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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 6, Issue: June
Article Id: JPRS-PCS-00001296
Title: Formulation design and optimization of novel mouth dissolving tablets for venlafaxine hydrochloride using sublimation technique
Category: Pharmaceutics
Section: Research Article
Country: India
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Aim: Venlafaxine hydrochloride, commonly used as antidepressant, has poor bioavailability due to extensive first pass metabolism. The objective of present study is to develop novel method of preparing compressed tablets for venlafaxine hydrochloride with high porosity which dissolves rapidly in mouth, using camphor as sublimating agent. Methods: A 32 factorial design was used to investigate effect of amount of camphor and superdisintegrant namely indion 234 as independent variable. Friability, disintegration time, percent drug release were taken as dependent variables. Different concentrations (3%, 4%, 5%)of superdisintegrant indion 234 and camphor (5%, 10%, 15%) were used respectively.Tablets were prepared by direct compression method. Pearlitol SD-200 was used as bulking agent. The compressed tablets were dried for 6 h to allow sublimation of camphor to increase the porosity of the tablets to improve their dissolution. The tablets were evaluated for hardness, thickness, friability, weight variation, porosity, wetting time, disintegration time, drug content and in-vitro drug release. Drug-excipient interaction was investigated by FTIR study. Optimized formulation was evaluated for stability as per ICH guideline. Results: All tablets had hardness 3e3.5 kg/cm2 and friability of all formulations was less than 1.08%. Weight variation and drug content were within USP limits. FTIR study revealed no drug-excipient interaction. SEM study showed the porous surface morphology of tablets. A stability study for optimized F3 formulation as per ICH guideline for 90 days showed no changes in drug content. Conclusion: Therefore, it may be concluded that developed novel method of preparing compressed tablets for venlafaxine hydrochloride with high porosity which dissolve rapidly in mouth, could be industrially feasible.

Journal: Journal of Pharmacy Research , Volume: 6, Issue: June
Article Id: JPRS-P'Col-00001297
Title: Investigation of analgesic potential and in vitro antioxidant activity of two plants of Asteraceae family growing in Bangladesh
Category: Pharmacology
Section: Research Article
Country: India
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Background: The present study was designed to investigate analgesic potential and in vitro antioxidant activity of crude ethanolic extract of two plants (Ageratum conyzoides L. and Mikania cordifolia L.) of Asteraceae family growing in the coastal region of Bangladesh. Methods: The analgesic potentials of the plants were evaluated using acetic acid induced writhing in mice and for investigating the antioxidant activity, four complementary test methods namely DPPH free radical scavenging assay, reducing power assay, ferrous ion chelating ability assay, and total phenolic content determination were carried out. Results and discussion: The analgesic activities of the crude extracts were found significant at doseof 500 mg/kg-body weight inhibition ( p < 0.001) in comparison with standard Diclofenac sodium. The results of the antioxidant tests showed that A. conyzoides is fairly strong with antioxidant properties in comparison with standards used, whereas M. cordifolia got moderate antioxidant potentiality. Conclusion: The study tends to suggest potent analgesic activity of crude ethanolic extract of leaves of A. conyzoides L. and M. cordifolia L., and justify their traditional use for antioxidant and analgesic treatment; however, in vivo antioxidant activity and active component(s) of the extract for antioxidant and analgesic potentiality are yet to be discovered.

Journal: Journal of Pharmacy Research , Volume: 6, Issue: June
Article Id: JPRS-PCS-00001298
Title: Development and validation of ratio-derivative spectrophotometric method for simultaneous estimation of Gabapentin, Methylcobalamin and alpha lipoic acid in tablet formulation
Category: Pharmaceutics
Section: Research Article
Country: India
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Aim: The purpose of this study is to develop simple, economic, specific, rapid, reliable, and reproducible method for simultaneous estimation of the Gabapentin, Methylcobalamin and Alpha lipoic acid. Method: In this method the overlapping spectra of Gabapentin, Methylcobalamin and Alpha lipoic acid were well resolved by making use of the first-derivative of the ratios of their direct absorption spectra. The derivative ratio absorbance of Gabapentin, Methylcobalamin and Alpha lipoic acid were measured at 731.10 nm, 768.53 nm and 242.21 nm for their quantification. The method was validated for accuracy, precision, linearity, robustness and sensitivity. Result & discussion: Gabapentin, Methylcobalamin and Alpha lipoic acid were shown linearity in the concentration range of 100-500 mg/ml, 0.5e2.5 mg/ml and 100e500 mg/ml respectively. The LOD & LOQ were found to be 3.09 mg/ml and 9.37 mg/ml; 0.03 mg/ml and 0.10 mg/ml; and 4.79 mg/ml and 14.52 mg/ml respectively. The % labelled claim for Gabapentin, Methylcobalamin and Alpha lipoic acid were found to be 98.71, 98.94 and 98.44 respectively. Conclusion: Thus, the described method is suitable for routine analysis and quality control of pharmaceutical preparations containing these drugs in combination.

Journal: Journal of Pharmacy Research , Volume: 6, Issue: June
Article Id: JPRS-PB-00001299
Title: Efficacy of Helicteres isora L. against free radicals, lipid peroxidation, protein oxidation and DNA damage
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Background: Free radicals are implicated with cellular disorders through their detrimental actions on proteins, lipids and DNA and are causative factors for large number of degenerative diseases and aging process. Antioxidants of plant origin hold great significance and have therefore gained utmost importance in recent past. Present investigation was a step in this direction, with an objective to comprehensively evaluate the protective effects of Helicteres isora fruits against free radicals, protein oxidation and DNA damage. Methods: Aqueous (AqE), aqueous-methanol (AqME), methanol (ME) and acetone (AE) extracts of mature pods (fruits) were obtained and concentrated in vacuo. Total phenols, flavonoids, ascorbic acid and carotenoids were estimated from extracts using standard methods. Antioxidant activities of extracts with varying concentrations (200-1000 mg/ml) were determined by total antioxidant activity (TAA), ferric reducing antioxidant power, DPPH, and OH radical scavenging assays besides lipid peroxidation inhibition. Extracts were assessed for protection against AAPH (2,20-Azobis(2-methylpropionamidine) dihydrochloride) induced-protein oxidation using SDS-PAGE and Fenton’s reagent induced- DNA damage using DNA nicking assay. Results: The results postulated that the plant is a rich source of total phenols, flavonoids and ascorbic acid. Extracts showed concentration-dependent free radical scavenging activities and lipid peroxidation inhibition. Amongst all four extracts, AqME showed highest antioxidant potential in terms of reducing power (360  5.9 gallic acid equivalent: GAE), TAA (150  5.6 GAE), scavenging of free radicals including DPPH (75.6%) and OH (100%) besides maximal (97.4%) lipid peroxidation inhibition at 1000 mg/ml concentration. All the extracts barring ME effectively protected the DNA from hydroxyl radical-induced damage. Similarly, fruit extracts effectively protected the AAPH-induced-protein oxidation. Conclusions: H. isora fruits exhibited broad-spectrum antioxidant potencies against free radicals and significantly ameliorated various impairments associated with free radical formation including lipid peroxidation, protein oxidation and DNA damage.