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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-P'Col-0000669
Title: Antioxidant efficacy of Cynodon dactylon leaf protein against ela implanted swiss albino mice
Category: Pharmacology
Section: Research Article
Country: India
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The levels of enzymic and non enzymic antioxidants were determined in Ehrlich’s Lymphoma Ascite (ELA) transplanted Swiss albino mice treated with the protein fraction of Cynodon dactylon (Cdpf). ELA induced mice showed significant decrease in the level of enzymic antioxidants like catalase (73.43 to 55.03), superoxide dismutase (4.49 to2.47) and glutathione peroxidase (48.48 to 36.98) in units/mg protein and non enzymic antioxidant like vitamin A (7.18 to 3.25), vitamin E (8.55 to 3.18) in µg/g protein and reduced glutathione (2.38 to 1.65) in nmoles/g protein which indicated the production of free radicals in the liver. Administration of protein fraction to the ELA induced mice showed enhanced level of enzymic antioxidants (69.18, 4.11 and 49.39 units/mg protein) and non enzymic antioxidants (5.63, 5.20 µg/g protein and 3.43 nmoles/g protein) respectively which proved their protective action against the free radical damage caused by ELA tumor cells and maintains the normal function of the organ and confirmed their antioxidant activity.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-MB-00001382
Title: Phytochemical Analysis of Cocos nucifera L
Category: Microbiology
Section: Research Article
Country: India
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The phytochemical screening of Cocos nucifera L was studied. The aim of the study was to determine the phytochemical constituents of the endosperm of Cocos nucifera L. The nuts of Cocos nucifera were collected from a coconut tree in the Botany Department of the University of Nigeria, Nsukka. The nuts were broken to release the solidified endosperm (kernel). The endosperm was cut, washed, dried and milled using a laboratory mill. The phytochemical analyses carried out on the milled kernel showed the presence of terpenoids, alkaloids, resins, glyco-sides and steroids. Flavonoids and acidic compounds were not detected. The macronutrient analyses, on the order hand showed the presence of carbohydrate, proteins, reducing sugar, fats and oil. Of the above macronutrients, oil is known to be the major constituent that is necessary for the medicinal uses of coconut, though the phytochemicals: alkaloids, steroids and terpenoids are known to have antioxidant properties. The nutritional and health implication of coconut consumption are also discussed.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-ND-00001381
Title: Phytochemical and pharmacological potential of Artemisia absinthium Linn. and Artemisia asiatica Nakai : A Review
Category: Natural Drugs
Section: Review Article
Country: India
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A world health organization survey indicated that about 75-80% of the world’s populations rely on non-conventional medicine, mainly of herbal sources, in their primary healthcare. There has been an explosion of scientific information concerning plants, crude plant extracts and various substances from plants as medicinal agents during last 30-40 years. Although herbal medicine has existed since the dawn of time, our knowledge of how plants actually affect human physiology remains largely unexplored. Numbers of plants are claiming various medicinal uses and many researches are going on in this view. They are believed to be much safer and proved elixir in the treatment of various ailments. The genus Artemisia consists of about 500 species, occurring throughout the world. Among the different species of Artemisia, A. absinthium and A. asiatica have a vast range of biological activities including cytotoxic, antihepatotoxic, antibacterial, antifungal, antioxidant, antimalarial etc. Terpenoids, flavonoids, coumarins, caffeoylquinic acids, sterols and acetylenes constitute major classes of phytoconstituents of the genus Artemisia. The present review comprises the phytochemical, ethnopharmacological and pharmacological reports of A. absinthium and A. asiatica. The future scopes of these plants have been emphasized with a view to isolate bioactive moieties which could be used for multifarious biological activities.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-PC-0000680
Title: Synthesis and antimicrobial activity of some newer benzimidazole derivatives – an overview
Category: Pharmaceutical Chemistry
Section: Review Article
Country: India
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Benzimidazole derivates play vital role in biological field such as antimicrobial, antiviral, antidiabetic, and anticancer activity. Therapeutic significance of these clinically useful drugs in treatment of microbial infections encouraged the development of some more potent and significant compounds. Benzimidazoles are remarkably effective compounds both with respect to their bacteria inhibitory activity and their favorable selectivity ratio. Extensive biochemical and pharmacological studies have confirmed that these molecules are effective against various strains of microorganisms. This comprehensive overview summarizes the chemistry of different derivatives of substituted benzimidazole along with their antimicrobial activity.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-PCS-0000681
Title: Potentiation of solvent character by mixed-solvency concept :A novel concept of solubilization
Category: Pharmaceutics
Section: Research Article
Country: India
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A new, simple, safe, accurate and reproducible titrimetric method was developed for the quantitative estimation of frusemide in the bulk drug sample and tablets by the novel application of mixed solvency concept. Ethanol has weaker solubilizing power for frusemide. The addition of 15% w/v niacinamide (a solubilizer) in ethanol showed very good solubility of frusemide (about three fold enhancement) and hence, this solvent system was employed to solubilize frusemide for its titrimetric analysis. This is a safer (non toxic) solvent system than dimethyl formamide (which is employed in pharmacopoeial method). Like this, ethanol (which is a relatively safer organic solvent) can be made a strong solvent by proper choice of solubilizers, precluding the use of hazardous, toxic organic solvents. Mixed solvency concept may be utilized to prepare the concentrated (say 30% w/v or so, in strength) combined aqueous solutions of various water-soluble additives from the categories of so called, hydrotropes (sodium benzoate, sodium ascorbate, sodium citrate, niacinamide, urea), co-solvents (glycerin, propylene glycol, ethanol, PEG 200, 300, 400, 500, 600 ), water soluble solids (PVP, PEG 4000, 6000, 8000, 10000), cyclodextrins (beta cyclodextrin, HP beta cyclodextrin) employing them in small, safe (GRAS) concentrations to solubilize the poorly water-soluble drugs to develop their dosage forms (solutions, syrups, injections, topical solutions etc) and thus, the toxicity issues of solubilizers may not raise concern (to illustrate one example, a 30% w/v aqueous solution may be made by employing 5% w/v, each, of glycerin, PVP, PEG 4000, niacinamide, HP beta cyclodextrin and tween 80).

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-PCS-0000672
Title: Nanosuspension:A novel drug delivery system
Category: Pharmaceutics
Section: Review Article
Country: India
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During the last two decades, many modern technologies have been established in the pharmaceutical research and development area. The automation of the drug discovery process by technologies such as high-throughput screening, combinatorial chemistry, and computer- aided drug design is leading to a vast number of drug candidates possessing a very good efficacy. Unfortunately, many of these drug candidates are exhibiting poor aqueous solubility. The use of drug nanosuspension is an universal formulation approach to increase the therapeutic performance of these drugs in any route of administration. A nanosuspension is a submicron colloidal dispersion of drug particles which are stabilized by surfactants. Nanosuspension is defined as very finely dispersed solid drug particles in an aqueous vehicle for either oral and topical use or parenteral and pulmonary administration. The particle size distribution of the solid particles in nanosuspensions is usually less than one micron with an average particle size ranging between 200 and 600 nm. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion.This review article describes the physicochemical properties of drug nanosuspension, preparation methods and; its potential clinical advantages.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-PCS-0000671
Title: Design, Evaluation, Parameters and Marketed Products of transdermal patches: A Review
Category: Pharmaceutics
Section: Review Article
Country: India
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Transdermal drug delivery system (TDDS) established itself as an integral part of novel drug delivery systems. In a broad sense, the term transdermal delivery system includes all topically administered drug formulations intended to deliver the active ingredient into the general circulation. Transdermal drug delivery systems are polymeric formulations which when applied to skin deliver the drug at a predetermined rate across dermis to achieve systemic effects. Transdermal dosage forms, though a costly alternative to conventional formulations, are becoming popular because of their unique advantages. Controlled absorption, more uniform plasma levels, improved bioavailability, reduced side effects, painless and simple application and flexibility of terminating drug administration by simply removing the patch from the skin are some of the potential advantages of transdermal drug delivery. Development of controlled release transdermal dosage form is a complex process involving extensive efforts. This review article describes the methods of preparation of different types of transdermal patches, evaluation parameters and some available marketed products.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-P'Col-0000683
Title: Phytochemistry and pharmacological activities of Haritaki – A review
Category: Pharmacology
Section: Research Article
Country: India
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Haritaki (Terminalia chebula) family Combretaceae is important plant used traditionally for medicinal purposes. It is component of the classic Ayurvedic combination called “Triphala”. The important active constituents are hydrolysable tannins, chebulagic acid, chebulinic acid and corilagin. Animal model studies indicate potent antibacterial activity, antifungal activity, anti-carcinogenic activity, antioxidant activity, hypocholesterolemic activity, antispasmodic activity. However clinical studies showed antibacterial activity, anti-inflammatory activity, cardio protective activity. This paper explains the Evidence-based information regarding the phytochemistry and pharmacological activity of this plant.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-PA-0000667
Title: Validation of Quantitative Spectrophotometric Methods for the Determination of Repaglinide in Pharmaceutical Formulations
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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Three simple and sensitive spectrophotometric methods (A, B, C) have been described for the assay of repaglinide either in pure form or in pharmaceutical formulations. The methods A and B are based on the oxidation of the drug by Fe3+ and subsequent chelation of the Fe2+ produced with either 1,10 phenanthroline (method A) or a, a’ bipyridyl (method B) to produced red colored chromogens. Method C is based on the measurement of blue colored species formed due to the reduction of phosphomolybdic acid present in folin ciocalteau (F/C) reagent by the drug in the presence of sodium hydroxide. The formed colored complexes showed absorbance maxima at 520, 530 and 650 nm for 1, 10 phenanthroline, a, a’ bipyridyl and folin ciocalteau, respectively. Beer’s law is obeyed in the concentration ranges 4-20, 2-10 and 2-10mg/ml with molar absorptivity of 0.565 x 104, 1.855 x 104 and 1.606 x 104 Litre.mole-1.cm-1 and relative standard deviation of 1.3, 0.870 and 1.14% for 1,10 phenanthroline, a, a’ bipyridyl and folin ciocalteau, respectively. These methods have been successfully applied for the assay of drug in pharmaceutical formulations. No interference was observed from common pharmaceutical adjuvants. Results of analysis were validated statistically and through recovery studies.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-P'Col-0000668
Title: Antianxiety effect of aqueous extract of fruits of Emblica officinalis(EO) on acute and chronic administration in rats.
Category: Pharmacology
Section: Research Article
Country: India
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The present study was undertaken to evaluate the anti-anxiety activity of aqueous extract of fruits of Emblica officinalis (EO) on acute and chronic administration in rats. Male Wistar albino rats weighing 150-180gms were divided into five groups (n=6) for acute and chronic study separately. Diazepam (1.0mg/kg) and EO (0.8, 2.0 & 4.0 mg/kg) were suspended in 1% gum acacia and administered orally. In acute study vehicle/drugs were given 60 minutes before, while in chronic study they were given once daily for 10 days and the last dose was given 60 min prior to exposure to the experimental paradigms viz., elevated plus maze and bright and dark arena. EO significantly increased the number of entries into, time spent and rears in the open arms. Also, it increased the percentile ratio of open arm to total arm entries in elevated plus maze paradigm both on acute and chronic administration. In bright and dark arena paradigm the EO both on acute and chronic administration it significantly increases the number of entries, time spent and rears in the bright chamber, also it reduced the duration of immobility. These behavioural changes were comparable to that produced by the standard anxiolytic drug diazepam. The behavioural disinhibition produced by EO suggestive of its anxiolytic like activity.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-P'Col-0000670
Title: Antidiabetic activity of Capparis decidua Forsk Edgew.
Category: Pharmacology
Section: Research Article
Country: India
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Ethnopharmacological relevance: Capparis decidua (Forsk.) Edgew (Capparidaceae) is well known for curing a variety of ailments such as toothache, cough, asthma, intermittent fever and rheumatism.Aim of the study: The present study was to evaluate antidiabetic activity of aqueous & ethanolic extract of Capparis decidua stem in alloxan-induced diabetic rats.Materials and methods: Albino rats were rendered diabetic by alloxan (150 mg/kg, intraperitoneally). The aqueous & ethanolic extracts were orally administered to diabetic rats at 250 and 500 mg/kg doses daily for 21 days to determine antidiabetic activity. Results: The fasting blood glucose level decreases by 58.5, 83.6 % (aqueous extract) and 60.2, 98.51 (ethanolic extract) after 21st day in diabetic rats treated with a different doses of 250 mg and 500 mg/kg body weight respectively.Conclusion: In conclusion, the present study using biochemical assays pertaining to blood glucose level of different animal models reveals that aqueous and ethanolic extract of stem has significant hypoglycemic and antidiabetic potential.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-MB-0000673
Title: Fascinating diversity and Potent biological activities of Actinomycete metabolites
Category: Microbiology
Section: Review Article
Country: India
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Microbial diversity constitutes an infinite pool of novel chemistry, making up a valuable source for innovative biotechnology. There are over 23,000 known microbial secondary metabolites, 42 % of which are produced by actinobacteria, 42 % by fungi, and 16 % by other bacteria. Actinomycetes are one of the most important groups of secondary metabolite producers. Among various genera, Streptomyces, Saccharopolyspora, Amycolatopsis, Micromonospora and Actinoplanes are the major producers of commercially important biomolecules. The streptomycetes are very potent producers of secondary metabolites. Out of the approximately 10,000 known antibiotics, 45-55 % are produced by streptomycetes. The secondary metabolites produced by actinomycetes have a broad spectrum of biological activities such as antibacterial, antifungal, antiviral, antiparasitic, immunosuppressive, antitumor, insecticidal, antiinflammatory, antioxidant, enzyme inhibitory, diabetogenic and others. Existence of actinomycetes has been reported in the marine habitats. Marine actinomycetes are efficient producers of new secondary metabolites that show a range of biological activities. Bioactive compounds from marine actinomycetes possess distinct chemical structures that may form the basis for synthesis of new drugs. Additional actinomycetes- produced antibiotics could be discovered by subjecting terrestrial and marine samples to innovative enrichments and screening methods. Sequencing actinomycetes genomes may provide insights useful in devising novel agents. This review article highlights the potential activities of actinomycetes.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-P'Col-0000674
Title: In vitro antioxidant activity of ethanolic extract of the leaves of Lagenaria siceraria (Molina) Standl.
Category: Pharmacology
Section: Research Article
Country: India
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Free radical scavenging activity of the ethanolic extract of the leaves of Lagenaria siceraria (Molina) Standl was evaluated in vitro by using DPPH radical scavenging activity, hydrogen peroxide radical scavenging activity, hydroxyl radical scavenging activity, reducing power method and nitric oxide radical scavenging activity. Significant results were obtained in the estimated parameters, thus indicating that the leaves of Lagenaria siceraria (Molina) Standl has got promising antioxidant activity.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-PHDRS-0000675
Title: Studies on phytochemical analysis and antioxidant activity of selected medicinal plants from kolli hills
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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In the present study we carried a systematic record of the qualitative and the antioxidant activity in Desmodium gangeticum and Premna tomentosa willd plant species.The distribution of the main active principles [alkaloid, flavanoids, phenols, steroids and tannins] in desmodium gangeticum and premna tomentosa willd. The ethanolic extracts of leaves Desmodium gangeticum and Premna tomentosa willd were screened for their in vitro enzymatic and non-enzymatic antioxidant activity. The extract was found to possess excellent antioxidant activity.The antioxidant may be attributed to the presence of flavanoids and phenolics present in the drug.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-PHDRS-0000676
Title: Phytochemical and pharmacological potential of Artemisia absinthium Linn. and Artemisia asiatica Nakai : A Review
Category: Pharmacognosy and Herbal Drugs related study
Section: Review Article
Country: India
View Article

A world health organization survey indicated that about 75-80% of the world’s populations rely on non-conventional medicine, mainly of herbal sources, in their primary healthcare. There has been an explosion of scientific information concerning plants, crude plant extracts and various substances from plants as medicinal agents during last 30-40 years. Although herbal medicine has existed since the dawn of time, our knowledge of how plants actually affect human physiology remains largely unexplored. Numbers of plants are claiming various medicinal uses and many researches are going on in this view. They are believed to be much safer and proved elixir in the treatment of various ailments. The genus Artemisia consists of about 500 species, occurring throughout the world. Among the different species of Artemisia, A. absinthium and A. asiatica have a vast range of biological activities including cytotoxic, antihepatotoxic, antibacterial, antifungal, antioxidant, antimalarial etc. Terpenoids, flavonoids, coumarins, caffeoylquinic acids, sterols and acetylenes constitute major classes of phytoconstituents of the genus Artemisia. The present review comprises the phytochemical, ethnopharmacological and pharmacological reports of A. absinthium and A. asiatica. The future scopes of these plants have been emphasized with a view to isolate bioactive moieties which could be used for multifarious biological activities.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-PA-0000677
Title: HPTLC Method Development and Validation for the Simultaneous Estimation of Amlodipine Besylate and Nebivolol Hydrochloride in tablet dosage form
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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The simple, accurate and precise method for Simultaneous quantification of Nebivolol hydrochloride ( NEB-H) and Amlodipine Besylate (AML) in tablets by HPTLC methods were developed In this method, the chromatograms were developed using a mobile phase of Methylene Chloride : Methanol : Ammonia ( 8.5:1:0.5 v/v ) on precoated plate of silica gel 60 F254 and quantified by densitometric absorbance mode at 285 nm. The Rf of AML and NEB-H were 0.19 and 0.41 respectively. Recovery studies of 99.96 – 102.11%, percentile relative standard deviation of not more than 0.8 and correlation coefficient (linearity range) of 0.9984 – 0.9998 shows that developed methods were accurate and precise for AML and NEB-H respectively. The LOD and LOQ values were found to be 30ng/ml, 30ng/ml and 80ng/ml, 80ng/ml for AML and NEB-H respectively. The mean percentage recovery values close to 100% it indicates there is no interferences of additives with Nebivolol hydrochloride (NEB-H) and Amlodipine Besylate (AML) present in tablet dosage forms. The method has been validated as per ICH guide lines. This method can be employed for the routine analysis of tablets containing AML and NEB-H.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-PCS-0000678
Title: Buccoadhesive Drug Delivery System of Captopril: Formulation and In Vitro Evaluation
Category: Pharmaceutics
Section: Research Article
Country: India
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Captopril, a drug widely used in the treatment of hypertension. However, its extensive first pass metabolism results in poor bioavailability. The objective of this research work is to design and evaluate the controlled release of mucoadhesive buccal tablets of Captopril with a goal to increase the bioavailability, reduce dosing frequency and improve patient compliance. The tablets were prepared by using Carbopol-934, Hydroxy Propyl Cellulose (HPC), Hydroxy Ethyl Cellulose (HEC) as mucoadhesive polymers. Six formulations were developed with varying concentration of polymers. The tablets were evaluated for hardness, weight variation, thickness, percentage of drug content, surface pH, in-vitro swelling studies, matrix erosion, in-vitro mucoadhesive strength, in-vitro drug release and subjected to stability studies. Formulation (F4) containing carbopol 934P and HEC in the ratio of (2:4) showed good mucoadhesive strength (38.4g) and maximum drug release of 98.51% in 10 hours. Swelling increases with increase in concentration of HEC in tablets. Surface pH was found to be 6.10. Formulation (F4) follows zero-order drug release. FTIR studies showed no evidence on interaction between drug and polymers. The results indicate that the mucoadhesive buccal tablets of Captopril may be a good choice to bypass the extensive hepatic first pass metabolism with an improvement in the bioavailability of captopril through buccal mucosa.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-PCS-0000679
Title: Lipophilicity Measurement Through Newer Techniques
Category: Pharmaceutics
Section: Review Article
Country: India
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This review describes lipophilicity parameters used in drug designing. Lipophilicity is an important parameter related to drug properties, such as drug absorption, plasma protein binding, hydrophobic drug-receptor interactions and partly the pharmacokinetic behaviour and toxicological properties and recognized today as one of the major challenges in oral delivery of new drug substances. The tremendous knowledge accumulated on biological factors and as well as on the physicochemical characteristics of the drug substances lipophilcity affecting oral bioavailability. The new methods (RP-HPLC, RP-TLC, Liposomes partitioning, IAM Chromatography, Electrokinetic approaches) have been discussed to measure the lipophilicity of xenobiotics and to overcome the problems with existing methods.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 2.
Article Id: JPRS-PHDRS-0000682
Title: Evaluation of cinnamon oil, peppermint oil, cardamom oil & orange oil as antimicrobial agents
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The essential oil of Cinnamon, Peppermint, Cardamom and Orange tested against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans strains, isolated from regular patients of V.S.S. medical college Burla. Attempts have been made for determination of Minimum Inhibitory Concentration as well as the antimicrobial activity. It was found that Cinnamon oil have marked antimicrobial activity against Escherichia coli, Staphylococcus aureus, Candida albicans.