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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).



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Journal: Journal of Pharmacy Research , Volume: 4, Issue: June
Article Id: JPRS-PA-00001358
Title: Validated HPLC method for the simultaneous estimation of gemifloxacin mesylate and ambroxol hydrochloride in bulk and tablet dosage form
Category: Pharmaceutical Analysis
Section: Research Article
Author Affiliation: Department of pharmaceutical Analysis, Adhiparasakthi college of pharmacy, Melmaruvathur-603319, Kancheepuram, District Tamil Nadu (INDIA)
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A High-performance liquid chromatography was developed and validated for the quantitative determination of two drugs. A simple, selective, rapid, precise and economical Reverse phase HPLC method has been developed for the simultaneous estimation of Gemifloxacin mesylate and Ambroxol HCl in combined tablet dosage by using Acetonotrile, Methanol and 0.1% Trifluro acetic acid in the ratio 25:20:55 % v/v as a solvent system. The method was carried out on a phenomenex C18 (15cm × 4.6mm i.d., 5 mm particle size) column, at a flow rate of 1.0mL/min. Detection was carried out at 248 nm. The retention time of Gemifloxacin mesylate and Amboxol HCl were 2.69 and 3.43 min, respectively. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification and solution stability. The proposed method can be used for the estimation of these drugs in combined pharmaceutical dosage
forms.