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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 3, Issue: October
Article Id: JPRS-MPDI-00001042
Title: Anticancer property of sponge associated Actinomycetes along palk strait
Category: Marine Pharmacy Drug Investigation
Section: Research Article
Country: India
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The present study was made an attempt to find out the diversity of sponge associated actinomycetes and their anticancer property along Palk Strait. Among the actinomycetes, Streptomyces sp. (67%) were predominant followed by Nocordiopsis sp. (17%), Micromonospora sp. (8%) and Glycomyces sp. (8%). Cell free extracts from Streptomyces sp. ACT12 showed LC50 124.58 µg.ml-1 followed by ACT11 146.09 µg.ml-1. The cytotoxic index (MTT assay) of ACT12 and ACT11 on breast cancer cell lines (MCF 7) exhibited the IC50 values of 70.12±1.11 and 89.75±1.84 at 24hrs and 27.37±1.52 and 29.75±3.22 at 48 hrs. The results suggest that, the sponge associated Streptomyces sp. (ACT11 and ACT12) isolated from Thondi coast of southern India, might indeed have potential anticancer drugs.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: October
Article Id: JPRS-PA-00001039
Title: Validation of Uv Spectrophotometric method for estimation of Levocetirizine Dihydrochloride in bulk and pharmaceutical formulation
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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A selective, simple, accurate and reproducible spectrophotometric method has been developed for the estimation of levocetirizine dihydrochloride in bulk and pharmaceutical formulation. The drug obeyed the Beer’s law and showed good correlation. It showed absorption maxima at 231nm; in Phosphate Buffer Solution pH 7.0. The developed method was validated with respect to linearity, accuracy and precision. The linearity was observed between 0-36µg/ml having line equation Y=0.032046X + 0.007151 with correlation coefficient of 0.9994. Results of the analysis were validated statistically and by recovery study.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: October
Article Id: JPRS-PCS-00001036
Title: Review on various techniques of solubility enhancement of poorly soluble drugs with special emphasis on solid dispersion
Category: Pharmaceutics
Section: Review Article
Country: India
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A success of formulation depends on how efficiently it makes the drug available at the site of action. Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules especially in oral formulation. But most of the time it becomes challenging to formulate poorly water soluble drugs. Therefore it is necessary to improve solubility of drug by various ways like salt formation, co-solvency, and addition of solublizing agent, micronization, and complexation. Although these techniques have commonly been used to increase dissolution rate of the drug, there are practical limitations with these techniques, the desired bioavailability enhancement may not always be achieved. One such formulation approach that has been shown to significantly enhance absorption of such drugs is to formulate/prepare solid dispersions.In this review we concentrated on improvement of the solubility of poorly water soluble drugs by preparing solid dispersion using various methods.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: October
Article Id: JPRS-PCS-00001040
Title: Optimization of Rofecoxib Liquisolid Tablets usingBox-Behnken Design and Desirability Function
Category: Pharmaceutics
Section: Research Article
Country: India
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The aim of the present study were (1) to optimize and evaluate main effect, interaction effects and quadratic effects of the formulation ingredients on the flowability of liquisolid formulations (Y1), the hardness of liquisolid tablets (Y2), and the in-vitro release after 45 minutes (Y3) of Rofecoxib from liquisolid tablets as the dependent variables; and (2) to optimize the formulation by response surface methodology (RSM). A three-factor, three-level Box-Behnken statistical design was used for the optimization procedure with liquid load factor (X1), amount of coating material ‘Cab-O-Sil’ (X2) and amount of magnesium oxide (X3) as the independent variables. Box-Behnken design was suitable for exploring quadratic response surfaces and constructing second order polynomial models. The design consists of replicated center points and the set of points lying at the midpoint of each edge of the multidimensional cube that defines the region of interest. The non-linear quadratic model generated by the design is of the form: Y = A0 + A1X1 + A2X2 + A3X3 + A4X1X2 + A5X2X3 + A6X1X3 + A7X12 + A8X22 +A9X32 + E, where Y is the measured response associated with each factor level combination. Contour and response surface plots were depicted based on the equation given by the model. The optimization procedure generated the maximum overall desirability value. A formulation was prepared under the optimized conditions yielding response values, which were close to the predicted values.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: October
Article Id: JPRS-PB-00001041
Title: Extraction of pharmaceutically important Chitin and Carotenoids from shrimp biowaste by microbial fermentation method
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Chitin and carotenoid have many industrial applications including pharmaceutical, medical, cosmetic and biomedical fields. Extraction of chitin and carotenoids from shrimp biowaste by chemical treatment is a source of pollution. Fermentation of shrimp biowaste was studied with Lactic acid bacteria based on pH reduction. The Lactobacillus plantarum (NRRL - B 14768) was tested for recovery of chitin and carotenoids and it was found to be efficient and an eco-friendly process. The inoculated waste was incubated for 72 h at 37oC. Among various glucose concentrations tested (0, 2.5,5,10,15 % w/w) 15% was found to be ideal for fermentation. The efficiency of microbial demineralization and deproteinization was found to be 76% and 89% respectively. The carotenoid recovery was 72.8% at the end of 72 h. The results suggested that Lactobacillus plantarum (NRRL –B 14768) is an attractive source for recovery of chitin and carotenoids.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: October
Article Id: JPRS-P'Col-00001043
Title: Evaluation of Anti-Inflammatory Activity of Methanol Extract of Abutilon indicum And Pedalium murex- A Comparative Study
Category: Pharmacology
Section: Research Article
Country: India
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There is an increasing demand for the medicinal plants in developing countries like India. Attention need to be given to assess the medicinal value of such plants to explore the potential drugs out of it. Inflammation is the condition associated with many of the disease states and this review elaborate the medicinal plants, their parts used in the effective management of Inflammation and its associated conditions. Medicinal plants constitute important components of flora and are widely distributed in different region of India. The various parts of Abutilon indicum and Pedalium murex such as root, leaves and seeds are documented to possess various medicinal properties. Animal studies were performed using Carrageenan induced paw edema principle in albino wistar rats. Both the plants possessed Anti-inflammatory activity. Out of the two plants Pedalium murex had shown more anti-inflammatory activity, when compared with Abutilon indium species.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: October
Article Id: JPRS-PC-00001044
Title: Synthesis and antioxidant activity of novel ketone hydrazones bearing 5-(Pyridine-3-yl)-1,3,4-thiadiazole
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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A new series of Ketone 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)-hydrazone derivatives (4a-h) were synthesized in good yield by the condensation of 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)hydrazine with substituted and unsubstituted ketones and evaluated their antioxidant property by using 1,1-diphenyl-2-picryl-hydrazil (DPPH.) method. All the compounds showed good antioxidant activity.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: October
Article Id: JPRS-PCS-00001389
Title: Transdermal Drug Delivery Systems with major emphasis on Transdermal patches : A Review
Category: Pharmaceutics
Section: Review Article
Country: India
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Due to the recent advances in this technology and as the incorporation of the drug to the site of action is done without rupturing the skin membrane, the transdermal route is becoming very widely accepted route of drug administration. When transdermal formulations are applied to the intact skin , they deliver the drug through the skin at a controlled rate to the systemic circulation. Any formulation like ointments , creams , gels can be used as transdermal formulations for a particular drug, after careful selection of the base and addition of the penetration enhancers . Transdermal patches are the best available TDDS systems which are applied on the surface of the skin to deliver a specific dose of medication through the skin to the blood stream, thus this review mostly revolves around TDDS patches. Various other methods used for drug transport to the blood through skin are Intophoresis, Electroporation, Ultrasound, Reverse electrporation, Photochemical wave etc which also come under TDDS. This review is an attempt to compile the relevant information and techniques under Transdermal Drug Delivery Systems (TDDS) along with the evaluation (in vitro and in vivo) of these. This review also includes recent advances in the field of TDDS. Authors have also made a comment on the limitations of TDDS, comparision of topical and TDDS and toxicity considerations of topical preparations.

Journal: Journal of Pharmacy Research , Volume: 3, Issue: October
Article Id: JPRS-PCS-00001394
Title: RP-HPLC method for simultaneous estimation of Atorvastatin Calcium and Fenofibrate in tablet dosage forms
Category: Pharmaceutics
Section: Research Article
Country: India
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A reverse phase high performance liquid chromatographic method was developed for simultaneous estimation of atorvastatin calcium and fenofibarte in tabletformulation. The separation was achieved by HiQ sil C-8 (4.6×250mm) column with a mobile phase consisting of methanol: water pH 3.2 (90:10v/v), at a flow rateof 1ml/min. Detection was carried out at 260 nm. Retention time of atorvastatin calcium and fenofibrate was found to be 3.32 and 4.51 min, respectively. The method has been validated for linearity, accuracy and precision. Developed method was found to be accurate, precise, selective and rapid for simultaneous estimation of atorvastatin calcium and fenofibrate in tablets.