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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-MB-0000752
Title: Bioprospecting of mangrove rhizosphere actinomycetes from pitchavaram with special reference to antibacterial activity
Category: Microbiology
Section: Research Article
Country: India
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Marine actinomycetes were isolated from sediment samples collected from of eight mangrove species of Pitchavaram mangrove ecosystem. The actinomycetes population ranged between 2.1 X 104 and 6.4 X 104 cfu g-1 of dry sediment. Maximum actinomycetes population was noted in rhizosphere of Avicennia marina and the minimum with Excoecaria agallocha. About 50% of the isolates showed activity against S. aureus followed by B. subtilis, E. coli, V. cholerae, K. pheumoniae, P. vulgaris and S. typhi. Bioactive compound from one potential strain Rh1 was produced using soybean meal medium. The culture filtrate and its ethyl acetate extract showed 8-15 mm and 12-20 mm inhibition, respectively. Based on the studied phenotypic characteristics, strain Rh1 was identified as Streptomyces fradiae (Rh1). Purification and characterization of potential actinomycetes strain Rh1 is in progress, to prove its potential further.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-P'Col-0000753
Title: In-vitro anthelmintic activity of Caesalpinia bonducella (Linn). Flem. leaves.
Category: Pharmacology
Section: Research Article
Country: India
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Helminth infections remain a major constraint to livestock productivity across all agro-ecological Zones. 1Today, the principal mode for control of gastrointestinal parasites is based on the commercial anthelmintic. However, wide spread increase of anthelmintic resistance, scarcity and high cost especially to farmers of low income in developing countries led to the need of other alternative helminth control methods 2 Among other alternative methods, there is considerable and expanding interest in traditional herbal dewormers.3 In present communication methanolic and aqueous extracts of leaves of Caesalpinia bonducella Linn. Flem were investigated for their anthelmintic activity against Pheretima posthuma and Ascardia galli. Various concentrations were used in the bioassay, which involved paralysis and death time of the worms. Both the extracts showed significant anthelmintic activity.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-PCS-0000765
Title: Suitability of Factorial Design in Determining the Processing Factors Affecting Entrapment Efficiency of Albumin Microspheres
Category: Pharmaceutics
Section: Research Article
Country: India
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Introduction: A trend in NSAID development has been to formulate them into sustained release microspheres to improve therapeutic efficacy and to reduce the severity of upper gastro intestinal side effects. Many processing variables can influence the characteristics of the resultant albumin microspheres. Objective: The objective of the present study was to study the effect of some selected process variables (drug/albumin ratio, amount of glutaraldehyde, and duration of cross-linking time) on the encapsulation efficiency, by applying 3-level full factorial design analysis, accounting for percent drug entrapment as dependant variable. Methods: Sustained-release formulations of ketorolac tromethamine loaded albumin microspheres were prepared by chemical cross-linking method. F-statistic was applied to reduce polynomial equation by neglecting non-significant (P>0.05) terms.The coefficient value for independent variable, drug/albumin ratio, was found to be maximum (19.33) and hence this variable was considered to be a major contributing variable for percent drug entrapment. Response surface plots clearly showed optimal drug/albumin ratio, amount of glutaraldehyde and duration of cross-linking. The conformity of the established equation was checked by preparing three batches of microspheres thrice, taking values of the independent variables from the contour plots for prefixed value of percent drug entrapment. Conclusion: Findings established the role of the statistical design in predicting the values of independent variables for preparation of microspheres having predetermined percent drug entrapment.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-PHDRS-00001341
Title: Preliminary phytochemical screening and HPTLC fingerprinting of Nicotiana tabacum leaf
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The leaf of Nnicotiana tabacum was collected, gabbled, pulverized air dried and subjected to gradient extraction with soxhlet apparatus and the different extracts were screened phytochemically for its chemical components. This revealed the presence of alkaloids, reducing compounds (carbohydrates), flavonoids, saponins, terpenes and steroids in moderate concentration. hptlc fingerprintint parameters had been developed for alcoholic leaf extract of nicotiana tabacum. At wavelength (550 nm), resolution was better for this extracts and hence, this wavelength can be taken for obtaining optimum hptlc fingerprinting for this medicinal plant.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-MB-0000760
Title: Cow Urine Concentrate : A potent agent with Antimicrobial and Anthelmintic activity
Category: Microbiology
Section: Research Article
Country: India
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Cow, often called Kamadhenu, has been considered as a sacred animal in India. The present study was undertaken to determine antibacterial, antifungal and anthelmintic activity of Cow urine concentrate (CUC) which is obtained by complete evaporation of cow urine. The antibacterial activity was tested against Gram positive and Gram negative bacteria by disc diffusion method. Antifungal activity was tested against species of Aspergillus by Agar well diffusion method. Anthelmintic activity was studied using adult Indian earthworm model. Marked inhibition of Gram positive bacteria was observed by the CUC. Inhibition of fungi was found to be dose dependent. Among fungi tested, A. niger was more affected than others. In anthelmintic assay, concentration dependent mortality of worms was observed and the effect by CUC was found to be more superior as compared to the standard drug Piperazine citrate. The antimicrobial and anthelmintic activity of CUC may be due to the presence of constituents present in it. The CUC could be used in the treatment of diseases caused by pathogenic bacteria, opportunistic fungi and parasitic helminthes. Further studies on isolation of inhibitory components and in vivo experiments are to be carried out.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-P'Col-0000761
Title: In-vitro Anthelmintic Activity of ethanolic and aqueous fruit Extract of Terminalia belerica
Category: Pharmacology
Section: Research Article
Country: India
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The aim of present study was to evaluate anthelmintic potential of ethanolic and aqueous extract of fruit pulp of Terminalia belerica using Pheretima posthuma as test worms. Various concentrations (10, 25, 50 and 100 mg/ml) of ethanolic and aqueous extract were tested in the bioassay, which involved determination of time of paralysis (P) and time of death (D) of the worms. Levimasole (0.55 mg/ml) was included as standard reference and distilled water as control. The results of present study indicated that the ethanolic and aqueous extract significantly demonstrated paralysis, and also caused death of worms especially at higher concentration as compared to standard reference levimasole. In conclusion, the use of fruit pulp of the plant Terminalia belerica as an anthelmintic have been confirmed and further studies are suggested to isolate the active principle/s responsible for the activity.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-PCS-0000754
Title: Fabrication and in vitro Evaluation of Glibenclamide Abelmoschus esculentus Fruit Mucilage Controlled Release Matrix Tablets
Category: Pharmaceutics
Section: Research Article
Country: India
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The main objective of the present study was to develop matrix tablets of Glibenclamide with Abelmoschus esculentus fruit mucilage and to study its functionality as a matrix forming agent for controlled release tablet formulations. Physicochemical properties of dried powdered mucilage of Abelmoschus esculentus mucilage were studied. Various formulations of Glibenclamide Abelmoschus esculentus mucilage were prepared. They found to have better uniformity of weight and drug content with low SD values. The swelling behavior and release rate characteristics were studied. The dissolution study proved that the dried Abelmoschus esculentus mucilage can be used as a matrix forming material for making Controlled release matrix tablets.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-P'Col-0000755
Title: Dose dependent antioxidant activity of fresh juice of leaves of Coriandrum sativum
Category: Pharmacology
Section: Research Article
Country: India
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The dose dependent antioxidant activities of fresh juice of Coriandrum sativum was evaluated by various methods in vivo. Scavenging effects on the hydroxyl and super oxide radicals, level of glutathione and protection against reactive oxygen species induced lipid were evaluated. The fresh juice exhibited high antioxidant activities, evidenced by its ability to scavenge hydroxyl- and superoxide-radicals, high reducing power, and protection against biological macromolecular oxidative damage and by increasing the level of glutathione.Presence of flavonoids confirms its antioxidant activity .In conclusion, these results demonstrate potential antioxidant activity of fresh juice of Coriandrum sativum.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-PHDRS-0000756
Title: Pharmacognostical Evaluation of Dendrophthoe falcata
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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This study presents a detailed pharmacognostical study of the leaves and stems of Dendrophthoe falcata Linn (Loranthaceae), an important plant in the Indian system of medicine. The leaves and stems were studied using procedures of light, conofocal microscopy, WHO recommended physico-chemical determinations, and authentic phytochemical procedures. The physicochemical, morphological and histological parameters presented in this paper may be proposed as parameters to identify and establish the authenticity of D. falcata.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-P'Col-0000757
Title: Anthelmintic activity of Drynaria quercifolia (L.) J. Smith.
Category: Pharmacology
Section: Research Article
Country: India
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Present study was carried out to scientifically evaluate anthelmintic potential of the fern Drynaria quercifolia as it is used by the tribes of Tripura and the same is also highlighted in traditional uses of the fern. Activity was performed using adult earthworms and piperazine citrate was used as a standard. Various doses (2.5, 5, 10, 25, 50 mg/ml) of alcoholic extracts of leaves and rhizomes of Drynaria quercifolia were used for the study. From results of the study it is clear that potency of the extracts is inversely proportional to the time taken for paralysis and death of worms. All the tested doses showed significant activity (P<0.01) compared to the standard and activity also confirms dose dependant nature of the extracts.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-PCS-0000758
Title: Mucoadhesive Thermoreversible nasal delivery system
Category: Pharmaceutics
Section: Review Article
Country: India
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Nasal route has been identified as a very important route for the administration of therapeutic compounds. Function of mucoadhesive polymers has been sucessesfully demonstrated which serve to increase the residence time in the nasal cavity as well as enhance the permeation of drug. In the last two decades several thermoreversible formulations have been reported many of which are liquid nasal formulations. A combination of mucoadhesive polymer along with thermoreversile polymer can be utilized for easy and safe delivery of therapeutic agents including biopharmaceuticals. This article reviews the background of thermoreversible nasal mucoadhesive drug delivery system with special reference to mechanisms that lead to mucoadhesion and thermoreversible property of polymers in the formulation of in situ gels. New classes of mucoadhesive and thermoreversible polymers, factors which affect the performance of formulation and future requirements for the betterment of the formulations are also discussed.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-PHDRS-0000759
Title: Carica papaya Linn: A Potential source for various health problems
Category: Pharmacognosy and Herbal Drugs related study
Section: Review Article
Country: India
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Carica papaya is cultivated for its fruits; it is flavored by the people of the tropics, as breakfast and as ingredients in jellies, preserves or cooked in various ways. Papain the proteolytic enzyme has a wealth of industrial uses. It is used for meat tenderizers and chewing gums. In traditional practices juice of plants is used for curing warts, cancer, and tumors. Recent researches in different parts of the world have shown that C. papaya has the great potential against a number of health problems. C. papaya preparations can be efficiently used in tissue burn, microbial/helmintic infection. It can be used as antioxidant, immunomodulatory, hypoglycemic and hypolipidemic effects. Instead of these effects, it can be also used as insecticidal/molluscicidal activity against various pests. The present review highlights the some important pharmacological uses of papaya plants in ancient as well as recent time.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-PCS-0000762
Title: Simultaneous Estimation and Validation of Ezetimibe and Simvastatin in Combined Tablet Dosage Forms by Hydrotropic Solubilization Technique Using 3.0 M Urea
Category: Pharmaceutics
Section: Research Article
Country: India
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In the present investigation, 3.0 M Urea solution was employed as hydrotropic solubilizing agent to solubilize poorly water-soluble drug Ezetimibe and Simvastatin for its spectrophotometric analysis. Hydrotropy is one of the reliable methods to enhance aqueous solubility of poorly soluble drugs. In the present investigation, hydrotropic solution of urea (3 M) was employed as a solubilizing agent to solubilize the poorly water-soluble drug, Ezetimibe and Simvastatin, in the tablet form and determined with the help of spectrophotometric determination in ultraviolet region. Ezetimibe and Simvastatin shows maximum absorbance at wavelength 267 nm and 277 nm respectively and isobestic point was observed at 258 nm. Beer’s law was obeyed in the concentration range 5-35 µg/ml Ezetimibe and 5-40µg/ml for Simvastatin. Method-I is based on simultaneous equation method and method II is based on determination of Q-value. Results of analysis for methods were tested and validated for various parameters according to ICH guidelines, hence can be adopted for the routine analysis of Ezetimibe and Simvastatin in tablet dosage form.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-PB-0000763
Title: Investigations on purification ,characterization and antimicrobial activity of enzyme papain from Carica papaya Linn.
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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The proteolytic enzyme papain was extracted from the latex of the fruit Carica papaya Linn. in a highly purified manner, where the extracted enzyme has been characterized to determine its efficiency and its molecular weight is found to be 23,000 daltons to 25,000 daltons from the bands obtained. Papain showed more significant activity against bacteria than fungi. The zone of inhibition of papain against Pseudomonas aerogenosa, Bacillus subtilis, Escherichia coli, and Staphylococcus aureus was 25, 22, 24 and 18mm where as for fungal clinical isolates Candida albicans was 18 mm. From this study, we conclude that papain has good therapeutic property and can be used as potential drug for bacterial and fungal diseases.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-PC-0000764
Title: Anti-inflammatory and analgesic activities of Tephrosia purpurea Linn. aerial and root extracts
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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An ethanolic extract of the aerial (EETPA) and root parts of Tephrosia purpurea Linn. (EETPR) was investigated for anti-inflammatory and analgesic activities. The extract (250, 500 mg/kg, b.w) produced dose-related inhibition of carrageenan-induced paw edema and cotton pellet-induced granuloma in rats. At the same doses, analgesic activity was also observed by tail immersion method maintained at 55°C. The results of the present study further confirms that the use of Tephrosia purpurea Linn. Traditionally used for the treatment of painful inflammatory pathological conditions like fracture and dislocation.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: May
Article Id: JPRS-PB-00001410
Title: In-vitro hemolytic activity of Allium stracheyi baker
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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The present study reveals the phytochemical profile and in-vitro hemolytic property of Allium stracheyi Baker, an ethno botanically important medicinal and aromatic plant endemic to western Himalaya. The leaves were sequentially extracted by using different solvents according to their increasing polarity. The qualitative phytochemical screening of the extracts revealed the presence of alkaloids, saponins, fixed oils, phytosterols, phenolics and flavonoids. The extracts were tested for their hemolytic property with three different concentrations. The butanol extract has shown maximum amount of hemolysis where as the water extract has shown least amount of hemolysis. All the extracts have shown dose dependent activity. Thus the present study indicates the hemolytic potential of this plant.