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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 6, Issue: 7.
Article Id: JPRS-PHDRS-00001302
Title: Phenolic content of Ruprechtia salicifolia leaf and its immunomodulatory, anti-inflammatory, anticancer and antibacterial activity
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Objectives: This work aimed to isolate phenolics from leaves of Ruprechtia salicifolia and evaluate its immunomodulatory, anti-inflammatory, anticancer and antibacterial activity. Methods: 80% MeOH leaf extract was subjected to chromatographic separation, structures of the isolated compounds were established by different chromatographic and spectral techniques UV, MS, 1H and 13C NMR. Immunomodulatory was evaluated through RAW 264.7 macrophages proliferation by MTT assay. Anti-inflammatory was evaluated byinhibition of NO and TNF-alpha factor generation in LPS-stimulated cells through bicinchoninici acid assay and ELISA assay, respectively. Cytotoxicity estimated through Hep-G2, MCF-7 and HCT-116 cell lines measured by MTT assay. Antibacterial activity tested by agar diffusion method. Results: Eleven known phenolic compounds were isolated for the first time from this species including five flavonoid glycosides viz; Rutin 3, quercetin 3-O-arabinoglucoside 4, apigenin 7- O-beta-D-glucoside 5, quercetin 3-O-alpha-L-arabinofuranoside 6 and isoquercetin 7 along with four aglycones viz; kaemferide 8, apigenin 9, quercetin 10 and naringenin 11 and two phenolic acids; caffeic 1 and gallic 2. Compounds 5 showed the most activity increasing macrophage proliferation implying immunomodulatory activity. 80% MeOH extract, 4, 5 and 11 inhibited nitrite oxide by 68.19%, 52.95%, 20.33% and 15.22%, respectively and TNF-alpha generation by 70.82%, 29.88%, 13.13% and 6.14%,respectively in LPS-stimulated cells implying antiinflammatory activity. 80% MeOH leaf extract and the tested compounds 4 and 5 were safe possessing no cytotoxic activity against hepatocellular carcinoma (Hep-G2), breast adenocarcinoma (MCF-7) and colon carcinoma (HCT-116), while Compound 11 had cytotoxicity against only HCT-116 cells (IC50 ¼ 27.67 mg/ml). Also 80% MeOH leaf extract showed antibacterial activity against both G þve and G ve bacteria, moreover it inhibits growth of Klebsiella pneumonia strain, which is resistant to Ciprofloxacin broad-spectrum antibiotic. Conclusions: R. salicifolia contain phenolics of immunomodulatory anti-inflammatory, cytotoxicity and antibacterial activity, giving R. salicifolia grate potential as a medicinal natural drug.

Journal: Journal of Pharmacy Research , Volume: 6, Issue: 7.
Article Id: JPRS-PHDRS-00001303
Title: Evaluation of the diuretic activity of the ethanolic extract of Geranium seemannii Peyr. in Wistar rats
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Background: Although Geranium seemannii Peyr. is widely used in Mexican traditional medicine, there is as yet no scientific study to explore the validity of this practice. Therefore, the aim of the present study was to evaluate the diuretic activity of the ethanolic extract of G. seemannii Peyr. to provide evidence about its effect. Methods: G. seemannii Peyr. was orally administered to adult male Wistar rats at 25 and 50 mg/kg, and its diuretic activity was evaluated and compared to the reference drug furosemide (20 mg/kg, administered intraperitoneally). Acute toxicity and lethality (LD50) of the extract were assessed. Results: Compared to control rats, there was significantly higher urinary output, as well as sodium, potassium and chloride ion excretion, in animals administered the ethanolic extract of G. seemannii Peyr. This effect was dose dependent, and there was no evidence of either acute toxicity or lethality with twice the maximum dose employed. Discussion: The diuretic activity of some plants has been attributed to the presence of flavonoids, and G. seemannii Peyr. has a relatively large concentration of ellagitannins. This could be responsible for the effect demonstrated herein, which was similar to that produced by the reference drug furosemide. The mechanism of action of furosemide is by inducing a loss of water through the inhibition of NaCl reabsorption. The results suggest that this receptor-mediated mechanism may account for the diuretic effect of G. seemannii Peyr. as well.