Journal Menu

Issues

Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-P'Col-0000219
Title: Melatonin affords protection against myocardial ischemia-induced cerebral mitochondrial dysfunction: an in vivo study.
Category: Pharmacology
Section: Research Article
Country: India
View Article

Background: Ischemic Heart Disease (IHD) is a health problem of global concern. The studies on myocardial ischemia induced changes in brain particularly cerebrum portion are scanty. Lacunae exist in the knowledge whether such changes can be protected by antioxidant(s). The present work was carried out to explore the ameliorating potential of melatonin against isoproterenol induced changes in tissue and mitochondria isolated from heart and brain of male Wistar rats. Methods: The adverse changes were induced by administering isoproterenol bitartrate subcutaneously at a dose of 25mg/kg body weight. Protective effects of melatonin was examined by administering melatonin at the dose of 40mg / kg body weight. After the treatment period, biomarkers of organ damage and oxidative stress biomarkers, activities of mitochondrial antioxidant as well as Kreb’s cycle enzymes, and tissue and mitochondrial morphology was studied. Results: Isoproterenol administration caused remarkable deleterious changes in oxidative stress biomarkers like lipid peroxidation level, reduced glutathione and protein carbonyl content of tissue and mitochondria. Moreover, isoproterenol unfavorably altered the activity of antioxidant enzymes like Mn-SOD, glutathione peroxidase (GPx) and glutathione reductase (GR) in mitochondria thus confirming the generation of oxidative stress in mitochondria. Altered activity of some of the important Kreb’s cycle enzymes indicated the disturbance in energy metabolism. The degeneration of mitochondria was observed by scanning electron microscopy and fluorescence confocal microscopy. Melatonin pre-treatment successfully restored all the parameters to normal level at a dose of 40mg/kg body weight. Conclusion: Isoproterenol causes deleterious changes in cardiac and cerebrum portion of the brain tissue as well as the mitochondria and melatonin pre-treatment protects against such changes. Thus, therapeutic use of melatonin may be considered in treating cardiovascular diseases along with subsequent brain damages as there may be strong relationship between cardiovascular diseases and cognitive functioning of brain.

Cite this article as: Auroma Ghosh, Mousumi Dutta, Arnab Kumar Ghosh, Aindrila Chattopadhyay, Debajit Bhowmick and Debasish Bandyopadyay,Melatonin affords protection against myocardial ischemia-induced cerebral mitochondrial dysfunction: an in vivo study. Journal of Pharmacy Research 2015,9(2),105-118

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-PC-0000371
Title: Synthesis and Biological Activity of Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid as Anticancer, Analgesic and Anti-inflammatory Agents
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
View Article

A series of acyl hydrazone derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid have been synthesized and screened for in vivo anti inflammatory, analgesic and in vitro anti cancer activities. The key intermediate N-acylhydrazine is prepared in good yield from NSAID oxaprozin, was coupled with a variety of aromatic aldehydes under conventional as well as microwave irradiation conditions. The microwave approach utilized solvent free condition, required short time and resulted in very good yields. The newly synthesized compounds have been characterized by IR, 1H NMR, 13C NMR and Mass analysis. The results of the biological activities showed that the compounds 5b, 5d and 5e exhibited significant in vivo analgesic and anti inflammatory activities than reference compound oxaprozin. Compounds 5a, 5b, 5e, 5g, 5h, 5i and 5j revealed promising in vitro cytotoxicity than reference compound Cisplatin.

Cite this article as: Parsharamulu Rayam, Jaya Shree Anireddy, Naveen Polkam, Tejeswara Rao Allaka, Kalyani Chepuri and Mukharjee Nadendla,Synthesis and Biological Activity of Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid as Anticancer, Analgesic and Anti-inflammatory Agents, Journal of Pharmacy Research 2015,9(2),157-164

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-PHDRS-0000419
Title: Multivitamin plant: pharmacognostical standardization and phytochemical profile of its leaves
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
View Article

To explore the micro morphology and physio chemical parameters of the leaves of Sauropus androgynus L. Merrill. (Euphorbiaceae). Macroscopy, microscopy, physicochemical analysis, preliminary phytochemical screening and other WHO recommended parameters for standardizations were performed. Leaves: Stipules lanceolate or linear-lanceolate, 1.5-3mm long. Petioles 2-4 mm long; leaf blade sub membranous or thin-papery, ovate-lanceolate, oblong-lanceolate or lanceolate, 3-10cm long, 1.5-3.5 cm wide, base cuneate, rounded or truncate, apex acuminate; lateral veins 5-7 pairs, flattened adaxially, elevated abaxially, reticular nerves obscure. Microscopic evaluation revealed the Midrib of the leaf is flat on the adaxial side and triangular with conical abaxial part. The adaxial epidermis of the midrib is fairly distinct with squarish cells and abaxial epidermis has small radially oblong cells. The vascular bundle is single broadly top shaped and collateral. The xylem elements are several parallel lines they are thick walled and angular in outline phloem occurs in wide band beneath the xylem. The lamina has bifacial symmetry of the mesophyll and the midrib. The lamina has smooth and even surface. The adaxial epidermis has dilated rectangular cells and small squarish cells. The abaxial epidermis also has circular or spindle shaped dilated cells. The adaxial epidermis is apostomatic. The cuticle layer is fairly thick, smooth and highly waxy. The cells are random in orientation. The abaxial epidermal is stomatiferous. They are paracytic type with two unequal, parallel subsidiary cells for each stoma. The epidermal cells are amoeboid with highly wavy anticlinal walls. Vein islet numbers, vein termination numbers, stomatal number, stomatal index and other physico chemical tests like ash values, loss on drying, extractive values were determined. Preliminary phytochemical screening showed the presence of alkaloids, proteins and aminoacids, tannins, flavonoids, carbohydrates, sterols and absence of mucilage, saponin, glycosides, volatile oil and fixed oil. Microscopic analysis was informative and provides useful information in the botanical identification, standardization for purity & quality and immense value in authentication of the leaf.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-PC-0000370
Title: Synthesis of some derivatives of dimedone, gamma pyrone and barbituric acid.
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
View Article

Aim: Dimedone , gamma pyrone and barbituric acid and their derivatives have also been found to be very important from their application point of view. Thus our aim was to prepare more derivatives from them. Method : Dimedone , gamma pyrone and barbituric acid have been treated with dimethyl sulphoxide and acetic anhydride reagent under varying temperature conditions in order to get more compounds. Result: The interaction of DMSO-Acetic anhydride with Dimedone (1) gives (2) and (3), with gamma pyrone (5) gives (6) ,(7), and with barbituric acid (10) gives (11 ) and (12). Conclusion: A number of compounds were synthesized .

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-PCS-0000373
Title: Design, development and In vitro characterization of Felodipine Mucoadhesive buccal tablets
Category: Pharmaceutics
Section: Research Article
Country: India
View Article

In recent years, there has been a growing interest in the use of delivery of therapeutic agent through various transmucosal routes to provide a therapeutic amount of drug to the proper site in body. The objective of this investigation was to develop and evaluate felodipine mucoadhesive buccal tablets using mucoadhesive polymers like HPMC K4M, SCMC and Carbopol 934P. The buccal tablets prepared by direct compression method. Pre and post compression parameters were found to be within specified limits. The tablets were evaluated for weight variation, drug content, hardness, friability, permeation studies and In vitro residence time. FTIR studies indicate that there is no interaction between drug and polymers. The result of permeation of drug indicates that the formulation- F5 showed maximum drug permeation up to 12 h and maximum in vitro residence time. The result indicates that felodipine mucoadhesive buccal tablets may be good choice to bypass hepatic first pass metabolism with an improvement in the bioavailability through buccal mucosa.

Cite this article as: P. Dwarakanadha Reddy, R. Balanjineyulu, D.Swarnalatha, A.V Badarinath, C.Gopinath,Design, development and In vitro characterization of Felodipine Mucoadhesive buccal tablets,Journal of Pharmacy Research 2015,9(2),170-176.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-PCS-0000431
Title: Formulation and Evaluation of Fast Dissolving Tablets of Ranitidine Hydrochloride
Category: Pharmaceutics
Section: Research Article
Country: India
View Article

Aim: The present work fast dissolving tablets of Ranitidine Hydrochloride were designed with a view to provide quick onset of action. Ranitidine Hydrochloride which is a histamine H2-receptor antagonist belongs to class–III of Biopharmaceutical classification system. Methods: Fast dissolving tablets were prepared by direct compression method by using various super disintegrants like kollidon, croscarmellose sodium, kyron and sodium starch glycolate. Results: The powder blend was evaluated for pre-compression parameters in order to assess the flow properties of powder like bulk density, tapped density, compressibility index, hausner’s ratio, angle of repose. The powder blend showed excellent flow properties. The prepared tablets were evaluated for thickness, hardness, friability, disintegration time and in vitro dissolution studies for a period of 1 hour. Conclusion: Among all prepared tablets the (F -5) formulation containing kollidon 12.5 % w/w were emerged as the best formulation and the in vitro drug release was found to be within 30 min compared to all superdisintegrants.

Cite this article as: Bookya Padmaja, Raparla Ramakrishna, Goutham Goud, Formulation and Evaluation of Fast Dissolving Tablets of Ranitidine Hydrochloride,Journal of Pharmacy Research 2015,9(2),165-169.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-PTD-0000225
Title: Reverse micellar extraction: technological aspects, applications and recent developments
Category: Pharmaceutical Technology Development
Section: Review Article
Country: India
View Article

The final objective of any bioprocess industry is to obtain product of desired purity with maximum activity recovery especially in case of proteinaceous products. The unit operation involved for the separation and purification of the desired product is known as the downstream processing (DSP). Among various processes reverse micellar extraction (RME) has gained a wide attention in recent years due to its several advantages over other techniques which include ease of scale up, protein separation with maximum activity recovery, continuous operation, biocompatibility, high capacity and off course the cost effectiveness which inherently comes with the recycling opportunity of the organic phase. This review article is a detailed account of the RME system and its applications. The whole tri-component system is mainly composed of solvent, cosolvent and surfactant. The process of extraction is controlled by various factors viz. concentration and type of surfactant, size of the reverse micelle (RM), water content, aqueous phase pH, ionic strength and type, temperature etc. There are three methods of protein solubilisation dry addition, injection and phase transfer. Although it has currently wide range of applications especially in case of food products, integration of RME with the other DSPs has shown promise able results with the increase of protein recovery and purification fold. Recently patents have also been issued on the use of RME in supercritical fluid and in case of extraction of protein from a solid support. Development of reliable RME technique has also been resulted in separation of pharmaceutical grade plasmid DNA from RNA. Potential edge of this technology over others has opened a new field of research for future. Works are required to be done in making the technology friendly for scale up and commercialisation with continuous development in case of more biocompatibility, economic feasibility and better solute transfer rate.

Cite this article as: Aritra Saha, Richa Yadav,Reverse micellar extraction: technological aspects, applications and recent developments, Journal of Pharmacy Research 2015,9(2),145-156.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-PCS-0000224
Title: Formulation and evaluation of solid dispersions of valsartan for dissolution rate enhancement
Category: Pharmaceutics
Section: Research Article
Country: India
View Article

Objective: The objective of the study was to formulate solid dispersions of Valsartan using hydrophilic carriers in different concentrations and to determine their effect on solubility of drug. Methods: Solid dispersions of Valsartan were prepared using urea, PEG4000 as carriers in different drug: carrier ratios of 1:1, 1:2, and 1:4 by employing solvent evaporation method. Physical mixtures were also prepared for the above ratios. The prepared physical mixtures and solid dispersions were evaluated for flow properties, solubility studies, drug content and In-vitro dissolution studies. Results: The prepared physical mixtures and Solid dispersions of Valsartan showed good flow property and uniformity in drug content. From the saturated solubility studies and In-vitro dissolution studies it was observed that there was increase in solubility of drug and enhanced dissolution rate in solid dispersions compared to physical mixtures respectively. Formulation containing 1:4 ratio of drug: PEG4000 is considered as best formulation as it has shown highest drug release in short time i.e. 99.86 % in 20min. Conclusion: Our studies showed that the solubility of the drug can be significantly enhanced with solid dispersions of the studied polymers. With increase in the carrier content there is increase in the solubility resulting in enhanced dissolution rate.

Cite this article as:T. S. N. S. Varalakshmi, Ch. Siva Ramesh, I. Jyothi, Y. Jyothi, G. Bharathi, P. Chinni Babu,Formulation and evaluation of solid dispersions of valsartan for dissolution rate enhancement,Journal of Pharmacy Research 2015,9(2),139-144.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-P'Col-0000223
Title: Evaluation of Cissampelos pareira root for antifertility activity
Category: Pharmacology
Section: Research Article
Country: India
View Article

Bacground: The practice of traditional medicine for the control of fertility in most parts of India is based on the uses of plant medicines for many years. Cissampelos pareira Linn. is one of the folk medicinal plants commonly used as antifertility agent in some places of India. Objective: The aim of the present study was to evaluate the antifertility effect of the methanolic extract of Cissampelos pareira root with mechanism of action. Methods: The methanolic extract of Cissampelos pareira root were investigated for its effect on estrous cycle, effect on implantation and reproductive hormones in female rats at two oral dose level: 250 mg/kg and 500 mg/kg. Serum estradiol and progesterone level were estimated by ELISA method. Serums were isolated from blood samples collected on 12th, 19th, and 21st day of pregnancy.Results: No significant effect on extending the estrous cycle has been found with methanolic extracts of Cissampelos pareira root [CPR] treated group as compared to control group. Reduction in the number of implants in CPR treated group is significant. Furthermore, there is no significant change in serum estradiol and progesterone level from day 12th to 19th in CPR treated groups as compared to control group. Conclusion: All these observations suggest that CPR neither has any effect on extending the estrous cycle nor on implantation. We may conclude that alkaloids, the chief chemical constituent, present in CPR has no role in regulating the fertility.

Cite this article as:Jhuma Samanta , Dr. Snehendu Bhattacharya, Dr.Avtar Chand Rana,Evaluation of Cissampelos pareira root for antifertility activity,Journal of Pharmacy Research 2015,9(2),134-138.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-PA-0000222
Title: Development and Validation for the Simultaneous Estimation of Moxifloxacin Hydrochloride and Bromfenac Sodium by RP- HPLC
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
View Article

In the present study an HPLC method was developed and validated for the simultaneous determination of Moxifloxacin Hydrchloride and Bromfenac Sodium. The chromatographic system was equipped with SULPELCO 516 C-18 column and UV detector set at 275 nm, in conjunction with a mobile phase of 0.05 M Potassium Dihyrdrogen Phosphate (pH 4.5) and Acetonitrile (60:40%V/V) at a flow rate of 1.0 ml/min and the injection volume set at 20 μl with 10 minutes of runtime. The described method was linear over a concentration range of 5.5-27.5 μg/mL for MOX and 1-5 μg/mL for BROM with a with good linearity response of 0.9996 and 0.9994 respectively. The retention time of Moxifloxacin Hydrchloride was 3.970 min ± 0.29 and of Bromfenac Sodium was 5.000 min ± 0.15. The results of analysis were validated. The results of the study showed that the proposed RP-HPLC method was simple, rapid, precise and accurate, which is useful for the routine determination of Moxifloxacin Hydrochloride and Bromfenac sodium in bulk drug and in pharmaceutical dosage form.

Cite this article as:S. P. Desai, K. J. Kalaveni, P. Malairajan,Development and Validation for the Simultaneous Estimation of Moxifloxacin Hydrochloride and Bromfenac Sodium by RP- HPLC ,Journal of Pharmacy Research 2015,9(2),129-133

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-PC-0000221
Title: Synthesis of Novel Hetero Cyclic Dithiocarbamate Metal Complexes and Study of their Biological Activity
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
View Article

Dithiocarbamates (DTC) are well known compounds to bind strongly and selectively to many metal ions, so in the past few years self-assembly directed by metal–dithiocarbamate coordination has emerged as a useful supramolecular methodology for the preparation of macrocycles, cages, catenanes, and nanoparticles. Most of the applications are based on complexation properties of DTC ligands with metal ions, especially with transition metal ions. DTC ligands readily form chelates with all transition metal ions through its two donor sulfur atoms. In the present investigation carried out a synthesis of as such new dithiocarbamates derived from unique series of heterocyclic amines, 4 –amino 1,2,4-triazole ,2-amino-3-hydroxy pyridine, 3-amino-9-ethyl carbazole, furfryl amine and 2-amino-4-hydroxy-6-methyl pyrimidine with Carbon disulphide, and characterized using elemental analyses, FT-IR, NMR. The antibacterial activities of synthesized compounds were studied against two Gram-negative species, Escherichia coli, Klebsiella pneumoniae and one Gram-positive species, Bacillus subtilis.

Cite this article as: K. Venugopal, A. Jayaraju and J. Sreeramulu*,Synthesis of Novel Hetero Cyclic Dithiocarbamate Metal Complexes and Study of their Biological Activity,Journal of Pharmacy Research 2015,9(2),125-128

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-PC-0000220
Title: Determination and characterization of process impurities in Tolvaptan drug substance
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
View Article

An accurate and sensitive reverse phased liquid chromatographic method was developed for the determination of three process impurities in Tolvaptan (TPN) drug substance. Structural confirmation and characterization of these three process impurities was carried out by using proton and carbon magnetic resonance spectroscopy (PMR, CMR) and Liquid chromatography coupled with mass spectrometry (LC-MS). Based on the spectroscopic studies three unknown process impurities were characterized as (4-Amino-2-methylphenyl)(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-1-yl)methanone (TPNRC01) 7-Chloro-1-[2-methyl-4-[(2-methyl benzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine (TPNRC02) and 4-[(5-Hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl) carbonyl]-3-methylphenyl-2-methylbenzamide (TPNRC03) . The newly developed method was validated according to ICH guidelines considering three process impurities to demonstrate specificity, precision, linearity and accuracy of the method. The Limit of detection for the three process impurities were 0.0005, 0.0008 and 0.0005 mg mL-1 respectively and limit of quantitation detection for the three process impurities were 0.0015, 0.0016 and 0.0016 mg mL-1 respectively. The newly developed method was found to be highly efficient, selective, sensitive and accurate.

Cite this article as:Sharada Musty, Ravichandrababu Rupakula, Sitaram Cheekatla, and B N Reddy, Determination and characterization of process impurities in Tolvaptan drug substance,Journal of Pharmacy Research 2015,9(2),119-124.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-PHDRS-0000217
Title: Preliminary phytochemical analysis and anti-oxidant activity of Trichosanthes cucurmerina L. (Cucurbitaceae)
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
View Article

Trichosanthes cucumerina L. is an important medicinal plant belonging to the family Cucurbitaceae. It is an annual climber. It has wide range of medicinal properties like anti-diabetic, anthelmintic, anti-cardiac failure, hypoglycaemic, anti-fertility, anti-inflammatory and against to HIV. The present study is focused on phytochemical analysis of different solvent system of whole plant of the T.cucumerina. The phytochemical analysis is done in plant by using five different solvent systems (Benzene, petroleum ether, chloroform, methanol and distilled water). Result obtained in this study reveals that alkaloids, flavanoids, phenols and tannins are present with high intensity in methanolic extract. A standard procedure was adopted to identify the constituents present in the extract. In vitro antioxidant property of methanolic extract of the whole plant was assessed by DPPH spectrophotometric method. The DPPH radical scavenging activity of extract increased with the increasing concentration. Methanolic extract of whole plant showed significant antioxidant activity. The present study revealed that T.cucumerina is a source of phytochemical and have the activity of the whole plant may be due to the presence of various phytochemicals such as phenols, tannins, flavonoids and alkaloids and other active compounds which need to be investigated further.

Cite this article as:Stephin Stellus and Gangaprasad Appukuttan Nair,Preliminary phytochemical analysis and anti-oxidant activity of Trichosanthes cucurmerina L. (Cucurbitaceae),Journal of Pharmacy Research 2015,9(2),101-104

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-MB-0000330
Title: Effectiveness of a Bacillus megaterium, as a probiotic in Salmonella typhimurium induced infection in rats
Category: Microbiology
Section: Research Article
Country: India
View Article

Background: Bacterial infections are common despite prophylactic administration of antibiotics. The wide-spread use of antibiotics in patients has contributed to the emergence of multiresistant bacteria. A restricted use of antibiotics must be followed in most clinical situations. In patients there are several reasons for an altered microbial flora in the gut in combination with an altered barrier function leading to an enhanced inflammatory response. Several experimental and clinical studies have shown that probiotics may reduce the number of potentially pathogenic bacteria and restore a deranged barrier function. Methods: In this study Wistar albino rats were chosen to evaluate the effectiveness of Probiotic therapy by inducing them with infection using known bacterial pathogen Salmonella typhimurium and Treatment with common probiotics such as Bacillus megaterium.After the induction and treatment period the samples (Blood, Serum and tissues) were analyzed for haematological parameters, Biochemical markers and histopathological nature by comparing with non-induced and induced controls. Results and Discussion: The haematological, biochemical and the histopathological parameters studied were comparatively abnormal in induced animals and also they were very close to normal range in rats induced and treated with probiotics. The effectiveness was good for Bacillus megaterium. The reason behind that may be the ways and means how the organisms accommodate and accustom to the intestinal environment. Conclusion: The study has clearly indicated that probiotics could effectively be used for various ailments induced by pathogenic microorganisms.

Cite this article as:R. V. Kalaimathi, C. Kandeepan, P. Sivamani, D. Raghunathan,Effectiveness of a Bacillus megaterium, as a probiotic in Salmonella typhimurium induced infection in rats, Journal of Pharmacy Research 2015,9(2),177-181.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: 2.
Article Id: JPRS-PC-0000400
Title: Synthesis of some derivatives of dimedone, gamma pyrone and barbituric acid.
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
View Article

Aim: Dimedone , gamma pyrone and barbituric acid and their derivatives have also been found to be very important from their application point of view. Thus our aim was to prepare more derivatives from them. Method : Dimedone , gamma pyrone and barbituric acid have been treated with dimethyl sulphoxide and acetic anhydride reagent under varying temperature conditions in order to get more compounds. Result: The interaction of DMSO-Acetic anhydride with Dimedone (1) gives (2) and (3), with gamma pyrone (5) gives (6) ,(7), and with barbituric acid (10) gives (11 ) and (12). Conclusion: A number of compounds were synthesized .