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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-P'Col-00001405
Title: Antihyperglycaemic Activity of Ethanol Extract of Aerva javanica Leaves in Alloxan- Induced Diabetic Mice
Category: Pharmacology
Section: Research Article
Country: India
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The antihyperglycaemic activity of ethanol extract of Aerva javanica (EEAJ) leaves was studied by administering three doses of EEAJ (i.e. 100,200 and 400 mg/kg, p.o.) and glyburide (10 mg/kg) to alloxan (70 mg/kg, i.v.) induced diabetic mice. The serum glucose levels and body weights of mice were determined. In acute study the maximum reduction in serum glucose level was observed at 2h, peak at 6h but antihyperglycaemic effect was vanished at 24h. The sub acute study was also carried out which showed maximum reduction in serum glucose level at the dose of 400 mg/kg on 35th day. EEAJ (400 mg/kg) showed increased glucose threshold in non-diabetic and diabetic mice at 60 min after administration of glucose. EEAJ (400 mg/kg) prevented the loss of body weight. The EEAJ (400 mg/kg) showed significantly more hyperglycaemic activity than EEAJ (100 and 200 mg/kg).

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-PHDRS-0000561
Title: Pharmacognostical and Phytochemical Screening of Bauhinia variegata Linn leaves.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Pharmacognostical characters of the leaves of Bauhinia variegata Linn was studied which showed the presence of thin walled epidermis, parenchymatous cells, abundant solitary calcium oxalate crystals, vascular bundles and multicellular covering trichomes. Leaf constant viz., stomatal index -5.27, vein islet number - 8.3, vein termination - 6.6, palisade ratio -7.6 were also studied. Physiochemical parameter such as total ash - 8 % w/w, water soluble ash value-2 % w/w, acid insoluble ash value - 6 % w/w, alcohol extractive value- 8 % w/w, water soluble extractive value -18.4 % w/w and loss on drying - 7 % w/w were also determined. Phytochemical screening showed the presence of steroids, saponins, flavonoids, alkaloids and tannins.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-QA-0000555
Title: Hibiscus rosa sinensis Linn – ‘‘Rudrapuspa'': A Review
Category: Quality Assurance
Section: Review Article
Country: India
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“World Health Organization’’ has recommended that traditional health and folk medicine systems are has proved to be more effective in health problems worldwide. Hibiscus rosa sinensis Linn. is certain to emerge in the near future as a major player in the growing field of herbal health supplements and medicines both in daily self-care and in professionally managed health care system.The principal constituents of Hibiscus rosa sinensis Linn. are flvones. Flvones contain quercetin-3-diglucoside, quercetin-3,7-diglucoside, cyaniding-3,5-diglucoside, quercetin-3-sophorotrioside, kaempferol-3xylosylglucoside, cyaniding-3-sophoroside-5-glucoside and other constituent are cyclopeptide alkaloid, cyanidin chloride, hentriacontane, riboflavin, ascorbic acid, thiamine, taraxeryl acetate, ß-sitosterol , cyclicacids sterculic and malvalic acids. All the parts of Hibiscus rosa sinensis Linn and chemical constituents are used as anti-tumor, antifertility, antiovultory, antiimplantation, anti-inflammatory, analgesic, antiestrogenic, antipyretic, antispasmodic, antiviral, antifungal, antibacterial, hypoglycaemic, spasmolytic, CNS depressant, hypotensive and juvenoid activity. This article compile all the information related to Hibiscus rosa sinensis Linn.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-PCS-0000554
Title: Liposomes: A review
Category: Pharmaceutics
Section: Review Article
Country: India
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Liposomes are microparticulate lipoidal vesicles which are under extensive investigation as drug carriers for improving the delivery of therapeutic agents. Due to new developments in liposome technology, several liposome-based drug formulations are currently in clinical trial, and recently some of them have been approved for clinical use. Reformulation of drugs in liposomes has provided an opportunity to enhance the therapeutic indices of various agents mainly through alteration in their biodistribution. This review discusses the potential applications of liposomes in drug delivery with examples of formulations approved for clinical use, and the problems associated with further exploitation of this drug delivery system.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-PCS-0000568
Title: Phytosomes: a potential phyto-phospholipid carriers for herbal drug delivery
Category: Pharmaceutics
Section: Review Article
Country: India
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The potential uses of large number of herbal drugs are limited due to their poor absorption and poor bioavailability after oral administration. The bioavailability can be improved by formulating a appropriate drug delivery system, which can enhance the rate and the extent of drug absorption across the lipoid biomembrane. Phospholipids based drug delivery system have been found promising for better and effective delivery of drug and providing much appropriate systematic drug delivery. The phospholipid molecular structure includes a water-soluble head and two fat-soluble tails, because of this dual solubility, the phospholipid acts as an effective emulsifier, which is also one of the chief components of the membranes in our cells. “Phytosome” is formed by complexing the polyphenolic phytoconstituents in molar ratio with phosphatidylcholine. Phytosomes are advanced forms of herbal products that are better absorbed, utilized, and as a result produce better drug delivery than conventional herbal extracts. This article reviews the current trends in phytosomes drug delivery.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-PHDRS-0000565
Title: Antiinflammatory Activity of Ethanolic and Aqueous Extracts of Caralluma adscendens
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The aim of present study was to evaluate anti-inflammatory activity of aqueous and ethanolic extracts of whole plant of Caralluma adscendens in rats. The anti-inflammatory activity was evaluated by using Digital Plethysmometer. The study was carried out by using dose of 250 mg /kg of ethanolic and aqueous extract orally. All extract showed significant activity for all dose as compared to diclofenac sodium (10mg/ kg) against carrgenen induced rat paw edema. The percentage inhibition was also noted for both the extract.

Cite this article as: Jadge DR, Naik JB (2009). Anti-inflammatory Activity of Ethanolic and Aqueous Extracts of Carallumaadscendens. Journal of Pharmacy Research 2(7):1228-1229.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-P'Col-0000563
Title: Anti ulcer activity of Naravelia zeylanica leaves extract
Category: Pharmacology
Section: Research Article
Country: India
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The objective of present study is to evaluate the anti ulcer activity of ethanol extract of leaves of Naravelia zeylanica. The ethanol extract of N.zeylanica was investigated for its anti ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats. The antiulcer activity was assessed by determining and comparing gastric volume, free acidity and ulcer inhibition in aspirin plus pylorus ligation induced gastric ulcer model. The number of lesions in HCIEthanol induced peptic ulcer model and mean score value of ulcer inhibition in water immersion stress induced ulcer model. A significant antiulcer activity was observed in all the models. Pylorus ligation model showed significant (P<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. Also extract showed 89.71% ulcer inhibition in HCl- Ethanol induced ulcer and 95.3% ulcer protection index in stress induced ulcer. This present study indicates that Naravelia zeylanica leaves extract have potential anti ulcer activity in the three models tested.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-PCS-0000567
Title: Estimation of cefixime and ornidazole in its pharmaceutical dosage form by spectrophotometric method
Category: Pharmaceutics
Section: Research Article
Country: India
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Two accurate, precise, rapid and economical methods were developed for the estimation of Cefixime and Ornidazole in tablet dosage form. First method is first order derivative spectroscopy, wavelengths selected for quantitation were 311.5 nm for Cefixime (zero cross for Ornidazole) and 290.0 nm for Ornidazole (zero cross for Cefixime). Second method is area under curve method; area under curve in the range of 295.0-285.0 nm (for Cefixime) and 317.0-307.0 nm (for Ornidazole) were selected for the analysis. In both the methods linearity for detector response was observed in the concentration range of 10-50 μg/ml for both, Cefixime and Ornidazole. The proposed methods were successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-PCS-0000566
Title: Formulation and Evaluation of Satranidazole Microspheres For Colon Targeted Drug Delivery
Category: Pharmaceutics
Section: Research Article
Country: India
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The purpose of this research was to develop and evaluate Eudragit based microspheres exploiting pH sensitivity property and specific biodegradability for colon targeted delivery of Satranidazole. Eudragit based microspheres were prepared by oil-in-oil solvent evaporation method using different drug- polymer ratios (1:1 to 1:5), stirring speeds (1200-1400 rpm) and emulsifier concentrations (0.5%-1.0% wt/vol). Differential scanning calorimetry, study of the physical mixtures of drug and polymer revealed no drug-polymer interaction. All formulations were evaluated for particle size and shape, swellability and percentage drug entrapment. The yield of preparation and the encapsulation efficiencies were high for all Eudragit microspheres. The in vitro drug release study of optimized formulation was also performed in simulated gastrointestinal fluids (SGF). The release profile of satranidazole from Eudragit microspheres was pH dependent. In acidic medium, the release rate was much slower; however, the drug was released quickly at pH 7.4. It is concluded from the present investigation that Eudragit microspheres are promising controlled release carriers for colon-targeted delivery of satranidazole.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-PHDRS-0000562
Title: Antibacterial activity of Jasminum grandiflorum Linn leaves
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Extracts of Jasminum grandiflorum Linn (Oleaceae) were screened for their in vitro antibacterial activity by agar diffusion method in comparison with standard antibiotic penicillin. The antibacterial activity of petroleum ether, chloroform, acetone, methanol and aqueous extract of leaves of the plant were studied using Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa as test organism. Out of all extracts tested, petroleum ether, methanol and aqueous extracts were effective against all the four microorganisms. Chloroform extract was only effective against Bacillus subtilis and Pseudomonas aeruginosa. Acetone extract was most effective against Pseudomonas aeruginosa and Escherichia coli.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-PHDRS-0000560
Title: In-vitro Anthelmintic Activity of Seed Extract of Lagenaria siceraria (Molina.) Standley Fruit
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The aim of present study was to evaluate anthelmintic potential of crude extracts of seeds of Lagenaria siceraria (Molina) Standley using Pheretima posthuma as test worms. Various concentrations (10 – 100 mg/ml) of the extracts were tested in the bioassay, which involved determination of time of paralysis (P) and time of death (D) of the worms. Piperazine citrate (10 mg/ml) was included as standard reference and distilled water as control. The results of present study indicated that the methanol and benzene extracts significantly demonstrated paralysis, and also caused death of worms especially at higher concentration of 100 mg/ml, as compared to standard reference Piperazine citrate. In conclusion, the traditional use of seeds of the plant Lagenaria siceraria as an anthelmintic have been confirmed and further studies are suggested to isolate the active principle/s responsible for the activity.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-PHDRS-0000559
Title: Isolation of Phytoconstituents from the leaves of Chenopodium album Linn
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Fractionation of crude petroleum ether extract of the leaves of Chenopodium album Linn lead to the isolation of b-sitosterol (1), lupeol (2) and 3 hydroxy nonadecyl henicosanoate (3). Their structures were elucidated by spectroscopic methods such as UV, IR, NMR and LCMS. Compound 2 and 3 were isolated for the first time from this plant.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-PHDRS-0000558
Title: Butea monosperma (Lam.)Taubert: A Review
Category: Pharmacognosy and Herbal Drugs related study
Section: Review Article
Country: India
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The traditional systems of medicine together with homoeopathy and folklore medicine continue to play a significant role largely in the health care system of the population. Butea monosperma (Palas) belonging to the family leguminaceae grown wildly in many parts of India. The plant is highly uses by the rural and tribal people in curing various disorders. The present paper enumerates various traditional and medicinal utility of the plant and Attempt was made to gather information about the chemical composition and pharmacological aspects of the plant.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-PCS-0000557
Title: An overview on nanocarrier technology- Aquasomes
Category: Pharmaceutics
Section: Review Article
Country: India
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Aquasomes are the nanobiopharmaceutical carrier system contains the particle core composed of nanocrystalline calcium phosphate or ceramic diamond, and is covered by a polyhydroxyl oligomeric film. Aquasomes are spherical 60–300 nm particles used for drug and antigen delivery. Properties like protection and preservation of fragile biological molecules, conformational integrity, and surface exposure made it as a successful carrier system for bioactive molecules like peptide, protein, hormones, antigens and genes to specific sites. Three types of core materials are mainly used for producing aquasomes: tin oxide, nanocrystalline carbon ceramics (diamonds) and brushite (calcium phosphate dihydrate). Calcium phosphate is the core of interest, owing to its natural presence in the body. The brushite is unstable and converts to hydroxyapatite upon prolong storage. Hydroxyapatite seems, therefore, a better core for the preparation of aquasomes. It is widely used for the preparation of implants for drug delivery. It has been reported haemoglobin loaded aquasomes using hydroxyapatite core as potential artificial oxygen carrying system. Conformational integrity of aquasomes exploited as a red blood cell substitutes, vaccines for delivery of viral antigen (Epstein-Barr and Immune deficiency virus) to evoke correct antibody and as targeted system for intracellular gene therapy. Enzyme activity and sensitivity towards molecular conformation made aquasome as a novel carrier for enzymes like DNAses and pigment/ dyes.This report reviews the principles of self assembly, the challenges of maintaining both the conformational integrity and biochemical activity of immobilized surface pairs, and the convergence of these principles into a single functional composition.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 7.
Article Id: JPRS-PCS-0000564
Title: Development of UV-spectroscopic method for nabumetone in tablet formulation
Category: Pharmaceutics
Section: Research Article
Country: India
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Nabumetone is a non steroidal anti-inflammatory drug with good analgesic and anti-rheumatic properties. Various methods for analysis of the same are available but are time consuming and expensive. Here we have developed a new, precise and simple UV spectrophotometric method for estimation of nabumetone from bulk and tablet formulation. The drug obeyed the Beer’s law and showed the regression line (Y = 0.024 X – 0.003) and correlation coefficient 0.9998. It showed absorption maxima at 261 nm; in methanol. The linearity was observed between 5 – 45 μg/mL. The results of analysis were validated by recovery studies. The % recovery was found to be 99.2 – 100.2%. The method was found to be simple, accurate, precise, economical and robust.