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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-PB-0000991
Title: Biological aspects of proteolytic enzymes: A Review
Category: Pharmaceutical Biotechnology
Section: Review Article
Country: India
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Protease plays an important role in the management of defense mechanism of living organisms. This review presents a comprehensive and exhaustive account of plant, animal and microbial enzymes with special reference to proteolytic properties. A large number of biological sources of proteases described in this review clearly demonstrate the importance of plants and microbial proteases in applied and industrial uses. Proteases have potential applications in food, dairy, detergent, leather, alcoholic beverages, brewing, meat, pharmaceutical and photographic industries. The research work on protease has been going on since seven decades but no exhaustive review on protease from last eleven years is available in the literature. This review attempts to focus on some of the difficulties observed in the earlier work and tried to find out possible solutions and bridging up this gap by introducing recent information regarding proteinases. This review provides information on diverse groups of proteases with respect to scientific name, family, purification scheme, protease inhibitors, physiological functions, also industrial applications, sequence homology and the future scope of protease enzymes.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-PCS-0000773
Title: Solubility enhancement of poorly soluble drugs by solid dispersion technique – A review
Category: Pharmaceutics
Section: Review Article
Country: India
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The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Currently only 8% of the new molecules have both high solubility and permeability. The drugs therapeutic efficacy depends upon the bioavailability and ultimately upon the solubility. Salt formation, particle size reduction, etc. have commonly been used to increase the dissolution rate of drugs, there are some practical limitations with these techniques the desired bioavailability enhancement may not always be achieved. Solid dispersion seems to be a viable technique for overcoming this problem. In this review, it is intended to discuss the recent advances related on the area of solid dispersion. Finally industrially feasible alternative approaches in the manufacture of solid dispersion have been highlighted.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-PC-00001013
Title: Ultrasound-assisted synthesis of some new Schiff base derivatives incorporating Imidazole moiety, their characterization and biological evaluation
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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2-(2,4,5-triphenyl-1H-imidazol-1-yl)acetohydrazide (3) was utilized as key intermediate for the synthesis of some new Schiff bases 4a-k and 5 under reflux temperature and ultrasonic irradiation. All the synthesized compounds were characterized by IR, 1H NMR,13C NMR and mass spectral studies. The antibacterial and antifungal (MIC) activity studies were also carried out for all the synthesized compounds.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-PHDRS-0000997
Title: Phytochemical investigation and screening for anthelmintic activity of leafy extracts of various Ocimum (Tulsi) species
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The various species of Ocimum (Lamiaceae) i.e. Ocimum gratissimum linn., Ocimum americanum linn., Ocimum Sanctum linn. and Ocimum basilicum linn. are widely distributed in the tribal areas of Baipariguda, Koraput (Dt), Odisha and extensively used traditionally by the tribal people for common colds, headaches, stomach disorders, inflammation, heart diseases, treatment of various forms of poisoning, malaria and as anthelmintic. The present study is an attempt to preliminary investigation of phytochemical constituents and to explore the anthelmintic activity of methanolic extracts of leaves of various Ocimum species including the comparison of their activity. The Ocimum extracts were screened for phytochemical constituents and evaluated for their anthelmintic activities on adult Indian earthworms, Pheretima posthuma. All the tests for phytochemical constituents of methanolic extract of Ocimum species were found to be positive except anthraquinone glycosides and thiol group. All extracts were able to show anthelmintic activity at 60 mg/ml concentration. The activities are well comparable with the standard drug, albendazole. All the methanolic extracts showed better anthelmintic activity than the standard drug. The methanolic extract of Ocimum gratissimum linn showed better anthelmintic activity in comparison with other species of Ocimum. The data were verified as statistically significant by using one way ANOVA at 5 % level of significance (p < 0.05).

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-PA-0000994
Title: Simultaneous Estimation of Benzhexol Hydrochloride and Haloperidol by Absorbance Correction Method
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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Simple, sensitive and specific spectrophotometric method was developed and validated for quantization of Benzhexol HCl (BEZ) and Haloperidol (HALO) in tablet dosage form. The new analytical method wad developed based on the simultaneous estimation of drugs in a binary mixture without previous separation. In absorbance correction method was performed by absorbance at 210.00nm and 250.00nm. Both the drugs BEZ and HALO and its mixture follow beer-lambert’s law in the range of 5 -30 ìg/ml at all the selected wavelength. The percent estimation of mix drug in laboratory mixture was found out to be 100.03+ 0.168. The percent drug estimation in marketed formulation was found to be 100.01+ 0.336. The average percent recovery was found to be 99.204+0.968. The result of the method lies with in the prescribe limit of 98-102% shows that method is free form interference from excipients.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-P'Col-0000992
Title: A Review on Peptic ulcer : A Global Threat
Category: Pharmacology
Section: Review Article
Country: India
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It is common disorder where discontinuity in gastric mucosa is observed. Peptic ulcer refers to both gastric and duodenal ulcer. This is a major cause of mortality in developing countries. Pharmacological interventions like proton pump inhibitors, H2 blockers, anti helicobacter drugs, antacids etc has their potential role in management of various GIT (gastrointestinal) disorders and also at same time, they are liable for adverse effects. Efforts have been directed to made some herbal approach for preventing adverse effects. Although the original hopes for therapeutic usefulness were immediately realized. The purpose of antiulcer evaluation of traditional medicinal plants is obviously to ensure their therapeutic efficacy. Different therapeutic agents and plant extracts are used to treat gastric ulcers to gain the balance. This review includes aspects related to PUD (peptic ulcer disease) and herbal drugs for treatment of GIT ulcers.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-PCS-0000993
Title: Drug-excipient(s) interactions and compatibility study: A Review
Category: Pharmaceutics
Section: Review Article
Country: India
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To facilitate the development of novel drug delivery systems, the demand of new excipients has been increased. Excipients is selected and used because it contributes one or more functional attributes to the product characteristics. The quality of medicines depends not only on the active principles and production processes, but also on the performance of the excipients. In earlier days, excipient(s) were considered inactive ingredients, but they may have tremendous effect on performance of active pharmaceutical ingredients in dosage form. The magnitude of this effect will depend upon physicochemical properties of drugs as well as quantity and quality of excipients used. The aim of this article is to identify the various processes/factors that cause the drug-excipients interaction and regulatory implication of drug-excipients interaction.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-PA-0000995
Title: Estimation of Tizanidine HCl by UV-Spectrophotometric Method
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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A simple and sensitive spectrophotometric method has been developed for the determination of Tizanidine HCl. The method developed was the absorptivity value E (1%, 1cm) uv-spectrophotometric method. The 0.1N diluted solution of Tizanidine HCl was prepared so as to get concentration of 10.0 µg/mL, the solution obtained was scanned to get a spectrum shows four maxima at 240.0nm, 309.5nm, 318.5nm and 373.5nm. Tizanidine HCl obeys Beer Labert’s law over the range of 1-100 µg/mL for 309.5nm, 318.5nm and 373.5nm and 0-25 µg/mL for 240.0nm. Results along with statistical data are indicative of accuracy and precision of the proposed method at 240.0nm, 309.5nm and 318.5nm. However estimation of 373.5nm is on higher side with less precision. The recovery of the drug from tablet is also about 100% indicating complete extraction and estimation of Tizanidine HCl from matrix tablet.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-P'Col-0000996
Title: Analytical and Pharmacological Investigation of Amygdalin in Prunus armeniaca L. Kernels
Category: Pharmacology
Section: Research Article
Country: India
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Prunus armeniaca L. (Family Rosaceae) is well known in traditional medicine as being effective in treatment of cough, constipation and smooth muscles spasm. Amygdalin, the main active ingredient of P. armeniaca L., was previously estimated using different analytical methods including HPLC. In the present study, a high performance thin layer chromatographic separation method with UV spectrophotometric detection has been developed for the determination of amygdalin in Prunus armeniaca L. kernel. Different validation parameters were found to be satisfactory regarding requirements of the International Committee on Harmonization (ICH) guidelines. Separation of the spots was performed using ethyl acetate: methanol: water: glacial acetic acid (30:5:4:1) after development for 18 min and the linear compact zones were quantified by scanning at l 215 nm. The method has been successfully applied for the quantitative analysis of amygdalin without any interference of other components of the extract. Moreover, a comparative study for both pure amygdalin and total extract of Prunus armeniaca L. kernel was performed where it was proved that both of them exhibited significant analgesic, anti-inflammatory, and H1 receptor blocking effect. The toxicity studies revealed that they are safe up to a concentration of 100 mg / Kg of the animals’ body weight.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-P'Col-00001000
Title: Prescribing pattern of antihypertensives in patients having comorbid ischemic heart disease: Study in a tertiary care hospital
Category: Pharmacology
Section: Research Article
Country: India
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Hypertension is associated with significant morbidity and mortality. One of the leading causes of death in patients having hypertension is associated ischemic heart disease. Because of the high morbidity and mortality of ischemic heart disease, it is important to recognize the early manifestations of the disease and undertake appropriate therapeutic measures. Since a wide array of antihypertensives is available, the Joint National Committee puts forward guidelines for the treatment of hypertension associated with comorbid conditions including ischemic heart disease. The prescribing pattern of antihypertensives in patients having ischemic heart disease in a tertiary care hospital has been discussed in context of the guidelines. Such pharmacoepidemiological studies give an insight into the role of guidelines in drug selection by physicians. Case history of patients having hypertension along with IHD was noted down from the medical records department.IHD was sub classified into stable angina, acute coronary syndromes and congestive cardiac failure. Drugs prescribed in each of these groups were noted and pattern analyzed. A total of 78 prescriptions were of IHD, 55 having stable angina ,17 having acute coronary syndromes & 6 having CCF.45 of the patients having stable angina were prescribed a calcium channel blocker, 28 of them being amlodipine. In the patients having acute coronary syndromes, 10 patients were prescribed with either angiotensin enzyme inhibitors or angiotensin receptor blockers. The prescribing Pattern in general follows the joint national committee guidelines.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-PTD-00001002
Title: Effect of Hydrotropes on Solubility and Mass Transfer Co-Efficient of Curcuminoids
Category: Pharmaceutical Technology Development
Section: Research Article
Country: India
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The present study deals with the effect of hydrotropes such as sodium salicylate, resorcinol and sodium benzoate on solubility and mass transfer co-efficient of curcuminoids. Curcuminoids which is completely insoluble in water has been taken and its solubility has been increased through a novel technique hydrotropy. Hydrotropy is the phenomenon of increasing the solubility of insoluble or sparingly soluble organic compounds in aqueous solutions in the presence of hydrotropes. Hydrotropes themselves are highly water-soluble organic salts. All hydrotropes used in this work showed an enhancement in solubility and mass transfer coefficient of curcuminoids. The hydrotropes used in this work are freely soluble in water and all are non-reactive, non-toxic, and do not produce any significant heat effect when dissolved in water. The main property of the hydrotropes is related to the MHC (minimum hydrotropic concentration), which is defined as the concentration at which hydrotrope molecules begin to aggregate. The solubility data was fitted in the modified Setschenow model to find the best performing hydrotrope for curcuminoids. This would be useful in increasing the rate of output of the desired product made from curcuminoids.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-PHDRS-00001003
Title: Evaluation of Anti-inflammatory activity of Coccinia indica leaves extracts
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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The effects of Coccinia indica leaves extracts on different phases of acute inflammation were examined. Investigations were performed using different phlogistic agents-induced paw edema viz.Carrageenan-induced paw oedema and Dextran- induced paw oedema in rats. Various extracts (ethanol and aqueous) of Coccinia indica leaves extracts at a dose of 250 mg/kg and 500 mg/kg orally were tested. Diclofenac sodium at the dose of 10mg/kg was used as standard. Both the extracts showed significant activity (*p

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-P'Col-00001005
Title: Assessment of antidiabetic and antihyperlipidemic potential of Solanum nigrum and Musa paradisiaca in alloxan induced diabetic rats
Category: Pharmacology
Section: Research Article
Country: India
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In the present study Antihyperglycemic and hypolipidemic effects of aqueous leaf extracts of Solanum nigrum and Musa paradisiaca were evaluated in alloxan induced diabetes rats. The rats were concurrently treated with 200, 400 mg/kg b.w. for 21 days. The changes in blood glucose level and body weight were measured in 7 days interval. After 21 days of experimental period, rats were sacrificed by cervical decapitation and blood samples were collected. Biochemical estimation of blood glucose, cholesterol, triglycerides, LDL, HDL, and VLDL were done from blood sample. Administration of Solanum nigrum and Musa paradisiaca to alloxan induced diabetic rats caused significant antihyperglycemic and hypolipidemic effects when compared to diabetic control rats (p<0.0001, p< 0.001). Glibenclamide (0.6 mg/kg b.w.) was used as standard in present study.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-PB-00001007
Title: Preliminary phytochemical investigations and in vitro antioxidant activity in selected parts of Andrographis spp.
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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The present study describes the comparative evaluation of phytoconstituents and in vitro antioxidant activity of ethanolic crude extracts of selected plant parts (stem) of Andrographis lineata (AL)and Andrographis serpyllifolia (AS) .The ethanolic crude extracts of Andrographis lineata stem (ALS) and Andrographis serpyllifolia stem (ASS) were analyzed for the presence of phytoconstituents (qualitative and quantitative) and further assayed for in vitro free radical scavenging assays namely-DPPH (1,1-diphenyl-2-picrylhydrazil), nitric oxide, total reducing power, lipid peroxidation and superoxide radical scavenging assays. In all the in vitro assays ASS showed its ability to scavenge free radicals in dose dependent manner than ALS which was comparable to the standards. Further the extracts (ALS and ASS) were analyzed in GC-MS for its chemical composition which revealed the presence of high content of flavones, glycosides unsaturated fatty acids and phenolic compounds in ASS which may be responsible for higher antioxidant capacity than the ALS extracts.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-P'Col-00001008
Title: Analgesic study of methyl alcohol extract of Cassia fistula Pod
Category: Pharmacology
Section: Research Article
Country: India
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The present study was designed to investigate analgesic activity of Cassia fistula methyl alcohol extract (CF-MA), using hot plate method and tail clip method. CF-MA was administered intraperitoneal at doses of 250 mg/kg and 500 mg/kg to Wister albino rats and Swiss Albino mice. CF-MA showed significant (p<0.01) inhibition in pain response induced by thermal, mechanical and writhing stimuli in dose dependent manner. The obtained results provide promising baseline information for the potential use of these crude extract in the treatment of pain.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-P'Col-00001009
Title: Evaluation of antidiarrhoeal activity of alcoholic extract of stem of Berberis aristata DC.
Category: Pharmacology
Section: Research Article
Country: India
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The ethyl alcohol (EA) extract of the stem of Berberis aristata DC (BA) (Berberidaceae) was analysed for its anti-diarrhoeal activity. Like loperamide (3 mg/Kg body weight), a single oral dose of Berberis aristata ethyl alcohol extract (BA-EA) (250, 500 mg/Kg body weight) produced a significant decrease in the severity of diarrhoea. To understand the mechanism of its anti-diarrhoeal activity, its effect was further evaluated on intestinal transit, castor oil induced intestinal fluid accumulation (enteropooling) and electrolyte concentration in the small intestinal fluid. BA-EA produced a decrease in intestinal transit (10.92-30.70%), and unlike atropine, it significantly inhibited castor oil induced enteropooling. However, it did not alter the electrolyte concentration in intestinal fluid as compared to castor oil-treated rats.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-MB-00001010
Title: Study of the probiotic potential of lactic acid bacteria isolated from a variety of indian fermented food
Category: Microbiology
Section: Research Article
Country: India
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Pure cultures of Lactic acid bacteria (LAB) isolated from different types of Indian fermented food were investigated for their key probiotic properties. In vitro antibacterial ability was also studied against strains of Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 25619).Generally, all the reference strains were inhibited by probiotic strains but in comparison, the inhibition of Gram-positive bacteria was greater than that of the Gram-negative bacteria. Among the probiotic bacteria screened, GS4 exhibited the highest antibacterial activity against S. aureus with 25.03±2.13 mm as the average zone of inhibition. Regarding the bile salt (sodium thioglycollate) tolerance, all the nine isolates showed tolerance to 0.3% bile and the isolate GS4 showed the highest percentage of survival with an increase in the log value after 24 hours of incubation. All strains were acid tolerant when incubated at pH 3.5 over a period of 4 hours. The highest survival percentage in acidic conditions occurred with one strain, GS21 showing 99.4% survival and this isolate was found to produce the maximum amount of organic acids among the nine isolates. This study holds good in showing the potentials of LAB in traditional Indian food.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-P'Col-00001011
Title: In vitro study of Sphaeranthus indicus on glucose uptake by isolated rat hemi-diaphragm .
Category: Pharmacology
Section: Research Article
Country: India
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In the present investigation, the ethanol extract of aerial part of Sphaeranthus indicus was evaluated for antidiabetic activity. The antidiabetic activity was studied using the glucose uptake by isolated rat hemi-diaphragm in vitro model. S. indicus increased the uptake of glucose by isolated rat hemi-diaphragm significantly (P<0.01) and was found to be more effective than insulin. It appears that S. indicus has direct peripheral action on glucose uptake. The value of glucose uptake by rat hemi-diaphragm was 28.04 ± 1.27 as compared to control (5.6± 0.20) and positive {Insulin (14.53 ± 0.56)} in mg/g/30 min. In skeletal muscle, both insulin and contractile activity stimulate translocation of glucose transporter GLUT-4 protein from an intracellular membrane pool to the plasma membrane. The results strongly suggest the S. indicus will be alternative choice for the treatment of diabetes mellitus caused in the consequences of resistance to stimulatory effect of insulin on GLUT-4 protein.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-PA-00001012
Title: Simultaneous Spectrophotometric Determination of Escitalopram Oxalate and Clonazepam Using Multi-Component Mode of Analysis
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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Escitalopram oxalate and Clonazepam in combination are available as tablet dosage forms in the ratio of 20:1. A simple, precise, accurate, reproducible and efficient method for the simultaneous determination of Escitalopram oxalate and Clonazepam tablet dosage form was developed. The proposed method is based on the simultaneous estimation by UV Spectroscopy, using multi-component mode of analysis. 80% (v/v) aqueous methanol was used as blank (reference solvent). The developed method was validated and successfully applied to estimation of Escitalopram oxalate and Clonazepam in combination in tablet formulations.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: 9.
Article Id: JPRS-MB-00001014
Title: Antimicrobial and Anticancer Studies on Euphorbia heterophylla
Category: Microbiology
Section: Research Article
Country: India
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Euphorbia heterophylla is a local medicinal plant used in ethno medicine for the treatment of constipation, bronchitis and asthma. E. heterophylla is medicinal plant with the common name “spurge weed”. In the present study selected plant drug was screened for its anticancer activity by Invitro and Insilco methods. Preliminary phytochemical screening revealed the presence of Terpenoids, Quinones, Alkaloids, Sterol, Coumarin, Starch, and Protein. Ethanol extract was tested for their antibacterial property against various organisms. The extract showed significant antimicrobial activity particularly in Proteus vulgaris and Staphylococcus aureus. Alcoholic extract of plant material showed significant in-vitro cytotoxic activity on EAC (Ehrlich ascites carcinoma) cell lines. GC-MS was carried out in ethanol extract of Euphorbia heterophylla.31 compounds were identified. Bioinformatics tools were employed in understanding the mechanism of action. 14 of the compounds were docked with the Bcl-2 protein, among them Allantoic acid was considered as best candidate as it is having least energy in docking.