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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
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Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PC-0000813
Title: A computational design and docking studies on Escherichia coli b-Ketoacyl-Acyl carrier protein synthese III using auto dock
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Molecular docking is routinely used for understanding drug-receptor interaction in modern drug design. Type II fatty acid synthesis pathway has been recently reported as an attractive targeting for their efficacy against infections caused by multi resistant gram positive and negative bacteria. â-ketoacyl-acyl carrier protein synthase III (KAS III), is an essential target for novel antibacterial drug design. In this study, the docking studies were done using auto dock between computationally designed benzimidazole derivatives and â-ketoacyl-acyl carrier protein synthase III receptor (1HNJ). The newly designed ligands such as compound 5, 1, and 13 have shown good docking scores and predicated activities when compared to already report potent anti bacterial bezimidazole derivatives. In future, we planned to synthesis these benzimidazole derivatives and screen for in-vitro anti bacterial effect on Escherichia coli and other micro organisms.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PCS-0000814
Title: Preparation and In Vitro Evaluation of Controlled Release Matrix Tablets of Stavudine Using Natural and Synthetic Polymers
Category: Pharmaceutics
Section: Research Article
Country: India
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Stavudine is an anti-viral drug that is highly soluble in water. In the present investigation an attempt was made to reduce the frequency of dose administration and to improve the patient compliance by developing controlled release (CR) matrix tablet of Stavudine using naturally occurring (Guar gum and Xanthun gums) and Synthetic Polymers( HPMC and Ethyl cellulose). Six batches of CR matrix tablets of Stavudine were developed by using wet granulation technique. Tablets were evaluated for weight variation, hardness, friability and In vitro dissolution studies. All formulation showed compliance with pharmacopoeial standards. Among the six formulations, F3 showed controlled release of drug for 12 hours with 91.65% drug release. The release data was fitted to various mathematical models such as, Higuchi, Korsmeyer-Peppas, First-order, and Zero-order to evaluate the kinetics and mechanism of the drug release was found to be diffusion coupled with erosion.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-P'Col-0000815
Title: The protective role of vanillic acid against acetaminophen induced hepatotoxicity in rats
Category: Pharmacology
Section: Research Article
Country: India
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The potential protective role of vanillic acid one of the major phenolic derivatives from edible plants and fruits was evaluated against the acetaminophen (APAP) induced hepatotoxicity in rats. Toxicity was induced in adult male albino rats, weighing 140–160 g, by an intraperitoneal injection of APAP (750 mg/kg body weight) for 7 days. Rats were treated with vanillic acid (100 mg/kg body weight) by oral administration. We assessed the activity of hepatic markers (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT) and bilirubin) and lipid peroxidative markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides).The toxic effect of APAP was assessed by means of determining the activity and levels of antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), vitamin C, vitamin E and reduced glutathione (GSH) levels). Vanillic acid at an oral dose of 100 mg/kg showed a significant hepatoprotective effect by reading levels of liver marker enzymes and also bilirubin levels in serum. Regarding the antioxidant activity, vanillic acid increasing the enzymatic and non-enzymatic antioxidants and reducing TBARS and hydroperoxide levels. Histopathological findings of vanillic acid against the acetaminophen (APAP) induced hepatotoxicity rats liver confirmed the biochemical findings of this study. These results provide evidence that inhibition of TBARS and hydroperoxide over production and maintenance of intracellular antioxidant status may play a pivotal role in the protective effects of vanillic acid against APAP-induced hepatotoxicity in rats.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-P'Col-0000816
Title: Anti-Cancer Effect of Datura innoxia P.mill. Leaf Extract in vitro through Induction of Apoptosis in Human Colon Adenocarcinoma and Larynx Cancer Cell Lines
Category: Pharmacology
Section: Research Article
Country: India
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Native medicinal plants are traditionally used to prevent and treat a variety of diseases, including cancer. These herbal preparations alleged to have many biological activities, such as stimulation or suppression of immune responses and antiprolifeative effects on cancer cells. In the present study, we investigated the effects of methanolic leaf extracts from Datura innoxia, on the growth of human colon adenocarcinoma (HCT 15) and human larynx cancer cell lines (Hep-2). The methanolic leaf extracts from Datura innoxia potently inhibited growth of both cell lines in a dose dependent manner with IC50 value 300µg/ml and for HCT 15 and Hep-2 cells respectively. The results showed the anti-cancer action is due to nuclear fragmentation and condensation, associated with the appearance of apoptosis. In addition, Datura innoxia treated HCT 15 and Hep-2 cells had decrease expression of antiapoptotic Bcl-2 protein. These results demonstrated that Datura innoxia inhibits the proliferation of HCT 15 and Hep-2 cells through induction of apoptosis.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-P'Col-0000817
Title: Evaluation of anti-inflammatory activity of seeds extract of Luffa Cylindrica
Category: Pharmacology
Section: Research Article
Country: India
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The present work emphasizes on screening of the seed oils and other secondary metabolites from Cucurbitaceae seeds. The oil, CU-01, its unsaponifiable matter, CU-02 and the cucurbitacin, CU-03 extracted by Soxhlet method from the seeds of Luffa cylindrica was examined for its acute anti-inflammatory at doses of 1ml, 50mg and 50mg/kg body weight respectively. It was evident that CU-02 significantly inhibited the paw edema formation induced by carrageenan when compared to CU-01 and CU-03. However the percentage of inhibition was lesser when compared to the standards diclofenac sodium gel and flurbiprofen gel. So, by observing the all comparison studies, we concluded that CU-2 is having the maximum potency for the anti-inflammatory activity.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-P'Col-0000818
Title: Gastroprotective and antiulcer activity of mixture of Symplocos racemosa bark and Asarum europaeum root
Category: Pharmacology
Section: Research Article
Country: India
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Peptic ulcer is the most common GIT disorder in the present day life of the industrialized and civilized world. The prevention or cure of peptic ulcers is one of the most important challenges confronting medicine nowadays, as it is certainly a major human illness affecting nearly 8 to 10 % of the global population and of these 5% suffer from gastric ulcers. The aim of present study is to evaluate the gastric antisecretory and antiulcer activity of mixture of Symplocos racemosa bark and Asarum europaeum root. The mixture of Symplocos racemosa bark and Asarum europaeum root, were dried in shade and powdered coarsely and extraction was done according to standard procedure. The aqueous and ethanolic extract of mixture of Symplocos racemosa bark and Asarum europaeum root was used in the pylorus ligated, aspirin and ethanolic induced ulcer models. The aqueous and ethanolic extract of mixture of Symplocos racemosa bark and Asarum europaeum root showed significant anti-secretory activity as evidenced by decreased pepsin secretion, gastric juice volume and acid output in pylorus ligated rats. Pre-treatment with of mixture of Symplocos racemosa bark and Asarum europaeum root extract provided significant protection against the peptic ulceration caused by aspirin and ethanolic treated rats. It showed significant gastroprotective effects on the stomach wall in aspirin and ethanol treated rats by increasing the gastric wall mucous. The present findings demonstrate that aqueous and ethanolic extract of mixture of Symplocos racemosa bark and Asarum europaeum root has potent antisecretory and antiulcer effects and justify the traditional usage of this herb to treat peptic ulcer.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PCS-0000819
Title: Formulation and Evaluation of Guar gum microspheres of Aceclofenac for colon targeted drug delivery
Category: Pharmaceutics
Section: Research Article
Country: India
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Guargum microspheres were prepared by the emulsification method using glutaraldehyde as a cross linking agent. Characteristics of microspheres were greatly affected by varying guar gum concentration, glutaraldehyde concentration with 5% v/v span 80, at 4000 rpm stirring rate, for a period of 4 h stirring time at 50ºC. Aceclofenac loaded microspheres demonstrated high entrapment efficiency of 79.99%. The in vitro release was investigated in gastro intestinal medium of different pH and phosphate buffer saline with and without rat ceacal contents, which was found to be affected by changing the concentration of guar gum and glutaraldehyde. The drug release in phosphate buffer solution (pH 7.0) and simulated gastric fluids followed a similar pattern and had a similar release rate, while a significant increase in drug release (83.23%) was observed in the medium containing 4 % rat ceacal content. In vivo anti-inflammatory activity for the optimized formulation confirms after a lag time, drug released from the formulation, upon enzyme action after reaching to the colon. Thus concluded, guar gum microspheres showed adequate potential in targeting to colon for treating rheumatoid arthritis and to maximize the drug release upon enzymatic action of drug in in vitro release studies, and this finding was further endorsed with other in vivo studies.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PC-0000820
Title: Quinolones: A Therapeutic Review
Category: Pharmaceutical Chemistry
Section: Review Article
Country: India
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This therapeutic review discusses the Chemistry, Mechanism of Action, Resistance, Pharmacokinetics, Syntheses; Spectrum of activity, Clinical application, drug interactions. Particular emphasis is placed on clinical application of quinolones. The quinolones antibiotics are synthetic derivatives of nalidixic acid. These compounds are all synthetic; a variety of alterations of the basic quinolones molecule can be synthesized. This pliability of the basic quinolones nucleus accounts for the proliferation of new compounds on the market and in development. Several protocols for the synthesis of quinolones are available in the literature; essentially they are two-component reactions involving substituted aniline and diethyl 2-(ethoxy methylene) malonate. The process can be either a one-pot two-component condensation or a two-step process, because of the wide variety of quinolones antibiotics currently produced, the clinician can no longer consider this group of antibiotics as the bacterial coverage or clinical applications of the class as a whole remain appropriate. The activity of quinolone as anticancer in synthetic compounds is promising. The broad spectrum antibacterial and ocular activity of these compounds could lead to a new series of antimicrobials.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PCS-0000821
Title: Comparative Study of Ionotropic Gelation Technique To Entrap Diltiazem HCl In Mucoadhesive Microparticulate System.
Category: Pharmaceutics
Section: Research Article
Country: India
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The aim of present investigation was to compare the ionotropic gelation techniques for entrapping water soluble drug Diltiazem HCl in mucoadhesive microparticulate system. Mucoadhesive polymers HPMC K15 and Carbapol 934 were used in combination with sodium alginate which provides gastric retention for prolonged time. Diltiazem HCl microcapsules were formulated by orifice-ionic and emulsification-ionic gelation technique. The formulated microcapsules of Diltiazem HCl were evaluated for the following parameters viz. Particle size, entrapment efficiency, in-vitro drug release and percent mucoadhesive strength. FT-IR and SEM were used to characterize microcapsules. The results of both techniques were compared. It was evident from study that, the entrapment efficiency of Diltiazem HCl was improved (46% - 61%) in emulsification-ionic gelation technique, as compared to orifice-ionic gelation technique (<15%). Thus it was concluded that emulsification-ionic gelation technique is superior to orifice-ionic gelation technique to entrap water soluble drug Diltiazem HCl. The drug release from the microcapsules were found to be slow and spread over extended period of time, drug release depends on the percent of coat material, wall thickness and size of microcapsule. Microcapsule with a coat comprised sodium alginate, HPMC and carbapol exhibited good mucoadhesive properties as observed in in-vitro wash-off test.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-P'Col-0000822
Title: Pharmacological evaluation of Ammania baccifera Linn.
Category: Pharmacology
Section: Research Article
Country: India
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This study was intended to evaluate the anti-inflammatory and anti-arthritic activities of different extracts Ammania baccifera Linn. In this study both acute and chronic inflammation models were used to evaluate the anti-inflammatory and anti-arthritic activities of the Ammania baccifera. In acute model carrageenan was used to induce inflammation in rat hind paw and in chronic model , Freund’s adjuvant induced arthritis model was performed. Indomethacin (10 mg/kg bw) was used as a standard drug. The ethanol extract of A. baccifera exhibited significant dose dependent activity in acute inflammation and the doses of 100 mg/kg bw and 200 mg/kg bw produced 38.27% and 43.39% inhibition respectively after 3 h as compared with that of the standard drug which showed 48.52% inhibition. In Freund’s adjuvant induced arthritis model, the doses of 100 mg/kg bw and 200 mg/kg bw of the ethanol extract produced(38.83%) and (44.08%) inhibition respectively after 19 days when compared with that of the standard drug (55.47%). In conclusion the ethanol extracts of both doses of A. baccifera exhibit considerable anti-inflammatory and anti-arthritic activities.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PC-0000823
Title: Difference Spectrophotometric Method for the Determination of Olmesartan Medoxomil in Tablets
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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A simple, rapid and sensitive difference spectrophotometric method was used for the determination of Olmesartan Medoxomil in pharmaceutical dosage forms. The method is based on the induced spectral changes upon changing the pH of the medium that differ in their UVspectra. Difference spectrum, obtained by keeping Olmesartan medoxomil in 0.1N HNO3 in reference cell and Olmesartan medoxomil in 0.1N NaOH in sample cell, showed two characteristic peaks at 259nm and 290nm with positive and negative absorbance respectively. Difference of absorbance between these two maxima was calculated to find out the amplitude, which was plotted against concentration. The calibration curve is linear over the concentration range of 10-50ìg/ml (r2= 0.999), with a detection limit of 0.15ìg/ml. The method was successfully applied to the commercial pharmaceutical drug without interference from common ingredient accompanying the drug. The result statistically compared with those obtained by the reference method.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PCS-0000824
Title: Niosomes as ophthalmic drug delivery systems: A review
Category: Pharmaceutics
Section: Review Article
Country: India
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Efficiency of ocular therapy depends on presence of suitable drug at site of action in an effective concentration for desired period of time. Depending on the disorder site of action may be any ocular tissue or cell. Hence there are many sites within eye that should be targeted. Tear production, non productive absorption, transient residence time and impermeability of corneal epithelium leads to poor bioavailability of drug from ocular dosage form. The primitive ophthalmic solutions, suspensions and ointment dosage forms are less efficient to combat various ocular diseases. This article explores the importance of niosome as potential ocular drug delivery system, its formulation aspects and its characterization in in vito and in vivo.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PCS-0000825
Title: Comparative study on effect of natural and artificial superdisintegrants in the formulation of fast dissolving aspirin tablet
Category: Pharmaceutics
Section: Research Article
Country: India
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Aspirin is a salicylate drug and used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. In the present study, the effects of a natural superdisintegrants and synthetic superdisintegrants were compared in the formulations of fast dissolving tablets (FDT). FDTs of Aspirin were prepared by direct compression method. These tablets were evaluated for weight variation, hardness, thickness, disintegration time, dispersion time, friability, wetting time, water absorption ration and dissolution. Swelling index was also observed with an objective to compare the swelling property of Plantag ovata husk with Ac-di-sol, Crospovidone and sodium Starch glycolate. Plantago ovata husk showed the highest swelling index. Hence, it is concluded that natural superdisintegrants (husk of Plantago ovata ) showed better disintegrating property than the most widely used synthetic super disintegrants like Crospovidone, Ac-di-sol and Sodium starch glycolate in the formulations of FDTs.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-P'Col-0000826
Title: Effects of anti-inflammatory and anti-pyretic activity of Anisomeles malabarica R.BR.
Category: Pharmacology
Section: Research Article
Country: India
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The present study was carried out to investigate the anti-inflammatory and anti-pyretic properties of petroleum ether, alcoholic and aqueous extracts of Anisomeles malabarica R.Br., (Lamiaceae) leaves using experimental animal models. The antiinflammatory activity of the various extracts was studied based on their effects on carrageenan-induced paw oedema and cotton pellet granuloma in rats, while anti-pyretic activity was evaluated using the brewer’s yeast-induced pyrexia in rats. The extracts were screened for alkaloids, steroids, proteins, flavonoids, saponins, mucilage, carbohydrates, tannins, fats and oils. The extracts in dose levels of 50,100 and 200 mg/kg orally were used in both anti-inflammatory and anti-pyretic studies. The ethanol and aqueous extracts of leaves of A. malabarica produced significant (P<0.05) anti-inflammatory activities in a dose-dependent manner to that of standard drug indomethacin,while petroleum ether extract exhibit minimum inhibitory effect in carageenan induced hind paw oedema and cotton pellet granuloma in rats. On the other hand, the three extracts has shown a good anti-pyretic effect (P<0.05) with all the doses used when compared to the control group. The results obtained indicate that the crude leaf extracts of Anisomeles malabarica possess potent anti-inflammatory and anti-pyretic activity by supporting the folkloric usage of the plant to treat various inflammatory conditions.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PCS-0000827
Title: A Comprhensive Review On: Colon Specific Drug Delivery System (CSDDS)
Category: Pharmaceutics
Section: Review Article
Country: India
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Colon delivery is especially required for drugs intended to act locally or for drugs that exhibit maximum systemic absorption from the colon. However, exposure to extreme pH conditions, gastric enzymes, bile salts and variation in gastric emptying makes the development of colon release dosage forms extremely challenging. Colon delivery offers numerous therapeutic advantages drugs, which are destroyed by the stomach acid and metabolized by pancreatic enzymes, are minimally affected in the colon. Colon specific systems might also allow oral administration of peptide and protein drugs, which are normally inactivated in the upper parts of the gastrointestinal tract. The approaches generally used for formulating a colon release dosage form include use of pH dependent release polymers, time-release coatings, prodrugs and biodegradable polymers. Newly developed CSDDS, which includes pressure controlled colonic delivery capsules (PCDCS), and osmotic controlled drug delivery.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PB-0000828
Title: Chemical Composition of Leaf and Rhizome Oil of an Elite Genotype Curcuma longa L. from South Eastern Ghats of Orissa
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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The present study reports the extraction of essential oil from leaf and rhizome of a commercially important cultivar of Curcuma longa L. (cv. Suroma) of south eastern ghat of Orissa using hydro-distillation and identification of its constituents through gas chromatography and mass spectrometry (GC-MS). The essential oil from fresh rhizomes showed ar-tumerone (49.76%) as a principal constituent. However, essential oil from leaf showed alpha-phellandrene (57.8%) as a major constituent.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PC-0000829
Title: Study of inhibitory mechanism and binding mode of the thiazolo quinazoline compounds to HIV-1 integrase by docking
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Human immunodeficiency virus type 1 integrase (IN) is an essential enzyme in the life cycle of this virus and also an important target for the study of anti-HIV drugs. A new and very promising strategy for HIV drug discovery consists in blocking the multiple functional interactions between HIV-1 integrase (IN) and its cellular cofactors. In the present study, a series of novel thiazolo quinazoline derivatives were synthesized by condensation of different aromatic aldehydes with 4-nitro aniline. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, mass spectroscopy and elemental analyses. These compounds are close inhibitory analogues of human immunodeficiency virus type 1 integrase (HIV-1 IN). Some of the new derivatives show potency similar to that of the reference compounds, thus gaining further insight into the structure–activity relationship of this class of IN inhibitors.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-P'Col-0000830
Title: Evaluation of analgesic, Anti-Pyretic And Anti-Inflammatory activities of Andropogon Muricatus roots extract
Category: Pharmacology
Section: Research Article
Country: India
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The present study was planned to evaluate the analgesic, antipyretic and anti-inflammatory activities of ethanolic roots extract of Andropogon muricatus (AMEE) in albino rats following oral administration. The results showed that the ethanolic extract significantly reduce the acetic acid induce writhing in analgesic model. Its effects on antipyretic activity were also appreciable it significantly reduces fever at higher doses within 2 hrs. on yeast induce hyperthermia in rats. Edema induced by carrageenan was also significantly reduced within 1 to 7 hr. post dosing at all the dose levels used.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PRGS-0000832
Title: Comparative study of mineralo-herbal drugs (Kamadugha and Sutshekhar Rasa Sada) on gastric ulcer in experimental rats
Category: Pharmaceutical and Related General Science
Section: Research Article
Country: India
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There are number of mineralo-herbal formulations which are prescribed by the local prescribers but their scientific evaluation is not made yet. After realizing the potential use of these mineralo-herbal formulations in ulcer treatment, the present study was undertaken to study the effect of these formulations on different gastric ulcer models in rats. In this, acute toxicities study and antiulcer activity was evaluated using different ulcer models- cold restraint induced ulcers (CRU), pylorus-ligation (PL), ethanol-induced ulcers (EtOH), and indomethacin (INDO) induced ulcers model. In CRU model the Kamadugha (KD) and Sutshekhar Rasa Sada (SRS) significantly inhibited the formation of gastric lesions induced by cold restraint-stress by 74.37% and 74.83% respectively. Animals in the PL group showed a significant increase in the ulcer index and acid secretory parameters like gastric volume, pH, free and total acidity when compared with those of vehicle treated group. KD and SRS at a dose of 40 mg/kg body weight each showed protection index of 47.59% and 50.69%, respectively in EtOH model. In INDO model, the inhibition of ulcers were 55.91%, 57.52% for groups treated with KD and SRS each of 40 mg/kg and 66.13% with positive control (lansoprazole), respectively. From the results, KD shows better results in pylorus ligation model where as the SRS performs better in the rest of the other models.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PA-0000833
Title: Development and validation of a Hptlc method for simultaneous densitometric analysis of Cefotaxime Sodium and sulbactam sodium as the bulk drugs and in the pharmaceutical dosage form
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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A new simple high performance thin layer chromatographic (HPTLC) method for simultaneous determination of Cefotaxime Sodium and Sulbactam Sodium combined pharmaceutical dosage form has been developed and validated. The separation was carried out on Merck aluminum plates precoated with silica gel 60 F254, using Methanol: Benzene: Acetic acid 3.5:6.5:0.2 (v/v/v) as mobile phase. The separated spots were densitometrically evaluated at 254 nm. The retention factor for Cefotaxime Sodium and Sulbactam Sodium were found to be 0.31 ± 0.01 and 0.78 ± 0.01. The method was validated with respect to linearity, accuracy, precision, robustness, in accordance with ICH guidelines. The calibration curve was found to be linear over a range of 0.5–3.0 ìg per spot for Cefotaxime Sodium and 0.25-1.5 ìg per spot for Sulbactam Sodium. The method has been successfully applied for the analysis of drugs in pharmaceutical formulation. The % assay (Mean ± S.D.) was found to be 100.29± 1.578 for Cefotaxime Sodium and 99.58± 1.203 for Sulbactam Sodium.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PHDRS-0000834
Title: Comparative account of screening of bioactive ingredients of Premna integrifolia Linn. with special reference to root by using various solvents
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Premna integrifolia Linn. (Verbenaceae) is an important medicinal plant having potential curative properties. It roots have been studied for its bioactive ingredients. The root powder were successive extracted with petroleum ether, equal volume of chloroform: methanol (CH: ME, 1:1) and distilled water (aqueous). Results of present comparative screening of bioactive ingredients shows, alkaloids, carbohydrates, amino acids, steroids, flavonoids, glycosides, tannins and phenolic compounds present in both equal volume of CH: ME and aqueous extracts. Proteins absent in aqueous extract. Only alkaloids, amino acids, steroids, glycosides present in petroleum ether extract. Hence, through this study we provide an evidence of successive extraction of bioactive ingredients of Premna integrifolia root by using some solvents, which were not reported till date.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 7.
Article Id: JPRS-PCS-0000835
Title: Bioadhesive drug delivery systems: A Review
Category: Pharmaceutics
Section: Review Article
Country: India
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The term ‘bioadhesive’ describes materials that bind to biological substrates, such as mucosal membranes and in bioadhesive drug delivery systems, the term bioadhesion is used to describe the bonding or adhesion between a synthetic or natural polymer and soft tissues such as epithelial cells. The bioadhesive drug delivery formulation highlights the fact that readily accessible sites are utilised, with the eye, oral cavity and vegina being targeted. The GI tract and the nasal cavity have also been extensively examined as a site for bioadhesive drug delivery. The present review will explain the success achieved with the bioadhesive formulation as adhesion of bioadhesive drug delivery devices to mucosal membranes leads to an increased drug concentration gradient at the absorption site and therefore improved bioavailability of systemically delivered drugs and also used to target local disorders at the mucosal surface (e.g. mouth ulcers) to reduce the overall dosage required and minimize side-effects that may be caused by systemic administration of drugs.