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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 9, Issue: December
Article Id: JPRS-P'Col-00001408
Title: Liver disorder and its clinical investigation
Category: Pharmacology
Section: Review Article
Country: India
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Liver disorder is a common disorder seen with the people of almost all age groups due to infection, wrong food habit, sedentary life style, alcoholism etc. Disorder ranges from simple infection to scarring, cirrhosis and cancer. Treatment includes from simple medication to liver transplantation depending on the severity of the disease. The clinical examination and early detection plays a vital role in treating the disease. Jaundice, cholestasis, liver enlargement, portal hypertension, ascites, liver encephalopathy and liver failure are the common symptoms of liver diseases. When diagnosing liver diseases, the physician looks at the patient’s symptoms and conducts a physical examination. In addition, the physician may request a liver biopsy, liver function tests, an ultrasound, or a CT scan (computerized tomography scan). Early diagnosis translates into a better treatment and result.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: December
Article Id: JPRS-PSPA-00001109
Title: In vitro antioxidant, anti-inflammatory and anticholinesterase activities of Rumex vesicarius L
Category: Phytochemical Study and Pharmacological Activity
Section: Editorial
Country: India
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Objective:To investigate phenolic content, flavonoid content, the antioxidant, anti-inflammatory, and anticholinesterase activities of ethyl acetate extracts of Rumex vesicarius Lfrom leaf, stem, flower and seed. Materials and Methods: The assessment of the antioxidant potential of crude leaf, stem, flower and seed extracts, using the ferric reducing antioxidant power (FRAP) assays and 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) and β-Carotene radical scavenging capacity assays was carried out. Furthermore, the 15-lipoxygenase inhibitory activity was evaluated by the ferrous oxidation- xylenol orange (FOX) assay method. Moreover, Cholinesterase inhibitory activities were examined using Ellman’s colorimetric method. The total phenolic content measured by Folin-ciocalteu method was as well conducted. Results: The raw seed, flower, stem and leaf extracts of Rumex vesicarius L was found to contain a high content of total phenolic content (36.44 to 54.15 mg GAE/g DW) and flavonoids (12.36 to 21.97 mg CE/g DW). All extracts organs exhibited a higher antioxidant activity and inhibitory effect of radicals scavenging activity against FRAP, ABTS and β-Carotene. For the anti-inflammatory activity, the extracts tested had significant 15-lipoxygenase inhibitory ranging from 33.82 to 62.45% and had a noticeable inhibition towards AChE and BChE. Conclusion: the results suggest that the seed, flower, stem and leaf of Rumex vesicarius L exhibited high antioxidant and anti-inflammatory, this property may be related with high quantity of phenolic and flavonoid in extracts, this plant can be considered as a good source of natural antioxidant and anti-inflammation drugs as well as potent anticholinesterase effect.

Cite this article as: Laouini S Eddine*1, Ladjel Segni2, Ouahrani M Redha1,In vitro antioxidant, anti-inflammatory and anticholinesterase activities of Rumex vesicarius L, Journal of Pharmacy Research 2015,9(12),635-642.

 

 

Journal: Journal of Pharmacy Research , Volume: 9, Issue: December
Article Id: JPRS-PC-00001136
Title: Innovative Green synthesis of Schiff bases and their Antimicrobial Activity
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Objective: To optimize microwave assisted solvent free synthesis of Schiff bases of substituted benzaldehydes and aromatic amines (3-amino-6-bromo/Iodo-2-phenylquinazoline-4(3H) one) by using wetting reagent 000-ethoxyethanol. The goal of this study was to investigate the % yields and time required for the completion of reaction for Schiff bases by microwave and conventional conditions. Methods: Schiff bases have been synthesized by condensation of substituted various aromatic substituted benzaldehydes (0.001mol) with 3-amino-6-bromo/Iodo-2-phenylquinazoline-4(3H) one (0.001mol) by two different methods as by conventional method (Heating) & Microwave accelerated synthesis by using wetting reagent 000-ethoxyethanol. The reaction time for conventional method and microwave method is in the range of 4-7 hr. and 3-5 min. respectively. The % yield for conventional method and microwave method is in the range of 56-77%. and 77-90% respectively. All synthesized compounds were characterized by elemental analyses, IR spectroscopy, mass spectroscopy, 1H NMR and 13C NMR spectroscopy. Results: The simple microwave assisted solvent-free method for the synthesis of Schiff bases using a wetting reagent (-ethoxyethanol) led to improvement in the yield of all the target compounds with reduction in their reaction byproducts & substantially reduced the overall process time as expected as compare to traditional method. Excellent isolated yields (up to 90%) were attained within short reaction times (typically, 3 min.) when the reaction was performed under microwaves irradiation. Conclusion: Compared with traditional methods, these methods are more convenient and reaction can be carried out in higher yield, short reactions time and milder conditions, without generation of pollution, elimination of side products and safer to analyst. From these features present methods can be correlated for safer and efficient synthesis of other products.

Cite this article as: Omprakash G. Bhusnure1*,Yaswant B.Vibhute2, Padmaja S Giram3, Archana Y. Vibhute2, Innovative Green synthesis of Schiff bases and their Antimicrobial Activity, Journal of Pharmacy Research 2015,9(12),670-677.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: December
Article Id: JPRS-PA-00001135
Title: Sensitive liquid chromatography tandem mass spectrometry method for the quantification of Ropinirole in human plasma using liquid-liquid extraction technique
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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Background: A sensitive high-performance liquid chromatography – positive ion electroscopy tandem mass spectrometry method was developed and validated for the quantification of Ropinirole in human plasma. Methods: Following liquid-liquid extraction, the analyte and internal standard were separated using an isocratic mobile phase on a reverse phase C18 column and analyzed by MS/MS in the multiple reaction monitoring mode using the respective [M+H]+ ions, m/z is 261 to 114 for Ropinirole and m/z is 325 to 262 for the internal standard. Results and discussion: The assay exhibited a linear dynamic range of 10.0 pg/mL to 1006.3 pg/mL for Ropinirole in human plasma. The lower limit of quantification was 10.0 pg/mL with a relative standard deviation of less than 7%. This LC-MS/MS method was validated with between-batch and within-batch precision of 5.5 to 8.6% and 4.3 to 10.9%, respectively. The between-batch and within-batch accuracy was 99.0 to 104.4% and 94.1 to 107.4%, respectively. Conclusion: This validated method is simple, rapid, cost effective and repeatable enough to be used in pharmacokinetic studies.

Cite this article as: Sreekanth Kakarla1* and Ganapaty Seru1,Sensitive liquid chromatography tandem mass spectrometry method for the quantification of Ropinirole in human plasma using liquid-liquid extraction technique, Journal of Pharmacy Research 2015,9(12),662-669.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: December
Article Id: JPRS-PRGS-00001124
Title: Melatonin and aqueous curry leaf extract in combination protects against lead induced oxidative stress mediated injury to rat heart: a new approach
Category: Pharmaceutical and Related General Science
Section: Research Article
Country: India
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Objective(s): The objective(s) of the present study was to investigate whether a combination of melatonin and aqueous curry leaf extract is capable of providing protection against lead acetate induced oxidative stress mediated injury to cardiac tissue of experimental rats.

Methods: Male Wistar rats were used as an animal model for the present study. After acclimatization to laboratory condition, in the first set of experiments rats were divided in to different groups. In the second, rats were divided in to four groups, i.e., control, positive control, lead acetate treated and melatonin + curry leaf extract in combination protected. Rats were treated intraperitoneally (i.p.) with lead acetate (15 mg / kg body weight) for a period of seven consecutive days. Rats of the protected group were pre-treated with melatonin also for seven days. The control rats were treated with vehicle only while the positive control rats were treated with melatonin + aqueous curry leaf extract only. After the treatment period, rats were sacrificed; blood and cardiac tissue collected and processed for analysis.

Results: Treatment of rats with lead acetate caused accumulation of lead in the cardiac tissue and alterations in the biomarkers of organ damage and oxidative stress. It caused deteriorative changes to the cardiac tissue morphology and collagen content which were evaluated using light microscopy, electron microscopy and confocal microscopy. Involvement of oxidative stress is evident from the alterations in the level of lipid peroxidation and protein carbonyl content, activities of the antioxidant as well as pro-oxidant enzymes and some of the enzymes of the citric acid cycle and Electron Transport Chain (ETC) following lead acetate treatment. All changes were protected when the rats were pre-treated (fed orally) with melatonin (10 mg / kg body weight) and aqueous extract of curry leaves (50 mg/kg body weight) in combination for seven days.

Conclusion: The results of the current studies indicate protective effect of the combination of melatonin (a natural antioxidant in pure form) and the aqueous extract of curry leaves to mitigate lead acetate-induced oxidative stress in experimental rats possibly through their synergistic antioxidant mechanism(s) .This study opens up avenues for development of an effective drug formulation against lead induced oxidative stress mediated cardiac damage in people who get environmentally or occupationally exposed to lead.

Cite this article as:Debosree Ghosh Sudeshna Paul, Aindrila Chattopadhyay, Debasish Bandyopadhyay,Melatonin and aqueous curry leaf extract in combination protects against lead induced oxidative stress mediated injury to rat heart: a new approach,Journal of Pharmacy Research 2015,9(12),618-634.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: December
Article Id: JPRS-BMB-00001137
Title: Anticarcinogenic effects of cinnamomum verum on HL60 leukemia cell lines
Category: Biochemistry and Molecular Biology
Section: Research Article
Country: India
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Background: Phyto medicine are focused more by recent researchers for the treatment of different types of chronic diseases including cancer, because of its radical scavenging effect, antioxidant capacity and anticarcinogenic potentiality. The present study was aimed to assess to the presence of bioactive compounds and its anticarcinogenic activity of Cinnamomum verum (C.verum) bark. Methods : The quantitative and qualitative phytochemical analysis was carried out with the ethanol and methanol extracts C.verum. GCMS analysis, of methanolic extract was done. The radical scavenging activity and the antioxidant potentials were assessed by thio barbituric assay, metal chelating activity, superoxide anion radical scavenging activity, phospho molybdenum assay. Further studies were progressed with in vitro cell cytotoxicity assay, DNA fragmentation assay and cell morphology assay with ethanolic extract of C.verum using HL 60 leukemia cell lines. Results and Discussion : The quantitative phytochemical analysis showed the presence of tannin, saponin, alkaloids, flavonoids, polyphenols and steroids. The total phenolic and flavanoid contents were estimated as 176.7mg/g and 153.2mg/g. From GCMS results the bioactive phytochemicals and their structural characterizations were identified. The radical scavenging activity of ethanol and methanol extracts of C.verum showed better scavenging activity against free radical generation. In in vitro antioxidant assay the results showed both the extracts ethanol and methanol of C.verum have significant antioxidant potentiality. The results of cell cytotoxicity assay show good inhibitory effect. DNA fragmentation analysis confirms the characteristic nuclear fragmentation in the late stage of apoptosis. The morphological identification of DNA shows cellular shrinkage, membrane blebbing, and typical nuclear fragmentation. Conclusion : The present study proves that C.verum bark is a good source of bioactive compounds and exhibit the anticarcinogenic effect through various mechanism.

Cite this article as:S. Bhagavathy and S.Latha,Anticarcinogenic effects of Cinnamomum verum on HL60 leukemia cell lines,Journal of Pharmacy Research 2015,9(12),650-661

Journal: Journal of Pharmacy Research , Volume: 9, Issue: December
Article Id: JPRS-PC-00001141
Title: Synthesis, characterization and biological evaluation of novel C-2 substituted benzimidazole heterocycles
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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A series of new 1-(1H-benzo[d] imidazol-2-yl)-3-methyl-4-(substituted phenylhydrazono) -1H-pyrazol-5(4H)-ones (4a-i) were synthesized by the condensation of 2-hydrazinyl-1H-benzo[d]imidazole (2) with ethyl-2-arylhydrazono-3-oxobutyrates (3a-i) in glacial acetic acid. Also, 3-(1H-benzo[d]imidazol-2-ylamino)-2-(7-hydroxy-substituted-2-oxo-2H-chromen /quinolin -3-yl)thiazolidin-4-one)s (7a-d) were prepared via the cyclisation of Schiff bases 3-((2-(1H-benzo[d]imidazol-2-yl)hydrazono)substituted)-7-hydroxy-4-methyl-2H-chromen/quinolin-2-one (6a-d)with thioglycolic  acid in refluxing benzene. Structural assignments of these synthesized compounds were based on IR, 1HNMR, and Mass spectral data. The newly synthesized compounds (4a-i), (6a-d) and (7a-d) which possess a variety of heterocycles with benzimidazole as core nucleus were evaluated for their antimicrobial and anti-inflammatory activities by cup-plate method and formalin induced rat hind paw oedema method respectively.

Cite this article as: Naganna M. Goudgaon and Sheshikant B. Ummapure,Synthesis, characterization and biological evaluation of novel C-2substituted benzimidazole heterocycles, Journal of Pharmacy Research 2015,9(12),643-649.