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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-PHDRS-0000615
Title: Anti-inflammatory activity of aqueous extract of Cinnamomum tamala leaves by in vivo and in vitro methods
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Cinnamomum tamala (Family- Lauraceae) was used traditionally in the treatment of inflammation but there is no scientific evidence exists to validate the folkloric use of the plant. Thus the present work was aimed at investigating the anti-inflammatory effect of the aqueous extract of Cinnamomum tamala leaves (CTW) by various in vivo and in vitro screening methods. CTW at dose of 100, 200 and 400mg/kg was evaluated in acute inflammation against carrageenan induced paw edema in rats and acetic acid-induced vascular permeability in mice. In vitro anti-inflammatory activity of CTW extract (concentrations 0.2 – 1 mg/ml) was studied by membrane stabilizing activity i.e. red blood cells (RBC’s) exposed to hypotonic solution In vitro experiment was performed in triplicate to minimize the errors. Results were analyzed by One-way ANOVA followed by Dunnett’s test P

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-PC-0000619
Title: Stability-indicating HPTLC method for estimation of dexibuprofen in pharmaceutical dosage form
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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The present work describes a stability-indicating HPTLC method for analysis of Dexibuprofen in bulk and pharmaceutical dosage form. Precoated silica gel 60 F254 plate was used as stationary phase. The separation was carried out using n-Hexane: ethylacetate: glacial acetic acid (7.5:2.5:0.2v/v/v) as mobile phase. The densitometric scanning was carried out at 225 nm. The Rf value for the drug was found to be 0.38. The linearity was obtained in the range 100-350ng /band with correlation coefficients (r2 = 0.9973). The method was validated as per ICH guidelines. Dexibuprofen was subjected to forced degradation by acid, alkali, oxidation and dry heat. The degradation products were well resolved from the pure drug with significantly different Rf values.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-PCS-0000618
Title: Development of Non-Bitter Zolpidem Tartrate Mouth Dissolving Tablet
Category: Pharmaceutics
Section: Editorial
Country: India
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Purpose: Zolpidem tartrate is a centrally acting potent hypnotic agent. It is slightly bitter in taste. In the present study an attempt has been made to prepare bitterless mouth dissolving tablets of Zolpidem tartrate using ion exchange resin Tulsion 335 as a taste masking agent. Method: Ion exchange resinates and tasteless granules were prepared with Tulsion 335 in weight ratio of 1:3. Resinates and granules were evaluated for its taste sensation in human volunteers. Prepared complex was further examined through IR, DSC and XRD curves. The mouth dissolving tablets of both resinates and granules were prepared with two superdisintegrants e.g. crosscarmellose sodium and crospovidone in different concentration. The blend was examined for their flow properties. The tablets were evaluated for physiochemical properties. Pure drug and tablets were also evaluated loss of righting reflux in albino Mice.Results: The tasteless blends having good flow properties. The prepared zero defect mouth dissolving tablets were passed all the official and non-official parameters. The disintegration time was also tested and was found to be less than one minute. A tablet having resinates shows less time for onset of action of drug due to enhanced and fast release of Zolpidem Tartrate. Conclusion: It was concluded that tablets prepared by addition of superdisintegrant crospovidone has less disintegration time, fast and more dug release than those prepared by crosscarmelose sodium; which was also further founded in the in-vivo investigation.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-PA-0000617
Title: Derivative Spectrophotometric Method for Simultaneous Estimation of nicotine and Bupropion Hydrochloride in Synthetic Mixture by Derivative Spectrophotometric Method
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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The use of first order derivative spectroscophotometry allowed simultaneous determination of nicotine and bupropion hydrochloride in fixed dose combination products. The absorbance values at 251.2 nm and 259.8 nm of first derivative spectrum was used for the estimation of nicotine and bupropion hydrochloride, respectively without mutual interference. This method obeyed Beer’s law in the concentration range of 10-30 µg/ml for both nicotine and bupropion hydrochloride. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-PCS-0000611
Title: Indomethacin solid dispersions by kneading method with lactose monohydrate and different polymers.
Category: Pharmaceutics
Section: Research Article
Country: India
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Indomethacin (IM) is one of the most widely used non-steroidal anti-inflammatory active pharmaceutical agent. However, its limited aqueous solubility and poor flowability creates bioavailability and formulation related problems. Role of various water-soluble carriers was studied for dissolution enhancement of a poorly soluble model drug, Indomethacin, using solid dispersion approach. Solid dispersions of Indomethacin with lactose monohydrate and different polymers Polyethylene glycol- 6000(PEG), Hydroxy Propyl Methyl Cellulose (HPMC), Polyvinyl Pyrrolidine (Povidone-30), and Beta Cyclodextrin (BCD) were prepared by kneading method. In the present investigation by keeping the constant amount of lactose monohydrate the effect of different hydrophilic polymers on solubility and dissolution were studied. The prepared solid dispersions were evaluated for content, saturation solubility, and dissolution and flowability parameters. Powdered solid dispersion with lactose monohydrate and used hydrophilic polymers showed approximately 10-20 fold increases in solubility over the pure drug. The all prepared solid dispersions shows improvement in dissolution profile and flowability compared to the raw indomethacin. Thus, the bioavailability of this poorly water-soluble drug and their flowability was greatly enhanced by formulation as solid dispersions with different hydrophilic polymers.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-PCS-0000610
Title: Preparation and evaluation of solid dispersions of cefpodoxime proxetil
Category: Pharmaceutics
Section: Research Article
Country: India
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Solid dispersions (SDs) are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. This technology is mainly applied to improve the solubility of Class II and Class IV drugs. Cefpodoxime proxetil (CP) is chosen as drug as it belongs to Class IV i. e. having low solubility and low permeability (Solubility: 400 µg/ml). SDs were prepared by using PVPK 30 as carrier/polymer by varying Drug: Polymer ratio (D: P). Two techniques were used for preparing SDs viz Kneading and Spray drying. Prepared SDs were evaluated for drug content, Saturation solubility, pH dependent solubility, D0 value, and dissolution studies. From results of above studies, optimized SDs were decided which were further characterized for SEM, XRD, DSC and finally antimicrobial activity Studies. From the results obtained from above studies, it can be concluded that, solubility and dissolution of CP was improved as compared to pure drug and physical mixtures. Hence, Solid dispersion technology can be used to improve the solubility of CP.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-PCS-0000609
Title: RP-HPLC method development for determination of pioglitazone hydrochloride from tablets
Category: Pharmaceutics
Section: Research Article
Country: India
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A simple, rapid and precise reversed-phase HPLC method has been developed for the quantitation of pioglitazone in tablet on a C-8 (mm) column using a mobile phase consisting acetonitrile-water(60:40 %v/v) adjusted to ph 6.0 with 0.1 % v/v glacial acetic acid solution at a flow rate of 1 ml/min and detection at 266 nm. The retention time of pioglitazone have been found to be 6.40 min and recoveries were between 98.82- 101.21 %. Validation of the proposed method has also been done.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-PCS-0000608
Title: Development and evaluation of novel immediate release tablets of Metoclopramide HCl by direct compression using treated gellan gum as a disintegration-accelerating agent.
Category: Pharmaceutics
Section: Research Article
Country: India
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The aim of this study was to compare the disintegrants efficiency of the three superdisintegrants (Ac-Di-Sol, Polyplasdone XL and Explotab) and also to compare disintegrant properties and disintegrant efficiency of agar (AG) and gellan gum (GG) with treated agar (TAG) and treated gellan gum (TGG) by formulating metoclopramide HCl immediate release tablets by direct compression method. In the present investigation, we have attempted first time report on TGG as disintegrant. Disintegration efficiency of powder disintegrants compared by swelling & hydration capacity of disintegrants. While efficiency of disintegrants in tablets compared by various test like disintegration time, dissolution test, wetting time & maximal water uptake study of metoclopramide HCl immediate release tablets. The rapid disintegration observed for the TAG and TGG containing tablets due to high-porous structure of treated form of disintegrants which confirmed by photomicroscope study. Comparing three classes of superdisintegrants represented by Ac-Di-Sol, Polyplasdone XL and Explotab with AG, TAG, GG and TGG. The treated form of disintegrants (TAG, TGG) in which TAG was found to be more effective than TGG. The disintegration efficiency was found in following decreasing order Ac-Di-Sol, Explotab, Polyplasdone XL, TAG, TGG, AG and GG.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-PHDRS-0000607
Title: Antiulcer activity of Melia azedarach linn in aspirin induced and pylorus ligated rats
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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In the present study aqueous and alcohol extracts of leaves of Melia azedarach Linn. (Meliaceae) were screened for antiulcer activity in aspirin induced and pylorus – ligated rats. The effect was assessed by parameters like pH, free acidity, total acidity and ulcer index. Aqueous extract and alcohol extract of M. azedarach leaves (250 mg/kg b.w., p.o.) were administered orally. Antiulcer effects were compared with standard drug Omeprazole (20 mg/kg b.w., p.o.). These observations helped us to conclude that aqueous extract (250 mg/kg b.w., p.o.) is endowed with antiulcer property.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-MB-0000601
Title: Antimicrobial activity of Dalchini (Cinnamomum zeylanicum bark) extracts on some dental caries pathogens
Category: Microbiology
Section: Research Article
Country: India
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The objective of the study was to assess the antimicrobial potential of the cinnamon bark with a view of searching a novel extract as a remedy for dental caries pathogens. Acetone, ethanol, methanol and aqueous (cold and hot) extracts of dalchini, the bark of Cinnamomum zeylanicum, were tested against three bacteria and two yeasts causing dental caries using agar well diffusion method. The ethanolic, methanolic and acetonic cinnamon bark extracts showed greater antimicrobial activities than the water extracts against the tested bacteria (Streptococcus mutans and Staphylococcus aureus) and the yeasts (Candida albicans and Saccharomyces cerevisiae) while Lactobacillus acidophilus was resistant to all the five extracts. Of the five extracts of cinnamon bark screened, the acetonic extract showed greater antimicrobial activity than the corresponding water and alcoholic extracts. Strongest antimicrobial activity was observed in the acetonic extract against C.albicans (zone of inhibition 29.30mm and 12.5mg/ml MIC) showing higher inhibition zone than the standard antifungal drug amphotericin B (zone of inhibition 13mm).

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-P'Col-0000600
Title: To study analgesic activity of stem of Musa sapientum linn.
Category: Pharmacology
Section: Research Article
Country: India
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Musa sapientum Linn (Musaceae) commonly called ‘Kela’ in Hindi (English: Banana) is extensively cultivated throughout India. Till date different parts of Musa sapientum have been studied for anti ulcerogenic, hypoglycemic, hypolipidemic, antimicrobial, antihypertensive, wound healing, antacid, diuretic and antiestrogenic activities .The pill extract of banana was found to have analgesic property. But, there is no evidence in literature for analgesic activity of stem of Musa sapientum. Hence the present investigation was undertaken to study analgesic activity of aqueous (AMS) and ethanolic (EMS) extract of stem of Musa sapientum Linn. using hot plate method and tail immersion method. AMS and EMS (100mg/kg and 200mg/kg, i.p) significantly increased reaction time as compared to vehicle treated group. Maximum analgesic effect was observed at 30 min. interval for 100 mg/kg and 200 mg/kg, i.p. (P = 0.01). The present study indicates that AMS & EMS have central analgesic action.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-P'Col-0000599
Title: Anti-nociceptive Activity of the Fruits of Swietenia macrophylla King.
Category: Pharmacology
Section: Research Article
Country: India
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Fruits of Swietenia macrophylla King (Meliaceae) are used in Malay folk medicine as pain killer. The antinociceptive effect of ethanol and aqueous extracts was assessed by oral administration in acetic acid induced writhing, tail immersion and hot plate tests in mice. The ethanol extract 200 mg/kg treated group reduces the number of writhing on animal model, showed powerful anti-nociceptive effect (P < 0.01). Also the significant (P < 0.01) analgesic activity of S. macrophylla ethanolic extract at the dose of 200 mg/kg was further confirmed by tail-flick response and hot-plate response (P < 0.01).S. macrophylla extract produce analgesic in chemical and thermal pain models through a mechanism partially linked to either lipooxygenase and/or cyclooxygenase via the arachidonic acid cascade and/or opioid receptors. Our results corroborate the analgesic effects of S.macrophylla, and confirm its traditional use for treating pain.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-PB-0000606
Title: Proteolytic Enzymes of Some Laticiferous Plants Belonging to Khandesh Region of Maharashtra, India
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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To identify the potent source of protease that can be used as ideal milk clotting enzyme(s) in handmade dairy products of latex obtained from twenty one plant species belonging to Northern (Khandesh) region of Maharashtra, India, was analyzed for caseinolytic activity, milk clotting activity, gelatinolytic activity and peroxidase activity. Highest caseinolytic activity was noted in latex of Pedilanthus tithymaloides (L.) Poit., followed by Ficus carica L., Calotropis gigantea (L.) R. Br. and Carica papaya L. Moderate caseinolytic activity was seen in Euphorbia milii Desmoul., Ficus hispida L.f. and Calotropis procera (Ait.) R. Br., and remaining plants possess less activity. Milk clotting activity was found highest in stem latex of Euphorbia nivulia L., followed by Carica papaya L., Ficus carica L., Calotropis procera (Ait.) R. Br., and Tabernaemontana divaricata (L.) R. Br. Six plants showed moderate milk clotting activity, however, such activity was not noticed in remaining six plants. Highest gelatinolytic activity was found in the latex of twelve plants, lowest in four plants and remaining plants were devoid of such activity. The result of present study reveals some promising identification of few laticiferous plant species for their possible proteolytic activity. A comparative account on enzymes viz., caseinolytic activity, milk clotting activity, gelatinolytic activity and peroxidase activity are discussed in the present research.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-P'Col-0000605
Title: Studies on Hepatoprotective Activity of Ethanolic Extracts of Fruit pulp of Aegle marmelos (L.) Corr.
Category: Pharmacology
Section: Research Article
Country: India
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A number of ethnomedicinal plants and herbal preparations are used in traditional system of medicine for the management of hepatic disorders. However, many of them have not been investigated to volarize the traditional claims. Aegle marmelos (L.) Corr. is widely used in the treatment of hepatitis in folk medicine. Owing to its overwhelming ethnomedicinal significance, an attempt has been made to investigate effect of fruit pulp of A. marmelos for hepatoprotective activity. Hepatoprotective activities of ethanolic and aqueous extracts of fruit pulp of A. marmelos were examined against CCl4 induced liver damage in mice using silymarin as control. Enzyme activities of Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT) and Alkaline Phosphatase (ALP) were analyzed. Results indicate that ethanolic and aqueous fruit pulp extracts of A. marmelos had moderate to significant activity over CCl4 treatment as compared to the control. Results of the present investigation suggest that CCl4 induced liver damage in rats can substantially be ameliorated by treatment of ethanolic extracts from fruit pulp of A. marmelos. Also the study confirms the claim on this plant as a potential hepatoprotective agent in the traditional medicine.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-PCS-0000603
Title: Formulation Optimization of Sustained Release Pellets of Itopride Hydrochloride using Different Polymers
Category: Pharmaceutics
Section: Research Article
Country: India
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Purpose: The purpose of this study was to formulate sustained release pellets formulation and to investigate release profiles by using different polymers for the coating of pellets.Methods: The Itopride hydrochloride loaded pellets were coated with different polymers (ethyl cellulose and kollicoat SR 30 D) at different coating levels. Drug release from pellets as well as physical parameters such as size distribution, bulk density and tapped density etc. were evaluated. Results: Drug release from the pellets strongly depends on type of polymers and coating variables such as coating levels etc. The various polymers show different release mechanism. The sustained-release matrix pellets with good physical, mechanical and technological properties were obtained with a ethylcellulose polymer of coating level of 10 % (w/w). A comparative kinetic study of the present pellets and commercial Ganaton OD capsules was established. The value for the similarity factor (f = 77.6) suggested that the dissolution profile of the present two sustained-release oral dosage forms are similar. Conclusion : The type of polymer coating strongly affects the film microstructure and thus, the release mechanism and rate from pellets coated with different polymer.

Journal: Journal of Pharmacy Research , Volume: 2, Issue: 9.
Article Id: JPRS-PHDRS-0000602
Title: In - vitro antioxidant activity of Achyranthes aspera L.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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In the present study, antioxidant potential of the methanol extract of the leaves and roots of Achyranthes aspera Linn. was evaluated by using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay. The extract showed antioxidant activity in dose dependent manner. In DPPH scavenging assay the IC50 value of the leaves and root extracts were found to be 241.86μg/ml and 129.91μg/ml respectively, the IC50 value of the reference standard ascorbic acid was 7.81 μg/ml. This study revealed that methanolic extract of root possesses potent anti-oxidant activity than methanolic extract of leaves.