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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-PCS-0000663
Title: Solubility and Dissolution Enhancement: An overview
Category: Pharmaceutics
Section: Review Article
Country: India
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Poorly water soluble compounds have solubility and dissolution related bioavailability problems. The dissolution rate is directly proportional to solubility of drugs. Drugs with low aqueous solubility have low dissolution rates and hence suffer from oral bioavailability problems. The poor solubility and poor dissolution rate of poorly water soluble drugs in the aqueous gastro intestinal fluids often cause insufficient bioavailability. Other in-vivo consequences due to poor aqueous solubility include increased chances of food effect, more frequent incomplete drug release from the dosage form and higher inter-patient variability.Enhancement of solubility, dissolution rate and bioavailability of drug is a very challenging task in drug development, nearly 40% of the new chemical entities currently being discovered are poorly water soluble drugs. Aqueous solubility of any therapeutically active substance is a key property. As it governs dissolution, absorption and thus the in vivo efficacy. The present review deals in detail about the different techniques used for the improvement of the solubility and dissolution rate of poorly water soluble drugs include, Inclusion complexation with cyclodextrins, Size reduction technology, Functional polymer technology and Solid dispersions etc.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-MB-0000707
Title: Antifungal activity of twenty two ethanolic plant extracts against food-associated fungi
Category: Microbiology
Section: Research Article
Country: India
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In the present study, a total of 22 plant extracts were evaluated for antifungal activity against ten food-associated fungal isolates by poisoned food technique. Of the 22 plant extracts, clove and ginger ethanolic extracts showed inhibitory activity against all the test fungal isolates while garlic ethanolic extract also showed inhibitory activity against all the tested fungi except Penicillium oxalicum. Three extracts namely cumin, turmeric and cinnamon showed inhibitory activity against few of the tested fungi. Sixteen ethanolic extracts did not show any activity against any of the tested fungal isolates. The highest activity was observed in clove ethanolic extract with percent mycelial growth inhibition ranging from 70 to 100% followed by ginger extract (30 to 100%). On the basis of this finding, it may be suggested that these extracts may be used as natural antimicrobial additives to increase the shelf-life of foods.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-PCS-0000659
Title: Self micro-emulsifying drug delivery system (SMEDDS) : Review
Category: Pharmaceutics
Section: Research Article
Country: India
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Oral route has always been preferred route for formulators and has dominated over other routes of administrations. However this preferred route is limited to those drugs molecule that are permeable across the gastric mucosa and are at least sparingly soluble. Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. Realization that the oral bioavailability of poor water soluble drugs may be enhanced when co-administered with meal rich in fat has led to increasing recent interest in the formulation of poorly water soluble drugs in lipids. Also Lipid-based drug delivery systems have gained considerable interest after the commercial success of Sandimmune NeoralTM (Cyclosporine A), Novartis Pvt. Ltd. and Fortovase (Saquinavir), Roche Laboratories Inc. with much attention focused on self micro-emulsifying drug delivery systems (SMEDDS). SMEDDS are isotropic mixtures of oil, surfactant, co-surfactant and drug with a unique ability to form fine oil in water microemulsion upon mild agitation following dilution with aqueous phase. The hypothesis behind dissolution rate enhancement with SMEDDS is the spontaneous formation of the emulsion in the gastrointestinal tract which presents the drug in solubilized form, and the small size of the formed droplet provides a large interfacial surface area for drug absorption. This article gives a complete overview of SMEDDS as a promising approach to effectively tackle the problem of poorly soluble molecules.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-P'Col-0000657
Title: Hepatosuppression by Ricinus communis against CCl4 Induced Liver Toxicity in Rat
Category: Pharmacology
Section: Research Article
Country: India
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The present work deals with the use of Ricinus communis leaves powder against hepatosuppression induced by carbon tetrachloride. The results were documented by examination of blood and tissue biochemical serum marker enzymes like GOT, GPT, Alkaline phosphate, glucose, cholesterol, bilirubin, total protein etc. These biochemical parameters were significantly changed by the single dose of CCl4 which can be recovered by giving treatment of Ricinus communis. Silymarin was used as a reference standard for comparison. From the findings it is clear that the hepatoprotective potential of Ricinus communis against hepatosuppression possibly involve mechanism related to its ability to block the P-450 mediated CCl4 bioactivation through selective inhibitors of Reactive Oxygen Species like antioxidants brought about significant inhibition of TBARS suggesting possible involvement of O2 –, HO2, HO2–, H2O2 and OH. The hepatoprotective effects were supported by Light and Electron microscope studies. The overall results indicate that Ricinus communis has high potential in healing liver parenchyma and regeneration of liver cells. It shows best ability to protect liver may act even in humans as potent liver tonic due to presence of large number of antioxidants.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-MB-0000656
Title: Studies on antioxidant and anthelmintic activity of two Streptomyces species isolated from Western Ghat soils of Agumbe, Karnataka
Category: Microbiology
Section: Research Article
Country: India
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The Western Ghats are well known for their rich and unique assemblage of flora and fauna. The present study was conducted to determine antioxidant and anthelmintic potential of two actinomycetes isolates recovered from Western Ghats soils of Agumbe, Karnataka. The isolates were identified as Streptomycetes based on colony appearance, spore arrangement, biochemical and staining characteristics.The antioxidant activity of butanol extract of the culture broth of Streptomyces sp. No 1 and 2 was assessed using DPPH free radical assay and Fe+3 reducing assay. The solvent extracts of the isolates showed a dose dependent antioxidant activity. Anthelmintic activity was determined in adult Indian earthworm model. A marked dose dependent paralysis and death of worms was observed revealing anthelmintic activitiy. Among isolates, Streptomyces sp. No. 2 was found to possess marked antioxidant and anthelmintic efficacy than Streptomyces sp. No. 1. The observed activities of the isolates might be due to active principles present in the solvent extracts. Isolation and purification of the compounds possessing these potentials in the butanol extracts are to be carried.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-P'Col-0000655
Title: Antiinflammatory activity of Curcuma aromatica Salisb and Coscinium fenestratum Colebr : A comparative study
Category: Pharmacology
Section: Research Article
Country: India
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The ethanolic extracts of two traditionally used medicinal plants namely Curcuma aromatica Salisb and Coscinium fenestratum Colebr were investigated for antiinflammatory activity using the carrageenan-induced rat paw edema method. The ethanolic extracts of both the plants and the standard drug diclofenac sodium exhibited significant antiinflammatory activity in terms of inhibition of paw edema. It was found that ethanolic extracts of C. aromatica was more potent than C. fenestratum. The preliminary phytochemical analysis of extracts showed the presence of tannins and flavonoids. The observed activity could be mainly due to the presence of phytoconstituents such as flavonoids.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-HM-0000654
Title: Phytochemical and antimicrobial screening of Gymnema sylvestre, Mentha arvensis, Solanum surratense, extracts in dental caries.
Category: Herbal medicine
Section: Research Article
Country: India
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Hydro alcoholic dry extracts of Gymnema sylvestre, Mentha arvensis, Solanum surratense, for treatment of a dental caries were screened for antimicrobial activity by Agar well diffusion method against Streptococcus mutans, Staphylococcus aureus,Streptococcus mitis, and Candida albicans. Among them the extracts of Gymnema sylvestre dry extract showed strong antimicrobial activity against the bacteria and fungi with the zone of inhibition ranges from 16-20mm at 25mg/ml. The other extracts such as Solanum surratense, Mentha arvensis showed concentration–dependent activity against all the tested micro-organisms with the zone of inhibition ranges from 12-24mm at various concentrations.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-P'Col-0000653
Title: Antiulcer activity of aqueous suspension of Saraca indica flower against gastric ulcers in albino rats
Category: Pharmacology
Section: Research Article
Country: India
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The effect of aqueous suspension of Saraca indica flower was investigated in albino rats to evaluate the anticulcer activity by using two models, i.e., pyloric ligation and aspirin induced gastric ulcer. The parameters taken to assess antiulcer activity were free and total acidity and ulcer index. The control group received 2 ml of normal saline and varying doses of the Saraca indica flower extract were used for the remaining group (10–30 mgkg-1 b.w.). The results indicate that the aqueous flower extract Saraca indica significantly (P<0.005) decreases the free and total acidity and ulcer index with respect to control in a dose dependent manner thus justifying the use of Saraca indica flower extract as an antiulcer agent in folklore medicine.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-PB-0000652
Title: In vivo analysis of nephro & hepato protective effects and antioxidant activity of Madhuca longifolia against acetaminophen-induced toxicity & oxidative stress
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Madhuca longifolia is a folklore medicinal plant that is commonly used for the treatment of snakebite as antidote in Southern part of Tamilnadu, India. Stem bark is used to cure hydrocele, wounds in stomach (ulcer), scabies and rheumatism. Acetaminophen (APAP) is commonly used as an analgesic and an antipyretic agent that, in high doses, produces liver and kidney necrosis in mammals. The aim of the present study is to investigate the nephro, hepatoprotective and antioxidant activities of the ethanol extract of Madhuca longifolia (EEML) in two dose levels of 500 mg/kg & 750 mg/kg B/W on APAP induced toxicity in rats.Biochemical studies show that there is an increase in the levels of serum urea, hemoglobin (Hb), total leukocyte count, creatinine, packed cell volume, DLC, mean corpuscular volume and raised body weight along with reduced levels of neutrophils, mean corpuscular Hb content, mean corpuscular hematocrit, granulocytes, uric acid, and platelet concentrations.These values are retrieved significantly by the treatment with extracts at two different doses. The antioxidant studies reveal that the levels of renal superoxide dismutase, catalase, reduced glutathione and glutathione peroxidase in the APAP treated animals are increased significantly along with decreased MDA content in EEML treated groups. Apart from these, histopathological changes also reveal the protective nature of the Madhuca longifolia extract against APAP induced necrotic damage of hepato and renal tissues. In conclusion, these data suggest that the EEML can prevent both renal and liver damage from APAP induced toxicity in rats and it is likely mediated through its antioxidant activities.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-PCS-0000651
Title: New quantitative estimation of salicylic acid bulk sample using sodium saccharin as hydrotropic solubilizing agent
Category: Pharmaceutics
Section: Research Article
Country: India
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Solubilization of poorly water-soluble drugs has been a very important issue in screening studies of new chemical entities as well as in formulation research. A novel, safe and sensitive method of titrimetric estimation has been developed using 2 M sodium saccharin solution (an economic drug) as a hydrotropic solubilizing agent for the quantitative determination of salicylic acid in bulk, a sparingly water-soluble keratolytic drug. There was more than a 15-fold enhancement in aqueous solubility of salicylic acid in 2 M sodium saccharin solution as compared with the solubility in distilled water. The hydrotrope used in this work is freely soluble in water, non toxic and does not interfere in analysis. The results of analysis obtained by the proposed method are comparable with the results of analysis obtained by the Indian Pharmacopoeial method. The proposed method is new, simple, accurate and reproducible. Results of the analysis were validated statistically. Statistical data proved the accuracy, reproducibility and precision of the proposed method.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-PHDRS-0000665
Title: In vitro study on the radical scavenging and anti lipidperoxidative effects of Eugenia jambolana aqueous extracts
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The present study was planned to evaluate the radical scavenging and anti-lipidperoxidative activity of aqueous extracts of Eugenia jambolana seeds by three in vitro methods viz., DPPH free radical scavenging assay, reducing power and lipid peroxidation inhibition using rat liver homogenate as substrate. Further, the effect of heat treatment on the antioxidant activity was also studied. Both untreated and heat treated extracts exhibited significant radical scavenging activity comparable to that of butylated hydroxyl toluene (BHT); a synthetic antioxidant. Both the extracts exhibited similar reducing power which was significantly lower (p=0.05) than that of ascorbic acid. In case of anti-lipidperoxidation assay both the extracts inhibited the formation of lipid peroxides to a significant extent (p=0.05) and significantly (p=0.05) restored glutathione content in the liver homogenate. These findings emphasize that Eugenia jambolana possesses a strong antioxidant activity besides, being a proven hypoglycemic agent.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-PC-0000664
Title: Azetidinone : A bioactive moiety
Category: Pharmaceutical Chemistry
Section: Review Article
Country: India
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2-Azetidinone is a β-lactam cyclic amide with four atoms in a ring. Traditionally β-lactam is a part of structure of broad spectrum antibiotic class of drugs – penicillins and cephalosporins .The ring ultimately is proven to be a generic descriptor for penicillin family. These molecules operate by forming a covalent adducts with membrane bound bacterial transpeptidases which are also known as penicillin binding proteins (PBPs), involved in the biosynthesis of cell walls.Cycloaddition of monochloracetylchloride with imine (Schiff base) result in formation of 2-azetidinone(â-lactam).Present work is an attempt to review chemistry, synthesis, spectral studies and applications of 2-azetidinones.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-PA-0000662
Title: Current Trends in Herbal Medicines
Category: Pharmaceutical Analysis
Section: Review Article
Country: India
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Herbal medicines make up an important component of the trend toward alternative medicine. Herbal medicine is becoming ever more popular in today’s world as people seek out natural remedies. Herbal medicines have been used since the dawn of civilization to maintain health and to treat various diseases. To compete with the growing pharmaceutical market, there is an urgency to utilize and scientifically validate more medicinally useful herbal products. This article provides an overview of herbal medicines and aimed to explain the therapeutic efficacy of various herbal medicines, adverse drug reactions, drug interactions, standardization and stability testing of herbal medicines, pharmacovigilance and regulatory status of herbal medicines.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-PCS-0000661
Title: Smart polymers in drug delivery: An overview
Category: Pharmaceutics
Section: Review Article
Country: India
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Controlled drug delivery is useful because it is achieving better drug product effectiveness, reliability and safety. Smart polymers have various applications in biomedical field as delivery systems. Smart polymers are macromolecules that display a dramatic physiochemical change in response to small changes in their environment such as temperature, pH, light, magnetic field, ionic factors etc. Dual – stimuli responsive polymers are also used in the biomedical field.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-PCS-0000660
Title: Solid lipid nanoparticles :A promising tool for drug delivery system
Category: Pharmaceutics
Section: Review Article
Country: India
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Solid lipid nanoparticles (SLNs) technology represents a promising new approach to lipophilic drug delivery. Solid lipid nanoparticles are important advancement in this area. The biodegradable and bioacceptable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. SLNs can also be used to improve the bioavalability of drugs. In this present review this new approach is discussed in terms of their advantages, characterization, in-vivo studies, in-vitro studies, pharmacokinetic studies and special features.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-PA-0000658
Title: Spectrophothometric Determination of Nitazoxanide and Ofloxacin in Combined Dosage Form
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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The present investigation illustrates the simultaneous determination of nitazoxanide and ofloxacin using two simple, accurate and precise spectrophotometric methods. First method is based on the formation and solving of simultaneous equations, wherein, 340.0nm (λmax of nitazoxanide) and 300.0nm (λmax of ofloxacin) were used as the wavelengths of determination in acetonitrile. Second method is Q-analysis method, based on absorbance ratio at two selected wavelengths, 312.0 nm (iso-absorptive point) and 340.0 nm (λmax of nitazoxanide). Both the methods were validated statistically and recovery studies were carried out. The Beer’s law limits for each drug individually and in mixture was within the concentration range of 5- 40 µg/ml. Linearity of nitazoxanide and ofloxacin were in the range of 80-120% of the label claim. The proposed methods have been applied successfully to the analysis of the cited drugs either in pure form or in pharmaceutical formulations with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of drugs in pharmaceutical formulations.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: January
Article Id: JPRS-PC-00001409
Title: Synthesis and Anti-Inflammatory Activity of Some 5-Phenyl-1-(Acyl)-1, 2, 3, 4-Tetrazole.
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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A series of novel 5-phenyl,1-acyl 1,2,3,4-tetrazoles (3–10) have been synthesized via condensation of 5-phenyl-1,2,3,4-tetrazoles (2) with various acylating reagents. 5-phenyl- 1,2,3,4-tetrazoles was synthesized by the cycloaddition of Benzonitrile(1) with sodium azide and ammonium chloride in presence of Dimethylformamide as solvent. All synthesized compounds which were characterized to be new substituted Tetrazoles. Their structures were determined by 1H NMR,FT-IR, mass spectra and elemental analyses. The compounds synthesized were screened for anti-inflammatory activity. Compounds 4, 7 and 9 possess potent anti-inflammatory activity.