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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).



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Journal: Journal of Pharmacy Research , Volume: 6, Issue: March
Article Id: JPRS-PC-00001286
Title: Compositional variability in volatiles from different plant organs of Perilla frutescens L. cultivated in Uttarakhand (India)
Category: Pharmaceutical Chemistry
Section: Research Article
Author Affiliation: Centre for Aromatic Plants (CAP), Industrial Estate, Selaqui 248197, Dehradun, Uttarakhand, India
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Background: This investigation aims to determine the variation in essential oil compositions in plant parts (whole plant, leaves, spikes and husk) of Perilla (Perilla frutescens L.) at 3 different sowing times and also to ensure the suitability of this crop in Doon valley climatic conditions for commercial cultivation. Methods: During the course of study, seeds were sown at 25 days intervals in the month of May, June and July with 60  30 cm spacing. The essential oils from all the samples were hydro-distilled using a Clevenger-type apparatus and analyzed by GC/MS. Results and discussion: In all the oils, perilla ketone (43.49e90.28%) and 1-methyl-2- methylene trans-decalin (4.49e36.11%) were found to be the most abundant compounds. Conclusion: On the basis of comparative composition, D1 stage (seeds sown on 20th May) showed better results as compared with D2 (seeds sown on 15th June) and D3 (seeds sown on 10th July).

Journal: Journal of Pharmacy Research , Volume: 6, Issue: March
Article Id: JPRS-P'Col-00001287
Title: Free radical scavenging and antiepileptic activity of Leucas lanata
Category: Pharmacology
Section: Research Article
Author Affiliation: Department of Pharmacy, University College of Technology, Osmania University, Hydearabad, Andhra Pradesh 500017, India
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Objective: Oxidative stress was found to be the underlying mechanism in many disorders especially in neurodegenerative disorders like epilepsy. The main aim of the investigation was to evaluate invitro free radical scavenging potential and invivo antiepileptic activity of selected fraction of Leucas lanata. Methods: Ethanolic extract of L. lanata was taken for its phytochemical screening, invitro free radical scavenging, cytotoxic studies, fractionation with ethyl acetate and its HPTLC studies. Further the fraction was evaluated for invivo acute toxicity studies and antiepileptic activity in mice. Results: After the estimation of 64.412  8.44 mgGAE/g of phenolic and 63.723  8.01 mgRE/g of flavonoids contents, invitro free radical scavenging studies of ethanolic extract of the plant revealed its almost equal potential as quercetin. HPTLC studies of ethyl acetate fraction of extract revealed the presence of 3 unknown flavonoids with Rf values of 0.03, 0.48 and 0.93. In animal studies there was a decrease in the duration of hind limb extension like 7.8  0.1 s, 7.4  0.2 s and 7.1  0.2 s linearly with doses. In forced swim test animals were found to be active without any decreased locomotory activity indicated by more immobilized time in diazepam treatment (233.33  5.03 s) and less immobilized time with the treatment of fraction (161.66  5.686 s). From the studies of malondialdehyde estimation, there was a comparative decrease in the content which was not linear with dose. Conclusion: From the results of invitro and invivo studies it can be concluded that, flavonoid and phenolic rich ethyl acetate fraction of L. lanata can be used to treat epilepsy without any induction of depression.

Journal: Journal of Pharmacy Research , Volume: 6, Issue: March
Article Id: JPRS-MPDI-00001288
Title: Marine microbes: Invisible nanofactories
Category: Marine Pharmacy Drug Investigation
Section: Review Article
Author Affiliation: Herbal Drug Technological Laboratory, Department of Studies in Microbiology, University of Mysore, Manasagangotri, Mysore 570 006, Karnataka, India
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Biological synthesis of nanoparticles has emerged as rapidly developing research area in nanotechnology across the globe with various biological entities being employed in production of nanoparticles constantly forming an impute alternative for conventional methods. Simple prokaryotes to complex eukaryotic organisms including higher plants are
used for the fabrication of nanoparticles. One area of untapped potential is marine microorganism as nanofactories to fabricate nanoparticles. Marine microorganisms are known to interact with metal ions as marine ecosystems are constantly exposed to high metal salt concentration. These microorganisms may reduce the metallic ions rapidly for the formation of nanoparticles of desired shape and controlled size. The present review unearths marine microbial flora in synthesis of nanoparticles.