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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PHDRS-0000573
Title: Traditional medicinal uses of Hibiscus rosa-sinensis
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Medicinal and Aromatic Plants ( MAPS ) are the ingredients of herbal drugs, herbal preparations, and herbal medicinal products, besides traditional/ complementary medicines, house hold remedies and nutraceuticals. Over 100 million women world wide are currently using hormonal contraceptives. Hibiscus rosa-sinensis with these drugs, fertility can be suppressed at will, for as long as desired, with almost 100% confidence and complete return of fertility on discontinuation. The efficacy, convenience, low cost and overall safety of oral contraceptives ( OCS ) has allowed women to decide if and when they will become pregnant and to plan their activities. This article highlights some of the traditional medicinal uses, chemical composition, therapeutic evaluation of Hibiscus rosa-sinensis.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000571
Title: Sodium alginate: the wonder polymer for controlled drug delivery
Category: Pharmaceutics
Section: Review Article
Country: India
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The objective of this paper is to discuss the potential of sodium alginate as a biopolymer in the formulation development and its allied applications. There is a growing trend in pharmaceutical in food industry to avoid the harsh condition in the preparation for administration to the body or for the storage purpose as it induce the side effects, instability or loss of therapeutic effect of the medicament. The sodium alginate is a versatile functional biomaterial for viscosity enhancement, stabilizer, matrixing agent, encapsulation polymer, bioadhesive and film former in transdermal and transmucosal drug delivery. The present article reviews sources, preparation, properties, crosslinking methodology, compendial standards, methods utilized for preparation of drug delivery systems using sodium alginate and its potential applications.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PHDRS-0000604
Title: Antifeedant Activity of Selected Ethno-botanicals used by Tribals of Vattal Hills on Helicoverpa armigera (Hübner)
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Phytochemicals, especially botanical insecticides are currently of interest because of their successful application in plant protection as potential biocontrol agents. Biological activity of leaf aqueous extract of twenty five medicinal plants were evaluated against the VI instar larvae of gram pod borer Helicoverpa armigera (Hübner), (Lepidoptera: Noctuidae). Antifeedant activity of leaf aqueous extracts of Abutilon indicum, Acalypha fruticosa, Achyranthus aspera, Adhatoda zeylanica, Aegle marmelos, Aerva lanata, Albiziza amara, Andrographis lineaeta, Andrographis paniculata, Azadirachta indica, Cardiospermum halicacabum, Cassia tora, Catharanthus roseus, Datura metal, Gymnema sylvestre, Melia azedarach, Ocimum canum, Ocimum sanctum, Pergularia daemia, Plectranthus coleoides, Solanum nigrum, Solanum surattrense, Solanum trilobatum, Tribulus terrestris, Vitex negundo were evaluated in this study. Preliminary screening after 24h of exposure to leaf aqueous extracts of the selected plants at a concentration of 1,000 ppm exhibited significant larval mortality rate. The percentage mortality rate varied considerably between 11.8 and 78.9. The mortality rate was observed in the decreasing order of M. azedarach > A. indica > S. trilobatum > A. paniculata > A. marmelos > A. lineata > S. surattrense > C. roseus > A. zeylanica > A. fruticosa > D. metal > S. nigrum > O. canum > P. coleoides > O. sanctum > P. daemia > A. amara > G. sylvestre > C. halicacabum > V. negundo > A. indicum > C. tora > T. terrestris > A. aspera > A. lanata against the larvae of H. armigera. The results imply that leaf aqueous extract of M. azedarach, A. indica, S. trilobatum, A. paniculata, A. marmelos, A. lineata, S. surattrense, C. roseus, A. zeylanica, A. fruticosa and D. metal can potentially be used as eco-friendly pest control agents against the larvae of H. armigera.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000594
Title: Formulation of bilayer tablet containing metoprolol succinate and amlodipine besylate as a model drug for antihypertensive therapy
Category: Pharmaceutics
Section: Research Article
Country: India
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The purpose of the present work was to develop an optimized bilayer tablet for antihypertension patients using Metoprolol succinate and Amlodipine besylate as a model drug candidate by optimization technique. A 32 factorial design was employed in formulating bilayer tablet with individual release layer i.e. sustained release layer and immediate release layer. The independent variables selected both cases HPMC(X1), Starch 1500 (X2) and SSG (X1), MCC (X2), respectively. Two dependent variables were considered: t50 (Y1), Q12 (Y2) and t50 (Y1), Q2 (Y2), respectively. The main effect and interaction terms were quantitatively evaluated using mathematical model. Bilayer tablets were evaluated for thickness, hardness, friability, drug content and in vitro dissolution studies. The drug release of Amlodipine besylate and Metoprolol succinate depicted non-fickian diffusion and Super Case II transport mechanism, respectively.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-QA-0000580
Title: Chemical composition, pharmacological activities of Eclipta alba
Category: Quality Assurance
Section: Review Article
Country: India
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World Health Organization appreciated the importance of medicinal plants for public health care in developing nations. Eclipta alba (Bhringaraja ) having important role in the traditional Ayurvedic and Unani systems of holistic health and herbal medicine of the east. The principal constituents of Eclipta alba are coumestan derivatives like wedololactone[1.6%], demethylwedelolactone, desmethyl-wedelolactone- 7glucoside and other constituents are ecliptal, ß-amyrin, luteolin-7-O-glucoside, hentriacontanol, heptacosanol, stigmasterol. All the parts of Eclipta alba and chemical constituents are used as anticancer, antileprotic, analgesic, antioxidant, antimyotoxic, antihaemorrhagic, antihepatotoxic, antiviral, antibacterial, spasmogenic, hypotensive, ovicidal, promoter for blackening and growth of hair. This article highlights chief constituents their biological activities, uses of various parts, pharmacological activities, toxicity and clinical studies of Eclipta alba.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-HPh-0000598
Title: The world’s worst aquatic plant as a safe cancer medicine “Antitumor activity on melanoma induced mouse by Eichornia crassipes: in vivo studies”
Category: Hospital Pharmacy
Section: Research Article
Country: India
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Water hyacinth (Eichornia crassipes) is listed as one of the most productive plants on earth and is considered the world’s worst aquatic plant. Water hyacinths are a severe environmental and economic problem in all of the gulf coast states and in many other areas of the world with a sub-tropical or tropical climate. In spite of all these by our present study we can say “the worlds worst aquatic plant as a safe cancer medicine”. The in vivo growth response of a transplantable mouse melanoma with reference to 50% methanolic leaf extract of Eichornia crassipes (water hyacinth) was screened for its tumor inhibition potential by using B16F10 in vivo melanoma tumor bearing hybrid mice models (from Swiss albino female and C57BL male). The cell line was maintained in vivo in the department of research, Jawaharlal Nehru Cancer Hospital. Along with the standard diet the mice were treated with a daily oral dose of 200mg/kg body weight and 500mg/kg body weight of 50% methanolic extract Eichornia crassipes. On the other hand when these tumors has been subjected to herbal therapy followed by radio therapy, 4Gy in 3 fractions, revealed that the tumor inhibition is well appreciated by animal subjected to 500 mg/kg body weight followed by 200mg/kg body weight. The in vivo tumor regression was analyzed on day 1st-5th, 6 th-10th, 11th-16th and 17th-20th. The observations revealed that tumor volume of test groups decreased when compared with control groups.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000597
Title: Preparation, physicochemical characterization, dissolution and formulation studies of irbesartan cyclodextrin inclusion complexes: Comparison between ß-CD & HP-ß-CD
Category: Pharmaceutics
Section: Research Article
Country: India
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Evaluation of inclusion complexes of irbesartan with ß-cyclodextrin and hydroxypropyl-ß-cyclodextrin, for dissolution properties and its tablet formulation were studied. Phase solubility curve was A L type for evaluation of stoichiometry. The prepared complexes were characterized by Fourier-transform infrared spectroscopy, differential scanning calorimetry and powder x-ray diffraction studies. The result of present findings clearly indicates maximum improvement in dissolution of irbesartan with the complex prepared with hydroxypropyl-ß-cyclodextrin with the kneading method. Various dissolution parameters point out the significant difference between the release profile of pure irbesartan and its complexes especially with hydroxypropyl-ß-cyclodextrin. The more hydrophilic nature of hydroxypropyl-ß-cyclodextrin might be responsible for better complexation and greater solubility of irbesartan. Even formulation studies too, the hydroxypropyl-ß-cyclodextrinirbesartan complex showed a better dissolution profile over ß-cyclodextrin.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-ND-0000596
Title: GC-MS analysis of terpenoids from Eranthemum roseum (Vahl) R. Br.
Category: Natural Drugs
Section: Research Article
Country: India
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This works describes the simplest method for the identification of terpenoids and steroids from roots of Eranthemum roseum (Vahl) R.Br. (Acanthaceae), a medicinal plant widely used in India. By using gas chromatography coupled to mass spectrometry (GC-MS), six terpenoids and steroids were identified, all of them reported for the first time in Eranthemum roseum.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000595
Title: Preparation and characterization of ofloxacin non-ionic surfactant vesicles for ophthalmic use
Category: Pharmaceutics
Section: Research Article
Country: India
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Ofloxacin is a fluorinated 4-quinolone antibiotic which is used in the treatment of ophthalmic ailments like infections, inflammations, conjunctivitis, blepharitis, iritis, corneal ulcer etc. Commercially, ofloxacin eye drop solution is available and it is quite easy for the administration. However, the product has drawback of poor bioavailability due to several factors such as tear production, non-productive absorption, transient residence time, and impermeability of corneal epithelium. In order to improve the bioavailability, residence time and longer duration of action, an attempt was made to formulate the non ionic surfactant vesicle and characterized. In the present study, the nonionic surfactant vesicles were prepared by lipid film hydration method using span 60 and cholesterol with various molar ratios and characterized for entrapment efficiency, in-vitro drug release, surface charge, rheological character, physical stability, minimum inhibitory concentration, in-vivo drug release and ocular irritation were conducted. The span 60: cholesterol in molar ratio of 100:60 showed higher entrapment of drug and released 73.77 % at 10th h and the availability of drug in the aqueous humor was 4.373μg/ml (Cmax), confirmed by HPLC method. The histopathology study also confirmed the safe use of niosomes. Study may be concluded that the non-ionic surfactant vesicles formulated with span 60 and cholesterol in a molar ratio of 100:60 showed potential approach to improve the ocular bioavailability of ofloxacin for the prolonged period of time.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000593
Title: Formulation and in-Vitro evaluation of mesalamine matrix tablets using chitosan for colonic drug delivery
Category: Pharmaceutics
Section: Research Article
Country: India
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The objective of the present study is to develop colon targeted drug delivery system by using Chitosan as a carrier for Mesalamine. Matrix tablets containing various excipients and Chitosan were prepared by wet granulation technique using different binder systems. The prepared tablets were evaluated for Hardness, Weight variation, Drug uniformity, Friability and In-vitro Drug release study. The surface of the device of best formulation was coated with Eudragit S100 to ensure that the device was more pH dependent and trigger the drug release only at higher pH. The final product is expected to have the advantage of being biodegradable and pH dependant. The matrix tablet containing Chitosan as a carrier and Hydroxypropyl methyl cellulose as binder was found to be suitable for targeting mesalamine for local action in the colon as compare to other matrix tablets containing different binders. Matrix tablets containing Chitosan released 97-99% of mesalamine in simulated colonic fluid. The stability study for prepared tablets at 40oC/75% relative humidity for three months showed no significant change in In-vitro drug release pattern. The results of in-vitro study indicate that matrix tablets containing Chitosan as carrier and Hydroxypropyl methyl cellulose as binder are most suitable to deliver the drug specifically in colonic region. The final formulation of mesalamine for colonspecific drug delivery gives pH, time and enzyme controlled release.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-ND-0000591
Title: Isolation of Phytoconstituents from the leaves of Murraya koenigii Linn
Category: Natural Drugs
Section: Research Article
Country: India
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Fractionation of petroleum ether partitioned ethanol extract and crude petroleum ether extract of the leaves of Murraya koenigii Linn (Rutaceae) led to the isolation of 5,8-dimethyl furanocoumarin (1) and 1-al, 3[6’, 6’ dimethyl 5-hexene] carbazole (2) and b-sitosterol (3). Their structures were elucidated by spectroscopic methods such as UV, IR, NMR and LCMS. All the compounds were isolated for the first time from this plant.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PHDRS-0000589
Title: Evaluation of anti-inflammatory activity of Cassia fistula and Ficus benghalensis
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The aim of present study was to evaluate the anti-inflammatory property of aqueous extract of leaves and fruits of Cassia fistula and aerial roots of Ficus benghalensis in experimental animals. The anti-inflammatory activity was evaluated using digital plethysmometer (UGO Basile, Italy 7140). The study was carried out by using doses of 100-500 mg/kg. The preliminary pharmacological screening of the extract showed significant dose dependant anti-inflammatory profile.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000588
Title: Isolation And Physicochemical Characterization Of Bora Rice Starch From Assam As Pharmaceutical Excipients
Category: Pharmaceutics
Section: Research Article
Country: India
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Physicochemical properties of starch isolated from fruit of Assam Bora rice (Oryza sativa, family Gramineae) have been characterized. Amylose content was found to be nil. The starch granules are polygonal to spherical in shape. The granules exist as single entities. Degree of crystallinity of Assam Bora rice starch is significantly higher than potato starch, which reflects its resistance towards enzymatic hydrolysis during digestion in gastrointestinal tract, which also reflect its pharmaceutical use in controlled drug deliver system. Assam Bora rice starch can be used in colon targeted drug delivery system.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000587
Title: Formulation and evaluation of fast dispersible tablets of aceclofenac
Category: Pharmaceutics
Section: Research Article
Country: India
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Aceclofenac a non-steroidal anti-inflammatory drug, used in posttraumatic pain and rheumatoid arthritis. Aceclofenac fast-dispersible tablet have been prepared by direct compression method using microcrystalline cellulose as a direct compressible vehicle. Croscarmellose sodium and polyplasdone xl-10 were used as a superdisintegrants for the formulation. The disintegration time and dissolution parameter (t50% and t80%) decreased with increasing the concentration of polyplasdone. Those tablets were evaluated for weight variation, hardness, disintegration time, friability and dissolution.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000586
Title: Evaluation of seed mucilage of Vigna mungo (L.) as a binder in tablet formulations
Category: Pharmaceutics
Section: Research Article
Country: India
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The present work reports extraction of seed mucilage of Vigna mungo. Physiochemical characterization such as swelling index, hydration capacity, powder porosity, loss on drying, pH and viscosity were studied. The seed mucilage of Vigna mungo has been evaluated for its granulating and binding properties in tablets, using paracetamol as a model drug. The seed mucilages of Vigna mungo was used in four different concentrations- 2.5, 5.0, 7.5 and 10%w/w. The granules were prepared by wet granulation technique. The prepared granules were evaluated for percentage of fines, average particle size, compressibility index and flow properties. The properties were compared with starch, which was used as a standard binder at 10% w/w concentration. The tablets were prepared and evaluated for hardness, friability, content uniformity, disintegration time and in vitro dissolution profiles. They had good physicochemical properties, and the drug release was more than 80% within 2h. All the formulations (F1, F2, F3, and F4) were subjected to stability studies for three months at 40°C temperature and with RH 75±5%, only F1 and F2 showed stability with respect to release pattern and other parameters. Hence, 2.5% and 5% concentrations of mucilage of Vigna mungo can be considered as ideal concentrations for preparation of tablets.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000585
Title: RP-HPLC Estimation of Aspirin and Atorvastatin Calcium in Combined Dosage Forms
Category: Pharmaceutics
Section: Research Article
Country: India
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A reverse phase high performance liquid chromatography method was developed for simultaneous estimation of aspirin and atorvastatin calcium in capsule formulation. The separation was achieved by RP-18 column and methnol:water pH 6.0 (60:40v/v) as eluent, at flow rate 1.0 ml/min. Detection was carried out at 242nm. The retention time of aspirin and atorvastatin calcium was found to be 1.98 and 7.99 min, respectively. The method was validated for linearity, accuracy and precision. Linearity for aspirin and atorvastatin calcium were in the range of 4-20 μg/ml. The developed method was found to be accurate, precise, and selective for simultaneous estimation of aspirin and atorvastatin calcium in capsules.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PHDRS-0000584
Title: In vitro cytotoxic and anticancer activities of Curculigo orchioides Gaerten. rhizomes
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The rhizomes of the plant Curculigo orchioides Gaerten. was extracted with methanol by Soxhlet extraction. The extracts were vacuum dried and subjected to cytotoxic and anticancer activities on cultured cell line. Preliminary phytochemical screening was performed to identify the different phytoconstituents. From the results it was evident that the plant C. orchioides neither acts as an anti cancer or cytotoxic agent.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000583
Title: Effect of alkaloidal fraction of Elaeocarpus ganitrus Roxb. seeds on murine in vitro immune parameters
Category: Pharmaceutics
Section: Research Article
Country: India
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The alkaloidal fraction of Elaeocarpus ganitrus seeds (EGAF) was prepared and evaluated for in vitro effects on murine cells for release of immune mediators and cell proliferation. The EGAF was tested at concentrations ranging between 6.5-832μg/ml. The release of mediators assayed from peritoneal exudates cells (PEC) include nitric oxide (NO), superoxide (NBT reduction), lysosomal and myeloperoxidase. The fraction was also evaluated for cell proliferation in sulforhodamine B (SRB) assay on murine PEC, splenocytes and bone marrow cells. The data was statistically compared by using one way ANOVA followed by Dunnet’s multiple comparisons test. The fraction showed significant stimulation (P<0.05) of NBT reduction, NO release and myeloperoxidase activity of PEC cells. The effect on lysosomal enzyme activity was not significant. Significant proliferation (P<0.05) was observed in SRB assay with PEC and bone marrow cells. The effect of EGAF was not significant on proliferation of splenocytes. Positive control, phytohaemagglutinin showed stimulation of release of all the tested mediators and proliferation of immune cells. In conclusion, the EGAF showed in vitro stimulation of immune mediators from PEC and proliferation of immune cells.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000582
Title: In vitro-In vivo Correlation (IVIVC): A Review
Category: Pharmaceutics
Section: Review Article
Country: India
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Rapidity in Drug development can be achieved by researchers on finding a mathematical link between bioavailability and dissolution testing which leads to the concept of in vitro - in vivo correlation (IVIVC). IVIVC is a mathematical model that can be used to estimate in vivo behaviour from its in vitro performance. Among all the five levels of correlation, Level A correlation is widely accepted by the regulatory agencies. Biopharmaceutical Classification System (BCS) explains the suitability of IVIVC. Dissolution method design plays a pivotal role in the estimation of correlations. Apparatus qualification and guidelines is other essential parameters in the study of IVIVC. Several factors such as first pass effect, stereochemistry, should be considered while developing IVIVC. In the present scenario, research is focussed in oral novel dosage forms where knowledge of IVIVC is of paramount importance. Applications of IVIVC ranges from drug and product development, their scale up and post approval changes. Hence, IVIVC should be considered as an important tool in drug development.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PHDRS-0000581
Title: Eclipta alba Linn – ‘‘Kesharaja’’ : A Review
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The plant Eclipta alba Hassk [ Asteraceae ] having important role in the traditional Ayurvedic, Unani systems of holistic health and herbal medicine of the east. Eclipta alba Hassk is reported to possess Hepatoprotective, antimicrobial, anti-inflammatory, analgesic, immunomodulatory, antiviral and promoter for blackening and growth of hair. Important source of chemicals is wedelolactone, demethylwedelolactone exhibit antihepatotoxic activities. Hence in view of immense medicinal importance of the plant this review is therefore compile all the information related to Eclipta alba.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PHDRS-0000572
Title: Herbal medicine : Syzygium cumini :A Review
Category: Pharmacognosy and Herbal Drugs related study
Section: Review Article
Country: India
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Plants have provided mankind with herbal remedies for many diseases for many centuries and even to day. They continue to play a major role in primary healthcare as therapeutic remedies in developing countries. In India herbal medicines have been the bases of treatment and cure for various diseases in traditional methods practiced such as Ayurveda, Unani and Sidha . Syzygium cumini ( syn.Eugenia Jambolana ) commonly know as a “ Jamun ” having promising therapeutic value with its various phytoconstituents such as Tannins, Alkaloids, Steroids, Flavonoids, Terpenoids, Fatty acids, Phenols, Minerals, Carbohydrates and Vitamins. Its pharmacological actions like hypoglycaemic, diuretics, analgesic, anti-inflammatory, antiplaque, antimicrobial, antidiarrhoel, antioxidant,gastro-protective and astringent to bowels proven on animal models. Most importantly the studies have shown that it protects against the radiation induced DNA damage and it has significantly decreases the fertilizing capacity of the male albino rats, some clinical trial reports are also available for its antidiabetic activity.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000570
Title: Transdermal Drug Delivery: A Novel Approach to Skin Permeation
Category: Pharmaceutics
Section: Review Article
Country: India
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Transdermal therapeutic systems, or transdermal patches, facilitate controlled release of active ingredients through the skin and into the systemic circulation. Drugs administered through such systems escape first pass metabolism and steady state is maintained similar to a continuous intravenous infusion for up to several days.The transdermal route of drug delivery has attracted researchers due to many biomedical advantages associated with it. However, excellent impervious nature of skin is the greatest challenge that has to be overcome for successfully delivering drug molecules to the systemic circulation by this route. Few pharmacologically active substances can currently be administered through transdermal patches and production is technically demanding. Research is ongoing to improve the systems and expand the indications. This article gives a brief overview over principles behind transdermal drug delivery, as well as the advantages and disadvantages of transdermal therapeutic systems and the recent innovations in the field of transdermal drug delivery.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PCS-0000569
Title: A review of carbon nanotube: Boon to osteoporosis
Category: Pharmaceutics
Section: Review Article
Country: India
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This review describes the developing potential of carbon nanotubes (CNTs) in osteoporosis. Carbon nanotubes are sheets of graphite rolled up to make a tube. They make ideal artificial scaffolds for bones as the nanotubes are lightweight, very strong and the body doesn’t reject them. The carbon nanotubes are injected into the fractured bone and then the bone can be left to heal. Several chemical groups can be attached to the nanotube to assist with the growth and orientation of hydroxyapatite crystals. In this way, the treatment of bone breakages and fractures will be revolutionized by an injection of carbon nanotubes into the break or fracture. The strength of the nanotubes will hold the bones in place whilst the tissue heals. As this process of bone repair becomes more successful it will become possible that large casts won’t be needed to be worn by the patient as the bone re-grows. The speed of tissue growth will be rapidly increased because the carbon nanotubes provide a scaffold for the new bone to grow back by fusing the bone together, meaning that the mobility of the patient won’t be impaired for the long length of time it usually takes the bone to grow back at the present time.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-P'Col-0000590
Title: Analgesic , Anti-Inflammatory and CNS Depressant Activity of Capparis decidua Edgew Flowers
Category: Pharmacology
Section: Research Article
Country: India
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The aim of the present study was to evaluate the analgesic, anti-inflammatory and CNS depressant property of flowers of Capparis decidua Edgew. in experimental animals. The analgesic activity of aqueous extract was evaluated by Eddy’s hot-plate method and acetic acid induced writhing test. The depressant activity was evaluated by using digital actophotometer. The anti-inflammatory activity was evaluated by using digital plethysmometer (UGO Basile, Italy 7140). The study was carried out by using two different doses (50mg/Kg and 100mg/Kg i.p.) of the aqueous extract of Capparis decidua Edgew. flowers. The preliminary pharmacological screening of the extract showed significant dose dependant analgesic, CNS depressant activity with good anti-inflammatory profile

Journal: Journal of Pharmacy Research , Volume: 2, Issue: August
Article Id: JPRS-PHDRS-0000592
Title: Isolation of Phytoconstituents from the leaves of Bauhinia variegata Linn
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Fractionation of crude petroleum ether extract of the leaves of Bauhinia variegata Linn (Leguminosae) led to the isolation of dotetracont-8, 16,21-triene-13-ol (1), 12,17,18,23,24-pentamethyl dotetracont-13, 17,23-triene-12-ol (2), hexacos-11-en-15, 20-diol (3) and lupeol (4). Their structures were elucidated by spectroscopic methods such as UV, IR, NMR and LCMS. All the compounds were isolated for the first time from this plant.