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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
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Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PB-0000446
Title: Antibacterial activity and TLC Bioautography of Ocimum basilicum L. against pathogenic bacteria
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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The study was designed to examine the in vitro antibacterial activity of Ocimum basilicum Linn. Aerial parts of Ocimum basilicum were extarcted with organic solvents (ethanol, methanol, ethyl acetate and hexane) and then evaluated for in vitro activity by using agar well diffusion method against Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Pseudomonas aeruginosa, Escherischia coli, and Salmonella typhi. The methanol extract showed prominent effect on the tested microorganisms. However, Salmonella typhi was found to be most resistant against the extracts. The MIC and MBC of methanol extract against Staphylococcus aureus, Bacillus subtilis and Bacillus cereus were found to be 0.625 and 1.250 mg/mL ,respectively whereas it was 1.250 and 2.500 mg/mL against Escherischia coli. The TLC analysis of methanol extract showed the appearance of seven spots. The compounds eluted at Rf 0.14, Rf 0.25 and Rf 0.35, exhibited strong antibacterial activity against Staphylococcus aureus.The results provide evidence that Ocimum basilicum might be prominent sources of preservatives in food products.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PCS-0000455
Title: Formulation and evaluation of controlled release alginate microspheres using locust bean gum
Category: Pharmaceutics
Section: Research Article
Country: India
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The microspheres were prepared by ionic cross-linking technique. Chemical reaction between sodium alginate and calcium chloride to form calcium alginate was utilized for microspheres. For slowing the rate of release from microspheres the hydrophilic polymer Locust bean gum was used in different concentration with model drug as Diclofenac sodium, so that the drug will be release constantly for 12hrs. The formulation prepared showed the angle of repose within acceptable range having a good flow property. The drug entrapment efficacy of all the formulation was in the range of 90.6–98.9%. The drug entrapment efficacy of microspheres increases with increase in concentration of hydrophilic gums. In vitro drug release from microspheres was studied. The microspheres containing 1.5% of Locust bean gum shows 97.8% drug release. The values of co-efficient correlation (r) were calculated and were found to be linear for first order release as compare to zero order release. Stereo microscopy invade that the microspheres are spherical in shape and with porus surface. Stability studies reveled that polymers used were stable and compatible with the drug and there is no significant effect on physical characteristics, drug content and dissolution profile of the microsphere.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PCS-0000458
Title: Simultaneous estimation of Tamsulosin hydrochloride and Dutasteride in combined dosage form by UV spectroscopy method
Category: Pharmaceutics
Section: Research Article
Country: India
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Fixed dose combination tablets containing Tamsulosin hydrochloride & Dutasteride are used to treat the symptoms of an enlarged prostate, a condition technically known as benign prostatic hyperplasia or BPH. Several chromatographic methods have been reported for simultaneous estimation of these drugs and individual drug. The drugs individually and in mixture obeys Beer‘s law over conc. range 0.0347 mg/mL for Tamsulosin hydrochloride (TAM) and for Dutasteride 0.012 mg/mL (DUTA). The mean recoveries from tablet by standard addition method were 99.0% and 99.5 %. The present work reports simple, accurate and precise spectrophotometric method for the simultaneous estimation of Tamsulosin hydrochloride and Dutasteride in combined from tablet dosage form.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PHDRS-0000445
Title: Wound Healing Activity of Annona muricata extract
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The wound healing activity of alcoholic extract of stem bark of Annona muricata was evaluated in albino rats by open wound method for a period of 12 days. Extract showed marked reduction in area of the wound in comparison with that of the control group from 4th days onwards suggesting its possible use in healing the wound.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PHDRS-0000456
Title: Antioxidant activity of ethanolic extract of Piper betel leaves
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The present study was aimed to investigate the antioxidant activity of methanolic extracts of Piper betel leaves by different methods like DPPH photometric assay, reductive ability, Deoxyribose degradation assay and Superoxide scavenging activity. It belongs to the family Piperaceae used as ingredients in a chew commonly known as pan. Chemically Piper betel containing chavi betel, chavicol, betel oil, terpene, sesquiterpene. Biologically Piper betel have broad spectrum activities like antifungal, antibacterial, antitumour, hypotensive, respiratory depressant, anthelmintic, cardiotonic and antifertility. PBLE showed strong antioxidant activities like reducing power, DPPH radical, superoxide anion scavenging and deoxyribose degradation activities when compared with different standards such as ascorbic acid, DMSO and BHT. Presumably, PBLE functions as an antioxidant to scavenge free radicals and reduces free radical induced cell injury.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PHDRS-0000459
Title: Antidiabetic activity of leaves of Tephrosia villosa Pers. in alloxan induced diabetic rats
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Antidiabetic activity of ethanolic extract of leaves of Tephrosia villosa Pers. was studied on alloxan induced diabetic rats as two different doses were studied. It showed significant reduction in the blood glucose level. Concurrent histopathological examination of pancreas of these animals showed comparable regeneration by ethanolic extracts (lower and higher dose) which were earlier, necroses by alloxan.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-P'Col-0000457
Title: Radioprotective activity of Murraya koenigii (L.) on cellular antioxidants in Swiss albino mice
Category: Pharmacology
Section: Research Article
Country: India
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The radioprotective activity of methanolic extract of Murraya koenigii (L.) leaves was studied in mouse liver. Adult Swiss albino mice were injected i.p. with 100 mg/kg of the Murraya koenigii (L.) extract (MKE) for 5 consecutive days and exposed to 4Gy gamma radiation 30 min after last injection. The extract itself increased the GSH and enzymes significantly above levels, whereas radiation significantly reduced all values. Pretreatment with the extract could check the radiation induced depletion of GSH and all the enzymes and maintain their levels within or above control range. Pretreatment with the extract also reduces lipid peroxidation rate induced by radiation. The result demonstrates that Murraya koenigii (L.) leaves posses good antioxidant activity in vitro and is able to protect against radiation induced depletion in cellular antioxidants.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PCS-0000454
Title: Sustained Release Floating Drug Delivery System of In-Situ Gelling Suspension of Cinnarizine
Category: Pharmaceutics
Section: Research Article
Country: India
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This study aimed at developing sustained release floating drug delivery system of in-situ gelling suspension of cinnarizine. Cinnarizine has half life of 3-6 hours and required dose is 30mg three times a day. Hence sustained drug delivery system for pediatric patient was developed. Different formulations of cinnarizine were prepared, containing different concentration of gelling agent such as sodium alginate and calcium carbonate. Polysorbate 80 was used as wetting agent and methyl paraben was added as preservative. Sodium citrate was used to prevent gelation outside the gastric environment. Formulation containing 4% of sodium alginate and 0.5% of calcium carbonate showed the best gelling ability. A 32 full factorial design was employed to study the effect of independent variables viz. levels of sodium alginate and calcium carbonate which significantly influenced the in-vitro drug release behavior. The suspension was evaluated for rheological parameter, particle size analysis sedimentation rate, in-vitro gelling ability, in-vitro drug release study and floating ability. The drug release was studied by dissolution rate test with pH 1.2 simulated gastric fluid using the USP 24 type II apparatus at 50rpm to evaluate for the desired release pattern. The suspension showed pseudoplastic behavior, instant gelation, 98.90% release in 12 hours, instant floating ability with duration of floating for more than 24 hours in pH 1.2 buffer. Thus, sustained release floating drug delivery system of in-situ gelling suspension of Cinnarizine was formulated having sustained drug action for 12 hours.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PCS-0000450
Title: Formulation and Evaluation of Novel FDCs of Antitubercular Drugs
Category: Pharmaceutics
Section: Research Article
Country: India
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The objective of the present study was to formulate and evaluate novel FDCs of antitubercular drugs. The solid mixtures of rifampicin and sodium lauryl sulphate were prepared at molar ratio of 1:1 by co-grinding method. Characterization of Rifampicin-SLS mixture was performed using DSC, XRD and FTIR studies. In vitro dissolution studies were carried out in 0.1N HCl and phosphate buffer pH 6.8. Solid mixtures prepared by co-grinding method were found to be useful in delaying the dissolution of rifampicin in acidic medium in molar ratio 1:1.The release of rifampicin from novel fixed dose combination formulation was 0% in 0.1N HCl up to two hours and faster release within 15 minutes in alkaline pH was achieved, while Isoniazid was released completely within 20 minutes in 0.1 N HCl. A novel formulation comprising of rifampicin and sodium lauryl sulphate, prepared by co-grinding method proved effective to minimize the degradation of rifampicin in acidic environment by its retarded release pattern. Thus this approach is beneficial for the segregation of release pattern of rifampicin in alkaline environment and isoniazid in the acidic environment of the GI tract, which will lead to prevent the degradation of rifampicin alone & its interaction with isoniazid.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PHDRS-0000448
Title: Evaluation of anti-histaminic activity ofaqueous extract of ripe olives of olea-europea
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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According to Ayurveda, Olea europea is used in treatment of leprosy, dysentery, vaginal and uterine complaints, inflammation, burning sensation, fatigue, asthma, leucoderma etc. In the present study the histamine induced dose dependent contraction of goat tracheal chain and guinea pig ileum preparation was significantly inhibited (p< 0.01) by the aqueous extract of leaves of Olea europea (800 ug/ml and 100 ug/ml). Olea europea at the doses of 100and 200 mg/kg,i.p.,exhibited significant (p< 0.01) mast cell stabilizing activity against clonidine induced peritoneal mast cell degranulation in rats. Prior treatment with Olea europea extract (6.6 mg/kg and 10.2 mg/kg, i.p) significantly inhibited the clonidine-induced catalepsy in mice but, did not show any significant decrease in haloperidol induced catalepsy. Thus the present study revealed that the extract of olives of Olea europea has significant antihistaminic (H1 receptor antagonist) activity.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PHDRS-0000447
Title: Effect of ethanol extract of fruits of Passiflora foetida Linn. on CCl4 induced hepatic injury in rats
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Hepatoprotective activity of ethanolic extract of fruits of Passiflora foetida was studied against CCl4 induced hepatic injury in albino rats. Pretreatment of ethanolic extract (EPF 200 mg/kg/day, p.o.) significantly (p<0.001) reduced the biochemical markers of hepatic injury like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase (GGTP). Histopathological observations also revealed that pretreatment with EPF protected the animals from CCl4 induced liver damage. The results indicate that the fruits of P. foetida possess hepatoprotective activity. This property may be attributed to the flavonoids present in the fruits of P. foetida.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PHDRS-0000464
Title: Herbal Antioxidant: An Emerging Health Protector (Veggie route to healthy living)
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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In spite of several defense mechanisms existing in the physiological system of the body, the free radicals add on to hepatic damage, hypertension, Alzheimer’s disease, Parkinson’s disease and many more. Various herbs have been reported to contain number of bioactive moieties that render them powerful antioxidants, and have been cited as promising biochemical aids in the treatment of carcinogenic activities, atherosclerosis, and diabetes – posing antimicrobial, anti-inflammatory and neuro protective abilities. The model role of antioxidants has been approved to reduce the rate of particular oxidation reactions in a specific context, involving transfer of electron from a key substance to an oxidizing agent. Antioxidants scavenge free radicals and thus inhibit the oxidative mechanisms that lead to degenerative disorders. Reactive oxygen species like H2O2 and hydroxyl ions (-OH), which are highly unstable, damage cells by chain reactions. Researches of eminent scholars indicate that consumption of antioxidants – rich food stuffs reduces damage to cell membrane and certain biochemicals e.g. nucleic acids. They have been found to prevent, or even reverse various diseases that result from cellular damage and also to an extent slow down the natural ageing process. Since ancient times, Ayurvedic formulations have been used to cure several ailments with minimal side effects, as the herbs mentioned in the texts and manuscripts are considered safe for human consumption. Recent findings have indicated that there is inverse relationship between the dietary intake of antioxidant rich foods and the incidence of human disease. Thus antioxidants play a vital role in checking oxidative stress taking place in physiological processes. Studies are being carried out in various organizations to know about the details of antioxidative properties and pharmacological action of constituents in various herbs, vegetables and fruits. The enzymatically potential antioxidants hither to known are superoxide dismutase, catalase and glutathione peroxidase. In the non-enzymatic category, there are vitamin-A, vitamin-C, flavonoids, β- carotenoids, uric acid (urates), ubiquinone and other syntheticcompounds viz. DHEA, melatonins etc. The goal of present paper is to recommend the research for the development of inexpensive, highly available and effective naturally aesthetic antioxidants from biodiversified medicinal flora of the modern era, which is in fact an utmost need of hour.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-ND-0000463
Title: Effect of various Ayurvedic formulations and medicinal plants on carbohydrate hydrolyzing enzymes and glucose uptake by yeast cells-an in vitro study
Category: Natural Drugs
Section: Research Article
Country: India
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The present study evaluated the effect of three Ayurvedic formulations and five medicinal plants commonly used in the treatment of diabetes on α-amylase, α-glucosidase, sucrase and glucose uptake by yeast cells in vitro. All the Ayurvedic formulations inhibited the enzymes to varying degrees. Although all the medicinal plants studied inhibited a-amylase to an extent of 16-74%, only Eugenia jambulana and Ficus racemosa inhibited all the three enzymes while, Tinospora cardifolia and Gymnema sylvestrae activated α-glucosidase and sucrase. Aegle marmelos inhibited sucrase but increased the activity of α-glucosidase. All the samples except Aegle marmelos significantly increased (p=0.01) glucose uptake in yeast cells. The enhancement of glucose uptake was dependent on both the sample and glucose concentration. It is proposed that, the mechanism of hypoglycemic action varies greatly from one medicinal plant to other and hence, there is a need for in depth research to establish the mode of action of each medicinal plant for their effective utilization as therapeutic agents.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PCS-0000462
Title: Preparation and Evaluation of Fluconazole Topical Microemulsion
Category: Pharmaceutics
Section: Research Article
Country: India
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A fluconazole w/o microemulsion was developed for topical application using isopropyl myristate as the oil phase. Pseudoternary phase diagrams were constructed to determine the microemulsion existence region using surfactant (tween 80) and co-surfactant (polyethylene glycol 400). Different formulations were prepared to evaluate the effect of oil content, surfactant/ co-surfactant concentration on in-vitro permeation rates. In-vitro transdermal permeability of fluconazole from the microemulsions was evaluated using Keshary Chien diffusion cells mounted with 0.45μ cellulose acetate membrane. The amount of fluconazole permeated was analyzed by HPLC. The permeability of the fluconazole incorporated into the microemulsion systems was 2.5 - fold higher than that of the marketed formulation. These results indicate that the microemulsion system studied is a promising tool for the percutaneous delivery of fluconazole.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PC-0000461
Title: Isolation of Chemical Constituents from Prosopis juliflora bark and Anti-inflammatory activity of Its Methanolic Extracts
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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The methanolic extracts of Prosopis juliflora bark used for the evaluation of anti-inflammatory activity and isolation of constituents. For the evaluation of anti-inflammatory activity carrageenan and histamine induced paw oedema served as acute models and formation granulation tissues by cotton pellets served as a chronic model in rats. The effect was compared with diclofenac sodium, used as standard drug. The methanolic extract of Prosopis juliflora bark (MEPJ) 100, 200 and 400 mg/ kg (p.o.) exhibited significant anti-inflammatory activity in acute and chronic inflammatory models. At the dose level 400 mg/ kg (p.o.) showed maximum inhibition of 55.32% in carrageenan induced rat paw oedema while the standard diclofenac inhibited it by 61.33 % after 3 h of carrageenan injection. All the doses of MEPJ showed dose dependent inhibition against histamine and serotonin induced rat paw oedema as compared with control animals. Furthermore, the same dose levels successfully reduced formation granulation tissues by cotton pellets in rats. Alkaloids, 3’’’’-Oxo-juliprosopine and Secojuliprosopinal were isolated and characterized.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PCS-0000460
Title: Formulation and evaluation of matrix floating tablet of Famotidine
Category: Pharmaceutics
Section: Research Article
Country: India
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The objective of the present study was to develop single unit gastroretentive drug delivery system of Famotidine. Famotidine is histamine H2 receptor antagonist. It is widely for duodenal ulcers, gastric ulcers, gastro esophageal reflux disease and erosive esophagitis. Famotidine is having a short biological half-life of 2.5-3.5 hrs. The gastroretentive drug delivery system can be retained in the stomach and assist in improving the oral sustained delivery of drugs. The floating matrix drug delivery system of famotidine was prepared by using sodium alginate, HPMC K15M, sodium bicarbonate and citric acid. The formulated formulations showed good buoyancy, in vitro sustained release of famotidine and good stability at short term accelerated stability study.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PCS-0000443
Title: Formulation and release kinetic study of Hydrogel containing Acarbose using polymers as Hydroxypropylmethyl cellulose and Guar gum
Category: Pharmaceutics
Section: Research Article
Country: India
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Hydrogel matrix tablets of Acarbose was formulated using hydroxypropyl methyl cellulose and guar gum with the aim to study of release kinetic and to attain a near zero order release. In-vitro dissolution studies were carried out using USP type 2 dissolution test apparatus. The release of drug followed a typical Higuchian pattern. Matrix tablets formulated employing hydroxypropyl methyl cellulose and guar gum slow release of Acarbose over a period of 12 h and were found suitable for maintenance portion of oral controlled release tablets. Acarbose release from these tablets were diffusion controlled and followed zero order kinetics after a lag time of 1h.The most successful of the study, exhibited drug release pattern very close to theoretical release profile. A decrease in release kinetics of the drug was observed on increasing polymer ratio.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PHDRS-0000442
Title: Study the Effect of Phytochemical Constituents of Piper betel Leaves Extracts on Liver Disorders by in vivo Model
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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An in vivo study was conducted to evaluate the hepatoprotective activity of ethanolic extracts of Piper betel leaves. Liver damage was induced in male Wistar rats weighed 150-200 gm by administering CCl4 (2ml/kg i.p) regularly for 10 days and tissue damage was noted by various biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate Pyruvate transaminase (SGPT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Lipid peroxidation, Level of antioxidant enzyme like catalase (CAT), Superoxide dismutase (SOD), Glutathione (GSH) in liver. Ethanolic extract of piper betel 100 mg/kg and 200 mg/kg i.p administered regularly for 10 days and compared with a control group silymarin (25 mg/kg i.p.). A significant reduction in serum SGOT, SGPT, ALP, ACP, lipid peroxidation and improvement in CAT, SOD, GSH, MDA level in the liver were observed when compared with CCl4 administered rats. Piper betel leaves extract (PBLE) was able to protect the liver against the oxidative damage produced by CCl4.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PHDRS-0000440
Title: Wound healing activity of herbal formulation
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Topical drug delivery in the form of gel having antibacterial activity was formulated and characterized.Wound healing potential of herbal formulation for treatment of wound in rats was studied on excision wound model.Epithelization period along with wound contraction were used to evaluate the effect of herbal formulation on wound healing. The results obtained indicate that Herbal Formulation accelerates the wound healing process by decreasing the surface area of the wound. Silver sulfadiazine and ViccoTurmeric was used as a standard. Complete epithelization was observed within 14 days for formulation. Crude extracts of Punica granatum pericarp and Curcuma longa rhizome were used in the formulation with different concentration.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PHDRS-0000438
Title: Antibacterial Activity of Crude Extracts and Phlorotannin Isolated from the Diatom Cymbella spp.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Antibacterial activity of organic and aqueous extracts from the diatoms Cymbella spp. and it’s isolated phlorotannins, collected from Iraq were carried out against seven different species of pathogenic microorganisms: Staphylococcus aureus, Corynebacterium diphtheriae, Escherichia coli, Proteus mirabilis, Klebsiella pneumonia, Salmonella typhi and
Pseudomonas aeruginosa using disc diffusion and microdilution assay. All extracts showed antibacterial activity against most tested bacteria except, P. mirabilis. The highest growth inhibition was seen against P. aeruginosa (zone of inhibition: 23 mm in diameter) using the ethanol extract concentration 50 mg/ml; and the highest MIC value was observed against P. aeruginosa (MIC=0.19 mg/ml) using the same extract. The isolated compound (phlorotannin) with a concentration of 50 mg/ml achieved good antibacterial activity against all tested bacteria (zone of inhibition range: 9-25 mm) and MIC values in range: 1.56 - >3.12 mg/ml.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PHDRS-0000444
Title: Evaluation Of Wedelia Biflora (Linn) D.C For Anthelmintic And Antimicrobial Activity
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The alcoholic and aqueous extracts of roots of Wedelia biflora (Linn) D.C were screened for anthelmintic and antimicrobial activities. The anthelmintic activity was investigated against adult Indian earthworm, Pheretima posthuma, using Piperazine citrate as a reference standard. Both the extracts exhibited significant anthelmintic activity at higher concentration of 100mg/ml and moreover the ethanolic extract was found to be more potent than the reference control piperazine citrate. The results of Antimicrobial activity revealed that the ethanolic extract exhibited maximum activity against the tested organisms when compared to aqueous extract.

Cite this article as: G.Prakash Yoganandam, R.Gowri , Diptanu Biswas, Evaluation Of Wedelia Biflora (Linn) D.C For Anthelmintic And Antimicrobial Activity, Journal of Pharmacy Research Vol.2.Issue 3.March 2009, 375-377.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: March
Article Id: JPRS-PHDRS-0000441
Title: Phytochemical and Pharmacognostic Evaluation of Euphorbia hirta Linn. Leaves
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Euphorbia hirta linn.(Euphorbiaceae), a pantropic herbaceous wild plant which has been widely used in several countries as an antidiarrhoeal, antidiuretic, also as a treatment of expectorant and also remedy for bronchitis, asthama, intestinal ailments of children and for various skin diseases. The current study was therefore carried out to provide requisite pharmacognostic details about the plant. In the microscopic studies, the leaves showed the presence of trichomes, vascular bundles, collenchyma and anomocytic stomata. The total ash, acid insoluble ash, water-soluble ash and sulfated ash were observed to 5.5±0.3%, 2.5±0.5%,3.5±0.2% and 7.0% respectively. Water soluble, alcohol soluble and petroleum ether soluble extractive values were found to be 24±1.5%, 12±1.0% and 4±0.7% respectively.Moisture content was found to be 4.2±2.0%. The leaves were first defatted with petroleum ether and successively extracted with methanol finally fractionated in to diethyl ether, chloroform, ethyl acetate and n-butanol. Preliminary phytochemical showed the presence of alkaloids, steroids, carbohydrates and flavonoids.