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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 9, Issue: April
Article Id: JPRS-PC-0000616
Title: Spectroscopy and structure of transition metal complexes of hydrazone derivatives
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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The chelating behavior of hydrazones towards some metal complexes has been investigated. The complexes were synthesized using Cu(II), Fe(II) and Hg(II) ions and were characterized by elemental analyses, magnetic susceptibility, FTIR, NMR, Electronic and XRD data. The spectral data showed that the hydrazones were deprotonated during the complexation. The compounds were subjected to simultaneous thermogravimetric analysis to study their decomposition mechanism and thermal stability. The low molar conductivity values of the metal complexes indicate their non-electrolytic nature.

Cite this article as: Kamini J. Donde,pectroscopy and structure of transition metal complexes of hydrazone derivatives,Journal of Pharmacy Research 2015,9(4),299-305.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: April
Article Id: JPRS-P'Col-0000613
Title: Zinc-silibinin complex ameliorates oxidative stress in high fat fed low dose STZ induced type 2 diabetes in rats
Category: Pharmacology
Section: Research Article
Country: India
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Background: Diabetic oxidative stress coexists with a reduction in the antioxidant status, which can further increase the harmful effects of free radicals. Zinc, an essential trace element succeeding iron in the human system, has pivotal role in the synthesis, storage and functional aspects of insulin. Recently, we have designed, synthesized and characterized a novel zinc complex with silibinin as an organic ligand and evaluated its antidiabetic efficacy in high fat fed- low dose STZ induced experimental diabetes in rats. Methods: Diabetic rats were treated with the zinc-silibinin complex (5mg/kg b.w./rat/day) for 30 days showed a significant reduction in the levels of fasting blood glucose, glycosylated hemoglobin (HbA1c) and plasma insulin. The antidiabetic activity of the complex was comparable with metformin, a standard antidiabetic drug. Further, the extent of oxidative stress and the levels of enzymatic and non-enzymatic antioxidants were assayed in control and experimental groups of rats. The levels of proinflammatory cytokines such as (NF)-κB p65, tumor necrosis factors (TNF)-α, interleukin (IL) - 1α and IL-6 were also determined. Pancreatic tissue was subjected to histological observations. Results and Discussion: Oral administration of zinc-silibinin complex significantly controlled the oxidative stress and improved the levels of both enzymatic and non- enzymatic antioxidants. Further, the expression of increased levels of pro-inflammatory markers is also decreased. Histological observations revealed that the zinc-silibinin complex effectively protects pancreatic β- cells against oxidative damage. The results of the present study indicate that the zinc-silibinin complex possess significant antioxidative as well as anti-inflammatory properties.Conclusion: Zinc-silibinin complex significantly ameliorates the chronic hyperglycemia induced oxidative stress in experimental diabetes. The levels of proinflammatory cytokines also provide further evidence for the antioxidant properties of zinc-silibinin complex. Histological observations made on the pancreatic tissues indicate the beneficial as well as the tissue protective nature of zinc-silibinin complex.

Cite this article as: Jaishanker Umamaheswari and Sorimuthu Pillai Subramanian,Zinc-silibinin complex ameliorates oxidative stress in high fat fed low dose STZ induced type 2 diabetes in rats,Journal of Pharmacy Research 2015,9(4),288-298

Journal: Journal of Pharmacy Research , Volume: 9, Issue: April
Article Id: JPRS-PB-0000612
Title: Does hypothetical proteins of Yersinia pestis CO92 Capable of Coding Enzymes?
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Background: Yersinia pestis are known for the plague outbreak and when it has been sequenced for the genome; more than 900 hypothetical proteins have been marked but still the exact functions about those are obscure. Methods: The evidences brought up by the combined results of CDD BLAST, INTERPRSCAN, PFAM and CATH domain search programs enabled to search enzyme functions based on conserved domains available in hypothetical proteins. Results and Discussion: Y. pestis is showcasing 210 hypothetical proteins with enzyme coding ability evident from conserved domains. Conclusion: These Y. pestis hypothetical proteins possesing conserved domains of enzymes may be functioning in cellular metabolism to bring about the virulence.

 

Cite this article as: Sunil Pande and Dilip Gore,Does hypothetical proteins of Yersinia pestis CO92 Capable of Coding Enzymes?,Journal of Pharmacy Research 2015,9(4),278-287.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: April
Article Id: JPRS-ND-0000579
Title: Evaluation of Total Polyphenol and Antioxidant Activity of Leaves of Bambusa nutans and Bambusa vulgaris
Category: Natural Drugs
Section: Research Article
Country: India
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Background: Leaves of several bamboo species have been used to treat a variety of diseases for thousands of years. The medicinal effects of bamboo leaves are mostly attributed to their bioactive polyphenol constituents. However, different classes of polyphenol have different degree of solubility in various solvents, a single solvent will not fully extract all phenolic compounds, thus may exhibit varying antioxidant potency. Methods: The present study was designed to examine extractive values of leaves of Bambusa nutans and Bambusa vulgaris using chloroform, acetone and methanol successively and to evaluate the total polyphenols contents and free radical scavenging capabilities of each extract. The total phenolic content of the various extracts was determined spectrophotometrically using a modified Folin-Ciocalteu method and antioxidant efficacy by following DPPH radical scavenging protocol. The extracts were also subjected to preliminary screening for presence or absences of various phytochemical constituents. Results: The results showed that B. nutans produced better yield of polyphenol [methanol (15.3542 ± 0.1576 mg/ml GAE/100mg extract) > acetone (11.7992 ± 0.5502 mg/ml GAE/100mg extract) > chloroform (10.1618 ± 0.3284 mg/ml GAE/100mg extract)] than corresponding solvent extracts of B. vulgaris [methanol (12.7976 ± 0.4878 mg/ml GAE/100mg extract) > acetone (10.1328 ± 0.2135 mg/ml GAE/100mg extract) > chloroform (8.8549 ± 0.1747 mg/ml GAE/100mg extract)]. The DPPH radical scavenging assay showed that methanol extracts leaves of both the Bamboo species exhibited highest TPC and radical scavenging activity whereas leaves of B. nutans found to be superior to B. vulgaris in term of TPC and radical scavenging potency. Preliminary phytochemical screening of leaf extracts of the two bamboo species indicated the presence of major classes of phytochemicals. Conclusion: The study evidently showed that leaves of B. nutans and B. vulgaris are rich sources of phenolic compounds and natural antixodants and they could be used as natural antioxidant. The study further indicated methanol as the appropriate extractant for better yield of polyphenols and leaf extract of Bambusa nutans is superior to that of B. vulgaris in term of TPC and antioxidant efficacy.

Cite this article as: Y.C. Tripathi, Zayd Jhumka and Nishat Anjum ,Evaluation of Total Polyphenol and Antioxidant Activity of Leaves of Bambusa nutans and Bambusa vulgaris,Journal of Pharmacy Research 2015,9(4),271-277

Journal: Journal of Pharmacy Research , Volume: 9, Issue: April
Article Id: JPRS-PB-0000578
Title: Plumbago zeylanica Extract Inhibits Cyclin D1, NF-kß and Induces Apoptosis in Oral Cancer Cells
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Background: Plumbago zeylanica (PZ), a promising medicinal plant possess a variety of pharmacological activities, however, its anti-cancer activity in oral squamous cell carcinoma (OSCC) has not been investigated so far. Methods: In the present study, we investigated the anti-cancer effects of PZ in oral cancer cell lines (KB, SCC-4). MTT assay was used to evaluate tumour cell growth inhibition, flow cytometry and DNA analysis for cell cycle arrest, annexin-V binding assay for apoptosis and western blot assay for expression of different regulatory proteins such as cyclin D1, nuclear factor-kappa beta (NF-κß) and p53. Results and Discussion: Treatment with PZ extract (PZE) significantly decreased cell viability in a dose-dependent manner in both cell lines besides an increase in number of cells arrested in the G2M phase and apoptotic cells. Further PZE downregulated the expression of NF-κß and cyclin-D1, while tend to restored the expression of p53. Conclusion: These results suggest that PZ posses potent anti cancer potential and can be developed as suitable chemopreventive and chemotherapeutic drug for oral squamous cell carcinoma.

Cite this article as:V. Bharti, U. D. Gupta , S. N. Das ,Plumbago zeylanica Extract Inhibits Cyclin D1, NF-kß and Induces Apoptosis in Oral Cancer Cells,Journal of Pharmacy Research 2015,9(4),264-270.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: April
Article Id: JPRS-PCS-0000577
Title: Formulation of taste masked, compression coated, immediate release tablets of oseltamivir phosphate - a preliminary investigation
Category: Pharmaceutics
Section: Research Article
Country: India
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Oseltamivir phosphate, an antiviral drug, is used for prevention and treatment of influenza. It is the API in ‘Tamiflu’ which is widely being used against swine flu. It is an ethyl ester prodrug which gets hydrolyzed to the active oseltamivir carboxylate, a viral neuraminidase inhibitor. It is a water soluble, bitter drug. It is available only as a capsule and as oral suspension for reconstitution before use. Immediate release tablets of oseltamivir phosphate have been tried and subsequently compression coated. Initially the drug was evaluated for compression property and excipient compatibility. Core tablet was prepared by direct compression and gave 99.23% release in 20min. A dry compression coating technology using various fillers was employed to achieve taste masking and impart stability. Selected compression coated tablets of oseltamivir phosphate showed 99% release within 45min. In the taste masking study, no bitterness was perceived by the volunteers. The core tablet and compression coated tablets have been evaluated for stability for period of 2 months at 40°C /75%RH which indicated change in the core tablet that affected the dissolution characteristics of compression coated tablet. Dissolution study after one month stability test showed that only one compression coated formula (CC4) containing calcium sulphate dihydrate and lactose monohydrate as coat material has a mean dissolution time of 14.08 and 17.56 min before and after stability respectively with no significant change in the mean dissolution time as indicated by two sided paired t-test at 2 degrees of freedom, 5% level of significance (n=3) where calculated t value 3.1 is less than the table value 4.93. Further study at accelerated conditions revealed gradual discoloration of the core tablet from off-white to cream and then to yellow. Core and compression coated tablets randomly stored for one year between 15-25°C showed no significant change in physical properties of the tablets. Identifying the instability of discolored tablet is scope for further work. CC4 is the immediate release, taste masked tablet of oseltamivir phosphate suitable for excursions of the formulation beyond 25°C. All the compression coated tablets (except CC7) are suitable for taste masking and immediate release among which CC2 and CC9 gave quicker dissolution of the drug.

Cite this article as: Bala Bharathi P and Madhavi B L R,Formulation of taste masked, compression coated, immediate release tablets of oseltamivir phosphate - a preliminary investigation,Journal of Pharmacy Research 2015,9(4),255-263.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: April
Article Id: JPRS-P'Col-0000576
Title: In vitro study on anticancer activity of pomegranate fruit extract in lymphocytes of breast cancer patients.
Category: Pharmacology
Section: Research Article
Country: India
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Objective:The focal aim of the present study was to investigate the antigenotoxic activities of Pomegranate Fruit Extract (PFE) in human lymphocytes of breast cancer patients in vitro. Methodology:Chromosome aberration (CA) assay were performed. Ten venous blood samples were collected from breast cancer patients who attended the Valavadi Narayanasamy Cancer Centre, G. Kuppusamy Naidu Memorial Hospital, Coimbatore. Four extracts were analyzed for the genotoxicity. Results: Out of the four, methanol extract was found to reduce chromatid type aberration (CTA) and chromosome type aberration (CSA) (34.31±4.81) followed by chloroform extract (5.3 ±2.02). However, petroleum ether extract showed a minimum inhibition (2.9±1.03) and the percentage of inhibition with respect to water extract was found to be nil. The results indicates gradual decrease in the number of CTA in the experimental samples with methanolic extract (5.75 ± 1.5) when compared to control (8.75±3.59) (p=0.01). Meanwhile, CSA also found to reduce significantly in the experimental sample (3.25±1.5) compared to control samples (5.25±2.06) (p=0.01). When total CA (Chromosome aberration) was taken into account, decrease in the experimental samples (9±2.45) compared to that of control samples (13.25±3.40) was found. Conclusion: This study emphasizes the possibility of reduction of CA (Chromosome aberration) and thereby reducing carcinogenicity in people who consume pomegranate regularly. Hence the active ingredients of pomegranate fruits can be recommended for drug formulation.

Cite this article as: Mohan Srividya and Kumaran Sivanandan Santhy,In vitro study on anticancer activity of pomegranate fruit extract in lymphocytes of breast cancer patients,Journal of Pharmacy Research 2015,9(4),250-254.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: April
Article Id: JPRS-PC-0000574
Title: Biological synthesis of silver nanoparticles using aqueous leaf extract of Capparis decidua (FORSK.) EDGEW: A better alternative
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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We biosynthesized the silver nanoparticles (AgNPs) by monitoring the conversion using electrochemistry method. In this study, a simple and rapid biosynthesis of AgNPs using aqueous leaf extract of Capparis decidua have been expected. Stable AgNPs were formed by treating solution using the plant extracts as a reducing agents. Biosynthesized silver nanoparticles were characterized by UV-visible Spectroscopy, Transmission Electron Microscopy (TEM) and Fourier Transform Infra-Red Spectroscopy (FTIR). The UV-visible spectroscopy showed the maximum absorbance at 452 nm. The stability of nanoparticles after two months depicts almost no shift in the absorption intensity and the absorption maxima which indicated that the particle size remained same. The broadening of peak indicated that the particles are polydispersed. TEM analysis of silver nanoparticles (1.5-25 nm) showed formation of circular, triangular, rectangular and oval shaped nanoparticles. Very small size range of silver nanoparticles may make it a good antimicrobial agent. The stabilization of the nanoparticle is believed to occur by the functional groups like amines, amides, alkynes, alkenes, bromoalkanes etc. as identified by FTIR analysis. The absorbance bands analysis in bioreduction are observed in the region of 375-4000cm. This environmentally friendly method provides faster rates of biosynthesis and can potentially be used in various areas such as cosmetics, food, medicals and antibacterial effects.

Cite this article as: Jyoti Ahlawat and Anita R Sehrawat,Biological synthesis of silver nanoparticles using aqueous leaf extract of Capparis decidua (FORSK.) EDGEW: A better alternative,Journal of Pharmacy Research 2015,9(4),244-249.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: April
Article Id: JPRS-PCS-0000550
Title: Formulation and evaluation of ranitidine loaded eudragit rs100 microspheres
Category: Pharmaceutics
Section: Research Article
Country: India
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BACKGROUND: Microencapsulation is an innovative process by which small particles like solids and liquids are entrapped in a uniform shell. Microencapsulation technique employs coating of very small particle with protecting coating by various polymers with high potential that retards the drug release. Ranitidine is a histamine H2 receptor antagonist that restrain acid secretion in the stomach. More widely it is used in the treatment of peptic ulcer and gastroesophageal disease. AIM: The rationale that lies behind this technique is to achieve a controlled and delayed release with enhancement of stability and good shelf life. In the present study ranitidine loaded Eudragit RS100 microspheres were prepared by three different methods, characterized and evaluated to get more prolonged and effective delivery of ranitidine. MATERIALS AND METHODS: Three batches of Ranitidine loaded Eudragit RS 100 were prepared by solvent evaporation technique using the drug to polymer ratio (1:4), organic phase to aqueous phase ratio (1:5) and stabilizer concentration (1% w/v). Three batches of RES3 showed reproducibility of the products. The , particle size, yield and entrapment efficiency of RES3 which show there is prominent sustained drug release attributed on the nature of polymer. RESULTS AND DISCUSSION: The particle size measured by SEM was relatively smaller than the particle size measured by Malvern particle size analyzer. The drug release from the formulation RES3 was slow and extended beyond 12 h up to 24 h . After 4 h the rapid drug release occurred due to of polymer erosion in the surface of microspheres and consequent release of drug which has been loaded near the surface of the microspheres. It obeys Higuchi and Peppas equation suggesting mechanism for drug release from the microspheres follows diffusion an dissolution. CONCLUSION: RES3 batch showed good stability makes it a promising tool for sustained drug delivery and will enhance patient compliance. Hence it is concluded that is concluded that the method of preparation of microspheres was found to be simple, reproducible, and provides good yield.

Cite this article as: Gowri. R, Narayanan. N, Formulation and evaluation of ranitidine loaded eudragit rs100 microspheres,Journal of Pharmacy Research 2015,9(4),237-243.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: April
Article Id: JPRS-HM-0000549
Title: Pharmaceutical activities of Phytochemicals in Murraya spp. - a review
Category: Herbal medicine
Section: Review Article
Country: India
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Murraya is one of the 150 genera from the family Rutaceae. Of the 14 global species belonging to this genus, only three species i.e. Murraya koenigii, Murraya paniculata and Murraya exotica have been found in India. The plant Murraya paniculata is native to South-west Asia. The leaves have been reported to possess stimulant and astringent properties. The plant Murraya koengii is a tropical to sub-tropical tree. It is native to India and now widely distributed in most of Southern Asia. The plant has anti-inflammatory, antiamnesic, anti-diabetic, anti-fungal, anti-bacterial, anti-helminthic and anti-cancer and anti-oxidative properties. The leaf, flower and fruit extracts of Murraya exotica have been reported to show anti-bacterial effect. The main categories of phytochemicals present in Murraya spp. include carbazole alkaloids, coumarins and flavonoids. Keeping this in mind an attempt has been made to review briefly the pharmaceutical activities of phytochemicals of Murraya spp. belonging to the family Rutaceae.

Cite this article as: Saloni Sharma, Saroj Arora,Pharmaceutical activities of Phytochemicals in Murraya spp. - a review,Journal of Pharmacy Research 2015,9(4),217-236

Journal: Journal of Pharmacy Research , Volume: 9, Issue: April
Article Id: JPRS-PA-0000556
Title: Development and validation of stability indicating UPLC method for the quantitative determination of related substances in moxifloxacin hydrochloride
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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The present paper describes the development of a simple, economic and time efficient stability indicating UPLC method for Moxifloxacin HCl in the presence of its impurities and degradation products generated from forced degradation studies. The drug substance was subjected to stress conditions of acid hydrolysis, base hydrolysis, oxidative hydrolysis, photolysis and thermal degradation. The degradation of moxifloxacin hydrochloride was observed under oxidative hydrolysis and base hydrolysis. The drug was found to be stable in all other stress conditions applied. Successful separation of the drug from synthetic impurities and degradation products formed under forced degradation was achieved on a Acquity UPLC BEH C18 column using a mixture of potassium di hydrogen phosphate buffer and methanol (80:20, v/v) as mobile phase in a gradient elution mode. The eluents were monitored at 240 nm. The developed UPLC method was validated with respect to linearity, accuracy, precision, specificity and robustness. It can be used to test the stability samples of moxifloxacin HCl.

Cite this article as: B. Lakshmi Sushma, G. Madhusudhan , A. Jayashree ,P. Srinivasulu, Y.Koti Reddy, Development and validation of stability indicating UPLC method for the quantitative determination of related substances in moxifloxacin hydrochloride,Journal of Pharmacy Research 2015,9(4),211-216.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: April
Article Id: JPRS-BMB-0000548
Title: Modulatory effect of black tea on survival and apoptotic proteins in placental Trophoblast and explants during Preeclampsia
Category: Biochemistry and Molecular Biology
Section: Research Article
Country: India
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Preeclampsia is a multifactorial pregnancy-specific disease that involves the failure of various body systems and whose etiology has been associated with multiple causes. Oxidative stress plays a pivotal role in pathogenesis of preeclampsia. Induction of HO-1 occurs as an adaptive and beneficial response to several injurious stimuli including heme and this inducible nature of HO-1 signifies its importance in several pathophysiological disease states. CYP 19A1 is a prime enzyme that catalyzes the conversion of androgens to estrogens. Oxidative stress is one of the most potent activators of ASK1, which is essential for oxidative stress induced cell death. Black tea is an alternative natural medicine used for the management and treatment of preeclampsia and its associated complications. The present study aims to analyze the prophylactic effect of black tea in the modulation of oxidant-antioxidant status (4-HNE and GSH), HO-1, CYP 19A1 and ASK1 expressions during normotensive and preeclamptic placental trophoblast and placental explants. A significant increase in the level of 4-HNE, ASK1 along with decrease in the level of GSH, HO-1 and CYP 19A1 was observed in preeclamptic placental trophoblast and placental explants respectively. The level of 4-HNE, GSH, HO-1, CYP 19A1 and ASK1 was altered upon the incubation of black tea extracts in preeclamptic placental trophoblast and placental explants respectively. In view of these results, black tea may emerge as an effective antioxidant, protecting cells from adverse conditions and this may be useful for the treatment of pregnancy related complications like preeclampsia.

Cite this article as: Padmini Ekambaram, Christina Joseph Mary Susai, Tharani Jayachandran and Sheila Leonard,Modulatory effect of black tea on survival and apoptotic proteins in placental Trophoblast and explants during Preeclampsia,Journal of Pharmacy Research 2015,9(4),201-210