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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
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Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-PC-00001054
Title: The diverse pharmacological importance of Pyrazolone Derivatives : A Review
Category: Pharmaceutical Chemistry
Section: Review Article
Country: India
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Scientific research programs and reports are continuously pouring in with respect to improvised synthetic techniques to prepare numerous pyrazolone derivatives and with regard to their diverse biological, pharmacological and chemical applications. When pyrazolones were discovered, they were only known as NSAID but in recent times, they are known to exhibit antioxidant, anticancer, antibacterial and several other pharmacological actions. These derivatives were withdrawn from the market because of their adverse effects such as agranulocytosis, skin rashes and blood dyscrasis etc, but recently they are again finding their place in the market and are being extensively used in cerebral ischemia and cardio vascular diseases. Since its introduction into medicine, there have been more than 1000 compounds made in an effort to find others with more potent analgesic action combined with less toxicity. Keeping in view the increasing importance of these derivatives, a need for the review is felt. This review deals with up to-date literature on biological and pharmacological properties of pyrazolone derivatives.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-PCS-00001058
Title: Design and development of sustained release microspheres of Quetiapine Fumarate using 32 full factorial design
Category: Pharmaceutics
Section: Research Article
Country: India
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The objectives of this investigation were to prepare sustained release microspheres of the anti-psychotic drug, quetiapine fumarate, using ethyl cellulose as the polymer and evaluate it’s encapsulation efficiency, release characteristics in vitro; utilizing emulsion solvent evaporation and extraction technique. A 32 factorial factorial design was applied to investigate the influence of drug: polymer ratio and average particle size on release characteristics. The drug release was proportional to square root of time, indicating that the drug release from ethyl cellulose microspheres was diffusion controlled. The optimized batch showed no signs of interaction with sustaining the drug release up to 12 h along with identical release behavior to that of marketed sustained release tablet. The sphericity and smoothness of microspheres were also confirmed by scanning electron microscopy study.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-PCS-00001068
Title: Simultaneous estimation of rizatriptan, sumatriptan and zolmitriptan by RP-HPLC method in bulk
Category: Pharmaceutics
Section: Research Article
Country: India
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A simple reverse phase HPLC method was developed for the simultaneous estimation of Rizatriptan, Sumatriptan and Zolmitriptan in bulk form. Chromatography was performed by gradient reverse phase separation on a Stainless steel column 4.6 x 250mm, symmetry column packed with octa decyl silane bonded to porous silica (C18) with particle size 5 micron with mobile phase Acetonitrile: Sodium Phosphate buffer. The flow rate was 1.0ml/ min and effluent was monitored at 280 nm. The retention times were 7.215min, 8.432 and 9.185min for of Rizatriptan, Sumatriptan and Zolmitriptan respectively. The standard curve was linear over a working range of 1–10 µg/ml and gave an average correlation coefficient of 0.9996, 0.9992, and 0.9992 for Rizatriptan, Sumatriptan and Zolmitriptan respectively. The limit of quantitation (LOQ) of this method was 2µg/ml for rizatriptan Sumatriptan and Zolmitriptan. The absolute recovery was 101.84 for rizatriptan, 101.492 for sumatriptan and 101.44 for zolmitriptan. This method can be easily and conveniently adopted for routine analysis of Rizatriptan, Sumatriptan and Zolmitriptan in pure form and can also be used for dissolution or similar studies.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-MB-00001329
Title: A Comparative study on Antioxidant, Proximate analysis, Antimicrobial activity and phytochemical analysis of Aloe vera and Cissus quadrangularis by GC-MS
Category: Microbiology
Section: Research Article
Country: India
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Plants have been an important source of medicine with qualities for thousands of years. Mainly on traditional remedies such as herbs for their history it has been used as a popular folk medicine. Aloe vera and Cissus quadrangularis these are used as medicinal values, Aloe vera contains both medicine and cosmetic effect. Screening of phytochemical (Qualitative and Quantitative) analysis of Aloe vera and Cissus quadrangularis shows that almost of the chemical constituents are present Tannin, Phlobatannins, Saponin, Flavonoids, Steroids, Terpenoids, and Cardiac glycosides Anthroquinones which are used in medicinal purpose. Both Aloe vera and Cissus quadrangularis are having the antimicrobial activity against human pathogens. In 100% concentration of extraction zone of inhibition is high. But 25%, 50% and 75% shows the lowest inhibition activity. Proximate analysis indicates the nutrients efficacy. In GC-MS analysis some of the Phytocomponents are screened as Squalene Oleic Acid, Dodecanoic acid in Aloe vera. Eugenol, n-Hexadecanoic acid, 1,2-Benzenedicarboxylic acid, diisooctyl ester, Phenol, 2,4-bis(1- phenylethyl)- are present in Cissus quadrangularis.

Cite this article as: Sathyaprabha.G,  Kumaravel .S,Ruffina. D, Praveenkumar. P,A Comparative study on Antioxidant, Proximate analysis, Antimicrobial activity and phytochemical analysis of Aloe vera and Cissus quadrangularis by GC-MS,Journal of Pharmacy Research 2010, 3(12),2970-2973.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-PP-00001047
Title: Assessment of health complaints and use of medicines among adolescents in Tamil Nadu.
Category: Pharmacy practice
Section: Research Article
Country: India
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The period of adolescence is a period that is marked by anxiety associated with physical growth significant psychological development and changes in personal relationships. The stresses that adolescents experience may manifest themselves in psychosomatic health complaints. So we investigate self-reported health complaints and the use of medicines among adolescents in Komarapalyam, Tamil Nadu. A self-administered questionnaire was used to survey self-reported health complaints, the use and the sources of medicines that had been accessed, during the preceding 4 months. A stratified random sample design generated a sample size of 640 adolescents (aged 14-16 years). The health complaints and use of medicines that were investigated included hay fever, cold/cough, headache, skin problems, injuries, indigestion diarrhoea/constipation, eye and ear problems. Who formed the analytical sample, of which 57.2% were boys and 42.8 girls. The adolescents reported a total of 8 health complaints and 92.2% reported using at least 1 medicine during the preceding 4 months. The community pharmacy was cited as the most commonly accessed source for most of the medicines that were investigated. A proportion of 32.6% of the adolescents had taken at least 1 medicine without adult guidance during the preceding 4 months. Almost 32 % of those who had taken antibiotics had accessed them from the home medicine cabinet. A high proportion of adolescents reported the use of medicines to symptoms of common health complaints. A considerable proportion of adolescents in this study had obtained medicines without adult guidance. This highlights the importance of carefully designed education programs for adolescents about the proper use of medicines.

Cite this article as: Arul Prakasam K. C and Senthil Kumar N,Assessment of health complaints and use of medicines among adolescents in Tamil Nadu,Journal of Pharmacy Research 2010, 3(12),2799-2801.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-P'Col-00001045
Title: Ameliorative effect of Livina, a polyherbal preparation on Diclofenac-induced liver injury: A comparison with Silymarin
Category: Pharmacology
Section: Research Article
Country: India
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Comparative ameliorative activity of polyherbal formulation (Livina) against a well-established hepatoprotective drug Silymarin was assessed against Diclofenac induced hepatic injury in swiss albino mice. To clarify its effect on liver functions, eight-week-old male mice were injected with Diclofenac at the single dose of 150 mg kg-1 body weight intraperitonially once daily for 28 days. The hepatoprotective effect of polyherbal formulation (Livina) was comparatively evaluated with Silymarin (25 mg kg-1) by measuring levels of serum markers such as alanine aminotransferase (ALT), aspertate aminotransferase (AST), (γ-glutamyle transpeptidase (GGT), alkaline phosphatase (ALP), lipid peroxidase (MDA), serum total protein and total and direct bilirubin levels in mice serum along with the histopathological studies to support the above mentioned parameters. The study found that the supplementation of Livina significantly (P<0.05, P<0.001) reduced the damaging effects on liver by Diclofenac. Histopathological changes (congestion of central vein, centrilobular necrosis and sinusoidal congestion) induced by Diclofenac were also reduced to a moderate extent in Livina treated mice. In both the cases the effectiveness of Livina were found to be almost parallel with Silymarin, indicating the herbal formulation to be almost as effective as the standard drug.

Cite this article as: Soumendra Darbar*, Abhijit Bhattacharya, Shyamaprasad Chattopadhyay,Ameliorative effect of Livina, a polyherbal preparation on Diclofenac-induced liver injury: A comparison with Silymarin,Journal of Pharmacy Research 2010, 3(12),2794-2798.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-PHDRS-00001048
Title: Isolation of Stigmasterol from petroleum ether extract of aerial parts of Bryophyllum pinnatum (Crassulaceae)
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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General phytochemical screening of the aerial parts of Bryophyllum pinnatum (Crassulaceae) revealed the presence of bufadienolides, flavanoids, polyphenols, triterpenoids, phytosterols, glycosides and organic acids. The aim of this study is to identify and characterize the bioactive principle from the aerial parts of the plant. It has wide folk medicinal use. For isolation of the compound, the dried aerial parts powder of Bryophyllum pinnatum was subjected to hot extraction with petroleum ether; this Extract was saponified with alcoholic KOH and subjected to chromatography. The isolation and purification afforded white crystalline powder which was subjected to physical, chemical and spectral identification by IR, 1H-NMR, 13C-NMR and GC-MS. The compound was concluded as stigmasterol.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-PA-00001049
Title: Sensitive HPLC method for determination of related substance of levocetirizine dihydrochloride in solid oral formulations
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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A sensitive high performance liquid chromatography method has been developed and validated for the determination of Levocetirizine dihydrochloride related substances in solid oral formulation. Acetonitrile and diluted Sulphuric acid was used as a mobile phase for the elution and separation of Levocetirizine dihydrochloride and its related substance. Lichrocarrt Si60, 250 X 4.0, 5µ (Cartridge column) was used at 0.8 ml/min flow rate to achieve good resolution of the analyte and its impurities. Levocetirizine dihydrochloride was exposed to various stress conditions such as acid, base, oxidation & thermal degradations along with Placebo & Formulation. But it was found to be stable under all stress conditions. The detector linearity was established from concentrations ranging from 0.06 µg/ml to 0.60µg/ml for Levocetirizine dihydrochloride and 0.03 to 0.30 µg/ml for its impurities with a correlation co-efficient of 0.9999.The LOD and (LOQ) found to be in a range of 0.01 µg/ml and 0.06µg/ml for Levocetirizine dihydrochloride and 0.005 µg/ml and 0.03 µg/ml for related substances respectively. Sample Solutions stability was found stable for than 42 hours. The molecule was found stable in all the stress conditions and proved to be robust with respect to changes in flow rate and buffer composition. The proposed method is found to be sensitive, precise, rapid and reproducible.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-B&NPS-00001050
Title: In vitro Antioxidant Potential of Ethanolic Contents of Eclipta alba and Wedelia chinensis
Category: Botany/ Herbal/ Natural Pharmacological Study
Section: Research Article
Country: India
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Ethano botanical search reveals use of many traditional herbs in the treatment of cancer, which are usually free from side effects, are economical and also easily accessible to humans.Using DPPH, Nitricoxide, Superoxide radical scavenging activity and Ferric reducing antioxidant power assay to investigate the antioxidant potential of crude ethanolic extracts from the leaves of Eclipta alba and Wedelia chinensis, it was found that the ethanolic extracts exhibited a stronger antioxidant activity. The extracts showed the inhibition in a dose dependant manner. The results were expressed as IC50. Eclipta alba showed higher reducing activity in DPPH assay and FRAP assay. Wedelia chinensis showed potent radical scavenging activity for Nitricoxide and Superoxide radicals. Both the medicinal plants are a potential source of natural antioxidants.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-PCS-00001051
Title: Enhancement of dissolution rate of Efavirenz by solid dispersion technique
Category: Pharmaceutics
Section: Research Article
Country: India
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Efavirenz is an HIV-1 specific, non-nucleoside reverse transcriptase inhibitor (NNRTI).It is an antiretroviral agent indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection, which is not soluble in water and lower absorption in gastric fluid. In order to improve the solubility and oral absorption of the drug in gastric fluid and to enhance its dissolution rate, solid dispersion method is designed and evaluated. Solid dispersions of Efavirenz were prepared using PEG 6000. The effect of fusion-solvent methods of preparation of solid dispersion on dissolution behavior was also investigated. Dissolution studies indicated a significant increase in dissolution of Efavirenz when dispersed in PEG6000. Solid dispersions containing Efavirenz / PEG 6000, 1: 8, showed a 2-fold increase in dissolution after 180 min in the 0.1 N HCL systems.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-PCS-00001052
Title: Dissolution enhancement of Paracetamol by solid dispersion technique
Category: Pharmaceutics
Section: Research Article
Country: India
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Paracetamol is a potent anti-inflammatory analgesic agent indicated for acute and chronic treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylytis. Paracetamol is poorly water soluble and may show dissolution limited absorption. The solid dispersion of paracetamol by physical triturating method, and fusion method were prepared using 1:1,1:4 and 1:5 ratios of drug and polymers (PEG 4000, PEG 6000 and urea). The solid dispersion (SD) was characterized for physical appearance, solubility, IR, and in vitro dissolution studies. FTIR study revealed that drug was stable in SDs. Solubility of paracetamol from SDs increased in distilled water. The drug content was found to be high and uniformly distributed in the all formulation. The in vitro dissolution studies were carried using USP type XXVII (paddle) type dissolution apparatus. The prepared dispersion showed marked increase in the dissolution rate of paracetamol than that of pure drug. The dispersion with PEG 6000 (1:5) by fusion method showed faster dissolution rate (107.26%) as compared to other dispersions with PEG 4000 and urea (1:4 and 1:5) whichever prepared by physical mixture (PM) and fusion method). Of the three carriers used, dissolution of the drug was more in PEG 6000 based SDs. It is concluded that dissolution of the Paracetamol could be improved by the solid dispersion and PEG6000 based solid dispersions were more effective in enhancing the dissolution.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-P'Col-00001053
Title: Effect of Punica granatum fruits in inflammatory bowel disease
Category: Pharmacology
Section: Research Article
Country: India
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It has been demonstrated that Punica granatum Linn. (Punicaceae) is useful as an adjunctive therapy for inflammatory bowel disease. However, its effect on ulcerative colitis has not been investigated. In the present study, Punica granatum was tested for 2, 4 - dinitro benzene sulfonic acid (DNBS) induced colitis, and antioxidant activity was evaluated to clarify its possible mode of action. Male albino wistar rats were randomly divided into five groups: Normal control (Group I), vehical contol (Group II), colitis induced by DNBS without any therapy (Group III), colitis treated with standard 5-Amino salicylic acid (Group IV), colitis treated with test drug punica granatum (Group V). Treatment was given for 18 days. Rats were sacrificed on the 18th day after the procedure. Malondialdehyde (MDA), Nitric oxide (NO), Myeloperoxidase (MPO), Superoxide dismutase (SOD), activity were measured in the isolated colon tissue. MDA, NO, MPO levels in colon tissue homogenate were decreased & SOD level was increased in group IV & Group V as compare to those of Group III. There was also increase in food intake, water intake, % body weight & decreased colon weight in Group IV & Group V as compared to Group III. There was also improvement in inflammatory indices of colon mucosal damage index (CMDI) & Disease activity index (DAI) & histopathology of Group IV & Group V as compared to those of group III. The results of our study suggest that Punica granatum therapy has beneficial effects on the course of experimental colitis.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-P'Col-00001055
Title: Antioxidant and Healing Effect of Aqueous alcoholic Extract of Rhodomyrtus tomentosa (Ait.) Hassk on Chronic Gastric Ulcers in rats
Category: Pharmacology
Section: Research Article
Country: India
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Rhodomyrtus tomentosa is a medicinal plant used traditionally in gastric disorders like colic, diarrhoea, dysentery, abscesses, haemorrhage, and as an antiseptic wash for wounds. Based on the ethnomedical information of the plant, the antiulcerogenic activity of an aqueous alcoholic (70%) extract of Rhodomyrtus tomentosa was investigated using acetic acid-induced chronic ulcer model in rats. The reduction in ulcer index followed by increase in the levels of superoxide dismutase (SOD) and catalase (CAT) and decrease in lipid peroxidation proved the antiulcer and antioxidant activity of the extract. Histopathological studies further proved the gastroprotective property of the extract. It was concluded that the extract possesses significant anti-ulcer activity, which can be attributed to its antioxidant mechanism of action. The presence of triterpenoids, flavonoids and phenolic compounds is probably related to the potent antiulcerogenic and antioxidant activity.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-PA-00001056
Title: Analytical method development and validation of simultaneous determination of Diphenhydramine HCL, Guaiphenesin and Bromhexine HCL in liquid dosage form by RP-HPLC technique
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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The present paper deals with the simultaneous determination of the active ingredients in the multicomponent pharmaceutical product using a RP- HPLC Technique. Diphenhydramine hydrochloride, Guaiphenesin and Bromhexine Hydrochloride were separated and quantitated either in pure form or simultaneously in the other interfering substances such as methyl and propyl parabens which are present in cough syrup. Several trials were carried out to obtain good separation among Diphenhydramine hydrochloride, Guaiphenesin and Bromhexine hydrochloride in mixture. These trials involved the use of different ratios of the mobile phase component, different pH of buffer, different flow rates, and different wavelength. The mobile phase of choice was found to be 0.05M Sodium Acetate in distilled water pH adjusted to 3.0 with acetic acid and solvent (60:40) ratio with the flow rate of 1.3 ml/min on BDS HYPERSIL C18 column with an Internal diameter 250×4.6mm, and 5 micron particle size with UV detection at 258 nm gave a satisfactory Chromatogram with Diphenhydramine Hydrochloride, Bromhexine Hydrochloride and Guaiphenesin of retention time of 10.45min, 16.76 min and 3.5min (Mixed standard) respectively.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-QA-00001059
Title: Development and validation of a UV spectrophotometric method for estimation of Citicoline sodium in Bulk and Dosage Form
Category: Quality Assurance
Section: Research Article
Country: India
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Development and validation of a simple UV and derivative spectrophotometric method to quantify citicoline sodium used as a single active principle in pharmaceutical dosage forms were done. Pharmacopeias have not yet provided an official method for its quantification. A study was carried out considering all the parameters established by USP XXIV to validate an analytical method i.e. linearity, accuracy, range, precision and specificity. Based on spectrophotometric characteristic of citicoline sodium, a signal at 272nm for simple UV spectrum and at 286nm for derivative spectrum (1D286) was found adequate for quantification. The linearity signal and concentration of citicoline sodium in the range of 10-50µg/ml in aqueous solution presents a correlation coefficient (r2) of 0.999 for simple UV and 0.9997 for 1storder derivative spectrum. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.75µg/ml and 2.27µg/ml by simple UV and 0.69µg/ml and 2.09µg/ml by derivative spectrum respectively. The mean recovery percentage was 99.93±1.27% by simple UV and 101.08±0.5% by derivative spectrum. In addition, the proposed method is simple, easy to apply, low-cost, does not use polluting reagent and requires relatively inexpensive instruments.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-PCS-00001067
Title: Effect of Process Variables on the Size Distribution of Aluminium Chloride Cross-linked Sodium Alginate Microspheres
Category: Pharmaceutics
Section: Research Article
Country: India
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In the present study, spherical microspheres of diclofenac sodium using sodium alginate as the hydrophilic carrier and aluminium chloride as a cross-linker were prepared. The shape, surface and size characteristics were determined by binocular microscopy. The microspheres were found to be discreet and spherical in shape. Results of rheological study of polymer solutions showed the increase in viscosity with the increase in polymer concentration and increase in concentration of cross-linker (from 20.77 cP to 1283 cP and from 580.42 cP to 4800.82 cP, respectively). Micromeritic properties of microspheres were studied. It was observed that mean particle size of the microspheres increased from 81.76 ± 5.21 µm to 185.7 ± 2.47 µm and 57.46 ± 4.91 µm to 223.5 ± 5.71 µm with an increase in the concentration of polymer and drug:polymer ratio respectively. The increase in cross-linker concentration and stirring rate gave decrease in mean particle size of the microspheres from 165.7 ± 3.17 µm to 125.9 ± 4.78 µm and 290.5 ± 6.32 µm to 52.16 ± 7.39 µm, respectively. The desired size of microspheres can be obtained by using these process variables. Further these findings help the industry to scale up the commercial production.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-PC-00001332
Title: Heterocyclic 1, 3, 4-oxadiazole compounds with diverse biological activities: A comprehensive review
Category: Pharmaceutical Chemistry
Section: Review Article
Country: India
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The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4-oxadiazole constitutes an important class of compounds for new drug development. The synthesis of novel oxadiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. Oxadiazole compounds possess an extensive spectrum of pharmacological activities. In particular, compounds bearing 1,3,4-oxadiazole nucleus are known to exhibit unique antiinflammatory, analgesic, antimicrobial, antitumor, anticonvulsant, anthelmintic, antimycobacterial, herbicidal, antioxidant and antiviral activities. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new oxadiazole derivatives that possess varied biological activities and can be a lead nucleus for future developments to get safer and effective compounds. References of the most relevant literature published by various research groups around the world are provided.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 12.
Article Id: JPRS-PC-00001390
Title: Synthesis,characterization and antimicrobial activity of Schiff bases of isatin and isatin derivatives
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Several new Schiff’s base derivatives were prepared by the combination of Isatin and its prepared derivatives and Isoniazid in the presence of glacial acetic acid and ethanol. All the compounds were characterized by physical and spectral studies. The newly synthesized compounds were evaluated for their antimicrobial activities.