among the two methods emulsification ionotropic gelation method was found to be more suitable for slow and complete release of glipizide over a long period of time. These microcapsules exhibited good mucoadhesive property in the in-vitro wash-off test. In vivo testing into rabbits demonstrated significant hypoglycemic effect of glipizide.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: February
Article Id: JPRS-PHDRS-0000428
Title: In vitro and In vivo anti-cancer activity of leaves of Plumeria alba Linn.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The anti-cancer activities of different extracts of leaves of Plumeria alba Linn (Apocynaceae) were investigated for invitro cytotoxicity by the trypan blue exclusion method using DLA and L929 cell lines. The methanolic extract showed potent in vitro anti-cancer activity, then the extract screened for invivo anticancer activity using survival time, heamatological and histopathologial studies in ascitic fluid in mice. The potency of the extracts was compared with standard 5-flurouracil (20 mg/kg i.p.). The methanolic extract was also found to increase the lifespan, improvement in the haematological parameters like haemoglobin content, red blood cell and white blood cell count of the tumour bearing mice have also been observed. Histopathological studies have revealed a reduction in the mitotic activity and the appearance of vacuolization, necrosis in the treated tumour cells. The results of the present study suggest that methanolic extract of Plumeria alba has an anti-cancer activity.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: February
Article Id: JPRS-PCS-0000427
Title: Development and validation of spectrophotometric method for estimation of Etoricoxib in tablet dosage forms
Category: Pharmaceutics
Section: Research Article
Country: India
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A simple, specific, precise and accurate Spectrophotometric method was developed for the determination of Etoricoxib by Spectrophotometric method in tablet dosage forms. Etoricoxib shows absorption maximum at 284 nm. The calibration curve was developed at wavelength 284 nm and validated according to ICH Guidelines. Spectrophotometric method linear response obtained was in the concentration range of 2-24 mg/ml with correlation coefficient 0.9995, recovery of the drug was found to be 99.40% and relative standard deviation was found to be less than 2 % for precision studies. The newly developed methods can be used for routine analysis of Etoricoxib in tablet dosage forms.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: February
Article Id: JPRS-P'Col-0000425
Title: Cardiotonic activity from the fruit juice of Punica granatum
Category: Pharmacology
Section: Research Article
Country: India
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The Pomegranate (Punica granatum) is a fruit-bearing deciduous shrub. Various parts of this plant is used in the treatment of dyspepsia, bronchitis, hypotensive, throat inflammation, worm etc. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. In the present work fresh juice, dilution 1:1 ( juice: distilled water), dilution 1:2 (juice: distilled water), dilution 1:4 (juice: distilled water) are used to evaluate cardiac activity on hypodynamic frog heart and are labeled as A1, A2 , A3 & A4 respectively and compared with Digoxin (B1) as standard solution. It was found that sample A1 (Undiluted juice) showed better response as compared to the other samples. It has been also shown that Punica granatum has rapid onset of action compared to Digoxin. These preliminary studies confirm the better cardiotonic activity of Punica granatum.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: February
Article Id: JPRS-PCS-0000424
Title: Optimization techniques: An introductory overview
Category: Pharmaceutics
Section: Review Article
Country: India
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In today’s pharmaceuticals optimization is emerged as a technique for the best compromising answer to a particular question. The term optimization means to optimize something, or use something at its best. Optimization is finding a perfect, effective or functional answer. There is no single solution to design optimization tasks. Many techniques are available for this. In this article an attempt is made to give an introduction to the various parts and methods related to the optimization techniques such as terms used in optimization, optimization parameters, process of optimization and methods used in the optimization. Here a special emphasis is given to the factorial design which is the most used technique in the area of formulation development.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: February
Article Id: JPRS-PCS-0000437
Title: Development and Validation of Stability Indicating HPLC Method for Estimation of Metoclopramide Hydrochloride From A Novel Formulation
Category: Pharmaceutics
Section: Research Article
Country: India
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A new, simple, specific, precise and robust isocratic reversed-phase (RP) stability-indicating high-performance liquid chromatographic (HPLC) method was developed and validated for determination of metoclopramide hydrochloride from a novel pellet formulation. The liquid chromatographic separation was achieved isocratically using a mobile phase of acetonitrile: water (25:75), with 0.06 % triethylamine and pH adjusted to 4 using orthophosphoric acid. The analysis was carried out using Hi-Q-Sil C18 column [250 mm x 4.6 mm, 5 μm] at flow rate of 1 ml/min and the UV detection at 274 nm. The method was validated for accuracy, precision, linearity, range, selectivity and robustness. The linearity of the proposed method was investigated in the range of 0.5–18 μg/ml (r2 = 0.9985). The drug was subjected to oxidation, hydrolysis, heat and photolysis to apply stress conditions. The method provided good peak parameters with retention time of 6.2 ± 0.02 min. Degradation products resulting from stress studies did not interfere with the detection of metoclopramide hydrochloride and the assay can thus be considered as stability-indicating.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: February
Article Id: JPRS-PCS-0000435
Title: Enhancement of solubility and dissolution rate of Rifampicin by melt granulation technique
Category: Pharmaceutics
Section: Research Article
Country: India
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This work describes a melt granulation technique to improve the solubility and dissolution characteristics of a poorly water-soluble drug, rifampicin. Melt granulation technique is a process by which pharmaceutical powders are efficiently agglomerated by a meltable polymers and surfactants. The advantage of this technique compared to a conventional granulation is that no water or organic solvents is needed. Because there is no drying step, the process is less time consuming and uses less energy than wet granulation. Granules were prepared by using polymer like different grades of polyethylene glycol and surfactantlike different grades of poloxomers. The granules were characterized using powder XRD, DSC and FTIR techniques. A significant enhancement in the in vitro dissolution profiles of the melt granules was observed compared to the pure drug and drug excipient physical mixtures. Besides the remarkable enhancement of drug dissolution rate of the granulates in comparison to physical mixtures and pure drug, no significant differences were found between the dissolution profiles of the melted granulates containing lactose or crospovidone. XRD data confirmed crystalline drug in the melted granules. DSC results indicated change in internal energy of Rifampicin with polymers and surfactant in the melted granulated. In conclusion, the results of this work suggest that melt granulation is a useful technique to enhance the solubility and dissolution rate of poorly water-soluble drugs, such as, Rifampicin.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: February
Article Id: JPRS-P'Col-0000426
Title: Toxicity Studies on the Extracts of Amoora rohituka Roxb. Stem
Category: Pharmacology
Section: Research Article
Country: India
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The present communications describes the toxicity of Amoora rohituka Roxb stem on Swiss albino mice. In this study, successively prepared ethyl acetate and dichloromethane extracts from stem bark of Amoora rohituka were administered at 20 and 40 mg/kg doses in mice. Dichloromethane extract at 40 mg/kg, significantly (P<0.05) altered body weight gain, haemoglobin level, RBC and WBC count but the changes in haematological parameters were not clinically significant. Dichloromethane extract also significantly (P<0.05) increased the activity of SGPT, thereby indicating some extent of hepatic cell damage. Ethyl acetate extract did not show any adverse effect at 20 and 40 mg/kg doses.