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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 9, Issue: May
Article Id: JPRS-P'Col-00001073
Title: Protective effect of Cardiospermum halicacabum against Cadmium toxicity induced oxidative damage and biomarker enzymes alterations in the Fresh water Crab, Paratelphusa hydrodromaus
Category: Pharmacology
Section: Research Article
Country: India
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Cadmium is a heavy metal widely used in industrial processes, has been recognized to be a highly toxic and dangerous environmental pollutant. These excess amounts in addition to naturally occurring levels gradually build up to toxic levels causing damages to the biota of the aquatic ecosystem. The fresh water field crab, Paratelphusa hydrodromous is an important human food source in parts of South India.  Evaluation of the toxic effect of cadmium on the experimental crab for the LC50 value was carried out. Effect of cadmium on the oxidative damage and biomarkers antioxidant enzymes in the hepatopancreas was observed. Quantitative study of antioxidant enzymes GSH, GPx, ACP and ALP were undertaken, result and discussed in detail.

Cite this article as:K. Pugazhendy, A. Revathi, Kadarkarai Murugan and Jiang-Shiou Hwang,Protective effect of Cardiospermum halicacabum against Cadmium toxicity induced oxidative damage and biomarker enzymes alterations in the Fresh water Crab, Paratelphusa hydrodromaus,Journal of Pharmacy Research 2015,9(5),337-342.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: May
Article Id: JPRS-PA-0000712
Title: Novel extractive spectrophotometric methods for estimation of levofloxacin in Bulk and formulations
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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Sophisticated analytical methods like HPLC and Mass spectroscopic methods which being employed for analysis, are relatively expensive and hence there is a need for developing simple analytical methods. In the proposed work, such methods have been developed and applied for routine determination of levofloxacin in pharmaceutical formulations and bulk dosage forms. These methods were based on the formation of colored species on binding of Erichrome black-T (EBT) in the presence of chloroform for method A and binding of Bromo phenol blue (BPB) in the presence of chloroform for method B, and the colored chromogen obtained in each method was finally treated with the drug levofloxacin to produce yellow colored for method A and purple colored chromogen for method B with λmax at 600nm and 421 nm respectively. Statistical analysis of these methods exhibited Sandell’s Sensitivity of 0.0588 and 0.0277 (Method A and B) respectively, and the relative standard deviation (RSD) of these methods were found equal to 1.35 and 1.59 respectively, indicating that these methods are highly reproducible, based on the principle of absorption visible spectrophotometry for the determination of levofloxacin in formulations and bulk dosage forms.

Cite this article as: Vijaya Saradhi Settaluri, Samar Mohammed Khalaf Al-Saidi, Nahla Mubarak Saleh Al-Mashari,Novel extractive spectrophotometric methods for estimation of levofloxacin in Bulk and formulations, Journal of Pharmacy Research 2015,9(5),332-336

Journal: Journal of Pharmacy Research , Volume: 9, Issue: May
Article Id: JPRS-PC-00001025
Title: Determination of terbinafine hydrochloride in pharmaceuticals by ion-pair extractive spectrophotometry with thymol blue sodium
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Background: Terbinafine hydrochloride (TBH) is a powerful antifungal agent indicated for both oral and topical treatment of mycoses and dermatomycoses. The need for simple, rapid, sensitive and cost-effective methods in pharmaceutical quality control and clinical laboratories need not be overemphasized. The therapeutic importance of TBH prompted the development of three spectrophotmetric methods (methods A, B and C) for its determination in bulk form and tablets. Methods: The assays were developed using Systronics Model 166 digital spectrophotometer based on the reaction of TBH with the dye, thymol blue. Method A is based on the formation of ion-pair complex between TBH and thymol blue sodium (TBS) in acidic buffer, which was extracted into chloroform and measured at 420 nm. Method B and method C involve breaking the drug-dye complex with either alcoholic H2SO4 (method B) or alcoholic KOH (method C) followed by the measurement of the resulting pink colour at 570 nm or the blue colour at 620 nm. Results and discussion: Under optimum conditions, the absorbance of the coloured species was found to increase linearly with concentration of drug (r > 0.9988) and Beer’s law was obeyed over the ranges, 10-70, 5-50, and 10-60 µg mL-1, respectively, with corresponding molar absorptivity values of 3.91×103, 2.99×103, and 1.94×103, L mol-1 cm-1. The methods were validated with respect to limits of detection (LOD) and quantification (LOQ), accuracy and precision, and also robustness and ruggedness. The stoichiometry of the complex was determined to be 1:1 (drug: due) by Job’s method. All the three methods were applied to tablets without detectable interference from the associated additives and excipients. The results compared favourably with the label claim and those of the Pharmacopoeial method as shown by Student’s t and F- tests. The accuracy was further evaluated by recovery experiment using standard- addition method. The selectivity of the methods was established by placebo blank and synthetic mixture analyses. Conclusion: The content of TBH in tablets used in the treatment of mycoses and dermatomycoses was determined by three visible spectrophototmetric methods. Selectivity of the methods was established by placebo blank and synthetic mixture analyses with excellent recovery from the latter. The methods were demonstrated to be superior to many published methods with respect to vital performance characteristics such as linear range, sensitivity and selectivity.

Cite this article as:Nagib Abdullah S.Q, Basavaiah K, Swamy N, and Chandrashekar U,Determination of terbinafine hydrochloride in pharmaceuticals by ion-pair extractive spectrophotometry with thymol blue sodium, Journal of Pharmacy Research 2015,9(5),330-338.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: May
Article Id: JPRS-PHDRS-0000772
Title: Application and Analysis of the Folin Ciocalteu Method for the Determination of the Total Phenolic Content from Leaves, Stems and Seeds of Cucumis sativus L.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
Country: India
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Cucumis sativus L. is a annual climber belongs to the family cucurbitaceae. Cucumber is a native to the tropics and is one of the oldest cultivated vegetable crop. C. sativus (CS) is growing widely throughout the Bangladesh, Indian subcontinent, Sri Lanka. It is an important medicinal plant with diverse pharmacological spectrum widely used in Ayurveda, Siddha, Chinese medicine etc. Plant has many important phytoconstituents like glycosides, flavones, terpinoids, phytosterol, saponins etc responsible for many of the pharmacological activities such as antibacterial, antifungal, antidiabetic, cytotoxic, antacid, hepatoprotective activity, wound healing activities. The aim of the present study was to develop and validate an analytical method to determine the content of total polyphenols (TP) in an extract from C. sativus leaves, stems and seeds, by the UV/Vis spectrophotometric method. The crude extract was used to develop a method for TP assay. The optimum conditions for analysis time, wavelength and standard substance were 30 min, 760 nm and gallic acid, respectively. Under these conditions, validation as per ICH guidelines proved the method to be linear, specific, precise, accurate, reproducible, robust, and easy to perform. This methodology complies with the requirements for analytical application and to ensure the reliability of the results.

Cite this article as: Anjoo Kamboj, Ankita Rana, Ripanjot Kaur, Upendra K Jain,Application and Analysis of the Folin Ciocalteu Method for the Determination of the Total Phenolic Content from Leaves, Stems and Seeds of Cucumis sativus L.,Journal of Pharmacy Research 2015,9(5),323-329.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: May
Article Id: JPRS-PC-0000704
Title: Microwave assissted synthesis of pyrazoline-coumarin hybrids and their in-vitro antimalarial evaluation
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Aim: Synthesis of pyrazoline-coumarin hybrids and evaluation of their in-vitro antimalarial activity. Method: It involved three steps. In the first step 3-acetyl coumarin was synthesised which on reaction with different aromatic aldehydes yielded chalcones. These chalcones were then reacted with hydrazine hydrate, phenyl hydrazine and isoniazid (INH) to yield the corresponding pyrazolines. The synthesised compounds were characterised by using IR, NMR and Mass spectral data. Compounds were evaluated for their in-vitro antimalarial activity against 3D7 P. falciparum using chloroquine as standard drug by Schizont maturation inhibition assay. Result: The pyrazolines formed from INH are better inhibitors compared to those formed from hydrazine hydrate or phenyl hydrazine. Compound 3h was found to be the best active compound in the series with an IC50 9.684µg/mL. Conclusion: An increase in bulkiness of the molecule results in an increase in in-vitro antimalarial activity.

Cite this article as: Wasim Akhter, Akranth Marella, M. Shaquiquzzaman, Mymoona Akhter, M. Mumtaz Alam,Microwave assissted synthesis of pyrazoline-coumarin hybrids and their in-vitro antimalarial evaluation,Journal of Pharmacy Research 2015,9(5)318-322

Journal: Journal of Pharmacy Research , Volume: 9, Issue: May
Article Id: JPRS-PTD-0000695
Title: Validation of ultrasonic spray coating technology of coronary stents by micro-mist method - Evaluation and release studies on Everolimus coated stents with Biodegradable polymer
Category: Pharmaceutical Technology Development
Section: Research Article
Country: India
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Aim: This study was designed to evaluate the validated ultrasonic spray coating of coronary stents and its release kinetics. Methods and results: For evaluation of validated ultrasonic spray coating of coronary stents by micro-mist spray nozzle - gravimetric analysis of coated stents, total drug loading, coating thickness and uniformity and release kinetics methods were performed. The formulation loaded on 13mm, 24mm, 32mm lengths of coronary stents was 164.2±1.8, 289±12.21 , 390.6±12.84 µg and the total everolimus loaded on PRISTINE (Everolimus eluting coronary stent system) stents was 83.9±1.1, 154.8±1.1, 188.9±2.4 µg respectively. The Scanning Electron Microscopic (SEM) images of stents showed that there is uniformity in coating. There is a less than 5% deviation in in vitro elution profile of coated stents obtained from USP Apparatus-IV over 120 days Conclusion: These results demonstrate the accuracy and consistency of coating achieved by using ultrasonic micro-mist spray technology.

Cite this article as: Prashanth Srirangam, Indramani Singh Athokpam, Devender Poreddy, Madhu Burra, Srinivas Pilli,Vidya sagar Jinugu, Validation of ultrasonic spray coating technology of coronary stents by micro-mist method - Evaluation and release studies on Everolimus coated stents with Biodegradable polymer,Journal of Pharmacy Research 2015,9(5),313-317.