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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).



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Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-PA-0000640
Title: A new validated RP-HPLC method for estimation of eflornithine hydrochloride in tablet dosage form
Category: Pharmaceutical Analysis
Section: Research Article
Author Affiliation: Department of Pharmaceutical Analysis, Vinayaka Mission’s College of Pharmacy, Vinayaka Missions University, Salem-636008, Tamilnadu.
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A rapid, sensitive and specific RP-HPLC method involving UV detection was developed and validated for determination and quantification of Eflornithine hydrochloride in tablet dosage form.  Chromatography was carried out on a pre-packed Thermo Hypersil C18 (5µm, 250x4.6mm) column using filtered and degassed mixture of Acetonitrile:Buffer (900:100) as mobile phase at a flow rate of 0.8ml/min and effluent was monitored at 210nm. The buffer was prepared by dissolving 6.8gm of potassium dihydrogen orthophosphate in 100ml of water and the pH was adjusted to 5.0 by using O-phosphoric acid.  The method was validated in terms of linearity, precision, accuracy, and specificity, limit of quantification and limit of detection.  The assay was linear over the concentration range of 125mcg-750mcg/ml.  Accuracy of the method was determined through recovery studies by adding known quantities of standard drug to the pre analysed test solution and was found to be 100.30%-101.48% within precision RSD of 0.32 for Eflornithine hydrochloride.  The system suitability parameters such as theoritical plates, resolution and tailintg factor were found to be 9093.00, 1.4 and 1.08 respectively and the LOD and LOQ of Efflornithine hydrochloride were found within the limit(less than 2%).  The method does require only 10 minutes as run time for analysis which prove the adoptability of the method for the routine quality control of the drug.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-PCS-0000639
Title: Modified release dosage form and drug delivery
Category: Pharmaceutics
Section: Review Article
Author Affiliation: L.B. Rao Institute of Pharmaceutical Education & Research, B. D. Rao College Campus, Bethak Road,P.O.:Khambhat.Dist: Anand,Gujarat-388620.
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In past decade great interest got generated on replacing conventional administration of drugs by delivery system which would release effective quantities form a protected supply at a controlled rate over a long period of time. Ideally a drug to provide desired therapeutic action should arrive rapidly at the site of the action (receptor) in optimum concentration, remaining there for desired time, spare other site and get removed from the site, one of the most recent and interesting result of pharmaceutical research is the fact that absorption rate of release from the dosage form . The product so formulated are designed as sustained action, sustained release, prolonged action, depot, retard action, delayed action, that products in most case are similar in appearance.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-P'Col-0000638
Title: Lipid lowering activity of Abutilon indicum (L.) leaf extracts in rats
Category: Pharmacology
Section: Research Article
Author Affiliation: Department of Pharmacology,Institute of Pharmacy and Technology, Salipur, Cuttack – 754202, India
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Lipid lowering effect of the successive extracts of the leaf of Abutilon indicum (L.)  was evaluated in triton and diet induced hyperlipidemic models of wistar albino rats. The ethanolic and water extract at 400mg/kg dose levels inhibited the elevation in serum cholesterol and triglyceride levels on Triton WR 1339 administration rats. The extracts at the same dose level significantly attenuated the elevated serum total cholesterol and triglycerides with an increase in high-density lipoprotein cholesterol in high-fat diet-induced hyperlipidemic rats. The standard dose Atrovastatin in the former and Gemfibrozil in the later studies showed slightly better effects.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-PCS-0000637
Title: Formulation, Optimization and Evaluation of Mometasone Furoate Gel
Category: Pharmaceutics
Section: Research Article
Author Affiliation: Department of Pharmaceutics, S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Ganpat vidyanagar, Kherva, Mehsana-Gozaria Highway, PIN-390 001, Gujarat, India.
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The objective of this work was to develop the semi-solid topical gel formulations of mometasone furoate and study in vitro skin penetration through rat skin. The concentration of carbopol 940, ethanol and propylene glycol in gel formulation was optimized by Box-Behnken statistical screening design. The concentration of carbopol 940 (X1), concentration of ethanol (X2) and concentration of propylene glycol (X3) were selected as independent variables. The flux (j), total amount released at 8 hours (Q8) and enhancement Ratio (ER) were selected as dependent variables. All gel formulations showed good results for different parameters like drug content, pH, viscosity, and spredibility. A marked effect of independent variables (concentration of carbopol 940, ethanol and Propylene Glycol) on mometasone furoate permeation was observed when it was incorporated gel formulations. The values of J, ER and Q8 were strongly dependent on the independent variables.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-PHDRS-0000636
Title: In-vitro Antioxidant Activity of methanolic extract of Aerial Parts of Canna indica L.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Author Affiliation: Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Navi Mumbai400614
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The requirement of compound with antioxidant activity is increasing as there is realization of that formation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been linked in pathogenesis of several human diseases. The herb Canna indica L. is commonly known as Devkali, which is widely used in the indigenous system of medicine for the treatment of diuretic, fevers and dropsy. The aerial parts methanolic extract of the plant was studied for its in vitro antioxidant activity in different methods viz DPPH radical scavenging assay, Nitric oxide scavenging assay, Hydrogen peroxide Assay, Hydroxl radical scavenging Assay. Its free radical scavenging activity was estimated by IC50 value and the values at various concentrations 10 to 100ìg/ml. At 100µg/ml DPPH radical scavenging assay, Hydroxyl radical scavenging assay, Hydrogen peroxide assay and Nitric oxide assay showed maximum inhibition76.70% ,74.36%,  61.37% and 62.84% These results clearly indicate that Aerial Parts of Canna indica is effective in scavenging free radicals and has the potential to be a powerful antioxidant.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-PHDRS-0000635
Title: Antioxidant potential of tamarindus indica seed coat
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Author Affiliation: Rajeev Gandhi college of Pharmacy,Kolar road, Bhopal-462042, M.P., India.
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The study is an attempt to investigate antioxidant activity of ethanolic extract of seed coat of Tamarindus indica by DPPH (2, 2-diphenyl-1-picrylhydrazyl) free radical scavenging method using ascorbic acid as standard. In the present study, the extract of T. indica seed coat was found to possess strong antioxidant activity. This activity of T. indica extract may be attributed to their free radical-scavenging ability. The extent of antioxidant activity of T. indica extract was found significant as compared to standard.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-QA-0000634
Title: Dissolution method development and validation for combination of Cefixime Trihydrate and Erdosteine capsules
Category: Quality Assurance
Section: Research Article
Author Affiliation: Department of Quality Assurance, A.I.S.S.M.S. College of Pharmacy, Pune University, Pune-411014, India.
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The aim of this work was to develop and validate a dissolution test for Cefixime and Erdosteine capsules using spectrophotometric method. The dissolution test conditions established were: 900 ml of 0.05 M Potassium phosphate buffer pH 7.2 adjusted with1 N NaOH as dissolution medium for 45 minutes, using a basket apparatus at a stirring rate of 100 rpm at temperature 370C. UV spectrophotometric method was developed for evaluating drug release namely absorption correction method ( 295 nm is λmax  of  CEF ,where  ERDO has practically nil absorbance,detection of ERDO  was carried out at its  λmax   237 nm) The methods was validated to meet requirements for ICH guidelines.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-PHDRS-0000633
Title: Antimicrobial activity of the root extracts of T. pumila and T. tinctoria on clinical and phytopathogens
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Author Affiliation: Department of Botany, Andhra University, Visakhapatnam-530 003. A.P. India
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Tephrosia is a pantropical genus, known for its varied flavonoids and possesses insecticidal, piscicidal and many therapeutic properties. In the present study the methanolic extracts of the roots of T. pumila and T. tinctoria were examined for their antimicrobial activities. The methanolic root extract of T. tinctoria exhibited better antimicrobial activity than T. pumila. Both the plant extracts have showed good antibacterial properties at different dose levels (100mg/ml- 500mg/ml). Interestingly both the plant extracts have showed considerable activity against tested fungal pathogens except for Candida albicans.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-HM-0000632
Title: Dental Caries and Medicinal Plants –An Overview
Category: Herbal medicine
Section: Review Article
Author Affiliation: CARISM, Professor , Pharmacy, Shanmugha Arts, Science and Research Academy University,Thirunmalisamudram, Thanjavur – 613 402
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Medicinal plants are useful in many diseases dates back from the history. Plants like Acacia leucopholea, Albizzia lebback, Bridalia grandis, Drosera peltata, Erthrina variegata  and   many other  selective plants active against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis and lactobacillus species has been listed  and this review highlight the role of medicinal plants and phytochemicals like flavanoids, polyphenols, terpenes, alkaloids in the treatment of dental caries and infections associated with dental care.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-PC-0000631
Title: Putranjiva roxburghii Seeds: Oil Content and Fatty Acid Composition During Different Stages of Seed Maturity
Category: Pharmaceutical Chemistry
Section: Research Article
Author Affiliation: Putranjiva roxburghii Seeds, Euphorbiaceae, Oil content, fatty acid composition,
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New potential oilseed crops for industrial uses have been considered for agronomic traits and seed oil composition during last decades in different countries. In order to extend the knowledge of phytochemical biodiversity of higher plant lipids, seed fatty acid compositions of Putranjiva roxburghii (Euphorbiaceae) were investigated. This research was conducted to evaluate changes in the contents of oil and fatty acids of P. roxburghii seeds obtained from different maturity stages. Oleic and linoleic acids were found as abundant compounds.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-PHDRS-0000643
Title: Evaluation of Antioxidant potential of selected Mangrove Plants
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Author Affiliation: Department of Botany, Andhra University, Visakhapatnam 530003 (India)
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Antioxidants are vital substances which possess the ability to protect the body from damages caused by free radical-induced oxidative stress. A variety of free radical scavenging antioxidants are found in plants. The purpose of this study was to evaluate the antioxidant activity of methanolic extracts of mangrove plants. Our research indicates that India’s mangrove plants have the potential in scavenging free radicals and can be a vital source of antioxidant phytochemicals. Our results showed that plant extracts showed significant levels of enzymatic and non-enzymatic antioxidants and also exhibited antioxidant capacity.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-PC-0000642
Title: Comparative studies of conventional extraction with microwave assisted extraction of some selected phytoconstituents
Category: Pharmaceutical Chemistry
Section: Research Article
Author Affiliation: Department of Pharmaceutical Chemistry,Sri Padmavathi School of Pharmacy,Tiruchanoor,Tirupati-517503,A.P.,India.
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The traditional techniques of solvent extraction of plant materials require long extraction time and have low efficiency. Moreover, many natural products are thermally unstable and may degrade during thermal extraction. Microwave assisted extraction technique is one of the novel techniques which have been developed for the extraction of phytoconstituents from plants in order to shorten the extraction time, decrease the solvent consumption, increase the extraction yield and enhance the quality of extracts.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: November
Article Id: JPRS-P'Col-0000641
Title: Hypolipidemic Activity of Orthosiphon stamnineus Benth Bark Extract
Category: Pharmacology
Section: Research Article
Author Affiliation: A.S.P.M’s K.T. Patil College Of Pharmacy, Siddharth Nagar, Barshi Road, Osmanabad, (M.S.), India- 413501.
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The American heart association has identified the primary risk factor associated with atherosclerosis as evaluated levels of total cholesterol and triglyceride in the blood. Atherosclereosis, referred to as a “silent killer” is one of the leading causes of death in the developed countries and is on the rise in developing countries like India. Therefore therapists consider the treatment of hyperlipidemia to be one of the major approaches towards decelerating the atherogenic process. Allopathic hyperlipidemic drugs are available at large in the market but the side effects and contra- indications of these drugs have marred their popularity. Recently herbal hyperlipidemics have gained importance to fill the lacunae created by the allopathic drugs. The present study has been carried out to evaluate the antihyperlipidemic effect of plant Orthosiphon stamineus Benth against cholesterol diet induced hyperlipidemia in wister rats. Hydro-alcoholic extract of bark of Orthosiphon stamnineus Benth (HAEOSB) was studied for its in-vivo anti-hyperlipidemic potential using cholesterol diet induced hyperlipidemia model in rats. The result of study indicated that HAEOSB possess significant hypolipidemic activity at doses 500 and 750 mg/kg.