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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
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Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PHDRS-0000771
Title: Clitoria ternatea (L.): Old and new aspects
Category: Pharmacognosy and Herbal Drugs related study
Section: Review Article
Country: India
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Clitoria ternatea (L.) native to tropical Asia is a perennial, twining herbal medicinal plant, has a long tradition of use as a memory enhancer and anxiolytic agent. Various constituents are found in different parts of the plant. The active chemical constituents reported from this plant are tannins, resins, starch, taraxerol, taraxerone, alkaloids, flavonoids, saponins, proteins, anthocyanins and carbohydrates. In traditional medicine, the plant is used in treatment of jaundice, migraine, throat, eye infections, skin diseases, asthma, swollen joints, ear-ache, eruptions, fever, urinary tract infections, constipation, snake-bites, head-ache, indigestion, leprosy and central nervous system disorders. Its various extracts possess reported number of pharmacological activities such as nootropic, anxiolytic, anti-convulsant, sedative, anti-pyretic, anti-inflammatory, anti-diabetic, anti-oxidative, anti-stress, immunomodulatory, larvicidal, proteolytic, antihelmintic, diuretic, anti-microbial and memory enhancing. The present review is therefore, an effort to give a detailed survey of the literature on its pharmacognosy, phytochemistry, and its traditional uses along with special emphasis given on pharmacological activities.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-P'Col-00001024
Title: Isolation and characterization of an antioxidant protein from Turmeric (Curcuma longa L.) peel waste: A new biological source
Category: Pharmacology
Section: Research Article
Country: India
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The antioxidant protein from turmeric (Curcuma longa L.) peel waste was purified by successive gel permeation chromatography. Homogeneity of the protein was confirmed by its movement as single band in SDS-PAGE with an apparent molecular mass of approximately 20kDa. The protein was stable even after heating at 600C for 30min and showed 84% antioxidant activity in terms of inhibition of hydroxyl radical formation. The antioxidant activity was significantly reduced at 900C showing only 22% inhibition of hydroxyl radical formation. The protein when exposed to UV radiations at 345nm was stable till 20min showing 91% inhibition and upon increase in exposure time a significant decrease in the antioxidant activity was observed with only 11% inhibition of hydroxyl radical formation. Treatment of erythrocyte membranes with ferrous sulphate ascorbate as pro-oxidant inhibited the Na+K+ATPase enzyme activity. There was 82% decrease in the ATPase activity when compared to the untreated erythrocyte membrane. Incubating the membrane with antioxidant protein restored the ATPase activity by three folds. The mechanism of antioxidant activity of the antioxidant protein could probably be by counteracting and or quenching of reactive oxygen species. We report the purification and characterization of a potent antioxidant protein from turmeric peel waste.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PA-00001018
Title: Quantification of â- sitosterol from barks of three Acacia species by HPTLC
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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Acacia nilotica, Acacia leucophloea and Acacia farnesiana (Family- Mimosaceae) are the some of the Acacia species, used in Ayurveda and Ethnobotany mainly for the treatment of diarrhoea, liver disorders and inflammation. â-sitosterol is a phytosterols which is ubiquitous throughout the plant kingdom and reported to possess wide range of biological activities. In the present work the petroleum ether extracts of the selected plant species were quantified for â-sitosterol. Petroleum ether extracts were dissolved in methanol and the quantification of analytes has been carried out using mobile phase Toluene: Methanol (9:1 v/v) on Precoated aluminium Silica gel plates (Merck) and densitometric determinations was carried out after derivetization with anisaldehyde sulphuric acid reagent and plates were scanned at 525 nm by absorption / reflection mode. Calibration curve was prepared and the amount of β- sitosterol in the extracts has been estimated by comparing the respective peak areas of the standard. The linearity of standard was found in the concentration of range of 100-500 ηg. The correlation coefficient value was 0.99 High Performance Thin Layer Chromatography (HPTLC) method has been developed and validated for the analysis of β- sitosterol in bark of Acacia species. This was found to be faster, reliable and sensitive for quantification of â- sitosterol.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PA-00001015
Title: Application of TLC - densitometry method for estimation of acebrophylline in pharmaceutical dosage forms
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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A rapid, accurate and precise HPTLC method has been developed for the estimation of Acebrophylline in Pharmaceutical formulation. In this method standard and sample solutions of Acebrophylline were applied on pre-coated 6 x 10 silica gel 60F254 TLC plate, and developed using chloroform: isopropanol: toluene (8: 1: 1 v/v), as mobile phase. A Camag HPTLC system comprising of Camag Linomat -5-applicator, Camag twin trough chamber, Camag TLC-3 scanner was used for the analysis. The drugs on the plate were scanned at 254 nm. The dynamic linearity range was 1µl, 2µl, 3µl, 4µl & 5µl (1000-5000ng/spot) for Acebrophylline. The method was validated for precision, accuracy and recovery.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-P'Col-00001016
Title: Abrus precatorius Linnaeus: A Phytopharmacological Review
Category: Pharmacology
Section: Review Article
Country: India
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Medicinal plants are being widely used, either as a single drug or in combination in health care delivery system. Medicinal plants can be important source of previously unknown chemical substances with potential therapeutic effects. Abrus precatorius L. is commonly known as Gunja or Jequirity and abundantly available in all throughout the plains of India. Current review finds medicinal uses of leaves, root and seeds of jequirity. It principally contains flavonoids, triterpene glycosides, abrin and alkaloids. The plant have been reported for neuromuscular effects, Dalton’s lymphoma, Alzheimer’s disease, antiepileptic, antimalarial, aanthelmintic activity, antithrombin, antifertility, sperm antimotility activity, renal damage, nephroprotective, immunomodulator, immunostimulatory properties, anti-inflammatory activity and antidiabetic effect. It is now considered as a valuable source of unique natural products for development of medicines against various diseases and also for the development of industrial products. This review gives a bird’s eye view mainly on the pharmacognostic characteristics, traditional uses, phytochemistry and pharmacological actions of the plant.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PA-00001017
Title: Determination of Cefditoren Pivoxil in bulk by RP-HPLC in presence of its degradation products.
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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A reverse phase high performance liquid chromatographic (HPLC) method was developed for the assay of Cefditoren pivoxil in bulk forms and tablet dosage formulations. Isocratic separation was achieved on Nucleosil 100-5 C18 column (250mm×4.6mm i.d.,5mm particle size) using a mobile phase of water: methanol in the in ratio (20:80), pH 6.0 adjusted with 10% v/v ortho phosphoric acid at a flow rate of 1.0 ml/min and UV detection at 256 nm. retention time of 3.65 min with sharp symmetrical peak. The method was validated for specificity, linearity, solution stability, accuracy and precision. Accuracy of the proposed method was ascertained on the basis of recovery studies by standard addition method with standard deviation of 0.347 and coefficient of variation 0.348 suggesting good recovery. The drug was subjected to hydrolysis, oxidation, photolysis and dry heat to apply stress conditions. Complete separation was archived for the parent drug and the degradation products, with overall run time of 15 min with parent compound eluting at approximately at 3.65 min. The method was successfully used for analysis of Cefditoren pivoxil in bulk and tablet dosage form, and subsequent study of stability samples.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PHDRS-00001019
Title: Pharmacognostical and phytochemical studies of a mangrove ( sonneratia caseolaris ) from kochi of kerala state in India
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Mangroves are trees and shrubs that grow in tropical and subtropical tidelands throughout the world. Mangroves are able to thrive salt water inundation because of specialized rooting structures. Many of the mangrove species are a rich source of various important phyto constituents and they are useful in microbial infections. Various parts of mangroves are reported to possess medicinal properties. Sonneratia caseolaris (family Sonneratiaceae) is a true mangrove plant which is reported to be antioxidant and cytotoxic. It is traditionally used as an astringent and antiseptic, sprain poultices, in treating piles and arresting haemorrhage. In the present investigation, an attempt was made to study the Pharmacognostical and phytochemical features of the mangrove species. Pharmacognostic studies of leaf specimen and leaf powder which include morphological and microscopic characters were carried out. The successive extraction of the plant material was done with different solvents and various extracts were subjected for its preliminary phytochemical screening to find out the bioactive compounds present in these species. Phytochemical analysis showed the presence of various phytochemicals of therapeutic significance. The study will provide referential information for the correct identification of the mangrove species.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-P'Col-00001020
Title: Safety evaluation of the ethanol extract of Ammannia baccifera (Lythraceae): assessment of Acute and Subacute toxicity
Category: Pharmacology
Section: Research Article
Country: India
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Ethanolic extract of Ammannia baccifera was screened for its acute and subacute toxicological effects on rats, because the traditional healers of India use this plant to treat various ailments. Acute oral toxicological study of ethanolic extract of A. baccifera revealed that all the animals tolerated the maximum test doses (2000 mg Kg-1 body weight) of the ethanolic extract of A. baccifera and suggested that the extract does not cause any apparent acute toxicity. Thirty days subacute toxicity study of Ammannia baccifera in Wistar rats at the doses of 50, 100, 250 and 500 mg Kg-1 body weight /day respectively, did not produce any significant dose-related changes in hematological, biochemical parameters and histopathology of vital internal organs. Therefore, it is concluded that the ethanolic extract of A. baccifera at the given doses does not produce any significant toxic effect in rats and considered to be safe.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-MB-00001021
Title: Anti-bacterial efficacy of some plants used in folkaric medicines in arid zone
Category: Microbiology
Section: Research Article
Country: India
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The present investigation was undertaken to evaluate in vitro antimicrobial activities of ethanol and aqueous extracts of four plants used in folk medicines in arid zone. In vitro antimicrobial efficacy was assessed by disc diffusion method against Escherichia coli (MTCC 587) Pseudomonas aeruginosa (MTCC 424), Salmonella typhi (MTCC 733), Staphylococcus aureus (MTCC 3160), Streptococcus pyogenes (MTCC 442) and Bacillus cereus (MTCC 430). The most active plants were T. cordifolia and M. azedarach whereas, the least active plant was A. aspera. The most susceptible bacterium was B. cereus and S. aureus. The ethanol extract of T. cordifolia exhibited highest zone of inhibition and activity index against B. cereus (IZ= 18 mm; AI= 0.75) with low MIC values (0.078 mg/ml) whereas, petroleum ether extract of M. azedarach was found to effective against S. aureus (IZ= 18 mm; AI= 0.75) with low MIC values (0.078 mg/ml). However, aqueous extracts of selected plants showed moderate type of antibacterial activity. None inhibitory effect was shown by A. aspera against tested pathogenic bacterial strains. Results of the present investigation indicate that selected plants possess compounds with antimicrobial properties and hence can be exploited for future natural plant based antimicrobial agents.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PHDRS-00001022
Title: Phytochemical and Biological Investigations of Pterospermum acerifolium Wild Bark.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Bioactivity guided phytochemical investigations of crude methanolic bark extract of Pterospermum acerifolium wild resulted in the isolation of three compounds for the first time such as (1) pentadec-11-enoic acid methyl ester, (2) oleanolic acid and (3) â-sitosterol under silica gel CC and preparative TLC. The structures of the compound were elucidated by extensive spectroscopic studies (1H NMR spectroscopy). The petroleum ether, carbon tetrachloride, dichloromethane and aqueous soluble partitionate of methanolic extract were subjected to antimicrobial, antioxidant and brine shrimp lethality bioassay. The average zones of inhibition produced by dichloromethane and carbon tetrachloride extract were found to be 13-16 mm and 12-13 mm respectively at a concentration of 400 mg/disc. In the brine shrimp lethality bioassay, LC50 values obtained from the best fit line slope were 0.419, 1.362, 2.232, 1.867 and 2.874 µg/ml for Standard (Vincristine sulphate), petroleum ether, carbon tetrachloride, dichloromethane and aqueous soluble partitionate of methanolic extract respectively. All The four fractions showed significant antioxidant property using 1,1-diphenyl-2-pecrylhydrazyl (DPPH) scavenging assay along with total phenolic content, of which dichloromethane and aqueous soluble partitionate of methanolic extract demonstrated highest activity with IC50 value of 26.5 and 39.0 µg/ml respectively.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PA-00001023
Title: RP-HPLC Method Development and Validation for Simultaneous Estimation of Amlodipine besylate,Valsartan and Hydrochlorothiazide in Tablet Dosage Form
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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A simple, specific, accurate and precise Reverse Phase High Performance Liquid Chromatographic method was developed for simultaneous estimation of Amlodipine Besylate (AB), Valsartan (VAT) and Hydrochlorothiazide (HTZ) in tablet dosage form on RP C-18 Column (Hypersil 250*4.6 mm) using Acetonitrile: Mixed Phosphate buffer (6.8 pH) (55:45) ( buffer was prepared by mixing the equal proportions of 0.01M Potassium dihydrogenphosphate and 0.001M Dipotassium hydrogenphosphate. pH was adjusted with Orthophosphoric acid) as mobile phase. The flow rate was 1.0 ml/min and effluent was monitored at 237nm. The retention time for VAT, HTZ and AB was found to be as 2.28, 2.99 and 4.57 respectively. Proposed method was validated for Precision, Accuracy, Linearity range, Robustness and Ruggedness.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PB-00001028
Title: Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Red Beet root is a rich source of betacyanin. These are nitrogen containing compounds widely used as non toxic food colorants. The deep red color of beets is due to the presence of betalain pigments. There are two categories of betalains: the purple betacyanins and yellow betaxanthines pigments (Salisbury et al.,1991), functionally replace anthocyanins in 13 taxons grouped in Caryophyllales order. The major advantages of betalains as dietary antioxidants are their bioavailability, which is greater than most flavanoids, and their superior stability in comparison to anthocyanin. Although they are used as food colourants, remain understudied in terms of their antioxidant potential. So the present study was attempted to extract and to evaluate the content of betalain and its antioxidant potential by enzymatic and non enzymatic method from red beet root. This study has revealed that some of the antioxidant enzymes that are found to provide a protection against the reactive oxygen species are superoxide dismutase, catalase, peroxidase, glucose-6-phosphate dehydrogenase and ascorbate oxidase were found to be higher. The non-enzymatic method was done by quantification of vitamin C, and DPPH method. From HPTLC analysis, it was confirmed the presence of two flavanoid compounds. So the above study reveals that, the high antioxidant potential may be due to presence of these two flavanoid compounds. Because of its high antioxidant potential, the production of beet root pigments has to be performed using cell suspensions and transformed roots in bioreactors.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PHDRS-00001029
Title: Preliminary phytochemical and in vitro antioxidant properties of Brunfelsia americana L.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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This paper reports the preliminary phytochemicals and antioxidant activity in the leaves of Brunfelsia americana L. (Soalanaceae). The phytochemical analysis revealed the presence of steroids, flavonoids, tannins and sapoinins in the methanolic leaf extract while alkaloids, terpenoids, anthraquinones and cardiac glycosides were absent. The total phenolic content was 0.814±0.002. The presence of antioxidant activity was detected with TLC-DPPH screening method. DPPH radical scavenging activity of extract and ascorbic acid standard IC50 value was found to be 310µg/ml and 260µg/ml respectively. The reducing power assay confirms radical scavenging activity. The study revealed high level of antioxidant activity in this plant.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PHDRS-00001030
Title: Aloin: Medicinal properties and Future perspectives
Category: Pharmacognosy and Herbal Drugs related study
Section: Review Article
Country: India
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Aloin is a natural, highly promising compound having a wide range of biological spectrum. Aloin, C-glucoside of aloe emodin anthrone, contains many physiologically active substances that have effective anti-inflammatory, immunomodulatory and antimicrobial effects. Understanding the individual components and their effects is essential that aloin can be developed for therapeutic purpose.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PHDRS-00001032
Title: Preliminary phytochemical and in vitro antioxidant properties of Brunfelsia americana L.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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This paper reports the preliminary phytochemicals and antioxidant activity in the leaves of Brunfelsia americana L. (Soalanaceae). The phytochemical analysis revealed the presence of steroids, flavonoids, tannins and sapoinins in the methanolic leaf extract while alkaloids, terpenoids, anthraquinones and cardiac glycosides were absent. The total phenolic content was 0.814±0.002. The presence of antioxidant activity was detected with TLC-DPPH screening method. DPPH radical scavenging activity of extract and ascorbic acid standard IC50 value was found to be 310µg/ml and 260µg/ml respectively. The reducing power assay confirms radical scavenging activity. The study revealed high level of antioxidant activity in this plant.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-P'Col-00001033
Title: Effect of Alangium salvifolium (Alangiaceae) on Dexamethasone Induced Insulin Resistance in Rats
Category: Pharmacology
Section: Research Article
Country: India
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The present study was undertaken to investigate the antihyperglycemic and antihyperlipidemic effects of methanol extract of Alangium salvifolium (ASME) on low dose dexamethasone induced insulin resistance in rats. Male wistar rats weighing 250-300 g were divided into different groups. Dexamethasone was administered by injecting subcutaneously 2µg/day in divided doses for 28 days. ASME (200 mg & 400mg/kg/day/orally) was co-administered for 28 days. At the end of experimental period, blood samples were collected by retro-orbital plexus puncture for estimation of plasma glucose, insulin, triglycerides, total cholesterol TBARS & OGTT was carried out. Dexamethasone treatment for 28 days lead to significant increase in fasting plasma glucose, plasma insulin and triglyceride level, total AUC of plasma glucose during OGTT, HOMA-IR index, when compare to control. Co-administration with different doses of ASME significantly prevented the dexamethasone induced increase in all biochemimal parameters. Studies clearly demonstrated that methanolic extract of Alangium salvifolium leaves possess antihyperglycemic and antihyperlipidemic effects which may be due to the antioxidant and insulinotropic effect of extract.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-P'Col-00001034
Title: The protective role of S-allylmercaptocysteine against cadmium induced changes in sperm characteristics and testicular oxidative damage in rats
Category: Pharmacology
Section: Research Article
Country: India
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Cadmium is known to exert gonadotoxic and spermiotoxic effects. The present investigation was designed to assess the possible protective role of S-allylmercaptocysteine (SAMC) on Cd induced testicular damage and spermiotoxicity. The control group orally received 0.5 mL of normal saline and corn oil (2 mL/kg body weight/day). Cd group orally received Cd as CdCl2 (5 mg/kg body weight/day) in normal saline. Cd and SAMC treated group intragastrically administered with 40 mg/kg body weight/day of SAMC in corn oil and then simultaneously challenged with Cd as mentioned above. SAMC treated group orally received the SAMC alone in corn oil as prescribed earlier. All the experiments were carried out for the period of 4 weeks. At the end of the exposure period the testicular tissue oxidant/antioxidant status and sperm characteristics were determined. Cd caused a marked rise in testicular lipid peroxidation (LPO) and a drastic decrease in the levels of reduced glutathione (GSH) and the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx). Cd intoxication significantly decreased epididymal sperm concentration and sperm progress motility, increased percent total sperm abnormalities and live/dead count. Treatment with SAMC in Cd intoxicated rats successfully attenuated these adverse effects of Cd. Our study demonstrated that SAMC could proffer a measure of protection against Cd induced testicular oxidative damage and spermiotoxicity by possibly reducing LPO and increasing the antioxidant defense mechanism in rats.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PC-00001035
Title: Studies on antimicrobial activity of some hydrazones and its Copper complexes
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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The present study was designed to test the antimicrobial potential of some hydrazones and its copper complexes against selected bacterial and fungal strains Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger, Aspergillus flavus and Candida Albicans. The activity was performed by agar well diffusion method. Their microbiological assay is based on the comparison of inhibition of growth of microorganisms by measured concentration of some synthesized compounds to be examined with that produced by known concentration of standard preparation of antibiotic having known activity. All the synthesized compounds except 2, 3-NHB showed antibacterial activity against most tested bacteria except Pseudomonas aeruginosa. Positive antifungal activity was observed with NH and NHB against Aspergillus niger, Aspergillus flavus and Candida Albicans.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-PCS-00001371
Title: RP-HPLC Method Development and Validation for Simultaneous Estimation of Amlodipine besylate,Valsartan and Hydrochlorothiazide in Tablet Dosage Form
Category: Pharmaceutics
Section: Research Article
Country: India
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A simple, specific, accurate and precise Reverse Phase High Performance Liquid Chromatographic method was developed for simultaneous estimation of Amlodipine Besylate (AB), Valsartan (VAT) and Hydrochlorothiazide (HTZ) in tablet dosage form on RP C-18 Column (Hypersil 250*4.6 mm) using Acetonitrile: Mixed Phosphate buffer (6.8 pH) (55:45) ( buffer was prepared by mixing the equal proportions of 0.01M Potassium dihydrogenphosphate and 0.001M Dipotassium hydrogenphosphate. pH was adjusted with Orthophosphoric acid) as mobile phase. The flow rate was 1.0 ml/min and effluent was monitored at 237nm. The retention time for VAT, HTZ and AB was found to be as 2.28, 2.99 and 4.57 respectively. Proposed method was validated for Precision, Accuracy, Linearity range, Robustness and Ruggedness.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-P'Col-00001380
Title: Antiurolithiatic potential of the fruit extracts of Carica papaya on ethylene glycol induced urolithiatic rats
Category: Pharmacology
Section: Research Article
Country: India
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The fruit of Carica papaya Linn (Caricaceae) used in traditional medicine for the treatment of urinary stones. The present study was undertaken to evaluate the antiurolithatic effects of the aqueous and alcoholic extracts of the fruit of C. Papaya on ethylene glycol (EG) induced urolithiatic rats. EG administration resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Treatment with aqueous and alcoholic extracts of C. papaya fruit significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The increased deposition of stone forming constituents in the kidneys of calculogenic rats was also significantly lowered by curative and preventive treatment using aqueous and alcoholic extracts of the fruits of C. papaya. The results indicate that the fruit of C. papaya is endowed with antiurolithiatic activity and scientifically valid the traditional use of the fruit of C. Papaya in the treatment of urinary calculi.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 11.
Article Id: JPRS-P'Col-00001393
Title: Antiulcer activity of Methanolic extract of Acalypha indica Linn. (Euphorbiaceae) by PylorousLigture and Swim Stress Induced Ulceration
Category: Pharmacology
Section: Research Article
Country: India
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Medicinal plants are nature’s gift to mankind. The plant kingdom holds many species containing substances of medicinal properties; the plant was used in folk medicine against pneumonia asthma and anthelminitic, diuretic, carminative, expectorant and emetic properties. The phytochemical investigation showed the presence of amino acids, proteins, alkaloids, steroids, flavonoids, gums and mucilage. The present study intended to evaluate the anti-ulcer activity was done in pylorus ligature and swim stressed induced ulcer in Wistar rats by using methanolic extract of Acalipha indica (MEAI). The MEAI showed significant reduction of gastric volume secretion, acidity and ulceration in pylorus legated and swim stressed rats at p