Journal Menu

Issues

Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PCS-0000738
Title: Estimation of Thiocolchicoside And Ketoprofen in pharmaceutical dosage form by Spectrophotometric methods.
Category: Pharmaceutics
Section: Research Article
Country: India
View Article

Two rapid, economical accurate and precise, methods have been developed for estimation of Thiocolchicoside and Ketoprofen in tablet dosage form. First method is first order derivative spectroscopy, wavelengths selected for quantitation were 233.0 nm for Thiocolchicoside (zero cross for Ketoprofen) and 243.0 nm for Ketoprofen (zero cross for Thiocolchicoside). Second method is Absorbance correction method in which absorbance is measured at two wavelengths 372.0 nm at which ketoprofen has no absorbance and 260.0 nm at which both the drugs have considerable absorbance. In first order derivative spectroscopy linearity for detector response was observed in the concentration range of 3-15 ìg/ml for Thiocolchicoside and 12-60 ìg/ml for Ketoprofen. In Absorbance correction method linearity for detector response was observed in the concentration range of 1-5 ìg/ml for Thiocolchicoside and 10-50 ìg/ml for Ketoprofen. The proposed methods were successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PCS-0000751
Title: Formulation and evaluation of In-Situ gel of metoprolol tartrate for nasal delivery
Category: Pharmaceutics
Section: Research Article
Country: India
View Article

The objective of present investigation was to develop a mucoadhesive in-situ gel; formulation was developed with aim to reduce the mucociliary clearance by using mucoadhesive polymer in gel, thereby increasing the contact of formulation with nasal mucosa and hence improving the absorption of drug. The in-situ gelation was achieved by the use of pluronic F127, which exhibit thermoreversible gelation property. The formulation additives are having effect on thermodynamic of phase transitions at gelation (T1) and gel melting (T2) temperature. Result revealed that addition of mucoadhesive polymer Carbopol934 has decreased T1 whereas addition of PEG400 increased T1 and also PEG400 increased in- vitro drug release. In- vitro drug release shows that with increasing carbopol concentration increases viscosity of formulation and influences the diffusion of drug particle while addition of PEG 400 enhances in vitro drug release.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PHDRS-0000748
Title: Pharmacognostic, Phytochemical & Quantitative Investigation of Saraca asoca leaves
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
View Article

Saraca asoca family (Caesalpiniaceae) commonly known as Ashoka briksh. According to our traditional system of medicine, bark of Saraca asoca has tremendous therapeutic effects in menstrual problems. Establishment of Pharmacognostic profile of the leaves will assist in standardization which can guarantee quality, purity and identification of samples. In the present study we describe Pharmacognostical feature, including macroscopy, microscopy and analytical profile and to investigate the phytochemical and quantitative determination of phytoconstituents from the leaves of Saraca asoca. These observations would be of immense value in the botanical identification and standardization of the drug in crude form. This study would help distinguish the drug from its adultered species.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PCS-0000734
Title: Elemental analysis by Energy Dispersive X-Ray Spectroscopy (EDX) of Capparis zeylanica Linn. plant
Category: Pharmaceutics
Section: Research Article
Country: India
View Article

Capparis zeylanica (Capparaceae) is a many branched thorny, sub-scandent climbing shrub. The plant have been used extensively in India in indigenous medicine. The entire plant were investigated for its metal mineral content by using Energy Dispersive X-Ray Spectroscopy (EDX). The elemental analysis was performed to estimate eleven numbers of elements (C, O, Mg, Al, Si, Cl, K, Ca, Fe, Cu & Zn). The analysis of EDX showed that the entire plant possesses all essential elements except chloride (Cl).

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PCS-0000747
Title: Review: Osmotic drug delivery systems current scenario
Category: Pharmaceutics
Section: Review Article
Country: India
View Article

Osmotic drug delivery systems are new approach for a controlled release dosage form. Various patents available for osmotic drug delivery system like Rose-Nelson pump, Higuchi-leeper pump, higuchi-theeuwes pump, elementary osmotic pump etc. ODDS is useful for poorly soluble drug, for pulsatile drug release, zero order release. Varios techniques available for preparation of ODDS include push pull osmotic Pump, osmotic Brusting osmotic pump, liquid oral osmotic system, sandwiched osmotic tablets (SOTS), delayed delivery osmotic device, monolithic osmotic System and controlled porosity osmotic Pump. Osmotic ally controlled oral drug delivery systems utilize osmotic pressure for controlled delivery of active agent(s). Drug delivery from these systems, to a large extent, is independent of the physiological factors of the gastrointestinal tract. These systems can be utilized for systemic as well as targeted delivery of drugs. The release of drug(s) from osmotic systems is governed by various formulation factors such as solubility and osmotic pressure of the core component(s), size of the delivery orifice, and nature of the rate-controlling membrane. By optimizing formulation and processing factors, it is possible to develop osmotic systems to deliver drugs of diverse nature at a pre-programmed rate. In the present review, different types of oral osmotic systems, various aspects governing drug release from these systems, and critical formulation factors are discussed.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PCS-0000735
Title: Ethosomes: A novel tool for drug delivery through the skin
Category: Pharmaceutics
Section: Review Article
Country: India
View Article

Ethosomes are the ethanolic phospholipid vesicles which are used mainly for transdermal delivery of drugs. Ethosomes have higher penetration rate through the skin as compared to liposomes hence these can be used widely in place of liposomes. The increased permeation of ethosomes is probably due to its ethanolic content. Ethanol increases the cell membrane lipid fluidity which results in increased skin penetrability of the ethosomes. These ethosomes permeates inside the skin and fuse with cell membrane lipids and release the drug. Hot and cold methods are used for formulation of ethosomes. Evaluation parameters include size, shape, drug content, zeta potential etc. Ethosomes have been successfully evaluated for the delivery of many drugs for e.g. Cyclosporine A, insulin, salbutamol etc. Ethosomes can be important drug delivery tool in the future.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PHDRS-0000740
Title: Review on Achyranthes Aspera
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
View Article

Achyranthes aspera Linn (Amaranthaceae), commonly known as apamarga, is a commonly available plant in India. It is traditionally known as Latjira, and Prickly chaff. Different constituents are find in different part of the Achyranthes aspera (eg. Saponins A and B, amino acids, hentriacontane, hormones ecdysterone and Petrol extract of shoot 17-pentatriacontanol). Some alkaloids and fatty acids are also indicates. therefore its use in the treatment of different type of acute and chronic disease.whole plants of Achyranthes aspera have pharmacological activity. The claims were gathered by interviewing traditional healers, especially women.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PC-0000737
Title: Design and Synthesis of Novel Quinazolinone Derivatives as Broad Spectrum Anticonvulsant and Antimicrobial Agent
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
View Article

The present work was carried out to synthesize compounds with substituted quinazolinone semicarbazones at third position of the quinazoline nucleus and chemically modifying second position of quinazolinone to get the compounds with lesser side effects and more potent anticonvulsive agents. Although several new anticonvulsants are already in clinical use, some types of seizures are still not adequately treated with current therapy and have limitations, intolerable side effects. In response to these limitations, the development of new drugs to optimally manage seizures has been strongly advocated. Thus the search for new anticonvulsant drugs continues to be an active area of investigation in medicinal chemistry. The present study describes the synthesis of newer quinazoline derivatives and their anticonvulsant, antimicrobial activities. The newly synthesized compounds were evaluated intraperitoneally into the mice in the maximal electro shock (MES), subcutaneous strychnine threshold test (scSTY), using doses 30, 100, 300 mg/kg, and neurotoxicity screens, observation was carried out at two different time intervals. Almost all the synthesized analogue showed potent anticonvulsive activity. Some of the synthesized compounds were equipotent to the well known antiepileptic agent phenytoin. The synthesized compounds were found to potent anticonvulsant with less neurotoxicity.The synthesized compounds were also studied for antimicrobial potency. The antibacterial activity of synthesized quinazoline semicarbazones were characterized by antimicrobial screening against several gram-positive, gram negative bacteria. Antimicrobial screening for all the compounds exhibits characteristic microbial inhibition. A detailed study is in progress to modify the structural activity, and toxicological barriers for the enhanced pharmacological efficiency of synthetic antibiotics.

Cite this article as: Ponnilavarasan Ilangovan1* , Swastika ganguly2 , Vijay pandi1, Design and Synthesis of Novel Quinazolinone Derivatives as Broad Spectrum Anticonvulsant and Antimicrobial Agent, Journal of Pharmacy Research 2010, 3(4),703-706.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-P'Col-0000733
Title: Lipid lowering effect of aqueous extract of flower of Cassia auriculata on streptozotocin (STZ) induced diabetic male albino rats
Category: Pharmacology
Section: Research Article
Country: India
View Article

Cassia auriculata (Avarai in Tamil) flowers are used extensively in the indigenous system of medicine as an anti-diabetic agent.The present investigation focuses on the lipid lowering property of an aqueous extract of flowers of Cassia auriculata on streptozotocin (STZ) induced diabetic rats.The lipid profile such as serum total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL), high density lipoproteins (HDL), and very low density lipoproteins (VLDL) were studied.The levels of serum TC, TG, LDL, and VLDL were reduced significantly (P<0.00.1). Where as HDL levels were increased in the plant extract fed animals when compared to diabetic control group.These results further suggest that the flowers of Cassia auriculata may be useful in the therapy and management of diabetes induced hyperlipidemia.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-MB-0000736
Title: Evaluation of Antimicrobial Potential of Some Medicinal Plants Against Plant and Human Pathogens
Category: Microbiology
Section: Research Article
Country: India
View Article

The methanol crude extracts of Clitoria ternatea, Guazuma ulmifolia and Madhuca indica showed significant antibacterial activity against Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella typhi and antifungal activity against Aspergillus niger, Aspergillus flavous, Fusarium oxiporum and Penicillium chrysogenum. When compare all the three extracts, C. ternatea showed highest inhibition zone against Pseudomonas aeruginosa i.e. 16 mm and lowest antibacterial activity found in M. indica i.e. 7 mm against Pseudomonas aeruginosa. C. ternatea also have remedial antifungal activity i.e. 13 mm against Aspergillus flavous. M. indica found to be very poor antifungal activity against all pathogens. This study suggest that medicinal plant extracts may be possess some of the compounds with antibacterial and antifungal properties that can be used traditional medicine for the treatment of infectious diseases.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-P'Col-0000739
Title: Protective activity of Mussaenda frondosa leaf extracts against paracetamol induced hepatic damage in wistar rats.
Category: Pharmacology
Section: Research Article
Country: India
View Article

Aim:The objective of the present investigation was to study hepatoprotective activity of various leaf extract of Mussaenda frondosa- Linn in paracetamol induced liver damage model in Wistar rats.Materials and methods:Liver damage was produced by paracetamol (2gm/kg, p.o.) in 1% CMC. The Plant extracts (200mg/kg, p.o.) were administered every 24 hrs for seven days, while standard group received N-acetylcysteine. At the end of the study the marker enzymes in serum and histopathological analysis were carried out.Results:The aqueous as well as alcoholic extract showed significant hepatoprotective activity and efficacy of alcoholic extract was almost comparable to that of N-acetylcysteine.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PHDRS-0000741
Title: Free radical scavenging activity of various extracts of whole plant of Mucuna pruriens (Linn): an in-vitro evaluation
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
View Article

The present investigation was to examine the free radical scavenging activity of various extracts of whole plant of Mucuna pruriens by different in-vitro methods. The antioxidant activity was evaluated by Hydroxyl radical scavenging activity, Nitric oxide radical scavenging activity with reference standard Ascorbate and total phenol content respectively. An IC50 value was found that ethyl acetate extract of Mucuna pruriens is more effective in hydroxyl radical scavenging activity than that of methanolic and petroleum ether extract. The methanolic extract of Mucuna pruriens was found to more effective in the nitric oxide radical scavenging activity. The IC50 values of the methanolic extract of Mucuna pruriens and ascorbate were found to be 270µg/ml and 410µg/ml respectively. But when compare to the all the three extracts with ascorbate (standard), the methanolic extract of the Mucuna pruriens showed the better result. In addition, the methanolic and ethyl acetate extract of Mucuna pruriens was found to contain a noticeable amount of total phenols, which play a major role in controlling antioxidants. Moreover, the results were observed in a concentration dependent manner. All the above invitro studies clearly indicate that the methanolic and ethyl acetate extract of Mucuna pruriens has a significant antioxidant activity. These invitro assays indicate that this plant extracts is a better source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PCS-0000742
Title: Formulation and Evaluation of Colon Specific Matrix Tablet of Diethylcarbamazine Citrate
Category: Pharmaceutics
Section: Research Article
Country: India
View Article

The objective of the present study was to develop colon specific sustained release matrix tablets of an antifilarial drug diethylcarbamazine citrate (DEC), delivered to colon for its effective actions. The colon targeted matrix tablet was prepared by wet granulation technique using different percentage of guar gum as matrix carrier and coated with Eudragit L-100. The novelty in this study was to incorporate guar gum as carrier to retard the drug release in the region of stomach and small intestine. Eight batches of matrix tablet were subjected to various evaluations including the comparison with conventional marketed product. The dissolution study of DEC matrix tablet was in simulated colonic fluids (phosphate buffer pH 6.8) was 94% and in simulated colonic fluids (rat caecal content medium) was 98% after degradation into 2-3 pieces at the end of the 24 h study. The result of the studies showed that colon targeted matrix tablet containing 45% of guar gum was most likely to provide targeting of DEC for local action in the colon. The colon targeted matrix tablet of DEC showed no change either in physical appearance, drug content or in dissolution pattern after storage at 300± 20C / 65 ± 5% RH for 2 month. FT-IR spectrum showed no interaction between DEC and guar gum.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PCS-0000743
Title: Formulation and Evaluation of Torsemide intragastric buoyant sustained release microspheres
Category: Pharmaceutics
Section: Research Article
Country: India
View Article

The present study describes a gastroretentive floating controlled drug delivery system containing torsemide in the form of microsphere prepared by ionic gelation technique and evaluated for its processing parameters. Nine formulations containing retardant material such as sodium alginate and HPMC K15, foam forming agent sodium bicarbonate were prepared loaded with torsemide. Solid, discrete and reproducible free flowing microspheres were obtained. The microspheres had almost smooth surface with free flowing and good packing properties. The micromeretic study indicated that the obtained angle of repose, % compressibility index values were lie with in the limit.The prepared microspheres were characterized for their entrapment efficiency, particle size, floating ability, in-vitro release behavior, scanning electron microscopy (SEM) and differential scanning calorimeter (DSC).The in-vitro dissolution studies were carried out in the USP dissolution Apparatus-2 in 0.1N HCl at 50 rpm at 37±0.5 °C. Microspheres remain buoyant over a period of 8hrs in the release medium and the amount of sodium bicarbonate was found to be significant for remaining buoyant. It was found that the torsemide floating microspheres can be successfully prepared having high entrapment efficiency and prolonged released behavior with a substantial floating ability.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PB-0000744
Title: Morphological, anatomical and proximate analysis of Leaf, Root, Rhizome of Costus igneus
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
View Article

This study is based on anatomical and morphological investigations of Costus igneus. It is an important plant because of its value for medicinal uses. Plant samples were cultivated in Periyar Maniammai University nursery under net house and the morphological, anatomical features of various plant parts of Costus igneus such as young root, leaf and rhizome were investigated in detail and demonstrated by illustrations. The total ash value, acid insoluble ash and water-soluble ash of rhizome were significantly (p<0.001) higher than stem and leaf. Moisture content, protein and carbohydrate were significantly higher in leaf. In Fluorescent analysis, leaf, stem and rhizome powder were treated with various chemicals and were studied under UV light and daylight. At present finding, Costus igneus have characteristic morphological, anatomical and proximate features that could be used to distinguish it from other members of the Costaceae family.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-P'Col-0000745
Title: Protective action of Cuminum cyminum against gentamicin induced nephrotoxicity
Category: Pharmacology
Section: Research Article
Country: India
View Article

Objective: To evaluate the effect of aqueous extract of Cuminum cyminum (AEC) seeds on gentamicin induced nephrotoxicity in rats. Methods: The animals are divided into five groups of six animals each; normal saline, AEC 200mg/ kg p.o for 11 days, gentamicin 80 mg /kg i.p for 8 days, AEC 100 and 200 mg/kg for 3 days and concurrently with gentamicin for 8 days. End of the study urine sodium, potassium glucose, creatinine, urea, serum urea, serum creatinine, urea and creatinine clearance. Lipidperoxidation through thiobarbituric acid reacting substances (TBARS) method and histopathological examination was done. Results: Gentamicin treated group caused nephrotoxicity as evidenced by marked elevation of serum urea, creatinine and urine glucose. Decreased clearance of urea, creatinine and rise in lipidperoxidation level. The AEC 200 mg/ kg showed marked decrease in elevated levels of serum urea, creatinine, lipidperoxidation and increased clearance compare to the AEC 100 mg/ kg. Conclusion: The Cuminum cyminum showed the protective action against gentamicin induced nephrotoxicity

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-P'Col-0000746
Title: Hypolipidemic activity of Andrographis serpyllifolia Wt.Ic
Category: Pharmacology
Section: Research Article
Country: India
View Article

Andrographis serpyllifolia Wt.Ic (Acanthaceae) is a trailing and rooting procumbent herb widely distributed throughout South India. Previous chemical examinations of A. Serpyllifolia showed the presence of serpyllin, apigenin 7,4'-dimethyl ether and tectochrysin and reported for various biological activities but still there is no specific studies on A. Serpyllifolia for its Hypolipidemic activity. Hence, In the present study Ethanolic extract of roots of A. Serpyllifolia and its fractions were investigated for hypolipidemic activity on atherogenic diet induced albino rats.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PCS-0000749
Title: Formulation and Evaluation of Metformin Hydrochloride Sustained Release Matrix Tablets.
Category: Pharmaceutics
Section: Research Article
Country: India
View Article

An attempt was to formulate the oral sustained release Metformin hydrochloride matrix tablets by using hydroxyl methyl cellulose polymer (HPMC) as rate controlling factor and to evaluate drug release parameters as per various release kinetic models. It is observed that the basic goal of therapy in the development of Metformin hydrochloride release dosage form is to increase bioavailability; reduce risk of hospitalization, deliver drug at a near constant rate for approximately 12 hrs, independent of food intact and gastrointestinal PH. The dry granulation technique was used to compress the tablet as powder showed the poor flowability; less cohesiveness during direct compression and due to moisture sensitivity and tendency to hydrolyte, wet granulation techniques was not selected for the present work. Dry granulation improves the flow of the powder and reduces the use excipients. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity, drug content etc. and showed satisfactory results. The tablets were subjected to thickness, weight variation test, drug content, hardness, friability and in vitro release studies. The in vitro dissolution study was carried out for 12 hours using PH 4.0, 6.8 Phosphate buffer & pH 1.2 buffer in phosphate buffer as dissolution media. All the tablet formulations showed acceptable pharmacotechnical properties and complied with pharmacopoeial specifications. The mechanism of drug release form matrix tablet is govorenered by diffusion and as the drug is so highly soluble. However, when considering in-vivo behavior of this system, the erosion rate will be more important.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PA-0000750
Title: Adaptation of color reactions for Spectrophotometric determination of citicoline in Bulk drugs and in pharmaceutical formulations
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
View Article

Three simple, sensitive and cost effective Spectrophotometric methods are described for the determination of Citicoline (CT) in bulk drugs and in pharmaceutical formulations. These methods are based on the oxidation of CT by ferric chloride in presence of 1,10-phenanthroline (Method A) or 2, 2’ bipyridyl (Method B) or potassium ferricyanide (Method C). The colored complex formed was measured at 514, 522 and 720 nm for method A, B and C respectively against the reagent blank prepared in the same manner. The optimum experimental parameters for the color production are selected. Beer’s law is valid with in a concentration range of 2-10mcg for method A, 10-60mcg for method B and 10-50mcg for method C. The molar absorptivities are 4.1508 x 104, 8.1549 x 103 and 9.5955 x 103 L mol-1 cm-1. Where as sandell sensitivities are 0.045, 0.022 and 0.038 for method A, B and C respectively. The developed methods were applied for the determination of CT in bulk drugs and in pharmaceutical formulations.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-PCS-00001370
Title: Formulation and evaluation of oral disintegrating tablets of montelukast sodium: effect of functionality of superdisintegrants
Category: Pharmaceutics
Section: Research Article
Country: India
View Article

Montelukast sodium is a potent, selective and orally acting leukotriene receptor antagonist that acts by inhibiting physiological actions of the cysteinyl leukotrienes(LTC4,LTD4and LTE4) . It is used in the prophylaxis and treatment of asthma. As precision of dosing and patient’s compliance become important prerequisite for asthma management, there is a need to develop formulations for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling and patient’s acceptability. Hence in the present study an attempt has been made to prepare fast disintegrating tablets of Montelukast sodium in the oral cavity with enhanced dissolution rate. The tablets were prepared with three superdisintegrants i.e polyplasdone XL10,Ac-Di-Sol and Primojel. The pure drug and formulation blend was examined for angle of repose, bulk density, tapped density, Compressibility index and Haussner’s ratio. The tablets were evaluated for hardness, tensile strength, drug content, friability and were found satisfactory. The disintegration time in the oral cavity was also tested and was found to be around 9sec. Based on dissolution rate the disintegrants can be rated as Polyplasdone XL10 > Ac-di-sol > Primojel. Hence polyplasdone XL10 was recommended as suitable disintegrant for the preparation of direct compression melt-in-mouth tablets of Montelukast sodium. All the dissolution parameters were calculated and compared with market tablet. An increase in the dissolution rate was observed with M8 formulation when compared to market one. It was concluded that the rapidly disintegrating tablets with proper hardness, rapid disintegration in the oral cavity with enhanced dissolution rate can be made using super disintegrants.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: April
Article Id: JPRS-P'Col-00001396
Title: Pharmacological activity of Trachyspermum ammi : A Review
Category: Pharmacology
Section: Review Article
Country: India
View Article

Ayurveda is an important system of medicine and drug therapy in India. Among traditional potential herbs, Trachyspermum ammi family Apiaceaecommonly known as Ajwain is widely used for curing various diseases in both humans and animals. The active principle are extracted and purified fortherapeutic utility for their selective and regulated activities. The quality control of herbal drug and their bio-constituents are of prime importance justifyingtheir acceptability in modern system of medicine. Trachyspermum ammi is one of the most famous medicinal plants in the treatment of a large number ofhuman ailments is mentioned in Ayurveda, Sushrita Samhita and Charaka Samhita. This review deals with the evidence-based information regarding the pharmacological activity of Trachyspermum ammi.