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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
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Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-QA-0000542
Title: Simultaneous determination of Finasteride and Tamsulosin in pharmaceutical preparations by ratio derivative spectroscopy
Category: Quality Assurance
Section: Research Article
Country: India
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Simple, accurate, precise, and sensitive spectrophotometric method for simultaneous estimation of Tamsulosin(TAM) and Finasteride(FINA) in combined tablet dosage form have been developed and validated. The ratio derivative spectroscopic method involves measurement of first derivative amplitude of ratio spectra at 240.01nm for FINA and 229.91 nm for TAM as two wavelengths for estimation. Beer’s law is obeyed in the concentration range of 2-10 and 25-125 μg/mL for TAM and FINA, respectively.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PHDRS-0000553
Title: Flavonoids: An Overview
Category: Pharmacognosy and Herbal Drugs related study
Section: Review Article
Country: India
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Flavonoid constitute one of the largest class of naturally occurring plant products mostly phenols either in the Free State or as their respective glycosides. The main constituent of flavonoid drugs are 2-phenyl-g-benzopyrones. The family includes monomeric flavanols, flavanones, anthocyanidins, flavones, isoflavonoid and flavonols. It is very probable that a number of herbal remedies, whose constituents are yet unknown, will be shown to contain active flavonoids, quercetin and rutin in plant trigonella foenum seed, they are known for its antiinflammatory properties, The flavonones hesperidin and neohesperidin were shown to protect against the toxicity of hydrogen peroxide, as well as protecting against DNA damage. Most flavonoids have anti-tumor properties. A diet rich in flavonol such as onions, apples and berries may cut the risk of developing pancreatic cancer. Flavonoids are powerful antioxidant. Extract from onion contain quercetin which induce the cellular antioxidant system. Diets rich in either flavonoids including red wine, quercetin or catechin induce endothelium dependent vasorelaxation. More than 2000 of these compounds are known, with nearly 500 occurring in the free state. Flavonoid research began in an attempt to isolate the various individual flavonoids and to study the mechanism by which flavonoids act. There are many herbal drugs containing flavonoid which have different morphological characters and are not yet fully exhausted for their pharmacological activities.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PCS-0000529
Title: An Overview of Resealed Erythrocyte Drug Delivery
Category: Pharmaceutics
Section: Review Article
Country: India
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Among the various carriers used for drug delivery, erythrocytes (red blood cells, RBC) constitute potential biocompatible carriers since they possess several properties which make them unique and useful carriers. Erythrocytes are biocompatible, biodegradable, possess long circulation half lives, and can be loaded with a variety of biologically active compounds using various chemical and physical methods. This systemic review deals with advantages, requirement, methods of drug loading, characterizations, and application of erythrocyte mediated drug delivery.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-P'Col-0000552
Title: Analgesic, anti-inflammatory and antipyretic studies of Neolamarckia cadamba barks
Category: Pharmacology
Section: Research Article
Country: India
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The methanol extract of Neolamarckia cadamba (Family: Rubiaceae) barks showed significant analgesic, anti-inflammatory and antipyretic activity. The acute toxicity, orally evaluated in mice, was found to be higher than 3000 mg/kg. The antinociceptive response using writhing and tail immersion test in mice were examined. The antiinflammatory activity using carrageenan and antipyretic activity in yeastinduced pyrexia in rats, were also examined. The extract at the doses 400 and 600 mg/kg significantly reduced the numbers of writhings induced by intraperitoneal injection of acetic acid in mice. But the extract significantly exerted protective effects on heat-induced pain in mice at all tested doses (200, 400 and 600 mg/kg p.o.). The percentage inhibition of oedema due to injection of carrageenan was found to be in accordance with the doses tested. The extract showed significant effect on yeast-induced fever in rats at doses of 400 and 600 mg/kg and no promising results with 200 mg/kg dose level. Although these results provide a support for the traditional uses of N. cadamba barks, further studies are necessary to better evaluate its safety and modes of action.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PCS-0000539
Title: Taste Masking Methods and Techniques in Oral Pharmaceuticals: Current Perspectives
Category: Pharmaceutics
Section: Research Article
Country: India
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Undesirable taste is one of several important formulation problems that are encountered with certain drugs. The problem of bitter and obnoxious taste of is a challenge to the pharmacist in the present scenario. Taste is an important parameter governing compliance. Several oral pharmaceuticals and bulking agents have unpleasant, bitter-tasting components. In numerous cases, the bitter taste modality is an undesirable trait of the product or formulations and can considerably affect its acceptability by consumers. Bitter characteristics found in such systems have been eliminated or minimized by various known processes, but no universally applicable technology for bitterness inhibition has ever been recognized. The desire of improved palatability in these products has prompted the development of numerous formulations with improved performance and acceptability. This paper reviews different methods are available to mask undesirable taste of the drugs, with the applications. Popular approaches in the development of taste masking are based on coating, solid dispersion system and ion exchange resin.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-P'Col-0000536
Title: Pharmacological evaluation of ethanolic extract of flowers of Tagetes erecta on epilepsy
Category: Pharmacology
Section: Research Article
Country: India
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Aims: Flowers of Tagetes erecta (Et E) is considered to be effective in the treatment of epilepsy reported in Ayurveda, but the phytoconstituents present in Et E devoid of antiepileptic activity, but found with phytoconstituets which decrease seizure thresholds. Thus the work undertaken to evaluate the effect of ethanolic extract on epilepsy using in vivo models.Methods and Material: Et E was evaluated using the in vivo models such as pentobarbitone induced sleeping time, MES and PTZ induced convulsions , potentiation of PTZ induced convulsion, spontaneous locomotor activity, forced swim test, learned helplessness test and brewers yeast induced pyrexia model.Results: Present study revealed that extract is devoid of sedative, antiepileptic, proconvulsant activity. The Et E shown CNS stimulant activity, antidepressant and antipyretic activity. Conclusions: The findings suggested that ethanolic extract may reduce the seizure threshold in epileptic patients, chances of seizure precipitation is more, thus usage in epilepsy is cautious.

Cite this article as: Shetty JHarikiran HFernandes J. 2009. Pharmacological evaluation of ethanolic extract of flowers of Tagetes erecta on epilepsy. Journal of Pharmacy Research2(6):1035-1038

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PCS-0000545
Title: Preparation and Evaluation of In-Situ-Gels for Ocular Drug Delivery
Category: Pharmaceutics
Section: Research Article
Country: India
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The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by use of in –situ gel forming system that are instilled as a drops into the eye and it undergoes a sol-gel transition in the cul-de-sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent, ciprofloxacin, which is used in the treatment of eye infection such as dacrocystitis, bacterial conjunctivitis, corneal ulceration and blepharitis, based on the concepts of pH-triggered in-situ gelation, thermo reversible gelation and Ion activated system. Poly acrylic acid (Carbopol 940) was used as the gelling agent in combination of hydroxy propyl methylcellulose, which acted as a viscosity-enhancing agent. (pH-triggered system). Pluronic F-127 (14%) was used as the thermal reversible gelation in combination of HPMC (1.5%) incorporation of HPMC was to reduce the concentration of pluronic required for in-situ gelling property, with 25% w/w pluronic F-127 reported to form good gels. Gellan gum (Gelrite) is an anionic exocellular polysaccharide by the bacterium pseudo Monas elodea, having the characteristic property cation-induced gelation (0.6%). The developed formulation was therapeutically efficacious, stable, non irritant and provided sustained release of the drug over an 6 hours period, but Gelrite formulation showing long duration of release followed by combination of carbopol, HPMC and pluronic F-127 & HPMC. The developed system is thus a viable alternative to conventional eye drops.

Cite this article as:EC Mohan, JM KanduKuri, V Allenki,Preparation and Evaluation of In-Situ-Gels for Ocular Drug Delivery Journal of Pharmacy Research 2009, 2 (6), 1089-1094.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PC-0000551
Title: Microwave one-step synthesis and evaluation of antimicrobial activities of new fused [1,8]naphthyridine derivatives
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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A simple and efficient procedure has been described for the synthesis of benzo [g]naphtho[b][1,8]naphthyrindes 3 by the condensation of 2- chloro-3-formylquinoline 1 with 1-naphthylamine 2 under microwave irradiation condition. The structures of the newly synthesized compounds were confirmed by analytical and spectral (IR, NMR, and Mass) data. All these compounds were evaluated for their in vitro growth-inhibitory activity against several microbes.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PCS-0000546
Title: Formulation and optimization of controlled released floating matrix tablets of cefixime
Category: Pharmaceutics
Section: Research Article
Country: India
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The purpose of this research was to prepare a floating drug delivery system of Cefixime trihydrate (Cefixime). Floating matrix tablets of Cefixime were developed to prolong gastric residence time, increase its bioavailability and patient compliance. Rapid gastro-intestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by direct compression technique, using polymers such as HPMC K 100 LV, HPMC K4M, HPMC K15M and HPMC K100M, alone or in combination and other standard excipients. Sodium bicarbonate was incorporated as a gas generating agent and citric acid was incorporated as a release rate enhancer. The effect of Sodium bicarbonate, tablet hardness and content of citric acid on drug release profile and floating properties were investigated. A 32 full factorial design was applied to systematically optimize the drug release profile. The ratio of HPMC K4M to HPMC K100 LV (X1) and content of citric acid (X2) were selected as independent variables. The time required for 50 % (t50), percentage drug release at 12 hr (Q12), release rate constant (k) and diffusion exponent (n) were selected as dependent variables. The results of factorial design indicated that ratio of HPMC K4M to HPMC K100LV had dominant role on drug release from floating matrix tablets compared to citric acid, although the presence of later component in formulation with optimum concentration is essential to improve the drug release of hydrophobic molecules of drug. The linear regression analysis and model fitting showed that all these formulations followed Korsmeyer and Peppas model, which had a higher value of correlation coefficient (r).

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PHDRS-0000544
Title: Evaluation of antimicrobial and antioxidant properties of Momordica dioica Roxb. (Ex Willd)
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Momordica dioica Roxb is a perennial climbing creeper belonging to the family Curcurbitaceae and generally found in the forests of Southern India, Bengal, Maharashtra and Madhya Pradesh. In the present study the methanolic extract (MEFMD) and aqueous extract (AEFMD) of fruits of Momordica dioica Roxb were analyzed for the presence of different phytochemical constituents and total phenolic content. MEFMD after drying on rotary evaporator was used for screening of antimicrobial and antioxidant properties. The screening of antimicrobial activity was done using reported disc diffusion method on common gram positive and gram negative bacteria whereas DPPH (2,2-Diphenyl- 1-Picrylhydrazyl) and Nitrous oxide method was used to evaluate antioxidant activities of extract. The MEFMD showed the presence of phenolic compound, flavonoids and sterol whereas AEFMD showed the presence of flavonoids, glycosides, alkaloids and amino acids. Total phenolic content was expressed as GAE (Gallic acid equivalent) in mg per gram dry weight of sample. MEFMD showed more promising antimicrobial and antioxidant activity as compared to AEFMD.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PHDRS-0000543
Title: Antidiabetic effect of Cleome aspera in type 2 diabetic rats
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The antidiabetic effect of methanolic extract of whole plant of Cleome aspera was investigated in Streptozotocin induced type 2 diabetic rats. The C. aspera showed a dose dependent hypoglycemic effect and prevented rise in blood glucose levels in diabetic rats. The blood glucose levels were measured at 0, 2, 4, 6 and 8 h after the treatment. The methanolic extract of C. aspera at a doses of 100, 200 and 400 mg/kg body weight (b.w.) reduced the blood glucose levels of the normal rat from 75.29±6.4 to 68.18±6.59 mg/dl, 87.19±5.1 to 71.28±7.45 mg/ dl and 85.45±7.6 to 68.16±7.45 respectively at 6 h after oral administration of the extract (P<0.05) and also significantly lowered blood glucose levels in Streptozotocin induced diabetic rats from 238.62±9.60 to 176.96± 6.40 mg/dl at 4h after oral administration of the 400 mg/kg b.w. extract (P<0.05). In glucose tolerance test, extract markedly reduced the external glucose load. The antihyperglycemic activity of C. aspera was compared with glibenclamide (10 mg/kg), an oral hypoglycemic agent. The above results suggest that C. aspera is a potent antidiabetic agent.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PHDRS-0000541
Title: Comparative Screening of Selected Mangrove Plant Methanolic Extracts against Clinical and Plant Pathogens
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Antimicrobial effect of the crude methanol extracts of mangrove plants Tamarix aphylla, Sesuvium portulacastrum and Xylocarpus granatum. The antimicrobial activity was determined in methanol extracts using agar well diffusion method by measuring the diameter of the zone of inhibition in term of millimeter. Screening revealed that the crude methanol extract of the studied mangrove extracts possess antimicrobial activity against most of the test organisms depending upon the nature of their active ingredients in the extract and capacity of diffusion into the agar medium. Among the test organisms, the extract showed significant antimicrobial activity against Acremonium strictum Asperigillus niger, Candida albicans Erwinia carotovara, Fusarium oxysporum, Pseudomaonas marginales, Ustilago maydis, and no activity against Pseudomaonas marginales with S. portulacastrum.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PCS-0000540
Title: Formulation development and real time stability studies of herbal oral liquids containing natural sweetener
Category: Pharmaceutics
Section: Research Article
Country: India
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The present research work supports formulation, development of herbal oral liquids containing Withania somnifera, Asparagus racemosus, Ipoamea purga, Glycyrrhiza glabra, Terminalia chebula, Curcuma zedoria, Tinospora cordiofolia, Cyperus rotundus, Tribulus terrestris, and Sida cardifolia as active ingredients and Stevia rebaudiana as natural sweetener. Standardization was carried out using applicable parameters like color, odor, general appearance, taste, pH, viscosity, surface tension, clarity, specific gravity and other additional parameters like microbial count, TLC profile, HPTLC fingerprint, determination of heavy toxic metal ions and pesticide residue. Sweetness potency was determined by taste evaluation method. Effect of aqueous extract of natural sweetener in the formulation was determined by standardization. Use of this natural sweetener is most convenient, acceptable and palatable in sweet formulations.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PB-0000538
Title: Medicinal plants as alternative biocontrol agents in the control of seed borne pathogen Macrophomina phaseolina
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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In a search for plant extracts with potent antifungal activity against plant pathogenic fungi, the methanol extracts of different medical plants effectively controlled the development of plant diseases caused by Macrophomina phaseolina. The methanolic extracts of forty nine plants hexane, chloroform and methanolic extracts were used for the study, among them methanolic extracts of forty eight medicinal plants exhibited varying degrees of inhibition activity against M. phaseolina, extracts of Tephrosia pumila have no activity. Extracts of Avicenia officinales, Cleome viscose, Grewia arborea, Hyptis sueolences, Ocimum sanctum, Peltophorum pterophorus, Sesbanian grandiflora, Terminalia chebula, Tephrosia pumila, Tephrosia villosa, Withania somnifera showed high activity and Terminalia chebula having strong antifungal activity against M. phaseolina even at low concentrations. Chloroform extracts has very low antimicrobial activity where as hexane has no antimicrobial properties.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PHDRS-0000537
Title: In vitro antioxidant activity of Petrospermum acerifolium barks.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Antioxidant activity of ethanolic extract of Petrospermum acerifolium barks was studied for it free radical scavenging property in different in vitro models as 1, 1- Diphenyl – 2 picryl hydrazyl, nitric oxide, superoxide and hydroxyl radical model. The extract shows significant dose dependent free radical scavenging property in all model. The extract showed the presence of high phenolic content suggesting the plant to exhibit antioxidant activity.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PCS-0000535
Title: Formulation and evaluation of zidovudine sustained release matrix tablets
Category: Pharmaceutics
Section: Research Article
Country: India
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The objective of the study was to design oral sustained release matrix tablets of zidovudine using Hydroxy Propyl Methyl Cellulose (HPMC) K4M, Guar Gum and Ethyl Cellulose as the retardant polymers and study the effect of various formulation factors such as polymer proportion, polymer type and effect of filler type on the in vitro release of the drug. Matrix tablets were prepared by wet granulation method and prepared tablets were evaluated for weight variation percentage friability, hardness thickness and in vitro dissolution studies. All the granules and formulations showed compliance with pharmacopieal standards .In vitro release studies revealed that the release rate decreased with increase polymer proportion and hydrophobic polymers retard the drug release more than hydrophilic polymers .The formulations F2 and F8 sustained release of drug for 12 hrs with 96%, 98% release but F5 (15% of HPMC) using MCC as diluent drug releases 10 hours only. Because of swelling property of MCC increased the drug release profile to a small extent due to change in swelling at the tablet surface. The kinetic treatment showed that the mechanism of drug release non-Fickian for HPMC and Ficikian–Diffusion process for guar gum. The developed sustained release matrix tablets of zidovudine with good initial release for first 2hrs(20-25%) and extended the release up to 12hrs can over come the disadvantages of conventional zidovudine tablets.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PHDRS-0000534
Title: Antibacterial activity of leaves of Lagerstroemia speciosa (L) Pers.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Antibacterial activity of ethanol and water extracts of leaves of Lagerstroemia speciosa (L) pers. were tested cup-plate agar diffusion method against Gram positive and Gram negative bacteria. It was observed that all extracts have inhibitory effect, water extract being most effective.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PHDRS-0000533
Title: Antipyretic Activity of Different Fractions of Root Extract of Smilax chinensis Linn. (Liliaceae) in Albino Rats
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Antipyretic effect of chloroform, ethyl acetate and methanol soluble fractions of methanol extract of the roots of Smilax chinensis Linn. was investigated. Animals were given a subcutaneous injection of 10 ml/kg body wt. of 15 % w/v yeast suspended in 0.5% w/v methylcellulose solution which leads to pyrexia. Oral administration of chloroform, ethyl acetate and methanol soluble fractions of methanol extract of the roots of Smilax chinensis Linn. at a dose 50 mg/kg body weight into three groups of animal were shown significantly reduce the elevated body temperature of rat which was compared with standard aspirin (market product) and solvent used.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PCS-0000532
Title: Development and Evaluation of Polysaccharide Based Matrix Tablets of Celecoxib for Colonic Delivery
Category: Pharmaceutics
Section: Research Article
Country: India
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The main objective behind present investigation was development of more appropriate oral colon-specific formulation of celecoxib (COX-II inhibitor, drug which is reported in treatment of colon polyps) using the polysaccharides like gellan gum, pectin and guar gum. The matrix tablets were prepared by wet granulation method using starch paste as binder. The granules were evaluated for angle of repose, Carr’s index, porosity, drug content. Three month stability study, IR and DSC study were done for evaluation of chemical interaction and melting and crystallization endotherm deflection of drug in formulation. Tablets were evaluated for thickness, hardness, drug content, friability and in vitro drug release studies in SGF, SIF and SCF. Optimized formulation was in vivo evaluated by Roentgenography technique. It was found that native gellan gum and combination with pectin based matrix tablets are not appropriate in colon-specific formulations that might be because of highacyl gellan gum and water loving properties of gellan gum and pectin. The combination gellan gum and guar gum (1:1) is found to be suitable as they released the drug only 10.77 % in upper gastrointestinal tract and 98.85% drug released was after 24 hours dissolution study. Result of stability study showed that there is no degradation of celecoxib with gellan gum and guar gum. IR & DSC study suggest that no chemical interaction of celecoxib with gellan gum, guar gum and pectin and no change in crystallization endotherm (Tc) and melting endotherm (Tm) of celecoxib. The in vivo study of optimized formulation showed that matrix tablet formulation passes after two hour from stomach and after six hour from the small intestine without considerable physical changes of the tablet. Third and fourth reading of Roentgenography suggest that the tablet releases the drug for prolong time in colon.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-PRGS-0000531
Title: Antimicrobial Potentialities of Mangrove Plant Avicennia marina
Category: Pharmaceutical and Related General Science
Section: Research Article
Country: India
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In this present study Antimicrobial activity of aerial parts of Avicennia marina were evaluated against the pathogens belong to aquatic, human and plant origin, Soxhlet extraction method used to get the corresponding extracts of hexane, chloroform and methanol. The antimicrobial activities of the organic solvent extracts on the various test microorganisms, including bacteria and fungi investigated using agar well diffusion technique. The length of inhibition zone was measured in millimeters from the edge of the well to the edge of the inhibition zone. Methanol and chloroform extracts exhibited promising antimicrobial activity than hexane extracts. Among all microorganisms studied Erwinia caratovara and Streptococcus mutans showed the considerable growth inhibition with chloroform and methanolic extracts.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-P'Col-0000530
Title: Oral administration of insulin mixed Desmodium gangeticum root aqueous extract reduces oxidative stress mediated by myocardial ischemia reperfusion in isolated rat hearts
Category: Pharmacology
Section: Research Article
Country: India
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Acute hyperglycemia is reported to aggravate myocardial injury mediated by ischemia reperfusion injury (IRI). However, whether hyperglycemia prior or after myocardial ischemia that exacerbate the cardiac injury remains unclear. In this study we aimed to study the effect of insulin (suppose to reduce glucose level) on IRI, when supplemented prior to myocardial ischemia. Not only that we examined whether the delayed release of insulin (to establish hyperglycemia) prior to myocardial ischemia, established by mixing insulin with aqueous extract of Desmodium gangeticum (DG) can reduce IRI by oral route administration. Myocardial ischemia reperfusion injury was created in male Wister rats by Langendroff perfusion apparatus. Rats were divided into 3 groups consist of normal control, ischemia reperfusion control and drug group (drugs given at a dose of 0.5ml, consist of equi molar concentration of insulin and DG at a ratio of 1:1 administered both intra peritoneal and oral route, one hour before the experiment). Cardiac injury was assessed by the release of necrotic marker enzymes in myocardial perfusate and tissue homogenate. Further, hemodynamic parameters and antioxidant enzymes along with plasma concentration of glucose and insulin was used to reassess the functional recovery of myocardium. We observed a significant cardio protection in rat hearts administered orally with insulin mixed DG than other groups, suggesting the significance of delayed release of insulin prior to myocardial ischemia. This finding emphasis that hyper insulin prior to myocardial ischemia can exacerbates the myocardial ischemia reperfusion injury. This study also provides enough evidence for a novel concept of administrating insulin orally through herbal extracts.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: June
Article Id: JPRS-P'Col-0000528
Title: Evaluation of Anticonvulsant activity of methanolic extract of Artocarpus heterophyllus lam. (Moraceae) in mice.
Category: Pharmacology
Section: Research Article
Country: India
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The Artocarpus heterophyllus lam. has been documented as a potent agent for the treatment of convulsions and neurodegenerative disorders. Thus the methnolic extracts of Artocarpus heterophyllus lam. (Moraceae) was investigated for its anti-convulsant property. The methnolic extract of heart wood of Artocarpus heterophyllus (MEAH) at graded doses (250,500mg/kg, po) in mice was assessed using pentylenetetrazole (PTZ), strychnine and maximal electroshock seizure (MES) test. The extract significantly and dose dependently delayed the onset of clonic convulsion induced by pentylenetetrazole, strychnine, and duration of extensor phase in maximal electroshock seizure. MEAH has complex action on central nervous system although it exhibited anticonvulsant activity against PTZ, strychnine and MES induced.